메뉴 건너뛰기




Volumn 9, Issue 10, 2008, Pages 1103-1107

Application of ghrelin to gastrointestinal diseases

Author keywords

Age related anorexia; Chemotherapy induced dyspepsia; Gastrointestinal motility; Gastroparesis; Ghrelin; Postoperative ileus

Indexed keywords

BETHANECHOL; CISAPRIDE; CISPLATIN; CYTOTOXIC AGENT; ERYTHROMYCIN; GHRELIN; GHRELIN RECEPTOR AGONIST; GHRELIN RECEPTOR ANTAGONIST; IBUTAMOREN; METOCLOPRAMIDE; PLACEBO; RC 1139; TEGASEROD; TZP 101; UNCLASSIFIED DRUG;

EID: 53049086387     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (19)

References (50)
  • 1
    • 37349007443 scopus 로고    scopus 로고
    • The discovery of ghrelin - a personal memory
    • The history of ghrelin's discovery is described, •
    • Kojima M: The discovery of ghrelin - a personal memory. Regul Pept (2008) 145(1-3):2-6. • The history of ghrelin's discovery is described.
    • (2008) Regul Pept , vol.145 , Issue.1-3 , pp. 2-6
    • Kojima, M.1
  • 2
    • 33748664379 scopus 로고    scopus 로고
    • Drug insight: The functions of ghrelin and its potential as a multitherapeutic hormone
    • A review summarizing the diverse functions of ghrelin, and outlining the possibilities for its clinical implications in eating and GI disorders, cardiovascular disease, osteoporosis and aging, •
    • Kojima M, Kangawa K. Drug insight: The functions of ghrelin and its potential as a multitherapeutic hormone. Nat Clin Pract Endocrinol Metab (2006) 2(2):80-88. • A review summarizing the diverse functions of ghrelin, and outlining the possibilities for its clinical implications in eating and GI disorders, cardiovascular disease, osteoporosis and aging.
    • (2006) Nat Clin Pract Endocrinol Metab , vol.2 , Issue.2 , pp. 80-88
    • Kojima, M.1    Kangawa, K.2
  • 3
    • 27444446161 scopus 로고    scopus 로고
    • Peeters TL: Ghrelin: A new player in the control of gastrointestinal functions. Gut (2005) 54(11):1638-1649. • A review on the role of ghrelin in the control of gastrointestinal functions.
    • Peeters TL: Ghrelin: A new player in the control of gastrointestinal functions. Gut (2005) 54(11):1638-1649. • A review on the role of ghrelin in the control of gastrointestinal functions.
  • 4
    • 1042288138 scopus 로고    scopus 로고
    • Appetite regulation: From the gut to the hypothalamus
    • Neary NM, Goldstone AP, Bloom SR: Appetite regulation: From the gut to the hypothalamus. Clin Endocrinol (Oxf) (2004) 60(2):153-160.
    • (2004) Clin Endocrinol (Oxf) , vol.60 , Issue.2 , pp. 153-160
    • Neary, N.M.1    Goldstone, A.P.2    Bloom, S.R.3
  • 6
    • 0345528179 scopus 로고    scopus 로고
    • Activation of c-fos expression in the rat inferior olivary nucleus by ghrelin
    • Zhang W, Lin TR, Hu Y, Fan Y, Zhao L, Mulholland MW: Activation of c-fos expression in the rat inferior olivary nucleus by ghrelin. Neurosci Lett (2003) 353(3):157-160.
    • (2003) Neurosci Lett , vol.353 , Issue.3 , pp. 157-160
    • Zhang, W.1    Lin, T.R.2    Hu, Y.3    Fan, Y.4    Zhao, L.5    Mulholland, M.W.6
  • 10
    • 10644280945 scopus 로고    scopus 로고
    • Ghrelin enhances gastric motility through direct stimulation of intrinsic neural pathways and capsaicin-sensitive afferent neurons in rats
    • Fukuda H, Mizuta Y, Isomoto H, Takeshima F, Ohnita K, Ohba K, Omagari K, Taniyama K, Kohno S: Ghrelin enhances gastric motility through direct stimulation of intrinsic neural pathways and capsaicin-sensitive afferent neurons in rats. Scand J Gastroenterol (2004) 39(12):1209- 1214.
    • (2004) Scand J Gastroenterol , vol.39 , Issue.12 , pp. 1209-1214
    • Fukuda, H.1    Mizuta, Y.2    Isomoto, H.3    Takeshima, F.4    Ohnita, K.5    Ohba, K.6    Omagari, K.7    Taniyama, K.8    Kohno, S.9
  • 11
    • 0036083505 scopus 로고    scopus 로고
    • Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat
    • Trudel L, Tomasetto C, Rio MC, Bouin M, Plourde V, Eberling P, Poitras P: Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat. Am J Physiol (2002) 282(6):G948- G952.
