The prokinetic face of ghrelin

International Journal of Peptides

Volumn 2010, Issue , 2010, Pages

  Sallam, Hanaa S ^a   Chen, Jiande D Z ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; CAPROMORELIN; CAPSAICIN; CARBACHOL; CISPLATIN; CP 464709; EVANS BLUE; EX 1314; EX 1315; GHRELIN; GHRELIN RECEPTOR; GHRELIN RECEPTOR AGONIST; GROWTH HORMONE SECRETAGOGUE RECEPTOR; GSK 894281; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; IPAMORELIN; MORPHINE; N(G) NITROARGININE METHYL ESTER; NEUROPEPTIDE Y; NITRIC OXIDE; OCTANOIC ACID C 13; OPIATE; PARACETAMOL; PROKINETIC AGENT; RC 1139; RC 1141; TECHNETIUM 99M; TZP 102; ULIMORELIN; UNCLASSIFIED DRUG;

BURN; CANCER CHEMOTHERAPY; CHRONIC DISEASE; COLON; COMPUTER ASSISTED TOMOGRAPHY; CONSTIPATION; DIABETES MELLITUS; DOSE RESPONSE; DYSPEPSIA; ENDOTOXEMIA; GASTROINTESTINAL MOTILITY DISORDER; HORMONE ACTION; HUMAN; IDIOPATHIC DISEASE; ILEUS; INTESTINE CONTRACTION; INTESTINE FUNCTION; INTESTINE INNERVATION; NONHUMAN; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REAL TIME ECHOGRAPHY; REPEATED DRUG DOSE; REVIEW; SEPSIS; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SMALL INTESTINE; STOMACH; STOMACH EMPTYING; STOMACH PARESIS; TREATMENT OUTCOME; VAGOTOMY; VISUAL ANALOG SCALE;

EID: 79958088475     PISSN: 16879767     EISSN: 16879775     Source Type: Journal    
DOI: 10.1155/2010/493614     Document Type: Review

References (70)

1. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K., Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 1999 402 6762 656 660 (Pubitemid 129516334)
2. Tomasetto C., Wendling C., Rio M. C., Poitras P., Identification of cDNA encoding motilin related peptide/ghrelin precursor from dog fundus Peptides 2001 22 12 2055 2059
3. Peeters T. L., Old and new targets for prokinetic drugs: motilin and ghrelin receptors European Review for Medical and Pharmacological Sciences 2008 12 136 137
4. Poitras P., Tomasetto C., The potential of ghrelin as a prokinetic Regulatory Peptides 2009 155 13 24 27
5. De Smet B., Mitselos A., Depoortere I., Motilin and ghrelin as prokinetic drug targets Pharmacology and Therapeutics 2009 123 2 207 223
6. Sanger G. J., Motilin, ghrelin and related neuropeptides as targets for the treatment of GI diseases Drug Discovery Today 2008 13 5-6 234 239
7. Taniguchi H., Ariga H., Zheng J., Ludwig K., Takahashi T., Effects of ghrelin on interdigestive contractions of the rat gastrointestinal tract World Journal of Gastroenterology 2008 14 41 6299 6302
8. Camilleri M., Papathanasopoulos A., Odunsi S. T., Actions and therapeutic pathways of ghrelin for gastrointestinal disorders Nature Reviews Gastroenterology and Hepatology 2009 6 6 343 352
9. Venkova K., Greenwood-Van Meerveld B., Application of ghrelin to gastrointestinal diseases Current Opinion in Investigational Drugs 2008 9 10 1103 1107
10. Tack J., Prokinetics and fundic relaxants in upper functional GI disorders Current Opinion in Pharmacology 2008 8 6 690 696
11. Dass N. B., Munonyara M., Bassil A. K., Growth hormone secretagogue receptors in rat and human gastrointestinal tract and the effects of ghrelin Neuroscience 2003 120 2 443 453 (Pubitemid 37288779)
12. Bassil A. K., Dass N. B., Murray C. D., Muir A., Sanger G. J., Prokineticin-2, motilin, ghrelin and metoclopramide: prokinetic utility in mouse stomach and colon European Journal of Pharmacology 2005 524 13 138 144 (Pubitemid 41606826)
13. Bassil A. K., Dass N. B., Sanger G. J., The prokinetic-like activity of ghrelin in rat isolated stomach is mediated via cholinergic and tachykininergic motor neurones European Journal of Pharmacology 2006 544 13 146 152 (Pubitemid 44164450)
14. Fukuda H., Mizuta Y., Isomoto H., Ghrelin enhances gastric motility through direct stimulation of intrinsic neural pathways and capsaicin-sensitive afferent neurones in rats Scandinavian Journal of Gastroenterology 2004 39 12 1209 1214 (Pubitemid 39656835)
15. Depoortere I., De Winter B., Thijs T., De Man J., Pelckmans P., Peeters T., Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro European Journal of Pharmacology 2005 515 13 160 168 (Pubitemid 40779281)
16. Kitazawa T., De Smet B., Verbeke K., Depoortere I., Peeters T. L., Gastric motor effects of peptide and non-peptide ghrelin agonists in mice in vivo and in vitro Gut 2005 54 8 1078 1084 (Pubitemid 41025898)
17. Levin F., Edholm T., Ehrstrom M., Effect of peripherally administered ghrelin on gastric emptying and acid secretion in the rat Regulatory Peptides 2005 131 13 59 65 (Pubitemid 41392993)
18. Kitazawa T., Kaiya H., Taneike T., Contractile effects of ghrelin-related peptides on the chicken gastrointestinal tract in vitro Peptides 2007 28 3 617 624 (Pubitemid 46204997)
19. Kitazawa T., Maeda Y., Kaiya H., Molecular cloning of growth hormone secretagogue-receptor and effect of quail ghrelin on gastrointestinal motility in Japanese quail Regulatory Peptides 2009 158 13 132 142
20. Fujino K., Inui A., Asakawa A., Kihara N., Fujimura M., Fujimiya M., Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats Journal of Physiology 2003 550 1 227 240 (Pubitemid 36869283)
21. Ariga H., Tsukamoto K., Chen C., Mantyh C., Pappas T. N., Takahashi T., Endogenous acyl ghrelin is involved in mediating spontaneous phase III-like contractions of the rat stomach Neurogastroenterology and Motility 2007 19 8 675 680 (Pubitemid 47084125)
22. Tanaka R., Inui A., Asakawa A., Atsuchi K., Ataka K., Fujimiya M., New method of manometric measurement of gastroduodenal motility in conscious mice: effects of ghrelin and Y2 depletion American Journal of Physiology 2009 297 5 G1028 G1034
23. Zheng J., Ariga H., Taniguchi H., Ludwig K., Takahashi T., Ghrelin regulates gastric phase III-like contractions in freely moving conscious mice Neurogastroenterology and Motility 2009 21 1 78 84
24. Ohno T., Kamiyama Y., Aihara R., Ghrelin does not stimulate gastrointestinal motility and gastric emptying: an experimental study of conscious dogs Neurogastroenterology and Motility 2006 18 2 129 135
25. Kobashi M., Yanagihara M., Fujita M., Mitoh Y., Matsuo R., Fourth ventricular administration of ghrelin induces relaxation of the proximal stomach in the rat American Journal of Physiology 2009 296 2 R217 R223
