The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1

EMBO Journal

Volumn 26, Issue 21, 2007, Pages 4523-4534

  Cinar, Bekir ^a,b   Fang, Ping Ke ^a,b   Lutchman, Mohini ^a,b   Di Vizio, Dolores ^a,b   Adam, Rosalyn M ^a,b   Pavlova, Natalya ^b   Rubin, Mark A ^c   Yelick, Pamela C ^d,e   Freeman, Michael R ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d TUFTS UNIVERSITY   (United States)

^e Tufts University   (United States)

Author keywords

Apoptosis; Kinases; Lipid rafts; Prostate cancer; Protein complex

Indexed keywords

CASPASE; LIPID; MST1 PROTEIN; MULTIPROTEIN COMPLEX; PHOSPHOTRANSFERASE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL GROWTH; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME LOCALIZATION; HORMONE RESISTANCE; HUMAN; HUMAN CELL; MALE; METASTASIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN ISOLATION; PROTEIN TARGETING; SEQUENCE HOMOLOGY; TUMOR GROWTH; ZEBRA FISH;

ANIMALS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MEMBRANE MICRODOMAINS; MODELS, BIOLOGICAL; PHENOTYPE; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; ZEBRAFISH;

DANIO RERIO;

EID: 35649014941     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601872     Document Type: Article

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