    • (2002) Am J Physiol , vol.282 , Issue.6
    • Trudel, L.1    Tomasetto, C.2    Rio, M.C.3    Bouin, M.4    Plourde, V.5    Eberling, P.6    Poitras, P.7
  • 12
    • 2642565900 scopus 로고    scopus 로고
    • Ghrelin stimulates gastric emptying, but is without effect on acid secretion and gastric endocrine cells
    • Dornonville de la Cour C, Lindström E, Norlén P, Håkanson R: Ghrelin stimulates gastric emptying, but is without effect on acid secretion and gastric endocrine cells. Regul Pept (2004) 120(1-3):23-32.
    • (2004) Regul Pept , vol.120 , Issue.1-3 , pp. 23-32
    • Dornonville de la Cour, C.1    Lindström, E.2    Norlén, P.3    Håkanson, R.4
  • 13
    • 38149073220 scopus 로고    scopus 로고
    • Ariga H, Nakade Y, Tsukamoto K, Imai K, Chen C, Mantyh C, Pappas TN, Takahashi T: Ghrelin accelerates gastric emptying via early manifestation of antro-pyloric coordination in conscious rats. Regul Pept (2008) 146(1-3):112-116. •• Evidence that ghrelin enhances the coordinated motor pattern between the antral and pyloric regions of the stomach is provided. The enhanced antro-pyloric coordination is associated with acceleration of gastric emptying of solid food, and is important for the potential therapeutic use of ghrelin receptor agonists as gastroprokinetic drugs.
    • Ariga H, Nakade Y, Tsukamoto K, Imai K, Chen C, Mantyh C, Pappas TN, Takahashi T: Ghrelin accelerates gastric emptying via early manifestation of antro-pyloric coordination in conscious rats. Regul Pept (2008) 146(1-3):112-116. •• Evidence that ghrelin enhances the coordinated motor pattern between the antral and pyloric regions of the stomach is provided. The enhanced antro-pyloric coordination is associated with acceleration of gastric emptying of solid food, and is important for the potential therapeutic use of ghrelin receptor agonists as gastroprokinetic drugs.
  • 14
    • 0038031634 scopus 로고    scopus 로고
    • Growth hormone secretagogue receptor expression in the cells of the stomach-projected afferent nerve in the rat nodose ganglion
    • Sakata I, Yamazaki M, Inoue K, Hayashi Y, Kangawa K, Sakai T: Growth hormone secretagogue receptor expression in the cells of the stomach-projected afferent nerve in the rat nodose ganglion. Neurosci Lett (2003) 342(3):183-186.
    • (2003) Neurosci Lett , vol.342 , Issue.3 , pp. 183-186
    • Sakata, I.1    Yamazaki, M.2    Inoue, K.3    Hayashi, Y.4    Kangawa, K.5    Sakai, T.6
  • 15
    • 33646856625 scopus 로고    scopus 로고
    • Ghrelin receptors in rat and human nodose ganglia: Putative role in regulating CB-1 and MCH receptor abundance
    • Burdyga G, Varro A, Dimaline R, Thompson DG, Dockray GJ: Ghrelin receptors in rat and human nodose ganglia: Putative role in regulating CB-1 and MCH receptor abundance. Am J Physiol (2006) 290(6):G1289- G1297.
    • (2006) Am J Physiol , vol.290 , Issue.6
    • Burdyga, G.1    Varro, A.2    Dimaline, R.3    Thompson, D.G.4    Dockray, G.J.5
  • 17
    • 8444226059 scopus 로고    scopus 로고
    • Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus
    • Xu L, Depoortere I, Tomasetto C, Zandecki M, Tang M, Timmermans JP, Peeters TL: Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus. Regul Pept (2005) 124(1-3):119-125.
    • (2005) Regul Pept , vol.124 , Issue.1-3 , pp. 119-125
    • Xu, L.1    Depoortere, I.2    Tomasetto, C.3    Zandecki, M.4    Tang, M.5    Timmermans, J.P.6    Peeters, T.L.7
  • 18
    • 15544385058 scopus 로고    scopus 로고
    • Ghrelin: Structure and function
    • Kojima M, Kangawa K: Ghrelin: Structure and function. Physiol Rev (2005) 85(2):495-522.
