Reducing the genetic risk of age-related macular degeneration with dietary antioxidants, zinc, and ω-3 fatty acids: The Rotterdam Study

Archives of Ophthalmology

Volumn 129, Issue 6, 2011, Pages 758-766

  Ho, Lintje ^a   Van Leeuwen, Redmer ^a   Witteman, Jacqueline C M ^a   Van Duijn, Cornelia M ^a   Uitterlinden, André G ^a   Hofman, Albert ^a   De Jong, Paulus T V M ^a,b,c   Vingerling, Johannes R ^a   Klaver, Caroline C W ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; CAROTENOID; COMPLEMENT FACTOR H; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID; RETINOL; VITAMIN; XANTHOPHYLL; ZEAXANTHIN; ZINC;

ADULT; AGED; ARTICLE; DIETARY INTAKE; FEMALE; FOLLOW UP; GENETIC RISK; HUMAN; MALE; NUCLEOTIDE SEQUENCE; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETINA MACULA AGE RELATED DEGENERATION; RISK REDUCTION;

AGED; ANTIOXIDANTS; BLINDNESS; DIETARY SUPPLEMENTS; FATTY ACIDS, OMEGA-3; FEMALE; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INCIDENCE; MACULAR DEGENERATION; MALE; MIDDLE AGED; NETHERLANDS; PROSPECTIVE STUDIES; QUESTIONNAIRES; RISK FACTORS; TREATMENT OUTCOME; VISUAL ACUITY; ZINC;

EID: 79958726856     PISSN: 00039950     EISSN: 15383601     Source Type: Journal    
DOI: 10.1001/archophthalmol.2011.141     Document Type: Article

References (70)

