Identification of a novel CD4i human monoclonal antibody Fab that neutralizes HIV-1 primary isolates from different clades

Antiviral Research

Volumn 61, Issue 3, 2004, Pages 161-164

  Zhang, Mei Yun ^a,b   Shu, Yuuei ^a   Sidorov, Igor ^a   Dimitrov, Dimiter S ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b SAIC FREDERICK INC   (United States)

Author keywords

Antibody; gp120; HIV; Inhibitors; Phage display; Vaccines

Indexed keywords

CD4 ANTIGEN; CD4I ANTIBODY; GLYCOPROTEIN GP 140; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY M16; MONOCLONAL ANTIBODY X5; NEUTRALIZING ANTIBODY; RECOMBINANT GLYCOPROTEIN GP 120; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN;

ANTIGEN BINDING; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CELL FUSION; COMPLEX FORMATION; DRUG POTENCY; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; VIRUS ISOLATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0842311270     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.antiviral.2003.09.009     Document Type: Article

References (20)

1. Armbruster C., Stiegler G.M., Vcelar B.A., Jager W., Michael N.L., Vetter N., Katinger H.W. A phase I trial with two human monoclonal antibodies (hMAb 2F5, 2G12) against HIV-1. AIDS. 16:2002;227-233.
2. Burton D.R. Antibodies, viruses and vaccines. Nat. Rev. Immunol. 2:2002;706-713.
3. Burton D.R., Pyati J., Koduri R., Sharp S.J., Thornton G.B., Parren P.W., Sawyer L.S., Hendry R.M., Dunlop N., Nara P.L.et al. Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody. Science. 266:1994;1024-1027.
4. Conley A.J., Gorny M.K., Kessler J.A., Boots L.J., Ossorio-Castro M., Koenig S., Lineberger D.W., Emini E.A., Williams C., Zolla-Pazner S. Neutralization of primary human immunodeficiency virus type 1 isolates by the broadly reactive anti-V3 monoclonal antibody, 447-52D. J. Virol. 68:1994;6994-7000.
5. D'Souza M.P., Livnat D., Bradac J.A., Bridges S.H. Evaluation of monoclonal antibodies to human immunodeficiency virus type 1 primary isolates by neutralization assays: performance criteria for selecting candidate antibodies for clinical trials. AIDS Clinical Trials Group Antibody Selection Working Group. J. Infect. Dis. 175:1997;1056-1062.
6. Ferrantelli F., Ruprecht R.M. Neutralizing antibodies against HIV-back in the major leagues? Curr. Opin. Immunol. 14:2002;495-502.
7. Healey D., Dianda L., Moore J.P., McDougal J.S., Moore M.J., Estess P., Buck D., Kwong P.D., Beverley P.C.L., Sattentau Q.J. Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding. J. Exp. Med. 172:1990;1233-1242.
8. Labrijn A.F., Poignard P., Raja A., Zwick M.B., Delgado K., Franti M., Binley J., Vivona V., Grundner C., Huang C.C., Venturi M., Petropoulos C.J., Wrin T., Dimitrov D.S., Robinson J., Kwong P.D., Wyatt R.T., Sodroski J., Burton D.R. Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1. J. Virol. 77:2003;10557-10565.
9. Moulard M., Phogat S.K., Shu Y., Labrijn A.F., Xiao X., Binley J.M., Zhang M.Y., Sidorov I.A., Broder C.C., Robinson J., Parren P.W., Burton D.R., Dimitrov D.S. Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexes. Proc. Natl. Acad. Sci. USA. 99:2002;6913-6918.
10. Muster T., Steindl F., Purtscher M., Trkola A., Klima A., Himmler G., Ruker F., Katinger H. A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1. J. Virol. 67:1993;6642-6647.
11. Roben P., Moore J.P., Thali M., Sodroski J., Barbas C.F. III, Burton D.R. Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1. J. Virol. 68:1994;4821-4828.
12. Sanders R.W., Venturi M., Schiffner L., Kalyanaraman R., Katinger H., Lloyd K.O., Kwong P.D., Moore J.P. The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120. J. Virol. 76:2002;7293-7305.
13. Scanlan C.N., Pantophlet R., Wormald M.R., Ollmann S.E., Stanfield R., Wilson I.A., Katinger H., Dwek R.A., Rudd P.M., Burton D.R. The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1->2 mannose residues on the outer face of gp120. J. Virol. 76:2002;7306-7321.
14. Stiegler G., Armbruster C., Vcelar B., Stoiber H., Kunert R., Michael N.L., Jagodzinski L.L., Ammann C., Jager W., Jacobson J., Vetter N., Katinger H. Antiviral activity of the neutralizing antibodies 2F5 and 2G12 in asymptomatic HIV-1-infected humans: a phase I evaluation. AIDS. 16:2002;2019-2025.
15. Stiegler G., Kunert R., Purtscher M., Wolbank S., Voglauer R., Steindl F., Katinger H. A potent cross-clade neutralizing human monoclonal antibody against a novel epitope on gp41 of human immunodeficiency virus type 1. AIDS Res. Hum. Retroviruses. 17:2001;1757-1765.
16. Trkola A., Purtscher M., Muster T., Ballaun C., Buchacher A., Sullivan N., Srinivasan K., Sodroski J., Moore J.P., Katinger H. Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1. J. Virol. 70:1996;1100-1108.
17. Veazey R.S., Shattock R.J., Pope M., Kirijan J.C., Jones J., Hu Q., Ketas T., Marx P.A., Klasse P.J., Burton D.R., Moore J.P. Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120. Nat. Med. 9:2003;343-346.
18. Zhang, M.Y., Shu, Y., Phogat, S.K., Xiao, X., Cham, F., Choudhary, A., Feng, Y.R., Sanz, I., Rybak, S., Broder, C.C., Quinnan, G.V., Jr., Evans, T., Dimitrov, D.S., 2003a. Broadly cross-reactive HIV neutralizing human monoclonal antibody Fab selected by sequential antigen panning of a phage display library. J. Immunol. Methods, in press.
19. Zhang, M.Y., Shu, Y., Rudolph, D., Ponraj, P., Labrijn, A.F., Zwick, M.B., Lal, R.B., Dimitrov, D.S., 2003b. Improved breadth and potency of an HIV-1-neutralizing single-chain antibody by random mutagenesis and sequential antigen panning. J. Mol. Biol., in press.
20. Zwick M.B., Labrijn A.F., Wang M., Spenlehauer C., Saphire E.O., Binley J.M., Moore J.P., Stiegler G., Katinger H., Burton D.R., Parren P.W. Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41. J. Virol. 75:2001;10892-10905.