Mechanisms of resistance to photodynamic therapy

Current Medicinal Chemistry

Volumn 18, Issue 16, 2011, Pages 2486-2515

  Casas, A ^a,c   Di Venosa, G ^a   Hasan, T ^b   Batlle, Al ^a  

^a HOSPITAL DE CLÍNICAS JOSÉ DE SAN MARTÍN   (Argentina)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c NONE   (Argentina)

Author keywords

Apoptosis; Chemoresistance; Cross resistance; MDR; Mechanisms; PDT; Photodynamic therapy; Photosensitizer; Photosensitizers; Porphyrins; Resistance

Indexed keywords

2 (1 HEXYLOXETHYL) 2 DEVINYLPYROPHEOPHORBIDE A; AMINOLEVULINIC ACID; BREAST CANCER RESISTANCE PROTEIN; CASPASE; CHLORIN E6; DOXORUBICIN; FUMITREMORGIN C; GELONIN; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; HEAT SHOCK PROTEIN; HEMATOPORPHYRIN; HEPTAPORPHYRIN; HYPERICIN; MESO TETRA(3 HYDROXYPHENYL)PORPHYRIN; MESOPORPHYRIN; MITOXANTRONE; MULTIDRUG RESISTANCE PROTEIN 1; PADOPORFIN; PHEOPHORBIDE; PHEOPHORBIDE A; PHEOPHORBIDE A METHYL ESTER; PHOTOFRIN II; PHOTOSENSITIZING AGENT; PORPHYRIN DERIVATIVE; PROSTAGLANDIN SYNTHASE; PROTOPORPHYRIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; UROPORPHYRIN; VERTEPORFIN;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; AUTOPHAGY; BLOOD VESSEL INJURY; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RESISTANCE; CELL ADHESION; CELL ORGANELLE; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CELLULAR DISTRIBUTION; CROSS RESISTANCE; CYTOSKELETON; DNA DAMAGE; DNA REPAIR; DRUG EFFICACY; DRUG SYNTHESIS; ENZYME ACTIVATION; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPERTHERMIC THERAPY; HYPOXEMIA; INTERNALIZATION; METASTASIS; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; PHOTODYNAMIC THERAPY; PROTEIN EXPRESSION; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION;

ANIMALS; CELL PROLIFERATION; CELL SURVIVAL; DRUG RESISTANCE; HUMANS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; REACTIVE OXYGEN SPECIES;

EID: 79957962780     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986711795843272     Document Type: Review

References (306)

1. Gomer, C.J. Photodynamic Therapy; Pergamon Press: Oxford, England, 1987.
2. Dougherty, T.J. Photodynamic Therapy-new approaches. Semin. Surg. Oncol., 1989, 5, 6-16.
3. Weishaupt, K.; Gomer, C.; Dougherty, T. Identification of singlet oxygen as the cytotoxic agent in photoactivation of a murine tumour. Cancer Res., 1976, 36, 2326-2329.
4. Mayhew, S.; Vernon, D.; Schofield, J.; Griffiths, J.; Brown, S. Investigation of cross-resistance to a range of photosensitizers, hyperthermia and UV light in two radiation-induced fibrosarcoma cell strains resistant to photodynamic therapy in vitro. Photochem. Photobiol., 2001, 73, 39-46.
5. Singh, G.; Wilson, B.; Sharkey, S.; Browman, G.; Deschamps, P. Resistance to photodynamic therapy in radiation induced fibrosarcoma-1 and chinese hamster ovary-multi-drug resistant cells in vitro. Photochem. Photobiol., 1991, 54, 307-312.
6. Luna, M.; Gomer, C. Isolation and initial characterization of mouse tumor cells resistant to porphyrin-mediated photodynamic therapy. Cancer Res., 1991, 51, 4243-4249.
7. Casas, A.; Perotti, C.; Ortel, B.; Di Venosa, G.; Saccoliti, M.; Batlle, A.; Hasan, T. Tumor cell lines resistant to ALA-mediated photodynamic therapy and possible tools to target surviving cells. Int J Oncol., 2006, 29,397-405.
8. Henderson, B.; Miller, A. Effects of scavengers of reactive oxygen and radical species on cell survival following photodynamic treatment in vitro: comparison to ionizing radiation. Radiat. Res., 1986, 108, 196-205. (Pubitemid 17207553)
9. Gomer, C.; Ryter, S.; Ferrario, A.; Rucker, N.; Wong, S.; Fisher, A. Photodynamic Therapy-mediated oxidative stress can induce the expression of heat shock proteins. Cancer Res., 1996, 56, 2355-2360. (Pubitemid 26155168)
10. Shackley, D.C.; Haylett, A.; Whitehurst, C.; Betts, C.D.; O'Flynn, K.; Clarke, N.W.; Moore, J.V. Comparison of the cellular molecular stress responses after treatments used in bladder cancer. BJU Int., 2002, 90, 924-932. (Pubitemid 36693631)
11. Ruhdorfer, S.; Sanovic, R.; Sander, V.; Krammer, B.; Verwanger, T. Gene expression profiling of the human carcinoma cell line A-431 after 5- aminolevulinic acid-based photodynamic treatment. Int. J. Oncol., 2007, 30, 1253-1262.
12. Adams, K.; Rainbow, A.; Wilson, B.; Singh, G. In vivo resistance to Photofrin-mediated Photodynamic Therapy in radiation-induced fibrosarcoma cells resistant to in vitro Photofrin-mediated Photodynamic therapy. J. Photochem. Photobiol., 1999, 49, 136-141. (Pubitemid 29267483)
13. Morgan, J.; Potter, W.R.; Oseroff, A.R. Comparison of photodynamic targets in a carcinoma cell line and its mitochondrial DNA-deficient derivative. Photochem. Photobiol., 2000, 71, 747-57.
14. Peng, Q.; Moan, J.; Farrants, G.W.; Danielsen, H.E.; Rimington, C. Location of P-II and AlPCS4 in human tumor LOX in vitro and in vivo by means of computer-enhanced video fluorescence microscopy. Cancer Lett., 1991, 58, 37-47.
15. Lin, C.W.; Shulok, J.R.; Kirley, S.D.; Cincotta, L.; Foley, J.W. Lysosomal localization and mechanism of uptake of Nile blue photosensitizers in tumor cells. Cancer Res., 1991, 51, 2710-2719.
16. Van Hillesberg, R.; van der Berg, J.; Kort, W.; Terpstra, O.; Wilson, J. Selective accumulation of endogenously produced porphyrins in a liver metastasis model in rats. Gastroenterology, 1992, 103, 647-651.
17. Navone, N.; Polo, C.; Frisardi, A.; Batlle, A. Mouse mammary carcinoma PBGase and hydroxymethylbilane synthetase. Comp. Biochem. Physiol. B, 1991, 98, 67-71.
18. Madsen, S.J.; Sun, C.H.; Tromberg, B.J.; Hirschberg, H. Repetitive 5- aminolevulinic acid-mediated photodynamic therapy on human glioma spheroids. J Neurooncol., 2003, 62, 243-250. (Pubitemid 36591959)
19. Calzavara-Pinton, P. Repetitive photodynamic therapy with topical deltaaminolaevulinic acid as an appropriate approach to the routine treatment of superficial non-melanoma skin tumours. J. Photochem. Photobiol. B, 1995, 29, 53-57.
