Regulation of basal and induced expression of C-reactive protein through an overlapping element for OCT-1 and NF-κB on the proximal promoter

Journal of Immunology

Volumn 175, Issue 5, 2005, Pages 3386-3390

  Voleti, Bhavya ^a   Agrawal, Alok ^a,b  

^a East Tennessee State University   (United States)

^b EAST TENNESSEE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CYTOKINE; GENOMIC DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LUCIFERASE; OCTAMER TRANSCRIPTION FACTOR 1; STAT3 PROTEIN;

ACUTE PHASE RESPONSE; ARTICLE; ENZYME ASSAY; HEPATOMA CELL; HUMAN; HUMAN CELL; INFLAMMATION; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE;

EID: 23844516988     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.5.3386     Document Type: Article

References (32)

1. Agrawal, A. 2005. CRP after 2004. Mol. Immunol. 42: 927-930.
2. Kushner, I. 1982. The phenomenon of the acute phase response. Ann. NY Acad. Sci. 389: 39-48.
3. Agrawal, A., M. J. Simpson, S. Black, M. P. Carey, and D. Samols. 2002. A C-reactive protein mutant that does not bind to phosphocholine and pneumococcal C-polysaccharide. J. Immunol. 169: 3217-3222.
4. Suresh, M. V., S. K. Singh, and A. Agrawal. 2004. Interaction of calcium-bound C-reactive protein with fibronectin is controlled by pH: in vivo implications. J. Biol. Chem. 279: 52552-52557.
5. Hurlimann, J., G. J. Thorbecke, and G. M. Hochwald. 1966. The liver as the site of C-reactive protein formation. J. Exp. Med. 123: 365-378.
6. Kushner, I., and G. Feldmann. 1978. Control of the acute phase response: demonstration of C-reactive protein synthesis and secretion by hepatocytes during acute inflammation in the rabbit. J. Exp. Med. 148: 466-477.
7. Zhang, D., S.-L. Jiang, D. Rzewnicki, D. Samols, and I. Kushner. 1995. The effect of interleukin-1 on C-reactive protein expression in Hep3B cells is exerted at the transcriptional level. Biochem. J. 310: 143-148.
8. Ganter, U., R. Arcone, C. Toniatti, G. Morrone, and G. Ciliberto. 1989. Dual control of C-reactive protein gene expression by interleukin-1 and interleukin-6. EMBO J. 8: 3773-3779.
9. Li, S. P., T.-Y. Liu, and N. D. Goldman. 1990. Cis-acting elements responsible for interleukin-6 inducible C-reactive protein gene expression. J. Biol. Chem. 265: 4136-4142.
10. Majello, B., R. Arcone, C. Toniatti, and G. Ciliberto. 1990. Constitutive and IL-6-induced nuclear factors that interact with the human C-reactive protein promoter. EMBO J. 9: 457-465.
11. Li, S.-P., and N. D. Goldman. 1996. Regulation of human C-reactive protein gene expression by two synergistic IL-6 responsive elements. Biochemistry 35: 9060-9068.
12. Zhang, D., M. Sun, D. Samols, and I. Kushner. 1996. STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6. J. Biol. Chem. 271: 9503-9509.
13. Cha-Molstad, H., A. Agrawal, D. Zhang, D. Samols, and I. Kushner. 2000. The rel family member p50 mediates cytokine-induced C-reactive protein expression by a novel mechanism. J. Immunol. 165: 4592-4597.
14. Agrawal, A., H. Cha-Molstad, D. Samols, and I. Kushner. 2001. Transactivation of C-reactive protein by IL-6 requires synergistic interactions of CCAAT/enhancer binding protein b (C/EBPβ) and Rel p50. J. Immunol. 166: 2378-2384.
15. Ganapathi, M. K., D. Rzewnicki, D. Samols, S.-L. Jiang, and I. Kushner. 1991. Effect of combinations of cytokines and hormones on synthesis of serum amyloid A and C-reactive protein in Hep3B cells. J. Immunol. 147: 1261-1265.
