Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra

Experimental Neurology

Volumn 212, Issue 2, 2008, Pages 532-537

  Jiang, Hong ^a   Li, Lin Jing ^a   Wang, Jun ^a   Xie, Jun Xia ^a  

^a University Medical College   (China)

Author keywords

Apoptosis; Dopaminergic neuron; Ghrelin; GHS R; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; CASPASE 3; DOPAMINE; GHRELIN; GROWTH HORMONE SECRETAGOGUE RECEPTOR 1A; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; DOWN REGULATION; DRUG ANTAGONISM; DRUG INHIBITION; ENZYME ACTIVATION; MALE; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUBSTANTIA NIGRA; UPREGULATION;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANALYSIS OF VARIANCE; ANIMALS; CASPASE 3; CHI-SQUARE DISTRIBUTION; DISEASE MODELS, ANIMAL; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG INTERACTIONS; GHRELIN; MALE; MICE; MICE, INBRED C57BL; MPTP POISONING; NEURONS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, GHRELIN; SUBSTANTIA NIGRA; TYROSINE 3-MONOOXYGENASE;

EID: 47349087292     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2008.05.006     Document Type: Article

References (42)

1. Baldanzi G., Filigheddu N., Cutrupi S., Catapano F., Bonissoni S., Fubini A., Malan D., Baj G., Granata R., Broglio F., Papotti M., Surico N., Bussolino F., Isgaard J., Deghenghi R., Sinigaglia F., Prat M., Muccioli G., Ghigo E., and Graziani A. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J. Cell Biol. 159 (2002) 1029-1037
2. Barnham K.J., Masters C.L., and Bush A.I. Neurodegenerative diseases and oxidative stress. Nat. Rev., Drug Discov. 3 (2004) 205-214
3. Bennett P.A., Thomas G.B., Howard A.D., Feighner S.D., van der Ploeg L.H., Smith R.G., and Robinson I.C. Hypothalamic growth hormone secretagogue-receptor (GHS-R) expression is regulated by growth hormone in the rat. Endocrinology 138 (1997) 4552-4557
4. Bredesen D.E., Rao R.V., and Mehlen P. Cell death in the nervous system. Nature 443 (2006) 796-802
5. Chung H., Kim E., Lee D.H., Seo S., Ju S., Lee D., Kim H., and Park S. Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation. Endocrinology 148 (2007) 148-159
6. Date Y., Kojima M., Hosoda H., Sawaguchi A., Mondal M.S., Suganuma T., Matsukura S., Kangawa K., and Nakazato M. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141 (2000) 4255-4261
7. Dauer W., and Przedborski S. Parkinson's disease: mechanisms and models. Neuron 39 (2003) 889-909
8. Franklin K.B.J., and Paxinos G. The Mouse Brain in Stereotaxic Coordinates (2001), Academic Press, San Diego
9. Gomez C., Reiriz J., Pique M., Gil J., Ferrer I., and Ambrosio S. Low concentrations of 1-methyl-4-phenylpyridinium ion induce caspase-mediated apoptosis in human SH-SY5Y neuroblastoma cells. J. Neurosci. Res. 63 (2001) 421-428
10. Guan X.M., Yu H., Palyha O.C., McKee K.K., Feighner S.D., Sirinathsinghji D.J., Smith R.G., Van der Ploeg L.H., and Howard A.D. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res. Mol. Brain Res. 48 (1997) 23-29
11. Hartmann A., Hunot S., Michel P.P., Muriel M.P., Vyas S., Faucheux B.A., Mouatt-Prigent A., Turmel H., Srinivasan A., Ruberg M., Evan G.I., Agid Y., and Hirsch E.C. Caspase-3: a vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 2875-2880
12. Heikkila R.E., Hess A., and Duvoisin R.C. Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice. Science 224 (1984) 1451-1453
13. Hong Z., Wang G., Gu J., Pan J., Bai L., Zhang S., and Chen S.D. Tripchlorolide protects against MPTP-induced neurotoxicity in C57BL/6 mice. Eur. J. Neurosci. 26 6 (2007) 1500-1508
14. Hunot S., and Hirsch E.C. Neuroinflammatory processes in Parkinson's disease. Ann. Neurol. 53 Suppl 3 (2003) S49-S58 (discussion S-60)
15. Jenner P., and Olanow C.W. The pathogenesis of cell death in Parkinson's disease. Neurology 66 (2006) S24-36
16. Jiang H., Qian Z.M., and Xie J.X. Increased DMT1 expression and iron content in MPTP-treated C57BL/6 mice. Shengli Xuebao 55 (2003) 571-576
17. Jiang H., Luan Z., Wang J., and Xie J. Neuroprotective effects of iron chelator Desferal on dopaminergic neurons in the substantia nigra of rats with iron-overload. Neurochem. Int. 49 (2006) 605-609