20. Salim, A.; Leman, J.; McColl, J.; Chapman, R.; Morton, C. Randomized comparison of photodynamic therapy with topical 5-fluoruracil in Bowen's disease. Br. J. Dermatol., 2003, 148, 539-543. (Pubitemid 36461334)
21. Willey, A.; Mehta, S.; Lee, P.K. Reduction in the Incidence of Squamous Cell Carcinoma in Solid Organ Transplant Recipients Treated with Cyclic Photodynamic Therapy. Dermatol. Surg., 2010, 36, 652-658.
22. Mathews, M.S.; Angell-Petersen, E.; Sanchez, R.; Sun, C.H.; Vo, V.; Hirschberg, H.; Madsen, S.J. The effects of ultra low fluence rate single and repetitive photodynamic therapy on glioma spheroids. Lasers Surg. Med., 2009, 41, 578-584.
23. Luna, M.; Ferrario, A.; Rucker, N.; Gomer, C. Decreased expression and function of alpha-2 macroglobulin receptor/low density lipoprotein receptorrelated protein in photodynamic therapy-resistant mouse tumor cells. Cancer Res., 1995, 55, 1820-1823.
24. Bernal, S.; Shapiro, H.; Chen, L. Monitoring the effect of anticancer drug on L1210 cells by a mitochondrial probe, rhodamine 123. Int. J. Cancer, 1982, 30, 219-224. (Pubitemid 12055845)
25. Maftah, A.; Petit, J.; Rainaud, M.; Julien, R. 10-N nonyl acridine orange: a fluorescent probe which stains mitochondria independently of their energetic state. Biochem. Biophys. Res. Commun., 1989, 164, 185-190. (Pubitemid 19269713)
26. Wilson, B.; Olivo, M.; Singh, G. Subcellular localization of Photofrin and aminolevulinic acid and Photodynamic cross-resistance in vitro in radiationinduced fibrosarcoma cells sensitive or resistant to Photofrin-mediated Photodynamic Therapy. Photochem. Photobiol., 1997, 65, 166-176.
27. Hilf, R.; Smail, D.; Murant, R.; Leakey, P.; Gibson, S. Hematoporphyrin derivative induced photosensitivity of mitochondrial succinate dehydrogenase and selected cytosolic enzymes of R3230AC mammary adenocarcinomas of rats. Cancer Res., 1984, 44, 1483-1488. (Pubitemid 14125884)
28. Nelson, J.S.; Sun, C.H.; Berns, M.W. Study of the in vivo and in vitro photosensitizing capabilities of uroporphyrin I compared to photofrin II. Lasers Surg. Med., 1986, 6, 131-136. (Pubitemid 16112437)
29. Okunaka, T.; Eckhauser, M.L.; Kato, H.; Bomaminio, A.; Yamamoto, H., Aizawa, K.; Sarasua, M.M.; Koehler, K.A. Correlation between photodynamic efficacy of differing porphyrins and membrane partitioning behavior. Lasers Surg. Med., 1992, 12, 98-103
30. Strauss, W.S.; Sailer, R.; Schneckenburger, H.; Akgun, N.; Gottfried, V.; Chetwer, L.; Kimel, S. Photodynamic efficacy of naturally occurring porphyrins in endothelial cells in vitro and microvasculature in vivo. J. Photochem. Photobiol., 1997, 39, 176-184. (Pubitemid 27289164)
31. Musser, D.A.; Oseroff, A.R. The use of tetrazolium salts to determine sites of damage to the mitochondrial electron transport chain in intact cells following in vitro photodynamic therapy with Photofrin II. Photochem. Photobiol., 1994, 59, 621-626. (Pubitemid 2103363)
32. Hilf, R. Mitochondria are targets of photodynamic therapy. J. Bioenerg. Biomembr., 2007, 39:85-89. (Pubitemid 46877177)
33. Boegheim, J.P.; Lagerberg, J.W.; Dubbelman, T.M; Tijssen, K.; Tanke, H.J.; Van Der Meulen, J.; Van Steveninck, J. Photodynamic effects of hematoporphyrin derivative on the uptake of rhodamine 123 by mitochondria of intact murine L929 fibroblasts and Chinese ovary K1 cells. Photochem. Photobiol., 1988, 48, 613-620.
34. Salet, C.; Moreno, G. Photosensitization of mitochondria. Molecular and cellular aspects. J. Photochem. Photobiol. B: Biol., 1990, 5, 133-150.
35. Moor, A.C. Signaling pathways in cell death and survival after photodynamic therapy. J. Photochem. Photobiol. B., 2000, 57, 1-13.
36. Kessel D. Death pathways associated with photodynamic therapy. Med. Laser Appl., 2006, 21, 219-224. (Pubitemid 44636438)
37. Denis-Pouxveil, C.; Riesinger, I.; Buhler, C.; Brdiczka, D.; Murat, J. Regulation of mitochondrial hexokinase in cultured HT29 human cancer cells. An ultrastructural and biochemical study. Biochim. Biophys. Acta, 1987, 902, 335-348. (Pubitemid 17153262)
38. Tumilowicz, J.; Nichols, W.; Cholon, J.; Greene, A. Definition of a continuous human cell line derived from neuroblastoma. Cancer Res., 1970, 30, 2110-2118.
39. Zinkewich-Peotti, K.; Andrews, P. Loss of cis- diamminedichloroplatinum(II) resistance in human ovarian cells selected fro rhodamine 123 resistance. Cancer Res., 1992, 52, 1902-1906.
40. Crawford, D.R.; Wang, Y.; Schools, G.P.; Kochheiser, J.; Davies, K.J. Down-regulation of mammalian mitochondrial RNAs during oxidative stress. Free Radic. Biol. Med., 1997, 22, 551-559. (Pubitemid 27020130)
41. Shen, X.Y.; Zacal, N.; Singh, G.; Rainbow, A.J. Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells. Photochem. Photobiol., 2005, 81, 306-313. (Pubitemid 40551506)
42. Singh, K.; Russell, J.; Sigala, B.; Zhang, Y.; Williams, J.; Keshav, K. Mitochondrial DNA determines the cellular response to cancer therapeutic agents. Oncogene, 1999, 18, 6641-6646.
43. Wang, X. The expanding role of mitochondria in apoptosis. Genes & Development, 2001, 15, 2922-2933. (Pubitemid 33078942)
44. Sharkey, S.; Wilson, B.; Moorehead, R.; Singh, G. Mitochondrial alterations in Photodynamic Therapy-resistant cells. Cancer Res., 1993, 53, 4994-4999. (Pubitemid 23326198)
45. Roninson, I.B.; Chin, J.E.; Choi, K.G.; Gros, P.; Housman, D.E.; Fojo, A.; Shen, D.W.; Gottesman, M.M.; Pastan, I. Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proc. Natl. Acad. Sci. USA, 1986, 83, 4538-4542. (Pubitemid 16057084)
46. Gros, P.; Ben Neriah, Y.B.; Croop, J.M.; Housman, D.E. Isolation and expression of a complementary DNA that confers multidrug resistance. Nature, 1986, 323, 728-731. (Pubitemid 17172974)
47. Lage, H. An overview of cancer multidrug resistance: a still unsolved problem. Cell Mol. Life Sci., 2008, 65, 3145-3167.