16. Wang, Y., J. Ripperger, G. H. Fey, D. Samols, T. Kordula, M. Wetzler, R. A. Van Etten, and H. Baumann. 1999. Modulation of hepatic acute phase gene expression by epidermal growth factor and src protein tyrosine kinases in murine and human hepatic cells. Hepatology 30: 682-697.
17. Ochrietor, J. D., K. A. Harrison, K. Zahedi, and R. F. Mortensen. 2000. Role of STAT3 and C/EBP in cytokine-dependent expression of the mouse serum amyloid P-component (SAP) and C-reactive protein (CRP) genes. Cytokine 12: 888-899.
18. May, P., U. Schniertshauer, C. Gerhartz, F. Horn, and P. C. Heinrich. 2003. Signal transducer and activator of transcription STAT3 plays a major role in gp130-mediated acute phase protein gene activation. Acta Biochim. Polo. 50: 595-601.
19. Castell, J. V., M. J. Gomez-Lechon, M. David, R. Fabra, R. Trullenque, and P. C. Heinrich. 1990. Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6. Hepatology 12: 1179-1186.
20. Taylor, A. W., N.-O. Ku, and R. F. Mortensen. 1990. Regulation of cytokine-induced human C-reactive protein production by transforming growth factor-β. J. Immunol. 145: 2507-2513.
21. Toniatti, C., A. Demartis, P. Monaci, A. Nicosia, and G. Ciliberto. 1990. Synergistic trans-activation of the human C-reactive promoter by transcription factor HNF-1 binding at two distinct sites. EMBO J. 9: 4467-4475.
22. Wysocka, J., and W. Herr. 2003. The herpes simplex virus VP16-induced complex: the makings of a regulatory switch. Trends Biochem. Sci. 28: 294-304.
23. Agrawal, A., H. Cha-Molstad, D. Samols, and I. Kushner. 2003. Overexpressed NF-κB can participate in endogenous C-reactive protein induction, and enhances the effects of C/EBPβ and signal transducer and activator of transcription-3. Immunology 108: 539-547.
24. Hayden, M. S., and S. Ghosh. 2004. Signaling to NF-κB. Genes Dev. 18: 2195-2224.
25. Agrawal, A., D. Samols, and I. Kushner. 2003. Transcription factor c-Rel enhances C-reactive protein expression by facilitating the binding of C/EBPβ to the promoter. Mol. Immunol. 40: 373-380.
26. Kleemann, R., P. P. Gervois, L. Verschuren, B. Staels, H. M. G. Princen, and T. Kooistra. 2003. Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NF-κB-C/EBPβ complex formation. Blood 101: 545-551.
27. LeClair, K. P., M. A. Blanar, and P. A. Sharp. 1992. The p50 subunit of NF-κB associates with the NF-IL6 transcription factor. Proc. Natl. Acad. Sci. USA 89: 8145-8149.
28. Stein, B., P. C. Cogswell, and A. S. Baldwin, Jr. 1993. Functional and physical associations between NF-κB and C/EBP family members: a Rel domain-bZIP interaction. Mol. Cell. Biol. 13: 3964-3974.
29. Yang, X. P., U. Albrecht, V. Zakowski, R. M. Sobota, D. Haussinger, P. C. Heinrich, S. Ludwig, J. G. Bode, and F. Schaper. 2004. Dual function of interleukin-1β for the regulation of interleukin-6-induced suppressor of cytokine signaling 3 expression. J. Biol. Chem. 279: 45279-45289.
30. Osborne, A. R., H. Zhang, G. Fejer, K. M. Palubin, M. I. Niesen, and G. Blanck. 2004. Oct-1 maintains an intermediate, stable state of HLA-DRA promoter repression in Rb-defective cells: an Oct-1 containing repressosome that prevents NF-Y binding to the HLA-DRA promoter. J. Biol. Chem. 279: 28911-28919.
31. Boudreau, F., Y. Zhu, and P. G. Traber. 2001. Sucrase-isomaltase gene transcription requires the hepatocyte nuclear factor-1 (HNF-1) regulatory element and is regulated by the ratio of HNF-1α to HNF-1β. J. Biol. Chem. 276: 32122-32128.
32. Gonzalez-Gil, G., R. Kahmann, and G. Muskhelishvili. 1998. Regulation of crp transcription by oscillation between distinct nucleoprotein complexes. EMBO J. 17: 2877-2885.