The gastrointestinal hormone ghrelin modulates inhibitory neurotransmission in deep laminae of mouse spinal cord dorsal horn

Endocrinology

Volumn 149, Issue 5, 2008, Pages 2306-2312

  Vergnano, Angela M ^a   Ferrini, Francesco ^a   Salio, Chiara ^a   Lossi, Laura ^a,b   Baratta, Mario ^a   Merighi, Adalberto ^a,b,c  

^a UNIVERSITY OF TURIN   (Italy)

^b Istituto Nazionale di Neuroscienze   (Italy)

^c Department of Veterinary Morphophysiology ^*  (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; GHRELIN; GLYCINE; GROWTH HORMONE SECRETAGOGUE RECEPTOR 1A; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; PROTEIN FOS; TETRODOTOXIN;

AMPLITUDE MODULATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ELECTROPHYSIOLOGY; HISTOLOGY; IMMUNOREACTIVITY; LAMINA PROPRIA; MOLECULAR BIOLOGY; MOUSE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD DORSAL HORN; WESTERN BLOTTING;

ANALGESICS; ANIMALS; ANIMALS, NEWBORN; CAPSAICIN; GASTROINTESTINAL HORMONES; GHRELIN; INHIBITORY POSTSYNAPTIC POTENTIALS; MICE; MODELS, BIOLOGICAL; NEURAL INHIBITION; POSTERIOR HORN CELLS; PROTO-ONCOGENE PROTEINS C-FOS; RECEPTORS, GHRELIN; RNA, MESSENGER; SPINAL CORD; SYNAPTIC TRANSMISSION;

EID: 42449153846     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-1164     Document Type: Article

References (32)