48. Moorehead, R.; Armstrong, S.; Wilson, B.; Singh, G. Cross-resistance to cisplatin in cells resistant to Photofrin-mediated Photodynamic Therapy. Cancer Res., 1994, 54, 2556-2559. (Pubitemid 24173736)
49. Kessel, D.; Woodburn, K.; Skalkos, D. Impaired accumulation of a cationic photosensitizing agent by a cell line exhibiting multidrug resistance. Photochem. Photobiol., 1994, 60, 61-63. (Pubitemid 2114489)
50. Kessel, D.; Erickson, C. Porphyrin photosensitization of multi-drug resistant cell types. Photochem. Photobiol., 1992, 55, 397-399.
51. Robey, R.W.; Steadman, K.; Polgar, O.; Bates, S.E. ABCG2-mediated transport of photosensitizers: potential impact on photodynamic therapy. Cancer Biol. Ther., 2005, 4, 187-194. (Pubitemid 41351317)
52. Teiten, M.; Bezdetnaya, L.; merlin, J.; Bour-Dill, C.; Pauly, M.; Dicato, M.; Guillemin, F. Effect of meta-tetra(hydrophenyl)chlorin (mTHPC)-mediated photodynamic therapy on sensitive and multidrug-resistant human breast cancer cells. J. Photochem. Photobiol. B, 2001, 62, 146-152. (Pubitemid 32898835)
53. Li, W.; Zhang, W.; Ohnishi, K.; Yamada, I.; Ohno, R.; Hashimoto, K. 5- aminolevulinic acid-mediated photodynamic therapy in multidrug resistant leukemia cells. J. Photochem. Photobiol., 2001, 60, 79-86. (Pubitemid 32747237)
54. Chu, E.S.; Yow, C.M.; Shi, M.; Ho, R.J. Effects of photoactivated 5- aminolevulinic acid hexyl ester on MDR1 over-expressing human uterine sarcoma cells. Toxicol. Lett., 2008, 181, 7-12..
55. Tsai, T.; Hong, R.L.; Tsai, J.C.; Lou, P.J.; Ling, I.F.; Chen, C.T. Effect of 5- aminolevulinic acid-mediated photodynamic therapy on MCF-7 and MCF- 7/ADR cells. Lasers Surg. Med., 2004, 34, 62-72. (Pubitemid 38101761)
56. Tang, P.M.; Zhang, D.M.; Xuan, N.H.; Tsui, S.K.; Waye, M.M.; Kong, S.K.; Fong, W.P.; Fung, K.P. Photodynamic therapy inhibits P-glycoprotein mediated multidrug resistance via JNK activation in human hepatocellular carcinoma using the photosensitizer pheophorbide a. Mol. Cancer, 2009, 8, 56.
57. Selbo, P.K.; Weyergang, A.; Bonsted, A.; Bown, S.G.; Berg, K. Photochemical internalization of therapeutic macromolecular agents: a novel strategy to kill multidrug-resistant cancer cells. J. Pharmacol. Exp. Ther., 2006, 319, 604-612.
58. Merlin, J.L.; Gautier, H.; Barberi-Heyob, M.; Teiten, M.H.; Guillemin, F. The multidrug resistance modulator SDZ-PSC 833 potentiates the photodynamic activity of chlorin e6 independently of P-glycoprotein in multidrug resistant human breast adenocarcinoma cells. Int. J. Oncol., 2003, 22, 733-739.
59. Preise, D.; Mazor, O.; Koudinova, N.; Liscovitch, M.; Scherz, A.; Salomon, Y. Bypass of tumor drug resistance by antivascular therapy. Neoplasia, 2003, 5, 475-480. (Pubitemid 38045084)
60. Lou, P.J.; Lai, P.S.; Shieh, M.J.; MacRobert, A.J.; Berg, K.; Bown, S.G. Reversal of doxorubicin resistance in breast cancer cells by photochemical internalization. Int J Cancer, 2006, 119, 2692-2698. (Pubitemid 44696271)
61. Adigbli, D.K.; Wilson, D.G.; Farooqui, N.; Sousi, E.; Risley, P.; Taylor, I.; Macrobert, A.J.; Loizidou, M. Photochemical internalisation of chemotherapy potentiates killing of multidrug-resistant breast and bladder cancer cells. Br. J. Cancer, 2007, 97, 502-512. (Pubitemid 47258452)
62. Berg, K.; Selbo, P.K.; Prasmickaite, L.; Tjelle, T.E.; Sandvig, K.; Moan, J.; Gaudernack, G.; Fodstad, O.; Kjølsrud, S.; Anholt, H.; Rodal, G.H.; Rodal, S.K.; Høgset, A. Photochemical internalization: a novel technology for delivery of macromolecules into cytosol. Cancer Res., 1999, 59, 1180-1183. (Pubitemid 29136242)
63. Doyle, L.A.; Yang, W.; Abruzzo, L.V.; Krogmann, T.; Gao, Y.; Rishi, A.K.; Ross, D.D.A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc. Natl. Acad. Sci. USA 95, 1998, 15665-15670. (Pubitemid 29018757)
64. Allikmets, R.; Schriml, L.M; Hutchinson, A.; Romano-Spica, V.; Dean, M. A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res., 1998, 58, 5337-5339. (Pubitemid 28551112)
65. Doyle, L..A.; Ross D.D. Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2). Oncogene, 2003, 22, 7340-7358. (Pubitemid 37487163)
66. Haimeur, A.; Conseil, G.; Deeley, R.G.; Cole, S.P: The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation. Curr. Drug Metab., 2004, 5, 21-53. (Pubitemid 38294344)
67. Jonker, J.W.; Buitelaar, M.; Wagenaar, E.; Van Der Valk, M.A.; Scheffer, G.L.; Scheper, R.J.; Plosch, T.; Kuipers, F.; Elferink, R.P.; Rosing, H.; Beijnen, J.H.; Schinkel, A.H. The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria. Proc. Natl. Acad. Sci. USA 99, 2002, 15649-15654. (Pubitemid 35403986)
68. Tsunoda, Y.; Usuda, J.; Imai, K.; Kubota, M.; Maehara, S.; Ohtani, K. The expression of BCRP/ABCG2 causes resistance to Photofrin-PDT. Jpn. J. Laser Surg. Med., 2008, 28, 355-361.
69. Robey, R.W.; Steadman, K.; Polgar, O.; Morisaki, K.; Blayney, M.; Mistry, P.; Bates, S.E. Pheophorbide a is a specific probe for ABCG2 function and inhibition. Cancer Res., 2004, 64, 1242-1246. (Pubitemid 38235589)
70. Gupta, N.; Martin, P.M.; Miyauchi, S.; Ananth, S.; Herdman, A.V.; Martindale, R.G.; Podolsky, R.; Ganapathy, V. Down-regulation of BCRP/ABCG2 in colorectal and cervical cancer. Biochem. Biophys. Res. Commun., 2006, 343, 571-577.
