Ghrelin protects spinal cord motoneurons against chronic glutamate-induced excitotoxicity via ERK1/2 and phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3β pathways

Experimental Neurology

Volumn 230, Issue 1, 2011, Pages 114-122

  Lim, Eunjin ^a   Lee, Sungyoub ^a   Li, Endan ^a   Kim, Yumi ^a   Park, Seungjoon ^a  

^a Kyung Hee University Hospital   (South Korea)

Author keywords

Akt; Excitotoxicity; Ghrelin; Motoneuron; Neuroprotection; Organotypic spinal cord cultures

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3 HYDROXYASPARTIC ACID; GHRELIN; GHRELIN RECEPTOR; GLUTAMIC ACID; GLYCOGEN SYNTHASE KINASE 3BETA; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL TISSUE; ARTICLE; CELL LOSS; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXCITOTOXICITY; NERVE CELL DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD MOTONEURON; TISSUE CULTURE;

ANIMALS; ANIMALS, NEWBORN; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GHRELIN; GLUTAMIC ACID; GLYCOGEN SYNTHASE KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE 3; MOTOR NEURONS; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; ORGAN CULTURE TECHNIQUES; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GHRELIN; SPINAL CORD;

EID: 79958050031     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2011.04.003     Document Type: Article

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