1. Kojima M, Kangawa K 2005 Ghrelin: structure and function. Physiol Rev 85:495-522
2. Ghigo E, Broglio F, Me E, Prodam F, Ragazzoni F 2004 Ghrelin: more than a new frontier in neuroendocrinology. J Endocrinol Invest 27:101-104
3. Rindi G, Savio A, Torsello A, Zoli M, Locatelli V, Cocchi D, Paolotti D, Solcia E 2002 Ghrelin expression in gut endocrine growths. Histochem Cell Biol 117:521-525
4. Dornonville de la Cour C, Bjorkqvist M, Sandvik AK, Bakke I, Zhao CM, Chen D, Hakanson R 2001 A-like cells in the rat stomach contain ghrelin and do not operate under gastrin control. Regul Pept 99:141-150
5. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660
6. Hosoda H, Kojima M, Matsuo H, Kangawa K 2000 Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun 279:909-913
7. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong SS, Chaung LY, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji DJ, Dean DC, Melillo DG, Patchett AA, Nargund R, Griffin PR, DeMartino JA, Gupta SK, Schaeffer JM, Smith RG, Van der Ploeg LH 1996 A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273:974-977
8. Chan CB, Cheng CH 2004 Identification and functional characterization of two alternatively spliced growth hormone secretagogue receptor transcripts from the pituitary of black seabream Acanthopagrus schlegeli. Mol Cell Endocrinol 214:81-95
9. Lu S, Guan JL, Wang QP, Uehara K, Yamada S, Goto N, Date Y, Nakazato M, Kojima M, Kangawa K, Shioda S 2002 Immunocytochemical observation of ghrelin-containing neurons in the rat arcuate nucleus. Neurosci Lett 321:157-160
10. Cowley MA, Smith RG, Diano S, Tschop M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, Friedman JM, Liu H, Pinto S, Colmers WF, Cone RD, Horvath TL 2003 The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 20:649-661
11. Mitchell V, Bouret S, Beauvillain JC, Schilling A, Perret M, Kordon C, Epelbaum J 2001 Comparative distribution of mRNA encoding the growth hormone secretagogue-receptor (GHS-R) in Microcebus murinus (Primate, lemurian) and rat forebrain and pituitary. J Comp Neurol 429:469-489
12. Guan JL, Wang QP, Kageyama H, Takenoya F, Kita T, Matsuoka T, Funahashi H, Shioda S 2003 Synaptic interactions between ghrelin- and neuropeptide Y-containing neurons in the rat arcuate nucleus. Peptides 24:1921-1928
13. Zigman JM, Jones JE, Lee CE, Saper CB, Elmquist JK 2006 Expression of ghrelin receptor mRNA in the rat and the mouse brain. J Comp Neurol 494:528-548
14. Kumarnsit E, Johnstone LE, Leng G 2003 Actions of neuropeptide Y and growth hormone secretagogues in the arcuate nucleus and ventromedial hypothalamic nucleus. Eur J Neurosci 17:937-944
15. van den Top M, Lee K, Whyment AD, Blanks AM, Spanswick D 2004 Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. Nat Neurosci 7:493-494
16. Diano S, Farr SA, Benoit SC, McNay EC, da Silva I, Horvath B, Gaskin FS, Nonaka N, Jaeger LB, Banks WA, Morley JE, Pinto S, Sherwin RS, Xu L, Yamada KA, Sleeman MW, Tschop MH, Horvath TL 2006 Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci 9:381-388
17. Korbonits M, Goldstone AP, Gueorguiev M, Grossman AB 2004 Ghrelin - a hormone with multiple functions. Front Neuroendocrinol 25:27-68
18. Sibilia V, Lattuada N, Rapetti D, Pagani F, Vincenza D, Bulgarelli I, Locatelli V, Guidobono F, Netti C 2006 Ghrelin inhibits inflammatory pain in rats: involvement of the opioid system. Neuropharmacology 51:497-505
19. Vergnano AM, Salio C, Merighi A 2004 NK1 receptor activation leads to enhancement of inhibitory neurotransmission in spinal substantia gelatinosa neurons of mouse. Pain 112:37-47
20. Wu J, Fang L, Lin Q, Willis WD 2000 Fos expression is induced by increased nitric oxide release in rat spinal cord dorsal horn. Neuroscience 96:351-357
21. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D 1997 The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816-824
22. Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M 2000 Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141:4255-4261
23. Traebert M, Riediger T, Whitebread S, Scharrer E, Schmid HA 2002 Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus. J Neuroendocrinol 14:580-586
24. Willis WD, Coggeshall RE 2004 Primary afferent neurons and the spinal dorsal horn. In: Sensory mechanisms of the spinal cord. 3rd ed. New York: Plenum Press; 271-363
25. Yu Y, Jawa A, Pan W, Kastin AJ 2004 Effects of peptides, with emphasis on feeding, pain, and behavior. A 5-year (1999 -2003) review of publications in Peptides. Peptides 25:2257-2289
26. Chaudhri O, Small C, Bloom S 2006 Gastrointestinal hormones regulating appetite. Philos Trans R Soc Lond B Biol Sci 361:1187-1209
27. Li JJ, Zhou X, Yu LC 2005 Involvement of neuropeptide Y and Y1 receptor in antinociception in the arcuate nucleus of hypothalamus, an immunohistochemical and pharmacological study in intact rats and rats with inflammation. Pain 118:232-242
28. Rodgers RJ, Ishii Y, Halford JC, Blundell JE 2002 Orexins and appetite regulation. Neuropeptides 36:303-325
29. Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP, Purnell JQ 2002 Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 346:1623-1630
30. Banks WA, Tschop M, Robinson SM, Heiman ML 2002 Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure. J Pharmacol Exp Ther 302:822-827
31. Simpson DA, Headley PM, Lumb BM September 4 2007 Selective inhibition from the anterior hypothalamus of C- versus A-fibre mediated spinal nociception. Pain [Epub ahead of print]
32. Li WG, Gavrila D, Liu X, Wang L, Gunnlaugsson S, Stoll LL, McCormick ML, Sigmund CD, Tang C, Weintraub NL 2004 Ghrelin inhibits proinflammatory responses and nuclear factor-κB activation in human endothelial cells. Circulation 109:2221-2226