Stabilization of HIV-1 gp120-CD4 receptor complex through targeted interchain disulfide exchange

Journal of Biological Chemistry

Volumn 285, Issue 33, 2010, Pages 25743-25752

  Cerutti, Nichole ^b   Mendelow, Barry V ^a   Napier, Grant B ^b   Papathanasopoulos, Maria A ^a,b   Killick, Mark ^b   Khati, Makobetsa ^c   Stevens, Wendy ^a   Capovilla, Alexio ^a,b  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b Elevation Biotech   (South Africa)

^c DSI CSIR Nanotechnology Innovation Centre   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRAL ACTIVITIES; BIOPHYSICAL CONDITIONS; CHALCOGENS; DISULFIDE EXCHANGE; EXCHANGE MECHANISM; EXPERIMENTAL EVIDENCE; GEOMETRIC CONDITIONS; HIGH AFFINITY; HOST CELLS; INTERCHAIN DISULFIDE BONDS; NEW STRATEGY; RECEPTOR BINDING; RECEPTOR COMPLEX; RECEPTOR-LIGAND COMPLEX; REFOLDING; STRUCTURAL MODELS; VACCINE DEVELOPMENT; WILD-TYPE PROTEINS;

CELL MEMBRANES; COMPLEXATION; LIGANDS; MODEL STRUCTURES; STRATEGIC PLANNING;

PROTEINS;

CD4 ANTIGEN; CYSTEINE; DISULFIDE; GLYCOPROTEIN GP 120; SERINE; VIRUS ENVELOPE PROTEIN;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONTROLLED STUDY; DISULFIDE BOND; HUMAN IMMUNODEFICIENCY VIRUS 1; LIGAND BINDING; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PURIFICATION; PROTEIN TARGETING; RECEPTOR BINDING; STEREOCHEMISTRY; WILD TYPE;

ANTIGENS, CD4; CELL LINE; DISULFIDES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HIV ENVELOPE PROTEIN GP120; HUMANS; MODELS, BIOLOGICAL; PROTEIN BINDING; PROTEIN FOLDING; RECOMBINANT PROTEINS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77955476797     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.144121     Document Type: Article

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