Proteasome inhibitors up-regulate haem oxygenase-1 gene expression: Requirement of p38 MAPK (mitogen-activated protein kinase) activation but not of NF-κB (nuclear factor κB) inhibition

Biochemical Journal

Volumn 379, Issue 3, 2004, Pages 587-593

  Wu, Wen Tung ^a   Chi, Kwan Hwa ^b   Ho, Feng Ming ^c   Tsao, Wei Chia ^a   Lin, Wan Wan ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c TAO YUAN GENERAL HOSPITAL   (Taiwan)

Author keywords

Haem oxygenase 1; Leptomycin B; p38; Proteasome inhibitor; Pyrrolidine dithiocarbamate (PDTC); Reactive oxygen species

Indexed keywords

AMINO ACIDS; ANTIOXIDANTS; ENZYMES; GENES; SYNTHESIS (CHEMICAL);

CELL FUNCTIONS; OXIDATIVE INJURY;

BIOCHEMISTRY;

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ANTIOXIDANT; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CYCLOHEXIMIDE; DACTINOMYCIN; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEPTOMYCIN B; LIPOPOLYSACCHARIDE; MESSENGER RNA; MG 262; MITOGEN ACTIVATED PROTEIN KINASE; PROTEASOME INHIBITOR; PYRROLIDINE DITHIOCARBAMATE; SYNAPTOPHYSIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; GENE EXPRESSION; GENE EXPRESSION REGULATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; STEADY STATE;

ANIMALS; CELL LINE; CELL SURVIVAL; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; I-KAPPA B KINASE; LEUPEPTINS; LIPOPOLYSACCHARIDES; MEMBRANE PROTEINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MULTIENZYME COMPLEXES; NF-KAPPA B; NITRITES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROLINE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; THIOCARBAMATES; TIME FACTORS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; UP-REGULATION;

ANIMALIA;

EID: 2542626623     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20031579     Document Type: Article

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