18. Kane D.J., Sarafian T.A., Anton R., Hahn H., Gralla E.B., Valentine J.S., Ord T., and Bredesen D.E. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 262 (1993) 1274-1277
19. Kim M.S., Yoon C.Y., Jang P.G., Park Y.J., Shin C.S., Park H.S., Ryu J.W., Pak Y.K., Park J.Y., Lee K.U., Kim S.Y., Lee H.K., Kim Y.B., and Park K.S. The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes. Mol. Endocrinol. 18 (2004) 2291-2301
20. Kim S.W., Her S.J., Park S.J., Kim D., Park K.S., Lee H.K., Han B.H., Kim M.S., Shin C.S., and Kim S.Y. Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells. Bone 37 (2005) 359-369
21. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
22. Korsmeyer S.J. Regulators of cell death. Trends Genet. 11 (1995) 101-105
23. Lan J., and Jiang D.H. Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice. J. Neural Transm. 104 (1997) 469-481
24. Langston J.W., and Ballard P. Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): implications for treatment and the pathogenesis of Parkinson's disease. Can. J. Neurol. Sci. 11 (1984) 160-165
25. Nakazato M., Murakami N., Date Y., Kojima M., Matsuo H., Kangawa K., and Matsukura S. A role for ghrelin in the central regulation of feeding. Nature 409 (2001) 194-198
26. Nanzer A.M., Khalaf S., Mozid A.M., Fowkes R.C., Patel M.V., Burrin J.M., Grossman A.B., and Korbonits M. Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway. Eur. J. Endocrinol. 151 (2004) 233-240
27. Offen D., Beart P.M., Cheung N.S., Pascoe C.J., Hochman A., Gorodin S., Melamed E., Bernard R., and Bernard O. Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 5789-5794
28. Oltvai Z.N., Milliman C.L., and Korsmeyer S.J. Bel-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74 (1993) 609-619
29. Peino R., Baldelli R., Rodriguez-Garcia J., Rodriguez-Segade S., Kojima M., Kangawa K., Arvat E., Ghigo E., Dieguez C., and Casanueva F.F. Ghrelin-induced growth hormone secretion in humans. Eur. J. Endocrinol. 143 (2000) R11-14
30. Poirier J., Donaldson J., and Barbeau A. The specific vulnerability of the substantia nigra to MPTP is related to the presence of transition metals. Biochem. Biophys. Res. Commun. 128 (1985) 25-33
31. Przedborski S., Jackson-Lewis V., Djaldetti R., Liberatore G., Vila M., Vukosavic S., and Almer G. The parkinsonian toxin MPTP: action and mechanism. Restor. Neurol. Neurosci. 16 (2000) 135-142
32. Reed J.C. Double identity for proteins of the Bcl-2 family. Nature 387 (1997) 773-776
33. Schmidt N., and Ferger B. Neurochemical findings in the MPTP model of Parkinson's disease. J. Neural Transm. 108 (2001) 1263-1282
34. Singh S., and Dikshit M. Apoptotic neuronal death in Parkinson's disease: involvement of nitric oxide. Brain Res. Rev. 54 (2007) 233-250
35. Tatton N.A., and Kish S.J. In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining. Neuroscience 77 (1997) 1037-1048
36. Temlett J.A., Landsberg J.P., Watt F., and Grime G.W. Increased iron in the substantia nigra compacta of the MPTP-lesioned hemiparkinsonian African green monkey: evidence from proton microprobe elemental microanalysis. J. Neurochem. 62 (1994) 134-146
37. Tschop M., Smiley D.L., and Heiman M.L. Ghrelin induces adiposity in rodents. Nature 407 (2000) 908-913
38. Vila M., Jackson-Lewis V., Vukosavic S., Djaldetti R., Liberatore G., Offen D., Korsmeyer S.J., and Przedborski S. Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 2837-2842
39. Vila M., Vukosavic S., Jackson-Lewis V., Neystat M., Jakowec M., and Przedborski S. Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP. J. Neurochem. 74 (2000) 721-729
40. Xie J.X., Jiang H., Chen W.F., and Qian Z.M. Dopamine release rather than content in the caudate putamen is associated with behavioral changes in the iron rat model of Parkinson's disease. Exp. Neurol. 182 (2003) 483-489
41. Youdim M.B., and Arraf Z. Prevention of MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) dopaminergic neurotoxicity in mice by chronic lithium: involvements of Bcl-2 and Bax. Neuropharmacology 46 (2004) 1130-1140
42. Zigman J.M., Jones J.E., Lee C.E., Saper C.B., and Elmquist J.K. Expression of ghrelin receptor mRNA in the rat and the mouse brain. J. Comp. Neurol. 494 (2006) 528-548