1. Resnikoff S, Pascolini D, Etya'ale D, et al. Global data on visual impairment in the year 2002. Bull World Health Organ. 2004;82(11):844-851.
2. Augood CA, Vingerling JR, de Jong PT, et al. Prevalence of age-related maculopathy in older Europeans: the European Eye Study (EUREYE). Arch Ophthalmol. 2006;124(4):529-535.
3. World Health Organization. The Global Burden of Disease: 2004 Update. Geneva, Switzerland: World Health Organization; 2008:28-95.
4. Ip MS, Scott IU, Brown GC, et al; American Academy of Ophthalmology. Antivascular endothelial growth factor pharmacotherapy for age-related macular degeneration: a report by the American Academy of Ophthalmology. Ophthalmology. 2008;115(10):1837-1846.
5. Gillies MC, Wong TY. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2007;356(7):748-749, author reply 749-750.
6. de Jong PT. Age-related macular degeneration. N Engl J Med. 2006;355(14):1474-1485.
7. Hageman GS, Luthert PJ, Victor Chong NH, Johnson LV, Anderson DH, Mullins RF. An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration. Prog Retin Eye Res. 2001;20(6):705-732. (Pubitemid 32918285)
8. Scholl HP, Charbel Issa P, Walier M, et al. Systemic complement activation in age-related macular degeneration. PLoS One. 2008;3(7):e2593.
9. Crabb JW, Miyagi M, Gu X, et al. Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proc Natl Acad Sci U S A. 2002;99(23):14682-14687. (Pubitemid 35334544)
10. Zarbin MA. Current concepts in the pathogenesis of age-related macular degeneration. Arch Ophthalmol. 2004;122(4):598-614. (Pubitemid 38456297)
11. Beatty S, Koh H, Phil M, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol. 2000;45(2):115-134.
12. Hollyfield JG, Bonilha VL, Rayborn ME, et al. Oxidative damage-induced inflammation initiates age-related macular degeneration. Nat Med. 2008;14(2):194-198. (Pubitemid 351214555)
13. Winkler BS, Boulton ME, Gottsch JD, Sternberg P. Oxidative damage and age-related macular degeneration. Mol Vis. 1999;5:32.
14. Espinosa-Heidmann DG, Suner IJ, Catanuto P, Hernandez EP, Marin-Castano ME, Cousins SW. Cigarette smoke-related oxidants and the development of sub-RPE deposits in an experimental animal model of dry AMD. Invest Ophthalmol Vis Sci. 2006;47(2):729-737. (Pubitemid 46768404)
15. Despriet DD, Klaver CC, Witteman JC, et al. Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration. JAMA. 2006;296(3):301-309. (Pubitemid 44079314)
16. Klein RJ, Zeiss C, Chew EY, et al. Complement factor H polymorphism in age-related macular degeneration. Science. 2005;308(5720):385-389. (Pubitemid 40530070)
17. Edwards AO, Ritter R III, Abel KJ, Manning A, Panhuysen C, Farrer LA. Complement factor H polymorphism and age-related macular degeneration. Science. 2005;308(5720):421-424. (Pubitemid 40530082)
18. Haines JL, Hauser MA, Schmidt S, et al. Complement factor H variant increases the risk of age-related macular degeneration. Science. 2005;308(5720):419-421. (Pubitemid 40530081)
19. Hageman GS, Anderson DH, Johnson LV, et al. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A. 2005;102(20):7227- 7232. (Pubitemid 40696361)
20. Rivera A, Fisher SA, Fritsche LG, et al. Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk. Hum Mol Genet. 2005;14(21):3227-3236. (Pubitemid 41631297)
21. Dewan A, Liu M, Hartman S, et al. HTRA1 promoter polymorphism in wet age-related macular degeneration. Science. 2006;314(5801):989-992. (Pubitemid 44749943)
22. Yang Z, Camp NJ, Sun H, et al. A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science. 2006;314(5801):992-993. (Pubitemid 44749944)
23. Kanda A, Chen W, Othman M, et al. A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. Proc Natl Acad Sci U S A. 2007;104(41):16227-16232. (Pubitemid 350099389)
24. Jakobsdottir J, Conley YP, Weeks DE, Mah TS, Ferrell RE, Gorin MB. Susceptibility genes for age-related maculopathy on chromosome 10q26. Am J Hum Genet. 2005;77(3):389-407. (Pubitemid 41192646)
25. Francis PJ, Zhang H, Dewan A, Hoh J, Klein ML. Joint effects of polymorphisms in the HTRA1, LOC387715/ARMS2, and CFH genes on AMD in a Caucasian population. Mol Vis. 2008;14:1395-1400.