26. Yin J., Chen J., Inhibitory effects of gastric electrical stimulation on ghrelin-induced excitatory effects on gastric motility and food intake in dogs Scandinavian Journal of Gastroenterology 2006 41 8 903 909 (Pubitemid 43995465)
27. Tumer C., Oflazoglu H. D., Obay B. D., Kelle M., Tasdemir E., Effect of ghrelin on gastric myoelectric activity and gastric emptying in rats Regulatory Peptides 2008 146 13 26 32
28. Masuda Y., Tanaka T., Inomata N., Ghrelin stimulates gastric acid secretion and motility in rats Biochemical and Biophysical Research Communications 2000 276 3 905 908
29. Trudel L., Tomasetto C., Rio M. C., Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat American Journal of Physiology 2002 282 6 G948 G952
30. Dornonville De La Cour C., Lindstrom E., Norlen P., Hakanson R., Ghrelin stimulates gastric emptying but is without effect on acid secretion and gastric endocrine cells Regulatory Peptides 2004 120 13 23 32 (Pubitemid 38726188)
31. Poitras P., Polvino W. J., Rocheleau B., Gastrokinetic effect of ghrelin analog RC-1139 in the rat: effect on post-operative and on morphine induced ileus Peptides 2005 26 9 1598 1601 (Pubitemid 41169753)
32. Charoenthongtrakul S., Giuliana D., Longo K. A., Enhanced gastrointestinal motility with orally active ghrelin receptor agonists Journal of Pharmacology and Experimental Therapeutics 2009 329 3 1178 1186
33. De Winter B. Y., De Man J. G., Seerden T. C., Effect of ghrelin and growth hormone-releasing peptide 6 on septic ileus in mice Neurogastroenterology and Motility 2004 16 4 439 446 (Pubitemid 39140639)
34. De Smet B., Depoortere I., Moechars D., Energy homeostasis and gastric emptying in ghrelin knockout mice Journal of Pharmacology and Experimental Therapeutics 2006 316 1 431 439 (Pubitemid 41832623)
35. Tack J., Depoortere I., Bisschops R., Influence of ghrelin on interdigestive gastrointestinal motility in humans Gut 2006 55 3 327 333 (Pubitemid 43268268)
36. Bisschops R., Ligand and electrically induced acitivation patterns in myenteric neuronal networks. Confocal calcium imaging as a bridge between basic and human physiology Verhandelingen Koninklijke Academie voor Geneeskunde van Belgi 2008 70 2 105 145
37. Cremonini F., Camilleri M., Vazquez Roque M., Obesity does not increase effects of synthetic ghrelin on human gastric motor functions Gastroenterology 2006 131 5 1431 1439 (Pubitemid 44708949)
38. Ang D., Nicolai H., Vos R., Influence of ghrelin on the gastric accommodation reflex and on meal-induced satiety in man Neurogastroenterology and Motility 2009 21 5 528 533
39. Levin F., Edholm T., Schmidt P. T., Ghrelin stimulates gastric emptying and hunger in normal-weight humans Journal of Clinical Endocrinology and Metabolism 2006 91 9 3296 3302 (Pubitemid 44402094)
40. Qiu W.-C., Wang Z.-G., Wang W.-G., Yan J., Zheng Q., Gastric motor effects of ghrelin and growth hormone releasing peptide 6 in diabetic mice with gastroparesis World Journal of Gastroenterology 2008 14 9 1419 1424 (Pubitemid 351425225)
41. Qiu W.-C., Wang Z.-G., Wang W.-G., Yan J., Zheng Q., Therapeutic effects of ghrelin and growth hormone releasing peptide 6 on gastroparesis in streptozotocin-induced diabetic guinea pigs in vivo and in vitro Chinese Medical Journal 2008 121 13 1183 1188
42. Trudel L., Bouin M., Tomasetto C., Two new peptides to improve post-operative gastric ileus in dog Peptides 2003 24 4 531 534 (Pubitemid 36829341)
43. Liu Y.-L., Malik N. M., Sanger G. J., Andrews P. L. R., Ghrelin alleviates cancer chemotherapy-associated dyspepsia in rodents Cancer Chemotherapy and Pharmacology 2006 58 3 326 333 (Pubitemid 43800735)
44. Sallam H. S., Oliveira H. M., Gan H. T., Herndon D. N., Chen J. D. Z., Ghrelin improves burn-induced delayed gastrointestinal transit in rats American Journal of Physiology 2007 292 1 R253 R257
45. Venkova K., Fraser G., Hoveyda H. R., Greenwood-Van Meerveld B., Prokinetic effects of a new ghrelin receptor agonist TZP-101 in a rat model of postoperative ileus Digestive Diseases and Sciences 2007 52 9 2241 2248 (Pubitemid 47246531)
46. Chen Y. T., Tsai S. H., Sheu S. Y., Tsai L. H., Ghrelin improves lipopolysaccharide-induced gastrointestinal motility disturbances: roles of nitric oxide and prostaglandin E2 Shock 2010 33 2 205 212
47. Zheng Q., Qiu W.-C., Yan J., Prokinetic effects of a ghrelin receptor agonist GHRP-6 in diabetic mice World Journal of Gastroenterology 2008 14 30 4795 4799
48. Tack J., Depoortere I., Bisschops R., Verbeke K., Janssens J., Peeters T., Influence of ghrelin on gastric emptying and meal-related symptoms in idiopathic gastroparesis Alimentary Pharmacology and Therapeutics 2005 22 9 847 853 (Pubitemid 41568544)
