Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic

Biochemistry

Volumn 38, Issue 29, 1999, Pages 9405-9416

  Zhang, Wentao ^a   Canziani, Gabriela ^a   Plugariu, Carmela ^a   Wyatt, Richard ^b   Sodroski, Joseph ^b   Sweet, Raymond ^c   Kwong, Peter ^d   Hendrickson, Wayne ^d   Chaiken, Irwin ^a,e  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c SmithKline Beecham ^*  (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e Stellar Chance Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CD4 ANTIGEN; CHARYBDOTOXIN; CHEMOKINE RECEPTOR CCR5; EPITOPE; GLYCOPROTEIN GP 120; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; PHENYLALANINE;

ANIMAL CELL; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL FUSION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DROSOPHILA; HUMAN IMMUNODEFICIENCY VIRUS 1; ISOMERISM; MOLECULAR MIMICRY; NONHUMAN; PRIORITY JOURNAL; VIRUS CELL INTERACTION; VIRUS ENVELOPE;

AMINO ACID SEQUENCE; ANTIGENS, CD4; BINDING SITES, ANTIBODY; BINDING, COMPETITIVE; BIOSENSING TECHNIQUES; CHARYBDOTOXIN; EPITOPES, T-LYMPHOCYTE; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, CCR5; SEQUENCE DELETION; SOLUBILITY;

EID: 0033587488     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi990654o     Document Type: Article

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