71. Liu, W.; Baer, M.R.; Bowman, M.J.; Pera, P.; Zheng, X.; Morgan, J.; Pandey, R.A.; Oseroff, A.R. The tyrosine kinase inhibitor imatinib mesylate enhances the efficacy of photodynamic therapy by inhibiting ABCG2. Clin. Cancer Res., 2007, 13, 2463-2470. (Pubitemid 46698598)
72. Usuda, J.; Tsunoda, Y.; Ichinose, S.; Ishizumi, T.; Ohtani, K.; Maehara, S.; Ono, S.; Tsutsui, H.; Ohira, T.; Okunaka, T.; Furukawa, K.; Sugimoto, Y.; Kato, H.; Ikeda, N. Breast cancer resistant protein (BCRP) is a molecular determinant of the outcome of photodynamic therapy (PDT) for centrally located early lung cancer. Lung Cancer, 2009, 67, 198-204.
73. Jendzelovskč, R.; Mikes, J.; Koval', J.; Soucek, K.; Procházková, J.; Kello, M.; Sacková, V.; Hofmanová, J.; Kozubík, A.; Fedorocko, P. Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells. Photochem. Photobiol. Sci., 2009, 8, 1716-1723.
74. Krishnamurthy, P.; Ross, D.D.; Nakanishi, T., Bailey-Dell, K.; Zhou, S.; Mercer, K.E.; Sarkadi, B.; Sorrentino, B.P.; Schuetz, J.D. The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. J. Biol. Chem., 2004, 279, 24218-24225. (Pubitemid 38725283)
75. Oleinick, N.L.; Evans, H.H. The photobiology of photodynamic therapy: cellular targets and mechanisms. Radiat. Res., 1998, 150 (5 Suppl), S146-156. (Pubitemid 28519059)
76. Gomer C. DNA damage and repair in CHO cells following hematoporphyrin photoradiation. Cancer Lett., 1980, 11, 161-167. (Pubitemid 11179867)
77. Fiel, R.J.; Datta-Gupta, E.; Mark, E.; Howard, J. Induction of DNA damage by porphyrin photosensitizers. Cancer Res., 1981, 41, 3543-3545. (Pubitemid 11063635)
78. Ramakrishnan, N.; Oleinick, N.; Clay, M.; Horng, M.; Artunes, A.; Evans, H. DNA lesions and DNA degradation in mouse lymphoma L5178Y cells after photodynamic treatment sensitized by chloroaluminium phthalocyanine. Photochem. Photobiol., 1989, 50, 373-378.
79. Crute, J.; Walh, A.; Bambara, R.; Murant, R.; Gibson, S.; Hilf, R. Inhibition of mammalian DNA polymerases by hematoporphyrin derivative and photoradiation. Cancer Res., 1986, 46, 153-159. (Pubitemid 16189045)
80. Evans, H.; Rerko, R.; Mencl, J.; Clay, M.; Artunez, A.; Oleinick, N. Cytotoxic and mutagenic effects of the photodynamic action of chloroaluminium phthalocyanine and visible light in L5178Y cells. Photochem. Photobiol., 1989, 49, 43-47.
81. DiProspero, L.; Singh, G.; Wilson, B.; Rainbow, A. Cross-resistance to Photofrin-mediated Photodynamic Therapy and UV light and recovery from Photodynamic Therapy damage in Rif-8A mouse fibrosarcoma cells measured using viral capacity. J. Photochem. Photobiol., 1997, 38, 143-151. (Pubitemid 27277870)
82. Gomer, C.; Rucker, N.; Murphree, A. Transformation and mutagenic potential of porphyrin photodynamic therapy in mammalian cells. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med., 1988, 53, 651-659.
83. Schwarz, V.; Hornung, R.; Fedier, A.; Fehr, M.; Walt, H.; Haller, U.; Fink, D. Photodynamic therapy of DNA mismatch repair-deficient and proficient tumour cells. Br. J. Cancer, 2002, 86, 1130-1135. (Pubitemid 34438086)
84. Crawford, D.; Zbinden, I.; Amstad, P.; Cerutti, P. Oxidant stress induces the proto-oncogenes c-fos and c-myc in mouse epidermal cells. Oncogene, 1988, 3, 27-32.
85. Buscher, M.; Rahmsdorf, H.J.; Litfin, M.; Karin, M.; Herrlich, P. Activation of the c-fos gene by UV and phorbol ester: different signal transduction pathways converge to the same enhancer element. Oncogene, 1988, 3, 301-311.
86. Luna, M.; Wong, S.; Gomer, C.J. Photodynamic therapy mediated induction of early response genes. Cancer Res., 1994, 54:1374-1380. (Pubitemid 24108084)
87. Kick, G.; Messer, G.; Plewig, G.; Kind, P.; Goetz, A.E. Strong and prolonged induction of c-jun and c-fos proto-oncogenes by photodynamic therapy. Br. J. Cancer, 1996, 74, 30-36. (Pubitemid 26231974)
88. Nakagawa H, Matsumiya T, Sakaki H, Imaizumi T, Kubota K, Kusumi A, Kobayashi W, Kimura Expression of vascular endothelial growth factor by photodynamic therapy with mono-L-aspartyl chlorin e6 (NPe6) in oral squamous cell carcinoma. Oral Oncol., 2007, 43, 544-550. (Pubitemid 46856261)
89. Granville, D.J.; Carthy, C.M.; Jiang, H.; Levy, J.G.; McManus, B.M.; Matroule, J.Y.; Piette, J.; Hunt, D.W. Nuclear factor-kappaB activation by the photochemotherapeutic agent verteporfin. Blood, 2000, 95, 256-262. (Pubitemid 30017250)
90. Sanovic, R.; Krammer, B.; Grumboeck, S.; Verwanger, T. Time-resolved gene expression profiling of human squamous cell carcinoma cells during the apoptosis process induced by photodynamic treatment with hypericin. Int. J. Oncol., 2009, 35, 921-939.
91. Verwanger, T.; Sanovic, R.; Aberger, F.; Frischauf, A.M.; Krammer, B. Gene expression pattern following photodynamic treatment of the carcinoma cell line A-431 analysed by cDNA arrays. Int. J. Oncol., 2002, 21, 1353-1359.
92. Wild, P.J.; Krieg, R.C.; Seidl, J.; Stoehr, R.; Reher, K.; Hofmann, C.; Louhelainen, J.; Rosenthal, A.; Hartmann, A.; Pilarsky, C.; Bosserhoff; A.K.; Knuechel, R. RNA expression profiling of normal and tumor cells following photodynamic therapy with 5-aminolevulinic acid-induced protoporphyrin IX in vitro. Mol. Cancer Ther., 2005, 4, 516-528. (Pubitemid 40601832)
93. Rasch, M.H.; Tijssen, K.; Lagerberg, J.W.; Corver, W.E.; VanSteveninck, J.; Dubbelman, T.M. The role of protein kinase C activity in the killing of Chinese hamster ovary cells by ionizing radiation and photodynamic treatment. Photochem. Photobiol., 1997, 66, 209-213. (Pubitemid 127470168)
94. Xue, L.Y.; Qiu, Y.; He, J.; Kung, H.J.; Oleinick, N.L. Etk/Bmx, a PHdomain- containing tyrosine kinase, protects prostate cancer cells from apoptosis induced by photodynamic therapy or thapsigargin. Oncogene, 1999, 18, 3391-3398. (Pubitemid 29286985)
95. Zhuang, S.; Kochevar, I.E. Singlet oxygen-induced activation of Akt/protein kinase B is independent of growth factor receptors. Photochem. Photobiol., 2003, 78, 361-371.