49. Murray C. D. R., Martin N. M., Patterson M., Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study Gut 2005 54 12 1693 1698 (Pubitemid 41697666)
50. Binn M., Albert C., Gougeon A., Ghrelin gastrokinetic action in patients with neurogenic gastroparesis Peptides 2006 27 7 1603 1606 (Pubitemid 43866263)
51. Ejskjaer N., Vestergaard E. T., Hellstrom P. M., Ghrelin receptor agonist (TZP-101) accelerates gastric emptying in adults with diabetes and symptomatic gastroparesis Alimentary Pharmacology and Therapeutics 2009 29 11 1179 1187
52. Lasseter K. C., Shaughnessy L., Cummings D., Ghrelin agonist (TZP-101): safety, pharmacokinetics and pharmacodynamic evaluation in healthy volunteers: a phase I, first-in-human study Journal of Clinical Pharmacology 2008 48 2 193 202
53. Fraser G. L., Hoveyda H. R., Tannenbaum G. S., Pharmacological demarcation of the growth hormone, gut motility and feeding effects of ghrelin using a novel ghrelin receptor agonist Endocrinology 2008 149 12 6280 6288
54. Vestergaard E. T., Gormsen L. C., Jessen N., Ghrelin infusion in humans induces acute insulin resistance and lipolysis independent of growth hormone signaling Diabetes 2008 57 12 3205 3210
55. Ankersen M., Kramer Nielsen K., Kruse Hansen T., Raun K., Sehested Hansen B., Growth hormone secretagogues derived from NN703 with hydrazides as C-terminal European Journal of Medicinal Chemistry 2000 35 5 487 497 (Pubitemid 30395098)
56. Edholm T., Levin F., Hellstrom P. M., Schmidt P. T., Ghrelin stimulates motility in the small intestine of rats through intrinsic cholinergic neurons Regulatory Peptides 2004 121 13 25 30 (Pubitemid 38901058)
57. Olsson C., Holbrook J. D., Bompadre G., Identification of genes for the ghrelin and motilin receptors and a novel related gene in fish, and stimulation of intestinal motility in zebrafish (Danio rerio) by ghrelin and motilin General and Comparative Endocrinology 2008 155 1 217 226 (Pubitemid 350130249)
58. Wang Y., Dong L., Cheng Y., Zhao P., Effects of ghrelin on feeding regulation and interdigestive migrating complex in rats Scandinavian Journal of Gastroenterology 2007 42 4 447 453 (Pubitemid 46569391)
59. Date Y., Nakazato M., Murakami N., Kojima M., Kangawa K., Matsukura S., Ghrelin acts in the central nervous system to stimulate gastric acid secretion Biochemical and Biophysical Research Communications 2001 280 3 904 907 (Pubitemid 32924518)
60. Rauma J., Spangeus A., El-Salhy M., Ghrelin cell density in the gastrointestinal tracts of animal models of human diabetes Histology and Histopathology 2006 21 13 1 5 (Pubitemid 43033710)
61. Tebbe J. J., Mronga S., Tebbe C. G., Ortmann E., Arnold R., Schafer M. K.-H., Ghrelin-induced stimulation of colonic propulsion is dependent on hypothalamic neuropeptide Y1-and corticotrophin-releasing factor 1 receptor activation Journal of Neuroendocrinology 2005 17 9 570 576 (Pubitemid 41195410)
62. Tebbe J. J., Tebbe C. G., Mronga S., Ritter M., Schafer M. K. H., Central neuropeptide Y receptors are involved in 3rd ventricular ghrelin induced alteration of colonic transit time in conscious fed rats BMC Gastroenterology 2005 5, article 5
63. Shimizu Y., Chang E. C., Shafton A. D., Evidence that stimulation of ghrelin receptors in the spinal cord initiates propulsive activity in the colon of the rat Journal of Physiology 2006 576 1 329 338 (Pubitemid 44426240)
64. Shafton A. D., Sanger G. J., Witherington J., Oral administration of a centrally acting ghrelin receptor agonist to conscious rats triggers defecation Neurogastroenterology and Motility 2009 21 1 71 77
65. De Smet B., Thijs T., Moechars D., Endogenous and exogenous ghrelin enhance the colonic and gastric manifestations of dextran sodium sulphate-induced colitis in mice Neurogastroenterology and Motility 2009 21 1 59 70
66. Gonzalez-Rey E., Chorny A., Delgado M., Therapeutic action of ghrelin in a mouse model of colitis Gastroenterology 2006 130 6 1707 1720 (Pubitemid 43668852)
67. Konturek P. C., Brzozowski T., Engel M., Ghrelin ameliorates colonic inflammation. Role of nitric oxide and sensory nerves Journal of Physiology and Pharmacology 2009 60 2 41 47
68. Fraser G. L., Venkova K., Hoveyda H. R., Thomas H., Greenwood-Van Meerveld B., Effect of the ghrelin receptor agonist TZP-101 on colonic transit in a rat model of postoperative ileus European Journal of Pharmacology 2009 604 13 132 137
69. Venkova K., Mann W., Nelson R., Greenwood-Van Meerveld B., Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus Journal of Pharmacology and Experimental Therapeutics 2009 329 3 1110 1115
70. Tranzyme (R) Pharma, 2009, http://www.tranzyme.com/