Identification of critical residues in Gα13 for stimulation of p115RhoGEF activity and the structure of the Gα 13-p115RhoGEF regulator of G protein signaling homology (RH) domain complex

Journal of Biological Chemistry

Volumn 286, Issue 23, 2011, Pages 20625-20636

  Hajicek, Nicole ^a,d   Kukimoto Niino, Mutsuko ^b   Mishima Tsumagari, Chiemi ^b   Chow, Christina R ^a   Shirouzu, Mikako ^b   Terada, Takaho ^b   Patel, Maulik ^a   Yokoyama, Shigeyuki ^b,c   Kozasa, Tohru ^a,b,d  

^a UNIVERSITY OF ILLINOIS   (United States)

^b RIKEN   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DOMAIN COMPLEXES; G PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HETEROTRIMERIC G PROTEINS; P115RHOGEF;

CRYSTAL STRUCTURE; NUCLEOTIDES; POSITIVE IONS; PROTEINS; SIGNALING; WELL STIMULATION;

RHODIUM COMPOUNDS;

GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA 13; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PROTEIN P115RHOGEF; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; RH HOMOLOGY DOMAIN;

ALLOSTERIC REGULATION; ANIMALS; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MICE; MULTIENZYME COMPLEXES; MUTATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79957996853     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.201392     Document Type: Article

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