Amyloid precursor-like protein 1 is differentially upregulated in neuroendocrine tumours of the gastrointestinal tract

Endocrine-Related Cancer

Volumn 15, Issue 2, 2008, Pages 569-581

  Arvidsson, Yvonne ^a   Andersson, Elinor ^a   Bergström, Anders ^a   Andersson, Mattias K ^a   Altiparmak, Gülay ^a   Illerskog, Ann Christin ^a   Ahlman, Håkan ^a   Lamazhapova, Darima ^a,b   Nilsson, Ola ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR LIKE PROTEIN 1; AMYLOID PRECURSOR LIKE PROTEIN 2; AMYLOID PRECURSOR PROTEIN; PROTEIN PRECURSOR; SYNAPTOPHYSIN;

ARTICLE; CARCINOID; CELL ADHESION; CELL INVASION; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONFOCAL LASER MICROSCOPY; DISEASE MARKER; DOWN REGULATION; ENZYME REGULATION; GASTROINTESTINAL STROMAL TUMOR; GASTROINTESTINAL TRACT; GASTROINTESTINAL TUMOR; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MICROARRAY ANALYSIS; NEUROENDOCRINE TUMOR; NUCLEOTIDE SEQUENCE; PANCREAS TUMOR; PROTEIN EXPRESSION; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TISSUE MICROARRAY; UPREGULATION; WESTERN BLOTTING;

AMYLOID BETA-PROTEIN PRECURSOR; CARCINOID TUMOR; CELL LINE, TUMOR; ENDOSOMES; GASTROINTESTINAL NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; LUNG NEOPLASMS; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SYNAPTIC VESICLES; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 45849122542     PISSN: 13510088     EISSN: None     Source Type: Journal    
DOI: 10.1677/ERC-07-0145     Document Type: Article

References (48)

1. Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK & Rosenfeld MG 2002 Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell 110 55-67.
2. Baldus CD, Liyanarachchi S, Mrozek K, Auer H, Tanner SM, Guimond M, Ruppert AS, Mohamed N, Davuluri RV, Caligiuri MA et al. 2004 Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: amplification discloses overexpression of APP, ETS2, and ERG genes. PNAS USA 101 3915-3920.
3. Bimonte M, Gianni D, Allegra D, Russo T & Zambrano N 2004 Mutation of the feh-1 gene, the Caenorhabditis elegans orthologue of mammalian Fe65, decreases the expression of two acetylcholinesterase genes. European Journal of Neuroscience 20 1483-1488.
4. Bjerknes M & Cheng H 2006 Neurogenin 3 and the enteroendocrine cell lineage in the adult mouse small intestinal epithelium. Developmental Biology 300 722-735.
5. Borg JP, Ooi J, Levy E & Margolis B 1996 The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein. Molecular and Cellular Biology 16 6229-6241.
6. Cao X & Sudhof TC 2001 A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293 115-120.
7. Eggert S, Paliga K, Soba P, Evin G, Masters CL, Weidemann A & Beyreuther K 2004 The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation. Journal of Biological Chemistry 279 18146-18156.
8. van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F et al. 2005 Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 435 959-963.
9. Evers BM, Townsend CM Jr, Upp JR, Allen E, Hurlbut SC, Kim SW, Rajaraman S, Singh P, Reubi JC & Thompson JC 1991 Establishment and characterization of a human carcinoid in nude mice and effect of various agents on tumour growth. Gastroenterology 101 303-311.
10. Fischer DF, van Dijk R, Sluijs JA, Nair SM, Racchi M, Levelt CN, van Leeuwen FW & Hol EM 2005 Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP. FASEB Journal 19 1451-1458.
11. Hansel DE, Rahman A, Wehner S, Herzog V, Yeo CJ & Maitra A 2003 Increased expression and processing of the Alzheimer amyloid precursor protein in pancreatic cancer may influence cellular proliferation. Cancer Research 63 7032-7037.
12. Hazan RB, Qiao R, Keren R, Badano I & Suyama K 2004 Cadherin switch in tumour progression. Annals of the New York Academy of Sciences 1014 155-163.
13. Heber S, Herms J, Gajic V, Hainfellner J, Aguzzi A, Rulicke T, von Kretzschmar H, von Koch C, Sisodia S, Tremml P et al. 2000 Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members. Journal of Neuroscience 20 7951-7963.
14. Homayouni R, Rice DS, Sheldon M & Curran T 1999 Disabled-1 binds to me cytoplasmic domain of amyloid precursor-like protein 1. Journal of Neuroscience 19 7507-7515.
15. Jakobsen AM, Ahlman H, Wangberg B, Kolby L, Bengtsson M & Nilsson O 2002 Expression of synaptic vesicle protein 2 (SV2) in neuroendocrine tumours of the gastrointestinal tract and pancreas. Journal of Pathology 196 44-50.
16. Ko SY, Lin SC, Chang KW, Wong YK, Liu CJ, Chi CW & Liu TY 2004 Increased expression of amyloid precursor protein in oral squamous cell carcinoma. International Journal of Cancer 111 727-732.
17. von Koch CS, Zheng H, Chen H, Trumbauer M, Thinakaran G, van der Ploeg LH, Price DL & Sisodia SS 1997 Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiology of Aging 18 661-669.
18. Kölby L, Bernhardt P, Ahlman H, Wangberg B, Johanson V, Wigander A, Forssell-Aronsson E, Karlsson S, Ahren B, Stenman G et al. 2001 A transplantable human carcinoid as model for somatostatin receptor-mediated and amine transporter-mediated radionuclide uptake. American Journal of Pathology 158 745-755.
19. Kunnimalaiyaan M & Chen H 2007 Tumor suppressor role of Notch-1 signaling in neuroendocrine tumors. Oncologist 12 535-542.
20. Li C, Kato M, Shiue L, Shively JE, Ares M Jr & Lin RJ 2006 Cell type and culture condition-dependent alternative splicing in human breast cancer cells revealed by splicing-sensitive microarrays. Cancer Research 66 1990-1999.
21. Lorent K, Overbergh L, Moechars D, De Strooper B, Van Leuven F & Van den Berghe H 1995 Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein. Neuroscience 65 1009-1025.
22. Mattson MP, Cheng B, Culwell AR, Esch FS, Lieberburg I & Rydel RE 1993 Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein. Neuron 10 243-254.
23. Mauri P, Scarpa A, Nascimbeni AC, Benazzi L, Parmagnani E, Mafficini A, Delia Peruta M, Bassi C, Miyazaki K & Sorio C 2005 Identification of proteins released by pancreatic cancer cells by multidimensional protein identification technology: a strategy for identification of novel cancer markers. FASEB Journal 19 1125-1127.