    • (2005) Physiol Rev , vol.85 , Issue.2 , pp. 495-522
    • Kojima, M.1    Kangawa, K.2
  • 20
    • 3142534319 scopus 로고    scopus 로고
    • Ghrelin stimulates motility in the small intestine of rats through intrinsic cholinergic neurons
    • Edholm T, Levin F, Hellström PM, Schmidt PT: Ghrelin stimulates motility in the small intestine of rats through intrinsic cholinergic neurons. Regul Pept (2004) 121(1-3):25-30.
    • (2004) Regul Pept , vol.121 , Issue.1-3 , pp. 25-30
    • Edholm, T.1    Levin, F.2    Hellström, P.M.3    Schmidt, P.T.4
  • 21
    • 0037592273 scopus 로고    scopus 로고
    • Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats
    • Fujino K, Inui A, Asakawa A, Kihara N, Fujimura M, Fujimiya M: Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats. J Physiol (2003) 550(1):227-240.
    • (2003) J Physiol , vol.550 , Issue.1 , pp. 227-240
    • Fujino, K.1    Inui, A.2    Asakawa, A.3    Kihara, N.4    Fujimura, M.5    Fujimiya, M.6
  • 24
    • 13844255029 scopus 로고    scopus 로고
    • Excitatory stimulation of neurons in the arcuate nucleus initiates central CRF-dependent stimulation of colonic propulsion in rats
    • The important role of the arcuate nucleus and the paraventricular nucleus in the hypothalamus in the central regulation of GI function is described, ••
    • Tebbe JJ, Pasat IR, Mönnikes H, Ritter M, Kobelt P, Schäfer MK: Excitatory stimulation of neurons in the arcuate nucleus initiates central CRF-dependent stimulation of colonic propulsion in rats. Brain Res (2005) 1036(1-2):130-138. •• The important role of the arcuate nucleus and the paraventricular nucleus in the hypothalamus in the central regulation of GI function is described.
    • (2005) Brain Res , vol.1036 , Issue.1-2 , pp. 130-138
    • Tebbe, J.J.1    Pasat, I.R.2    Mönnikes, H.3    Ritter, M.4    Kobelt, P.5    Schäfer, M.K.6
  • 25
    • 33748916666 scopus 로고    scopus 로고
    • Shimizu Y, Chang EC, Shafton AD, Ferens DM, Sanger GJ, Witherington J, Furness JB: Evidence that stimulation of ghrelin receptors in the spinal cord initiates propulsive activity in the colon of the rat. J Physiol (2006) 576(1):329-338. •• New sites of action and pathways involved in stimulation of colonic propulsive motility by ghrelin receptor activation are described.
    • Shimizu Y, Chang EC, Shafton AD, Ferens DM, Sanger GJ, Witherington J, Furness JB: Evidence that stimulation of ghrelin receptors in the spinal cord initiates propulsive activity in the colon of the rat. J Physiol (2006) 576(1):329-338. •• New sites of action and pathways involved in stimulation of colonic propulsive motility by ghrelin receptor activation are described.
  • 26
    • 38849092560 scopus 로고    scopus 로고
    • Development of drugs for gastrointestinal motor disorders: Translating science to clinical need
    • Sanger GJ, Alpers DH: Development of drugs for gastrointestinal motor disorders: Translating science to clinical need. Neurogastroenterol Motil (2008) 20(3):177-184.
    • (2008) Neurogastroenterol Motil , vol.20 , Issue.3 , pp. 177-184
    • Sanger, G.J.1    Alpers, D.H.2
  • 27
    • 36549063027 scopus 로고    scopus 로고
    • Greenwood-Van Meerveld B: Emerging drugs for postoperative ileus. Expert Opin Emerg Drugs (2007) 12(4):619-626. • This review describes the medical need and existing treatments for POI. The emphasis is on the scientific rationale for using new therapies, including ghrelin agonists, for the treatment of POI.
    • Greenwood-Van Meerveld B: Emerging drugs for postoperative ileus. Expert Opin Emerg Drugs (2007) 12(4):619-626. • This review describes the medical need and existing treatments for POI. The emphasis is on the scientific rationale for using new therapies, including ghrelin agonists, for the treatment of POI.
  • 29
    • 23844433696 scopus 로고    scopus 로고
    • Gastrokinetic effect of ghrelin analog RC-1139 in the rat. Effect on postoperative- and on morphine-induced ileus
    • Poitras P, Polvino WJ, Rocheleau B: Gastrokinetic effect of ghrelin analog RC-1139 in the rat. Effect on postoperative- and on morphine-induced ileus. Peptides (2005) 26(9): 1598-1601.