96. Espada, J.; Galaz, S.; Sanz-Rodríguez, F.; Blázquez-Castro, A.; Stockert, J.C.; Bagazgoitia, L.; Jaén, P.; González, S.; Cano, A.; Juarranz, A. Oncogenic H-Ras and PI3K signaling can inhibit E-cadherin-dependent apoptosis and promote cell survival after photodynamic therapy in mouse keratinocytes. J. Cell Physiol., 2009, 219, 4-93.
97. Kocanova, S.; Buytaert, E.; Matroule, J.Y.; Piette, J.; Golab, J.; de Witte, P.; Agostinis, P. Induction of heme-oxygenase 1 requires the p38MAPK and PI3K pathways and suppresses apoptotic cell death following hypericinmediated photodynamic therapy. Apoptosis, 2007, 12, 731-741 (Pubitemid 46411467)
98. Tong, Z.; Singh, G.; Rainbow, A.J. Sustained activation of the extracellular signal-regulated kinase pathway protects cells from photofrin-mediated photodynamic therapy. Cancer Res., 2002, 62, 5528-5535.
99. Buytaert, E.; Matroule, J.Y.; Durinck, S.; Close, P.; Kocanova, S.; Vandenheede, J.R.; de Witte, P.A.; Piette, J.; Agostinis, P. Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells. Oncogene, 2008, 27, 1916-1929. (Pubitemid 351430819)
100. Keyse, S.M., Emslie, E.A. Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase. Nature, 1992, 359, 644-647.
101. Li, J.; Gorospe, M.; Hutter, D.; Barnes, J.; Keyse, S.M.; Liu, Y. Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation. Mol. Cell Biol., 2001, 21, 8213-8224. (Pubitemid 33051810)
102. Barbacid, M. ras genes. Annu. Rev. Biochem., 1987, 56, 779-827.
103. Downward, J. Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer, 2003, 3, 11-22. (Pubitemid 37328883)
104. Santibanez, J.F.; Hurtado, C. Ha-Ras sensitizes transformed mouse skin cells to anisomycin-induced apoptosis. FEBS Lett., 2005, 579, 6459-6464. (Pubitemid 41612168)
105. Wakabayashi, Y.; Mao, J.H.; Brown, K.; Girardi, M.; Balmain, A. Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice. Nature, 2007, 445, 761-765. (Pubitemid 46279707)
106. Rodriguez, L.; Di Venosa, G.; Batlle, A.; Macrobert, A.; Casas, A. Response to ALA-based PDT in an immortalised normal breast cell line and its counterpart transformed with the Ras oncogene. Photochem. Photobiol. Sci., 2007, 6, 1306-1310. (Pubitemid 350191099)
107. Rodriguez, L.; Di Venosa, G.; Schickinger, S.; Batlle, A.; MacRobert, A.; Casas, A. Resistencia a la Terapia Fotodinámica en células transfectadas con el oncogen H-ras. Medicina (B. Aires), 2007, 67, 79.
108. Oleinick, N.L.; Morris, R.L.; Belichenko, I. The role of apoptosis in response to photodynamic therapy: what, where, why, and how. Photochem. Photobiol. Sci., 2002, 1, 1-21. (Pubitemid 37069701)
109. Reiners, J.J.Jr; Agostinis, P.; Berg, K.; Oleinick, N.L.; Kessel, D. Assessing autophagy in the context of photodynamic therapy. Autophagy, 2010, 6, 7-18.
110. Kessel D. Relocalization of cationic porphyrins during photodynamic therapy. Photochem. Photobiol. Sci., 2002, 1, 837-840. (Pubitemid 37069807)
111. Kessel, D.; Luo, Y.; Deng, Y.; Chang, C.K. The role of subcellular localization in initiation of apoptosis by photodynamic therapy. Photochem. Photobiol., 1997, 65, 422-426. (Pubitemid 27158974)
112. Dellinger, M. Apoptosis or necrosis following Photofrin photosensitization: influence of the incubation protocol. Photochem. Phorobiol., 1996, 64, 182-187.
113. Kessel, D.; Castelli, M. Evidence that Bcl-2 is the target of three photosensitizers that induce a rapid apoptotic response. Photochem. Photobiol., 2001, 74, 318-322.
114. Kessel, D.; Luguya, R.; Vicente, M.G. Localization and photodynamic efficacy of two cationic porphyrins varying in charge distribution. Photochem. Photobiol., 2003, 78, 431-435.
115. Kessel, D.; Luo, Y.; Mathieu, P.; Reiners, J.J. Jr. Determinants of the apoptotic response to lysosomal photodamage. Photochem Photobiol, 2000, 71, 196-200.
116. Kessel, D.; Oleinick, N.L. Initiation of autophagy by photodynamic therapy. Methods Enzymol., 2009, 453, 1-16.
117. Kessel, D.; Arroyo, A.S. Apoptotic and autophagic responses to Bcl-2 inhibition and photodamage. Photochem. Photobiol. Sci., 2007, 6, 1290-1295. (Pubitemid 350191106)
118. Kessel, D.; Oleinick, N.L. Photodynamic therapy and cell death pathways. Methods Mol. Biol., 2010, 635, 35-46.
119. Almeida, R.D.; Manadas, B.J.; Carvalho, A.P.; Duarte, C.B. Intracellular signaling mechanisms in photodynamic therapy. Biochim. Biophys. Acta, 2004,1704, 59-86. (Pubitemid 39195350)
120. Granville, D.J.; Carthy, C.M.; Jiang, H.; Shore, G.C.; McManus, B.M.; Hunt, D.W. Rapid cytochrome c release, activation of caspases 3, 6, 7 and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy. FEBS Lett., 1998, 437, 5-10. (Pubitemid 28498230)
121. Reed, J. C. Bcl-2 family proteins. Oncogene, 1998, 17, 3225-3236. (Pubitemid 29043975)
122. Gross, A.; McDonnell, J.M.; Korsmeyer, S.J. BCL-2 family members and the mitochondria in apoptosis. Genes, 1999, 13, 1899-1911 (Pubitemid 29407357)
123. Granville, D.J.; Jiang, H.; An, M.T.; Levy, J.G.; McManus, B.M.; Hunt, D.W. Bcl-2 overexpression blocks caspase activation and downstream apoptotic events instigated by photodynamic therapy. Br. J. Cancer, 1999, 79, 95-100. (Pubitemid 28566932)
124. Srivastava, M.; Ahmad, H.; Gupta, S.; Mukhtar, H. Involvement of Bcl-2 and Bax in photodynamic therapy mediated apoptosis, J. Biol. Chem., 2001, 276, 15481-15488.