26. Kaur I, Katta S, Hussain A, et al. Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients. Invest Ophthalmol Vis Sci. 2008;49(5):1771-1776.
27. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report No. 8. Arch Ophthalmol. 2001;119(10):1417-1436.
28. van Leeuwen R, Boekhoorn S, Vingerling JR, et al. Dietary intake of antioxidants and risk of age-related macular degeneration. JAMA. 2005;294(24):3101-3107. (Pubitemid 43016801)
29. Chua B, Flood V, Rochtchina E, Wang JJ, Smith W, Mitchell P. Dietary fatty acids and the 5-year incidence of age-related maculopathy. Arch Ophthalmol. 2006;124(7):981-986. (Pubitemid 44043098)
30. Cho E, Hung S, Willett WC, et al. Prospective study of dietary fat and the risk of age-related macular degeneration. Am J Clin Nutr. 2001;73(2):209-218. (Pubitemid 32109848)
31. Chong EW, Kreis AJ, Wong TY, Simpson JA, Guymer RH. Dietary omega-3 fatty acid and fish intake in the primary prevention of age-related macular degeneration: a systematic review and meta-analysis. Arch Ophthalmol. 2008;126(6):826-833. (Pubitemid 351831334)
32. Wang JJ, Rochtchina E, Smith W, et al. Combined effects of complement factor H genotypes, fish consumption, and inflammatory markers on long-term risk for age-related macular degeneration in a cohort. Am J Epidemiol. 2009;169(5):633-641.
33. Klein ML, Francis PJ, Rosner B, et al. CFH and LOC387715/ARMS2 genotypes and treatment with antioxidants and zinc for age-related macular degeneration. Ophthalmology. 2008;115(6):1019-1025.
34. Hofman A, Breteler MM, van Duijn CM, et al. The Rotterdam Study: 2010 objectives and design update. Eur J Epidemiol. 2009;24(9):553-572.
35. Bird AC, Bressler NM, Bressler SB, et al; The International ARM Epidemiological Study Group. An international classification and grading system for age-related maculopathy and age-related macular degeneration. Surv Ophthalmol. 1995;39(5):367-374.
36. Goldbohm RA, van den Brandt PA, Brants HA, et al. Validation of a dietary questionnaire used in a large-scale prospective cohort study on diet and cancer. Eur J Clin Nutr. 1994;48(4):253-265. (Pubitemid 24123695)
37. Klipstein-Grobusch K, den Breeijen JH, Goldbohm RA, et al. Dietary assessment in the elderly: validation of a semiquantitative food frequency questionnaire. Eur J Clin Nutr. 1998;52(8):588-596. (Pubitemid 28395698)
38. Schultz DW, Klein ML, Humpert AJ, et al. Analysis of the ARMD1 locus: evidence that a mutation in HEMICENTIN-1 is associated with age-related macular degeneration in a large family. Hum Mol Genet. 2003;12(24):3315-3323. (Pubitemid 37541077)
39. van Poppel G, van Erp-Baart M-A, Leth T, et al. Trans fatty acids in foods in Europe: the TRANSFAIR Study. J Food Compos Anal. 1998;11(2):112-136. (Pubitemid 128370249)
40. van Poppel G. Intake of trans fatty acids in western Europe: the TRANSFAIR study. Lancet. 1998;351(9109):1099.
41. van Leeuwen R, Ikram MK, Vingerling JR, Witteman JC, Hofman A, de Jong PT. Blood pressure, atherosclerosis, and the incidence of age-related maculopathy: the Rotterdam Study. Invest Ophthalmol Vis Sci. 2003;44(9):3771-3777. (Pubitemid 37047945)
42. Willett WC. Nutritional Epidemiology. 2nd ed. New York, NY: Oxford University Press; 1998.
43. Botto LD, Khoury MJ. Commentary: facing the challenge of gene-environment interaction: the two-by-four table and beyond. Am J Epidemiol. 2001;153(10):1016-1020. (Pubitemid 32423788)
44. Rothman K. Modern Epidemiology. 2nd ed. Philadelphia, PA: Lippincott-Raven; 1998.
45. Skerka C, Lauer N, Weinberger AA, et al. Defective complement control of factor H (Y402H) and FHL-1 in age-related macular degeneration. Mol Immunol. 2007;44(13):3398-3406. (Pubitemid 46678196)
46. Laine M, Jarva H, Seitsonen S, et al. Y402H polymorphism of complement factor H affects binding affinity to C-reactive protein. J Immunol. 2007;178(6):3831-3836. (Pubitemid 46417652)
47. Johnson PT, Betts KE, Radeke MJ, Hageman GS, Anderson DH, Johnson LV. Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid. Proc Natl Acad Sci U S A. 2006;103(46):17456-17461. (Pubitemid 44788990)
48. Yamamoto K, Takahashi M. Inhibition of the terminal stage of complement-mediated lysis (reactive lysis) by zinc and copper ions. Int Arch Allergy Appl Immunol. 1975;48(5):653-663.