    • (2005) Peptides , vol.26 , Issue.9 , pp. 1598-1601
    • Poitras, P.1    Polvino, W.J.2    Rocheleau, B.3
  • 30
    • 38349084347 scopus 로고    scopus 로고
    • Ghrelin agonist (TZP-101): Safety, pharmacokinetics and pharmacodynamic evaluation in healthy volunteers: A phase I, first-in-human study
    • Lasseter KC, Shaughnessy L, Cummings D, Pezzullo JC, Wargin W, Gagnon R, Oliva J, Kosutic G: Ghrelin agonist (TZP-101): Safety, pharmacokinetics and pharmacodynamic evaluation in healthy volunteers: A phase I, first-in-human study. J Clin Pharmacol (2008) 48(2):193-202.
    • (2008) J Clin Pharmacol , vol.48 , Issue.2 , pp. 193-202
    • Lasseter, K.C.1    Shaughnessy, L.2    Cummings, D.3    Pezzullo, J.C.4    Wargin, W.5    Gagnon, R.6    Oliva, J.7    Kosutic, G.8
  • 31
    • 34547851716 scopus 로고    scopus 로고
    • Prokinetic effects of a new ghrelin receptor agonist TZP-101 in a rat model of postoperative ileus
    • This paper described the gastroprokinetic effect of TZP-101, a synthetic small-molecule agonist of the ghrelin receptor, which accelerates gastric emptying and small intestinal transit, in a rat model of POI, ••
    • Venkova K, Fraser G, Hoveyda HR, Greenwood-Van Meerveld B: Prokinetic effects of a new ghrelin receptor agonist TZP-101 in a rat model of postoperative ileus. Dig Dis Sci (2007) 52(9):2241-2248. •• This paper described the gastroprokinetic effect of TZP-101, a synthetic small-molecule agonist of the ghrelin receptor, which accelerates gastric emptying and small intestinal transit, in a rat model of POI.
    • (2007) Dig Dis Sci , vol.52 , Issue.9 , pp. 2241-2248
    • Venkova, K.1    Fraser, G.2    Hoveyda, H.R.3    Greenwood-Van Meerveld, B.4
  • 32
    • 53049109436 scopus 로고    scopus 로고
    • Ghrelin agonist activity restores gut transit and normalizes food intake in a rodent model of postoperative ileus
    • Venkova K, Fraser G, Hoveyda HR, Greenwood-Van Meerveld B: Ghrelin agonist activity restores gut transit and normalizes food intake in a rodent model of postoperative ileus. Gastroenterology (2007) 132(4):A-709.
    • (2007) Gastroenterology , vol.132 , Issue.4
    • Venkova, K.1    Fraser, G.2    Hoveyda, H.R.3    Greenwood-Van Meerveld, B.4
  • 35
  • 37
    • 41149108113 scopus 로고    scopus 로고
    • Gastric motor effects of ghrelin and growth hormone releasing peptide 6 in diabetic mice with gastroparesis
    • Qiu WC, Wang ZG, Wang WG, Yan J, Zheng Q: Gastric motor effects of ghrelin and growth hormone releasing peptide 6 in diabetic mice with gastroparesis. World J Gastroenterol (2008) 14(9):1419-1424.
    • (2008) World J Gastroenterol , vol.14 , Issue.9 , pp. 1419-1424
    • Qiu, W.C.1    Wang, Z.G.2    Wang, W.G.3    Yan, J.4    Zheng, Q.5
  • 38
    • 33744460486 scopus 로고    scopus 로고
    • Ghrelin alleviates cancer chemotherapy-associated dyspepsia in rodents
    • Liu YL, Malik NM, Sanger GJ, Andrews PL: Ghrelin alleviates cancer chemotherapy-associated dyspepsia in rodents. Cancer Chemother Pharmacol (2006) 58(3):326-333.
    • (2006) Cancer Chemother Pharmacol , vol.58 , Issue.3 , pp. 326-333
    • Liu, Y.L.1    Malik, N.M.2    Sanger, G.J.3    Andrews, P.L.4
  • 39
    • 44549089064 scopus 로고    scopus 로고
    • Adaptive upregulation of gastric and hypothalamic ghrelin receptors and increased plasma ghrelin in a model of cancer chemotherapy-induced dyspepsia
    • This study presented evidence that an adaptive upregulation of the ghrelin receptor may occur during cancer chemotherapy-associated dyspepsia, ••
    • Malik NM, Moore GB, Kaur R, Liu YL, Wood SL, Morrow RW, Sanger GJ, Andrews PL: Adaptive upregulation of gastric and hypothalamic ghrelin receptors and increased plasma ghrelin in a model of cancer chemotherapy-induced dyspepsia. Regul Pept (2008) 148(1-3):33-38. •• This study presented evidence that an adaptive upregulation of the ghrelin receptor may occur during cancer chemotherapy-associated dyspepsia.