125. Zacal, N.; Espiritu, M.; Singh, G.; Rainbow, A.J. Increased BNip3 and decreased mutant p53 in cisplatin-sensitive PDT-resistant HT29 cells. Biochem. Biophys. Res. Commun., 2005, 331, 648-657. (Pubitemid 40602683)
126. He, J.; Agarwal, M.; Larkin, H.; Friedman, L.; Xue, L.; Oleinick, N. The induction of partial resistance to photodynamic therapy by the protooncogene BCL-2. Photochem. Photobiol., 1996, 64, 845-852.
127. Kim, H.; Luo, Y.; Li, G.; Kessel, D. Enhanced apoptotic response to photodynamic therapy after bcl-2 transfection. Cancer res., 1999, 59, 3429-3432. (Pubitemid 29334504)
128. Zhang, W.G.; Ma, L.P.; Wang, S.W.; Zhang, Z.Y.; Cao, G.D. Antisense bcl- 2 retrovirus vector increases the sensitivity of a human gastric adenocarcinoma cell line to photodynamic therapy, Photochem. Photobiol., 1999, 69, 582-586.
129. Kawaguchi, T.; Yamamoto, S.; Naka, N.; Okishio, K.; Atagi, S.; Ogawara, M.; Hosoe, S.; Kawahara, M.; Furuse, K. Immunohistochemical analysis of Bcl-2 protein in early squamous cell carcinoma of the bronchus treated with photodynamic therapy, Br. J. Cancer, 2000, 82, 418-423. (Pubitemid 30045391)
130. McGarrity T. J., L. P. Peiffer, D. J. Granville, C. M. Carthy, J. G. Levy, M. Khandelwal and D. W. Hunt, Apoptosis associated with esophageal adenocarcinoma: influence of photodynamic therapy, Cancer Lett., 2001, 163, 33-41. (Pubitemid 32121828)
131. Koukourakis, M.; Corti, L.; Skarlatos, J.; Giatromanolaki, A.; Krammer, B.; Blandamura, S.; Piazza, M.; Verwanger, T.; Schnitzhofer, G.; Kostandelos, J.; Beroukas, K. Clinical and experimental evidence of Bcl-2 involvement in the response to photodynamic therapy. Antinacer Res., 2001, 21, 663-668. (Pubitemid 32267590)
132. Xue, L.Y.; Chiu, S.M.; Oleinick, N.L. Photochemical destruction of the Bcl- 2 oncoprotein during photodynamic therapy with the phthalocyanine photosensitizer Pc 4. Oncogene, 2001, 20, 3420-3427. (Pubitemid 32588990)
133. Usuda, J.; Azizuddin, K.; Chiu, S.M.; Oleinick, N.L. Association between the photodynamic loss of Bcl-2 and the sensitivity to apoptosis caused by phthalocyanine photodynamic therapy. Photochem. Photobiol., 2003, 78, 1-8.
134. Chiu, S.M.; Xue, L.Y.; Usuda, J.; Azizuddin, K.; Oleinick, N.L. Bax is essential for mitochondrion-mediated apoptosis but not for cell death caused by photodynamic therapy. Br. J. Cancer, 2003, 89, 1590-1597. (Pubitemid 37386619)
135. Usuda, J.; Hirata, T.; Ichinose, S.; Ishizumi, T.; Inoue, T.; Ohtani, K.; Maehara, S.; Yamada, M.; Tsutsui, H.; Okunaka, T.; Kato, H.; Ikeda, N. Tailor-made approach to photodynamic therapy in the treatment of cancer based on Bcl-2 photodamage. Int. J. Oncol., 2008, 33, 689-696.
136. Wan, Q.; Liu, L.; Xing, D.; Chen, Q. Bid is required in NPe6-PDT-induced apoptosis. Photochem Photobiol., 2008, 84, 250-257. (Pubitemid 350265108)
137. Ichinose, S.; Usuda, J.; Hirata, T.; Inoue, T.; Ohtani, K.; Maehara, S.; Kubota, M.; Imai, K.; Tsunoda, Y.; Kuroiwa, Y.; Yamada, K.; Tsutsui, H.; Furukawa, K.; Okunaka, T.; Oleinick, N.L.; Kato, H. Lysosomal cathepsin initiates apoptosis, which is regulated by photodamage to Bcl-2 at mitochondria in photodynamic therapy using a novel photosensitizer, ATXs10 (Na). Int. J. Oncol., 2006, 29, 349-355.
138. Caruso, J.A.; Mathieu, P.A.; Joiakim, A.; Leeson, B.; Kessel, D.; Sloane, B.F.; Reiners, J.J. Jr. Differential susceptibilities of murine hepatoma 1c1c7 and Tao cells to the lysosomal photosensitizer NPe6: influence of aryl hydrocarbon receptor on lysosomal fragility and protease contents. Mol. Pharmacol., 2004, 4, 1016-1028. (Pubitemid 38420508)
139. Shaw, P.; Bovey, R.; Tardy, S.; Sahli, R.; Sordat, B.; Costa, J. Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc. Natl. Acad. Sci. USA, 1992, 89, 4495-4499.
140. Siognov, R.V.; Haupt, Y. The cellular response to p53: the decision between life and death. Oncogene, 1999, 18, 6145-6157.
141. Fisher, A.M.R.; Danenberg, K.; Banerjee, D.; Bertino, J.R.; Danenberg, P.; Gomer, C.J. Increased photosensitivity in HL60 cells expressing wild-type p53, Photochem. Photobiol., 1997, 66, 265-270. (Pubitemid 127470176)
142. Fisher A.M.; Rucker, N.; Wong, S.; Gomer, C.J. Differential photosensitivity in wild-type and mutant p53 human colon carcinoma cell lines. J. Photochem. Photobiol., 1998, 42, 104-107. (Pubitemid 28142331)
143. Tong, Z.; Singh, G.; Rainbow, A.J. The role of the p53 tumor suppressor in the response of human cells to photofrin-mediated photodynamic therapy, Photochem. Photobiol., 2000, 71, 201-210.
144. Fisher, A.M.R.; Ferrario, A.; Rucker, N.; Zhang, S.; Gomer, C.J. Photodynamic therapy sensitivity is not altered in human tumor cells after abrogation of p53 function. Cancer Res., 1999, 59, 331-335. (Pubitemid 29048863)
145. Zawacka-Pankau, J.; Krachulec, J.; Grulkowski, I.; Bielawski, K.P.; Selivanova, G. The p53-mediated cytotoxicity of photodynamic therapy of cancer: recent advances. Toxicol. Appl. Pharmacol., 2008, 232, 487-497.
146. Xue, L.Y.; Chiu, S.M.; Oleinick, N.L. Atg7 deficiency increases resistance of MCF-7 human breast cancer cells to photodynamic therapy.
147. Kessel, D.; Reiners, J.J.Jr. Apoptosis and autophagy after mitochondrial or endoplasmic reticulum photodamage. Photochem. Photobiol., 2007, 83, 1024-1028. (Pubitemid 47438509)
148. Dewaele, M.; Martinet, W.; Rubio, N.; Verfaillie, T.; de Witte, P.A.; Piette, J.; Agostinis, P. Autophagy pathways activated in response to PDT contribute to cell resistance against ROS damage. J. Cell Mol. Med., 2010. [In press]
149. Davids, L.M.; Kleemann, B.; Cooper, S.; Kidson, S.H. Melanomas display increased cytoprotection to hypericin-mediated cytotoxicity through the induction of autophagy. Cell Biol. Int., 2009, 33, 1065-1072.
