Stabilization of HIV-1 envelope in the CD4-bound conformation through specific cross-linking of a CD4 mimetic

Journal of Biological Chemistry

Volumn 286, Issue 24, 2011, Pages 21706-21716

  Martin, Grégoire ^a   Burke, Brian ^b   Thaï, Robert ^a   Dey, Antu K ^b   Combes, Olivier ^a   Heyd, Bernadette ^a   Geonnotti, Anthony R ^c   Montefiori, David C ^c   Kan, Elaine ^b   Lian, Ying ^b   Sun, Yide ^b   Abache, Toufik ^a   Ulmer, Jeffrey B ^b   Madaoui, Hocine ^a   Guérois, Raphaël ^a   Barnett, Susan W ^b   Srivastava, Indresh K ^b   Kessler, Pascal ^a   Martin, Loïc ^a  

^a SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

^b Novartis Vaccines and Diagnostics Corp   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY RESPONSE; CONSERVED REGIONS; COUPLING REACTION; COVALENT COMPLEX; MIMETICS; VIRUS INFECTION;

ANTIBODIES; VIRUSES;

DISEASES;

CD4 ANTIBODY; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 140; MINICD4 ANTIGEN; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CD4+ T LYMPHOCYTE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CROSS COUPLING REACTION; DISULFIDE BOND; DRUG ANTIGENICITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; GENETIC ENGINEERING; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOGENICITY; IMMUNOREGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN STABILITY; VIRUS NEUTRALIZATION; VIRUS STRAIN;

ANIMALS; ANTIGEN PRESENTATION; CD4-POSITIVE T-LYMPHOCYTES; CHO CELLS; CRICETINAE; CRICETULUS; CROSS-LINKING REAGENTS; CYSTEINE; DISULFIDES; HIV ENVELOPE PROTEIN GP120; HIV-1; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, CCR5; VIRAL ENVELOPE PROTEINS;

HUMAN IMMUNODEFICIENCY VIRUS 1; ORYCTOLAGUS CUNICULUS;

EID: 79958728198     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.232272     Document Type: Article

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