    • (2008) Regul Pept , vol.148 , Issue.1-3 , pp. 33-38
    • Malik, N.M.1    Moore, G.B.2    Kaur, R.3    Liu, Y.L.4    Wood, S.L.5    Morrow, R.W.6    Sanger, G.J.7    Andrews, P.L.8
  • 40
    • 33746531713 scopus 로고    scopus 로고
    • Therapeutic strategies for functional dyspepsia and the introduction of the Rome III classification
    • Suzuki H, Nishizawa T, Hibi T: Therapeutic strategies for functional dyspepsia and the introduction of the Rome III classification. J Gastroenterol (2006) 41(6):513-523.
    • (2006) J Gastroenterol , vol.41 , Issue.6 , pp. 513-523
    • Suzuki, H.1    Nishizawa, T.2    Hibi, T.3
  • 42
    • 28744458773 scopus 로고    scopus 로고
    • Anti-emetic activity of ghrelin in ferrets exposed to the cytotoxic anticancer agent cisplatin
    • A study in a ferret model of cisplatin-induced emesis demonstrating the ability of ghrelin to reduce the emetic response by activation of central ghrelin receptors, ••
    • Rudd JA, Ngan MP, Wai MK, King AG, Witherington J, Andrews PL, Sanger GJ: Anti-emetic activity of ghrelin in ferrets exposed to the cytotoxic anticancer agent cisplatin. Neurosci Lett (2006) 392(1-2):79- 83. •• A study in a ferret model of cisplatin-induced emesis demonstrating the ability of ghrelin to reduce the emetic response by activation of central ghrelin receptors.
    • (2006) Neurosci Lett , vol.392 , Issue.1-2 , pp. 79-83
    • Rudd, J.A.1    Ngan, M.P.2    Wai, M.K.3    King, A.G.4    Witherington, J.5    Andrews, P.L.6    Sanger, G.J.7
  • 43
    • 7044236966 scopus 로고    scopus 로고
    • Differential effects on gastrointestinal and hepatic vagal afferent fibers in the rat by the anticancer agent cisplatin
    • Horn CC, Richardson EJ, Andrews PL, Friedman MI: Differential effects on gastrointestinal and hepatic vagal afferent fibers in the rat by the anticancer agent cisplatin. Auton Neurosci (2004) 115(1-2):74-81.
    • (2004) Auton Neurosci , vol.115 , Issue.1-2 , pp. 74-81
    • Horn, C.C.1    Richardson, E.J.2    Andrews, P.L.3    Friedman, M.I.4
  • 44
    • 9644266858 scopus 로고    scopus 로고
    • Food intake and aging - the role of the gut
    • Parker BA, Chapman IM: Food intake and aging - the role of the gut. Mech Ageing Dev (2004) 125(12):859-866.
    • (2004) Mech Ageing Dev , vol.125 , Issue.12 , pp. 859-866
    • Parker, B.A.1    Chapman, I.M.2
  • 48
  • 49
    • 0031014558 scopus 로고    scopus 로고
    • Evidence for the anorexia of aging: Gastrointestinal transit and hunger in healthy elderly vs young adults
    • Clarkston WK, Pantano MM, Morley JE, Horowitz M, Littlefield JM, Burton FR: Evidence for the anorexia of aging: Gastrointestinal transit and hunger in healthy elderly vs young adults. Am J Physiol (1997) 272(1 Pt 2):R243-R248.
    • (1997) Am J Physiol , vol.272 , Issue.1 PART 2
    • Clarkston, W.K.1    Pantano, M.M.2    Morley, J.E.3    Horowitz, M.4    Littlefield, J.M.5    Burton, F.R.6
  • 50
    • 36549050805 scopus 로고    scopus 로고
    • Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging
    • Preclinical evidence for the potential of ghrelin receptor agonists to improve age-related deficiencies in endogenous ghrelin signaling, ••
    • Smith RG, Sun Y, Jiang H, Albarran-Zeckler R, Timchenko N: Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging. Ann NY Acad Sci (2007) 1119:147-164. •• Preclinical evidence for the potential of ghrelin receptor agonists to improve age-related deficiencies in endogenous ghrelin signaling.
    • (2007) Ann NY Acad Sci , vol.1119 , pp. 147-164
    • Smith, R.G.1    Sun, Y.2    Jiang, H.3    Albarran-Zeckler, R.4    Timchenko, N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.