150. Grune, T.; Merker, K.; Sandig, G.; Davies, K.J. Selective degradation of oxidatively modified protein substrates by the proteasome. Biochem. Biophys. Res. Commun., 2003, 305, 709-718. (Pubitemid 36579287)
151. Dunlop, R.A.; Rodgers, K.J.; Dean, R.T. Recent developments in the intracellular degradation of oxidized proteins. Free Radic. Biol. Med., 2002, 33, 894-906. (Pubitemid 35284029)
152. Lee, A.H.; Iwakoshi, N.N.; Anderson, K.C.; Glimcher, L.H. Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. Proc. Natl. Acad. Sci. USA, 2003, 100, 9946-9951. (Pubitemid 37087048)
153. Szokalska, A.; Makowski, M.; Nowis, D.; Wilczynski, G.M.; Kujawa, M.; Wójcik, C.; Mlynarczuk-Bialy, I.; Salwa, P.; Bil, J.; Janowska, S.; Agostinis, P.; Verfaillie, T.; Bugajski, M.; Gietka, J.; Issat, T.; Glodkowska, E.; Mrówka, P.; Stoklosa, T.; Hamblin, M.R.; Mróz, P.; Jakóbisiak, M.; Golab, J. Proteasome inhibition potentiates antitumor effects of photodynamic therapy in mice through induction of endoplasmic reticulum stress and unfolded protein response. Cancer Res., 2009, 69, 4235-4243
154. Carracedo, A.; Geelen, M.J.; Diez, M.; Hanada, K.; Guzman, M.; Velasco, G. Ceramide sensitizes astrocytes to oxidative stress: protective role of cannabinoids. Biochem. J., 2004, 380, 435-440. (Pubitemid 38788115)
155. Wispriyono, B.; Schmelz, E.; Pelayo, H.; Hanada, K.; Separovic, D. A role for the de novo sphingolipids in apoptosis of photosensitized cells. Exp. Cell Res., 2002, 279, 153-165.
156. Separovic, D.; Semaan, L.; Tarca, A.L.; Awad Maitah, M.Y.; Hanada, K.; Bielawski, J.; Villani, M.; Luberto, C. Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage. Exp. Cell Res., 2008, 314, 1860-1868.
157. Burow, M.E.; Weldon, C.B., Melnik, L.I.; Duong, B.N; Collins-Burow, B.M; Beckman, B.S.; McLachlan, J.A.. PI3-K/ KT regulation of NF-kappaB signaling events in suppression of TNF-induced apoptosis. Biochem. Biophys. Res. Commun., 2000, 271, 342-334.
158. Krebs J. The role of calcium in apoptosis. Biometals, 1998, 11, 375-382. (Pubitemid 29121543)
159. Levy-Strumpf, N.; Kimchi, A. Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions. Oncogene, 1998, 17, 3331-3340. (Pubitemid 29043985)
160. Rodriguez-Mora, O.G.; Lahair, M.M.; Evans, M.J.; Kovacs, C.J.; Allison, R.R.; Sibata, C.H.; White, K.S.; McCubrey, J.A.; Franklin, R.A. Inhibition of the CaM-kinases augments cell death in response to oxygen radicals and oxygen radical inducing cancer therapies in MCF-7 human breast cancer cells. Cancer Biol. Ther., 2006, 5, 1022-1030.
161. Kliukiene, R.; Maroziene, A.; Nivinskas, H.; Cenas, N.; Kirveliene, V.; Juodka, B. Biochem. Mol. Biol. Int., 1997, 41, 707-713.
162. Golab, J.; Nowis, D.; Skrzycki, M.; Czeczot, H.; Baranczyk-Kuzma, A.; Wilczynski, G.M.; Makowski, M.; Mroz, P.; Kozar, K.; Kaminski, R.; Jalili, A.; Kopec', M.; Grzela, T.; Jakobisiak, M. Antitumor effects of photodynamic therapy are potentiated by 2-methoxyestradiol. A superoxide dismutase inhibitor. J. Biol. Chem., 2003, 278, 407-414. (Pubitemid 36043590)
163. Dolgachev, V.; Oberley, L.W.; Huang, T.T.; Kraniak, J.M.; Tainsky, M.A.; Hanada, K.; Separovic, D. A role for manganese superoxide dismutase in apoptosis after photosensitization. Biochem. Biophys. Res. Commun., 2005, 332, 411-417. (Pubitemid 40724994)
164. Oberdanner, C.B.; Plaetzer, K.; Kiesslich, T.; Krammer, B. Photodynamic treatment with fractionated light decreases production of reactive oxygen species and cytotoxicity in vitro via regeneration of glutathione. Photochem. Photobiol., 2005, 81, 609-613. (Pubitemid 40901336)
165. Wang, H.; Qian, S.; Schafer, F.; Domann, F.; Oberley, L.; Buettner, G. Phospholipid hydroperoxide glutathione peroxidase protects against singlet oxygen-induced cell damage of photodynamic therapy. Free Radic. Biol. Med., 2001, 30, 825-835. (Pubitemid 32289260)
166. Dabrowski, M.J.; Maeda, D.; Zebala, J.; Lu, W.D.; Mahajan, S.; Kavanagh, T.J.; Atkins, W.M. Glutathione S-transferase P1-1 expression modulates sensitivity of human kidney 293 cells to photodynamic therapy with hypericin. Arch Biochem Biophys., 2006, 449, 94-103.
167. Borst, P.; Evers, R.; Kool, M.; Wijnholds, J. A family of drug transporters: the multidrug resistance-associated proteins. J. Natl. Cancer Inst., 2000, 92, 1295-1302. (Pubitemid 30662093)
168. Schlesinger, M. Heat shock proteins. J. Biol. Chem., 1990, 265, 12111-12114.
169. Gomer, C.J.; Luna, M.; Ferrario, A.; Rucker, N. Increased transcription and translation of heme oxygenase in Chinese hamster fibroblasts following photodynamic stress or Photofrin II incubation. Photochem. Photobiol., 1991, 53, 275-279.
170. Curry, P.M.; Levy, J.G. Stress protein expression in murine tumor cells following photodynamic therapy with benzoporphyrin derivative. Photochem. Photobiol., 1993; 58, 374-379.
171. Gomer, C.J.; Ferrario, A.; Rucker, N.; Wong, S.; Lee, A.S. Glucose regulated protein induction and cellular resistance to oxidative stress mediated by porphyrin photosensitization. Cancer Res., 1991, 51, 6574-6579.
172. Jozkowicz, A.; Was, H.; Dulak, J. Heme oxygenase-1 in tumors: is it a false friend? Antioxid. Redox Signal., 2007, 9, 2099-2117. (Pubitemid 350059009)
173. Gomer, C.; Rucker, N.; Wong, S. Porphyrin photosensitivity in cell lines expressing a heat-resistant phenotype. Cancer Res., 1990, 50, 5365-5368. (Pubitemid 20302989)
174. Hanlon, J.; Adams, K.; Rainbow, A.; Gupta, R.; Singh, G. Induction of HSP60 by Photofrin-mediated photodynamic therapy. J. Photochem. Photobiol., 2001, 64, 55-61. (Pubitemid 33064729)
175. Wang, H.; Hanlon, J.; Rainbow, A.; Espiritu, M.; Singh, G. Up-regulation of HSP27 plays a role in the resistance of human colon carcinoma HT29 cells to photooxidative stress. Photochem. Photobiol., 2002, 76, 98-104.
