Cancer and neurodegenerative disorders: Pathogenic convergence through microRNA regulation

Journal of Molecular Cell Biology

Volumn 3, Issue 3, 2011, Pages 176-180

  Du, Liqin ^a   Pertsemlidis, Alexander ^a,b,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

cancer; microRNA; neurodegenerative disease

Indexed keywords

DIAGNOSTIC AGENT; MICRORNA;

ANIMAL; DEGENERATIVE DISEASE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; NEOPLASM; PATHOPHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; GENE EXPRESSION REGULATION; HUMANS; MICRORNAS; NEOPLASMS; NEURODEGENERATIVE DISEASES; SIGNAL TRANSDUCTION;

EID: 79958237903     PISSN: 16742788     EISSN: 17594685     Source Type: Journal    
DOI: 10.1093/jmcb/mjq058     Document Type: Review

References (53)

1. Arvidsson, Y., Andersson, E., Bergstrom, A., et al. (2008). Amyloid precursor-like protein 1 is differentially upregulated in neuroendocrine tumours of the gastrointestinal tract. Endocr. Relat. Cancer 15, 569-581. (Pubitemid 351880844)
2. Bandres, E., Cubedo, E., Agirre, X., et al. (2006). Identification by real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues. Mol. Cancer 5, 29.
3. Boyerinas, B., Park, S.M., Hau, A., et al. (2010). The role of let-7 in cell differentiation and cancer. Endocr. Relat. Cancer 17, F19-F36.
4. Chen, X., Ba, Y., Ma, L., et al. (2008). Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 18, 997-1006.
5. Cogswell, J.P., Ward, J., Taylor, I.A., et al. (2008). Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. J. Alzheimers Dis. 14, 27-41. (Pubitemid 352039013)
6. Cole, S. L., and Vassar, R. (2007). The Basic Biology of BACE1: a key therapeutic target for Alzheimer's disease. Curr. Genomics 8, 509-530. (Pubitemid 351472400)
7. Cooper, T.A., Wan, L., and Dreyfuss, G. (2009). RNA and disease. Cell 136, 777-793.
8. Crawford, M., Batte, K., Yu, L., et al. (2009). MicroRNA 133B targets prosurvival molecules MCL-1 and BCL2L2 in lung cancer. Biochem. Biophys. Res. Commun. 388, 483-489.
9. Du, L., Schageman, J.J., Subauste, M.C., et al. (2009). miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1. Mol. Cancer Res. 7, 1234-1243.
10. Du, L., Schageman, J.J., Irnov Girard, L., et al. (2010). MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs. J. Exp. Clin. Cancer Res. 29, 75-80.
11. Fabbri, M., Garzon, R., Cimmino, A., et al. (2007). MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc. Natl. Acad. Sci. USA 104, 15805-15810. (Pubitemid 350035380)
12. Fabian, M.R., Sonenberg, N., and Filipowicz, W. (2010). Regulation of mRNA translation and stability by microRNAs. Annu. Rev. Biochem. 79, 351-379.
13. Garzon, R., Liu, S., Fabbri, M., et al. (2009). MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood 113, 6411-6418.
14. Hansel, D.E., Rahman, A., Wehner, S., et al. (2003). Increased expression and processing of the Alzheimer amyloid precursor protein in pancreatic cancer may influence cellular proliferation. Cancer Res. 63, 7032-7037. (Pubitemid 37413434)
15. Hebert, S.S., Horre, K., Nicolai, L., et al. (2008). Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc. Natl. Acad. Sci. USA 105, 6415-6420. (Pubitemid 351758360)
16. Hebert, S.S., Horre, K., Nicolai, L., et al. (2009). MicroRNA regulation of Alzheimer's amyloid precursor protein expression. Neurobiol. Dis. 33, 422-428.
17. Hu, G., Chen, D., Li, X., et al. (2010a). miR-133b regulates the MET protooncogene and inhibits the growth of colorectal cancer cells in vitro and in vivo. Cancer Biol. Ther. 10, 190-197.
18. Hu, H., Du, L., Nagabayashi, G., et al. (2010b). ATM is down-regulated by N-Myc-regulated microRNA-421. Proc. Natl. Acad. Sci. USA 107, 1506-1511.
19. Ivanovska, I., Ball, A.S., Diaz, R.L., et al. (2008). MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression. Mol. Cell. Biol. 28, 2167-2174. (Pubitemid 351429964)
20. Jiang, Z., Guo, J., Xiao, B., et al. (2010). Increased expression of miR-421 in human gastric carcinoma and its clinical association. J. Gastroenterol. 45, 17-23.
21. Johnson, S.M., Grosshans, H., Shingara, J., et al. (2005). RAS is regulated by the let-7 microRNA family. Cell 120, 635-647. (Pubitemid 40343076)
22. Kano, M., Seki, N., Kikkawa, N., et al. (2010). miR-145, miR-133a and miR-133b: tumor suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma. Int. J. Cancer 127, 2804-2814.
23. Karginov, F.V., Conaco, C., Xuan, Z., et al. (2007). A biochemical approach to identifying microRNA targets. Proc. Natl. Acad. Sci. USA 104, 19291-19296.
24. Kim, J., Inoue, K., Ishii, J., et al. (2007). A microRNA feedback circuit in midbrain dopamine neurons. Science 317, 1220-1224.