49. Blom AM, Kask L, Ramesh B, Hillarp A. Effects of zinc on factor I cofactor activity of C4b-binding protein and factor H. Arch Biochem Biophys. 2003;418(2):108-118. (Pubitemid 37159377)
50. Chen W, Esselman WJ, Jump DB, Busik JV. Anti-inflammatory effect of docosahexaenoic acid on cytokine-induced adhesion molecule expression in human retinal vascular endothelial cells. Invest Ophthalmol Vis Sci. 2005;46(11):4342-4347. (Pubitemid 44264641)
51. Micallef MA, Munro IA, Garg ML. An inverse relationship between plasma n-3 fatty acids and C-reactive protein in healthy individuals. Eur J Clin Nutr. 2009;63(9):1154-1156.
52. Ernst E, Saradeth T, Achhammer G. n-3 Fatty acids and acute-phase proteins. Eur J Clin Invest. 1991;21(1):77-82.
53. Erlinger TP, Guallar E, Miller ER III, Stolzenberg-Solomon R, Appel LJ. Relationship between systemic markers of inflammation and serum beta-carotene levels. Arch Intern Med. 2001;161(15):1903-1908. (Pubitemid 32762738)
54. Brighenti F, Valtueña S, Pellegrini N, et al. Total antioxidant capacity of the diet is inversely and independently related to plasma concentration of highsensitivity C-reactive protein in adult Italian subjects. Br J Nutr. 2005;93(5):619-625. (Pubitemid 43906345)
55. Agrawal A, Cha-Molstad H, Samols D, Kushner I. Overexpressed nuclear factor-kappaB can participate in endogenous C-reactive protein induction, and enhances the effects of C/EBPbeta and signal transducer and activator of transcription-3. Immunology. 2003;108(4):539-547. (Pubitemid 36469692)
56. Voleti B, Agrawal A. Regulation of basal and induced expression of C-reactive protein through an overlapping element for OCT-1 and NF-kappaB on the proximal promoter. J Immunol. 2005;175(5):3386-3390. (Pubitemid 41170561)
57. Fritsche LG, Loenhardt T, Janssen A, et al. Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA. Nat Genet. 2008;40(7):892-896. (Pubitemid 351913654)
58. Barron MJ, Johnson MA, Andrews RM, et al. Mitochondrial abnormalities in ageing macular photoreceptors. Invest Ophthalmol Vis Sci. 2001;42(12):3016-3022. (Pubitemid 33035304)
59. Feher J, Kovacs I, Artico M, Cavallotti C, Papale A, Balacco Gabrieli C. Mitochondrial alterations of retinal pigment epithelium in age-related macular degeneration. Neurobiol Aging. 2006;27(7):983-993. (Pubitemid 44262273)
60. Jarrett SG, Lin H, Godley BF, Boulton ME. Mitochondrial DNA damage and its potential role in retinal degeneration. Prog Retin Eye Res. 2008;27(6):596-607.
61. Liang FQ, Godley BF. Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration. Exp Eye Res. 2003;76(4):397-403. (Pubitemid 36299052)
62. Wang AL, Lukas TJ, Yuan M, Neufeld AH. Increased mitochondrial DNA damage and down-regulation of DNA repair enzymes in aged rodent retinal pigment epithelium and choroid. Mol Vis. 2008;14:644-651. (Pubitemid 351513456)
63. SanGiovanni JP, Chew EY. The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina. Prog Retin Eye Res. 2005;24(1):87-138. (Pubitemid 39535157)
64. Hennig B, Meerarani P, Toborek M, McClain CJ. Antioxidant-like properties of zinc in activated endothelial cells. J Am Coll Nutr. 1999;18(2):152-158. (Pubitemid 29157321)
65. Powell SR. The antioxidant properties of zinc. J Nutr. 2000;130(5S)(suppl):1447S-1454S.
66. Zago MP, Oteiza PI. The antioxidant properties of zinc: interactions with iron and antioxidants. Free Radic Biol Med. 2001;31(2):266-274. (Pubitemid 32607594)
67. Chakraborti T, Mandal A, Mandal M, Das S, Chakraborti S. Complement activation in heart diseases: role of oxidants. Cell Signal. 2000;12(9-10):607-617.
68. Sheu SS, Nauduri D, Anders MW. Targeting antioxidants to mitochondria: a new therapeutic direction. Biochim Biophys Acta. 2006;1762(2):256-265. (Pubitemid 43006031)
69. Malaiyandi LM, Vergun O, Dineley KE, Reynolds IJ. Direct visualization of mitochondrial zinc accumulation reveals uniporter-dependent and -independent transport mechanisms. J Neurochem. 2005;93(5):1242-1250. (Pubitemid 40776577)
70. Guan Z, Kukoyi B, Feng P, Kennedy MC, Franklin RB, Costello LC. Kinetic identification of a mitochondrial zinc uptake transport process in prostate cells. J Inorg Biochem. 2003;97(2):199-206. (Pubitemid 37152444)