Combinatorial Optimization of a CD4-Mimetic Miniprotein and Cocrystal Structures with HIV-1 gp120 Envelope Glycoprotein

Journal of Molecular Biology

Volumn 382, Issue 2, 2008, Pages 510-524

  Stricher, François ^a   Huang, Chih chin ^b   Descours, Anne ^a   Duquesnoy, Sophie ^a   Combes, Olivier ^a   Decker, Julie M ^c   Do Kwon, Young ^b   Lusso, Paolo ^d   Shaw, George M ^c   Vita, Claudio ^a   Kwong, Peter D ^b   Martin, Loïc ^a  

^a SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c University of Alabama at Birmingham   (United States)

^d SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

HIV 1 neutralization; induced CCR5 affinity; macromolecular interface transplantation; molecular mimicry; scorpion toxin scaffold

Indexed keywords

BINDING PROTEIN; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; GLYCINE; GLYCOPROTEIN GP 120; PHENYLALANINE; PROLINE; PROTEIN CD4M33; PROTEIN CD4M47; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; COMBINATORIAL CHEMISTRY; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIMIAN IMMUNODEFICIENCY VIRUS; SURFACE PLASMON RESONANCE; VIRUS NEUTRALIZATION;

HUMAN IMMUNODEFICIENCY VIRUS 1; SCORPIONES;

EID: 50249084524     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.06.069     Document Type: Article

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