24. Meng JY, Kataoka H, Itoh H & Koono M 2001 Amyloid beta protein precursor is involved in the growth of human colon carcinoma cell in vitro and in vivo. International Journal of Cancer 92 31-39.
25. Merdes G, Soba P, Loewer A, Bilic MV, Beyreuther K & Paro R 2004 Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila. EMBO Journal 23 4082-4095.
26. Milward EA, Papadopoulos R, Fuller SJ, Moir RD, Small D, Beyreuther K & Masters CL 1992 The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron 9 129-137.
27. Nakagawa T, Kabuto M, Kubota T, Kodera T & Sato K 1999 Production of amyloid beta protein precursor as a proteinase inhibitor by human astrocytic tumours. Anticancer Research 19 2963-2968.
28. Nakakura EK, Sriuranpong VR, Kunnimalaiyaan M, Hsiao EC, Schuebel KE, Borges MW, Jin N, Collins BJ, Nelkin BD, Chen H et al. 2005 Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumour cells by notch signalling. Journal of Clinical Endocrinology and Metabolism 90 4350-4356.
29. Paliga K, Peraus G, Kreger S, Durrwang U, Hesse L, Multhaup G, Masters CL, Beyreuther K & Weidemann A 1997 Human amyloid precursor-like protein 1 - cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid. European Journal of Biochemistry 250 354-363.
30. Paris D, Quadros A, Patel N, DelleDonne A, Humphrey J & Mullan M 2005 Inhibition of angiogenesis and tumour growth by beta and gamma-secretase inhibitors. European Journal of Pharmacology 514 1-15.
31. Perez RG, Zheng H, Van der Ploeg LH & Koo EH 1997 The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity. Journal of Neuroscience 17 9407-9414.
32. Pietrzik CU, Hoffmann J, Stober K, Chen CY, Bauer C, Otero DA, Roch JM & Herzog V 1998 From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells. PNAS 95 1770-1775.
33. Quast T, Wehner S, Kirfel G, Jaeger K, De Luca M & Herzog V 2003 sAPP as a regulator of dendrite motility and melanin release in epidermal melanocytes and melanoma cells. FASEB Journal 17 1739-1741.
34. Roncarati R, Sestan N, Scheinfeld MH, Berechid BE, Lopez PA, Meucci O, McGlade JC, Rakic P & D'Adamio L 2002 The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signalling. PNAS 99 7102-7107.
35. Sabo SL, Ikin AF, Buxbaum JD & Greengard P 2001 The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement. Journal of Cell Biology 153 1403-1414.
36. Saitoh T, Sundsmo M, Roch JM, Kimura N, Cole G, Schubert D, Oltersdorf T & Schenk DB 1989 Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts. Cell 58 615-622.
37. Sakai T & Hohjoh H 2006 Gene silencing analyzes against amyloid precursor protein (APP) gene family by RNA interference. Cell Biology International 30 952-956.
38. Scheinfeld MH, Ghersi E, Laky K, Fowlkes BJ & D'Adamio L 2002 Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription. Journal of Biological Chemistry 277 44195-44201.
39. Schubert D, LaCorbiere M, Saitoh T & Cole G 1989 Characterization of an amyloid beta precursor protein that binds heparin and contains tyrosine sulfate. PNAS 86 2066-2069.
40. Slunt HH, Thinakaran G, Von Koch C, Lo AC, Tanzi RE & Sisodia SS 1994 Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP). Journal of Biological Chemistry 269 2637-2644.
41. Soba P, Eggert S, Wagner K, Zentgraf H, Siehl K, Kreger S, Lower A, Langer A, Merdes G, Paro R et al. 2005 Homo- and heterodimerization of APP family members promotes intercellular adhesion. EMBO Journal 24 3624-3634.
42. Sprecher CA, Grant FJ, Grimm G, O'Hara PJ, Norris F, Norris K & Foster DC 1993 Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family. Biochemistry 32 4481-4486.
43. De Strooper B & Annaert W 2000 Proteolytic processing and cell biological functions of the amyloid precursor protein. Journal of Cell Science 113 1857-1870.
44. Tanzi RE, McClatchey AI, Lamperti ED, Villa-Komaroff L, Gusella JF & Neve RL 1988 Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease. Nature 331 528-530.
45. Wasco W, Bupp K, Magendantz M, Gusella JF, Tanzi RE & Solomon F 1992 Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. PNAS 89 10758-10762.
46. Wasco W, Gurubhagavatula S, Paradis MD, Romano DM, Sisodia SS, Hyman BT, Neve RL & Tanzi RE 1993 Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. Nature Genetics 5 95-100.
47. Zambrano N, Bruni P, Minopoli G, Mosca R, Molino D, Russo C, Schettini G, Sudol M & Russo T 2001 The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene. Journal of Biological Chemistry 276 19787-19792.
48. Zheng H, Jiang M, Trumbauer ME, Sirinathsinghji DJ, Hopkins R, Smith DW, Heavens RP, Dawson GR, Boyce S, Conner MW et al. 1995 beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81 525-531.