MST1-JNK promotes apoptosis via caspase-dependent and independent pathways

Genes to Cells

Volumn 6, Issue 6, 2001, Pages 519-530

  Ura, Seiji ^a   Masuyama, Norihisa ^a   Graves, Jonathan D ^b   Gotoh, Yukiko ^a,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CASPASE; CASPASE 3; CASPASE INHIBITOR; DNA FRAGMENT; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PROTEIN INHIBITOR; SYNAPTOPHYSIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CELL STRUCTURE; CHROMATIN CONDENSATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MEMBRANE; MUTANT; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; CASPASES; COS CELLS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0034933130     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.2001.00439.x     Document Type: Article

References (49)

1. Bacterial lipopolysaccharide disrupts endothelial monolayer integrity and survival signaling events through caspase cleavage of adherens junction proteins
2. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases
3. DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis
4. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation
5. The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain
6. Cloning and characterization of a member of the MST subfamily of Ste20-like kinases
7. Proteases to die for
8. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
9. A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA
10. Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1
11. SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis
12. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
13. Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development
14. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
15. Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death
16. Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis
17. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
18. Proteolytic activation of MST/Krs, STE20-related protein kinase, by caspase during apoptosis
19. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death
20. FAK and disassembly of focal adhesions in human endothelial cell apoptosis
21. The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis
22. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
23. UV irradiation-induced apoptosis leads to activation of a 36-kDa myelin basic protein kinase in HL-60 cells
24. Involvement of caspase 3-activated DNase in internucleosomal DNA cleavage induced by diverse apoptotic stimuli
25. An auxiliary mode of apoptotic DNA fragmentation provided by phagocytes
26. Extranuclear apoptosis. The role of the cytoplasm in the execution phase
27. The p38 signal transduction pathway: Activation and function
28. Expression of the baculovirus p35 gene inhibits mammalian neural cell death
29. Bisphosphonates act directly on the osteoclast to induce caspase cleavage of MST1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase
30. Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2
31. Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation
32. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
33. Apoptotic nuclear morphological change without DNA fragmentation
34. Caspases: Intracellular signaling by proteolysis
35. Role of TAK1 and TAB1 in BMP signaling in early Xenopus development
36. Two distinct pathways leading to nuclear apoptosis
37. Newly identified stress-responsive protein kinases, Krs-1 and Krs-2
38. DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis
39. Caspases: Enemies within
40. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
41. Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases
42. Cell death in development
43. Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
44. Activation of MST/Krs and c-Jun N-terminal kinases by different signaling pathways during cytotrienin A-induced apoptosis
45. Requirement of protein kinase (Krs/MST) activation for MT-21-induced apoptosis
46. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
47. Daxx, a novel Fas-binding protein that activates JNK and apoptosis
48. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
49. Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo