Rottlerin induces heme oxygenase-1 (HO-1) up-regulation through reactive oxygen species (ROS) dependent and PKC δ-independent pathway in human colon cancer HT29 cells

Biochimie

Volumn 92, Issue 1, 2010, Pages 110-115

  Park, Eun Jung ^a   Lim, Jun Hee ^a   Nam, Sung Il ^a   Park, Jong Wook ^a   Kwon, Taeg Kyu ^a  

^a Keimyung University   (South Korea)

Author keywords

Heme oxygenase 1; HT29 cells; NF E2 related factor 2 (Nrf2); PKC ; Rottlerin

Indexed keywords

ACETYLCYSTEINE; GLUTATHIONE; HEME OXYGENASE 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE C GAMMA; REACTIVE OXYGEN METABOLITE; ROTTLERIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2;

ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL STRAIN HT29; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION; WILD TYPE;

ACETOPHENONES; ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BENZOPYRANS; COLONIC NEOPLASMS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEME OXYGENASE-1; HT29 CELLS; HUMANS; LUCIFERASES; NF-E2-RELATED FACTOR 2; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE C-DELTA; PROTEIN KINASE INHIBITORS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 72049101622     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2009.10.001     Document Type: Article

References (31)

1. Tenhunen R., Marver H.S., and Schmid R. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc. Natl. Acad. Sci. 61 (1968) 748-755
2. Motterlini R., Foresti R., Bassi R., Calabrese V., Clark J.E., and Green C.J. Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols. J. Biol. Chem. 275 (2000) 13613-13620
3. Ishikawa K., Navab M., Leitinger N., Fogelman A.M., and Lusis A.J. Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL. J. Clin. Invest. 100 (1997) 1209-1216
4. Yet S.F., Layne M.D., Liu X., Chen Y.H., Ith B., Sibinga N.E., and Perrella M.A. Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling. FASEB. J. 17 (2003) 1759-1761
5. Immenschuh S., and Ramadori G. Gene regulation of heme oxygenase-1 as a therapeutic target. Biochem. Pharmacol. 60 (2000) 1121-1128
6. Motohashi H., and Yamamoto M. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol. Med. 10 (2004) 549-557
7. Chen X.L., and Kunsch C. Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases. Curr. Pharm. Des 10 (2004) 879-891
8. Gschwendt M., Müller H.J., Kielbassa K., Zang R., Kittstein W., Rincke G., and Marks F. Rottlerin, a novel protein kinase inhibitor. Biochem. Biophys. Res. Commun. 199 (1994) 93-98
9. Lim J.H., Park J.W., Choi K.S., Park Y.B., and Kwon T.K. Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC delta-independent mechanism in human malignant tumor cells. Carcinogenesis 30 (2009) 729-736
10. Y.A. Choi, D.K. Kim, S.S. Kang, J.K. Sonn, E.J. Jin. Integrin signaling and cell spreading alterations by rottlerin treatment of chick limb bud mesenchymal cells.
11. Shemon A.N., Sluyter R., and Wiley J.S. Rottlerin inhibits P2X(7) receptor-stimulated phospholipase D activity in chronic lymphocytic leukemia B-lymphocytes. Immunol. Cell Biol. 85 (2006) 68-72
12. Springael C., Thomas S., Vandamme A., Goldman M., Willems F., and Vosters O. Rottlerin inhibits human T cell response. Biochem. Pharmacol. 73 (2006) 515-525
13. Davies S.P., Reddy H., Caivano M., and Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351 (2000) 95-105
14. Bain J., Plater L., Elliott M., Shpiro N., Hastie C.J., McLauchlan H., Klevernic I., Arthur J.S., Alessi D.R., and Cohen P. The selectivity of protein kinase inhibitors: a further update. Biochem. J. 408 (2007) 297-315
15. Soltoff S.P. Rottlerin: an inappropriate and ineffective inhibitor of PKC delta. Trends Pharmacol. Sci. 28 (2007) 453-458
16. LeBel C.P., Ischiropoulos H., and Bondy S.C. Evaluation of the probe 2',7'- dichloro-fluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem. Res. Toxicol. 5 (1992) 227-231
17. Dinkova-Kostova A.T., Liby K.T., Stephenson K.K., Holtzclaw W.D., Gao X., Suh N., Williams C., Risingsong R., Honda T., Gribble G.W., Sporn M.B., and Talalay P. Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress. Proc. Natl. Acad. Sci. 102 (2005) 4584-4589
18. Jia Z., Hallur S., Zhu H., Li Y., and Misra H.P. Potent upregulation of glutathione and NAD(P)H:quinone oxidoreductase 1 by alpha-lipoic acid in human neuroblastoma SH-SY5Y cells: protection against neurotoxicant-elicited cytotoxicity. Neurochem. Res. 33 (2008) 790-800
19. Alvarez-Maqueda M., El Bekay R., Alba G., Monteseirín J., Chacón P., Vega A., Martín-Nieto J., Bedoya F.J., Pintado E., and Sobrino F. 15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes. J. Biol. Chem. 279 (2004) 21929-21937
20. McNally S.J., Harrison E.M., Ross J.A., Garden O.J., and Wigmore S.J. Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition. Int. J. Mol. Med. 19 (2007) 165-172
21. Gong P., and Cederbaum A.I. Transcription factor Nrf2 protects HepG2 cells against CYP2E1 plus arachidonic acid-dependent toxicity. J. Biol. Chem. 281 (2006) 14573-14579
22. Li H.Y., Zhong Y.F., Wu S.Y., and Shi N. NF-E2 related factor 2 activation and heme oxygenase-1 induction by tert-butylhydroquinone protect against deltamethrin-mediated oxidative stress in PC12 cells. Chem. Res. Toxicol. 20 (2007) 1242-1251
23. Itoh K., Wakabayashi N., Katoh Y., Ishii T., Igarashi K., Engel J.D., and Yamamoto M. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 13 (1999) 76-86
24. Cuadrado A., and Rojo A.I. Heme oxygenase-1 as a therapeutic target in neurodegenerative diseases and brain infections. Curr. Pharm. Des 14 (2008) 429-442
25. Nguyen T., Sherratt P.J., and Pickett C.B. Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu. Rev. Pharmacol. Toxicol. 43 (2002) 233-260
26. Chen K., and Maines M.D. Nitric oxide induces heme oxygenase-1 via mitogen-activated protein kinases ERK and p38. Cell. Mol. Biol. 46 (2000) 609-617
27. Kietzmann T., Samoylenko A., and Immenschuh S. Transcriptional regulation of heme oxygenase-1 gene expression by MAP kinases of the JNK and p38 pathways in primary cultures of rat hepatocytes. J. Biol. Chem. 278 (2003) 17927-17936
28. Wu C.C., Hsieh C.W., Lai P.H., Lin J.B., Liu Y.C., and Wung B.S. Upregulation of endothelial heme oxygenase-1 expression through the activation of the JNK pathway by sublethal concentrations of acrolein. Toxicol. Appl. Pharmacol. 214 (2006) 244-252
29. Cooper K.L., Liu K.J., and Hudson L.G. Contributions of reactive oxygen species and mitogen-activated protein kinase signaling in arsenite-stimulated hemeoxygenase-1 production. Toxicol. Appl. Pharmacol. 218 (2007) 119-127
30. Wu W.T., Chi K.H., Ho F.M., Tsao W.C., and Lin W.W. Proteasome inhibitors up-regulate haem oxygenase-1 gene expression: requirement of p38 MAPK (mitogen-activated protein kinase) activation but not of NF-kappaB (nuclear factor kappaB) inhibition. Biochem. J. 379 (2004) 587-593
31. Zhang X., Bedard E.L., Potter R., Zhong R., Alam J., Choi A.M., and Lee P.J. Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury. Am. J. Physiol. Lung Cell Mol. Physiol. 283 (2002) L815-L829