25. Ko, S.Y., Lin, S.C., Chang, K.W., et al. (2004). Increased expression of amyloid precursor protein in oral squamous cell carcinoma. Int. J. Cancer 111, 727-732.
26. Krause, K., Karger, S., Sheu, S.Y., et al. (2008). Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis. J. Endocrinol. 198, 291-299.
27. LaFerla, F.M., Green, K.N., and Oddo, S. (2007). Intracellular amyloid-beta in Alzheimer's disease. Nat. Rev. Neurosci. 8, 499-509.
28. Lawrie, C.H., Saunders, N.J., Soneji, S., et al. (2008). MicroRNA expression in lymphocyte development and malignancy. Leukemia 22, 1440-1446. (Pubitemid 352006091)
29. Lebanony, D., Benjamin, H., Gilad, S., et al. (2009). Diagnostic assay based on hsa-miR-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma. J. Clin. Oncol. 27, 2030-2037.
30. Lee, Y.S., and Dutta, A. (2007). The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes Dev. 21, 1025-1030. (Pubitemid 46686471)
31. Li, R., Lindholm, K., Yang, L.B., et al. (2004). Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients. Proc. Natl. Acad. Sci. USA 101, 3632-3637. (Pubitemid 38338246)
32. Lim, L.P., Lau, N.C., Garrett-Engele, P., et al. (2005). Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433, 769-773. (Pubitemid 40292988)
33. Lujambio, A., Ropero, S., Ballestar, E., et al. (2007). Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res. 67, 1424-1429. (Pubitemid 46383366)
34. Matsuoka, S., Ballif, B.A., Smogorzewska, A., et al. (2007). ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-1166. (Pubitemid 46877472)
35. Meng, F., Henson, R., Wehbe-Janek, H., et al. (2007). MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133, 647-658. (Pubitemid 47187346)
36. Mitchell, P.S., Parkin, R.K., Kroh, E.M., et al. (2008). Circulating microRNAs as stable blood-based markers for cancer detection. Proc. Natl. Acad. Sci. USA 105, 10513-10518.
37. Morris, L.G., Veeriah, S., and Chan, T.A. (2010). Genetic determinants at the interface of cancer and neurodegenerative disease. Oncogene 29, 3453-3464.
38. Ng, E.K., Chong, W.W., Jin, H., et al. (2009). Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening. Gut 58, 1375-1381.
39. Niwa, R., Zhou, F., Li, C., et al. (2008). The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans. Dev. Biol. 315, 418-425.
40. Pan, S., Yu, F., Gong, C., et al. (2009). Tumor Invasion, and metastasis initiated by miR-106b in breast cancer by targeting BRMS1 and RB. Cancer Res. 69 (Meeting Abstract Supplement), Abstract 6157.
41. Parent, M., and Parent, A. (2010). Substantia nigra and Parkinson's disease: a brief history of their long and intimate relationship. Can. J. Neurol. Sci. 37, 313-319.
42. Podlisny, M.B., Lee, G., and Selkoe, D.J. (1987). Gene dosage of the amyloid beta precursor protein in Alzheimer's disease. Science 238, 669-671. (Pubitemid 17158297)
43. Poliseno, L., Salmena, L., Riccardi, L., et al. (2010). Identification of the miR-106b-25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation. Sci. Signal 3, ra29.
44. Rovelet-Lecrux, A., Hannequin, D., Raux, G., et al. (2006). APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat. Genet. 38, 24-26. (Pubitemid 43011878)
45. Sampson, V.B., Rong, N.H., Han, J., et al. (2007). MicroRNA let-7a downregulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells. Cancer Res. 67, 9762-9770. (Pubitemid 47621223)
46. Schmitz, A., Tikkanen, R., Kirfel, G., et al. (2002). The biological role of the Alzheimer amyloid precursor protein in epithelial cells. Histochem. Cell Biol. 117, 171-180. (Pubitemid 34185623)
47. Shioya, M., Obayashi, S., Tabunoki, H., et al. (2010). Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neurone navigator 3. Neuropathol. Appl. Neurobiol. 36, 320-330.
48. Simunovic, F., Yi, M., Wang, Y., et al. (2009). Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology. Brain 132, 1795-1809.
49. Sonntag, K.C. (2010). MicroRNAs and deregulated gene expression networks in neurodegeneration. Brain Res. 1338, 48-57.
50. Theuns, J., Brouwers, N., Engelborghs, S., et al. (2006). Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease. Am. J. Hum. Genet. 78, 936-946. (Pubitemid 43787686)
51. Wong, K.K., Engelman, J.A., and Cantley, L.C. (2010). Targeting the PI3K signaling pathway in cancer. Curr. Opin. Genet. Dev. 20, 87-90.
52. Yu, S.L., Chen, H.Y., Chang, G.C., et al. (2008). MicroRNA signature predicts survival and relapse in lung cancer. Cancer Cell 13, 48-57.
53. Zhang, J.G., Wang, J.J., Zhao, F., et al. (2010). MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC). Clin. Chim. Acta 411, 846-852.