176. Xue, L.Y.; He, J.; Oleinick, N.L. Rapid tyrosine phosphorylation of HS1 in the response of mouse lymphoma L5178Y-R cells to photodynamic treatment sensitized by the phthalocyanine Pc 4. Photochem Photobiol., 1997, 66, 105-113. (Pubitemid 127470640)
177. Nowis, D.; Legat, M.; Grzela, T.; Niderla, J., Wilczek, E.; Wilczynski, G.M.; Głodkowska, E.; Mrówka, P.; Issat, T.; Dulak, J.; Józkowicz, A.; Waś, H.; Adamek, M.; Wrzosek, A.; Nazarewski, S.; Makowski, M.; Stokłosa, T.; Jakóbisiak, M.; Gołab, J. Heme oxygenase-1 protects tumor cells against photodynamic therapy-mediated cytotoxicity. Oncogene, 2006, 25, 3365-3374. (Pubitemid 43880305)
178. Järveläinen, H.; Sainio, A.; Koulu, M.; Wight, T.N.; Penttinen, R. Extracellular matrix molecules: potential targets in pharmacotherapy. Pharmacol Rev., 2009, 61,198-223.
179. Askari, J.A.; Buckley, P.A.; Mould, A.P.; Humphries, M.J. Linking integrin conformation to function. J. Cell Sci., 2009, 122, 165-170.
180. Cianfriglia, M.; Yassen, A.; Tombesi, M.; Samoggia, P.; Barca, S.; Caserta, M. Expression of lymphocyte homing receptor gene is lost in multi-drugresistant variant of human lymphoblastoid CCRF-CEM cells. Int. J. Cancer, 1991, 49, 394-397.
181. Thompson, E.; Paik, S.; Brunner, N.; Sommers, C.; Zugmaier, G.; Clarke, R.; Shima, T.; Torri, J.; Donhaue, S.; Lippman, M.; Martin, G.; Dickson, R. Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines. J. Cell. Physiol., 1992, 150, 534-544.
182. Hazlehurst, L.A.; Dalton, W.S. Mechanisms associated with cell adhesion mediated drug resistance (CAM-DR) in hematopoietic malignancies. Cancer Metastasis Rev., 2001, 20, 43-50. (Pubitemid 34074677)
183. Cordes, N.; Meineke, V. Cell adhesion-mediated radioresistance (CAM-RR): extracellular matrix-dependent improvement of cell survival in human tumor and normal cells in vitro. Strahlenther Onkol, 2003, 179, 337-344. (Pubitemid 36606025)
184. Cordes, N. Overexpression of hyperactive integrin-linked kinase leads to increased cellular radiosensitivity. Cancer Res., 2004, 64, 5683-5692. (Pubitemid 39095566)
185. Margaron, P.; Sorrenti, R.; Levy, J.G. Photodynamic therapy inhibits cell adhesion without altering integrin expression. Biochim. Biophys. Acta, 1997, 1359, 200-210. (Pubitemid 28027118)
186. Runnels, J.M.; Chen, N.; Ortel, B.; Kato, D.; Hasan, T. BPD-MA mediated photosensitization in vitro and in vivo: cellular adhesion and beta1 integrin expression in ovarian cancer cells. Br. J. Cancer, 1999, 80, 946-953. (Pubitemid 29233914)
187. Rousset, N.; Vonarx, V.; Eleouet, S.; Carre, J.; Kerninon, E.; Lajat, Y.; Patrice, T. Effects of photodynamic therapy on adhesion molecules and metastasis. J. Photochem. Photobiol. B, 1999, 52, 65-73. (Pubitemid 30011497)
188. Momma, T.; Hamblin, M.R.; Wu, H.C.; Hasan, T. Photodynamic therapy of orthotopic prostate cancer with benzoporphyrin derivative: local control and distant metastasis. Cancer Res., 1998, 58, 5425-5431. (Pubitemid 28551126)
189. Casas, A.; Di Venosa, G.; Vanzulli, S.; Perotti, C.; Mamome, L.; Rodriguez, L.; Simian, M.; Juarranz, A.; Pontiggia, O.; Hasan, T.; Batlle, A. Decreased metastatic phenotype in cells resistant to aminolevulinic acid-photodynamic therapy. Cancer Lett., 2008, 271, 342-351.
190. Foultier, M.; Vonarx-Coinsmann, V.; Cordel, S.; Combre, A. & Patrice, T. Modulation of colonic cancer cell adhesiveness by haematoporphyrin derivative photodynamic therapy. J. Photochem. Photobiol., 1994, 23, 9-17. (Pubitemid 24119068)
191. Vonarx, V.; Foultier, M.; de Brito, X.; Anasagasti, L.; Morlet, L.; Patrice, T. Photodynamic therapy decreases cancer colonic cell adhesiveness and metastatic potential. Res. Exp. Med., 1995, 195, 101-116.
192. Overhaus, M.; Heckenkamp, J.; Kossodo, S.; Leszcynski, D.; La Muraglia, G. Photodynamic therapy generates a matrix barrier to invasive vascular cell migration. Circ. Res., 2000, 86, 334-340. (Pubitemid 30108828)
193. Lee, C.; Wu, S.; Chen, L. Photosensitization by 3,3'- dihexyloxacarbocyanine iodide: specific disruption of microtubules and inactivation of organelle motility. Cancer Res., 1995, 55, 2063-2069.
194. Lambrechts, A.; Troys, M.; Ampe, C. The actin cytoskeleton in normal and pathological cell motility. Int. J. Biochem. Cell Biol., 2004, 36, 1890-1909 (Pubitemid 38760020)
195. Ruoslahti, E. Fibronectin and its integrin receptors in cancer (Review). Adv. Cancer Res., 1999, 76, 1-20. (Pubitemid 29190879)
196. Galaz, S., Espada, J.; Stockert, J.C.; Pacheco, M., Sanz-Rodriguez, F.; Arranz, R.; Rello, S.; Canete, M.; Villanueva, A.; Esteller, M.; Juarranz, A: Loss of E-cadherin mediated cell-cell adhesion as an early trigger of apoptosis induced by photodynamic treatment. J. Cell. Physiol., 2005, 205, 86-96. (Pubitemid 41262854)
197. Casas, A.; Sanz-Rodriguez, F.; Di Venosa, G.; Rodriguez, L.; Mamone, L.; Blázquez, A.; Jaén, P.; Batlle, A.; Stockert, J.C.; Juarranz, A. Disorganisation of cytoskeleton in cells resistant to photodynamic treatment with decreased metastatic phenotype. Cancer Lett., 2008, 270, 56-65.
198. Giese, G.; Schmidt, J.; Gilbert, M.; Albrecht, R.; Traub, P. TPA induces apoptosis in MPC-11 mouse plasmacytoma cells grown in serum-free medium. Biol. Cell, 1997, 89, 99-111. (Pubitemid 27453891)
199. Hashimoto, M.; Inoue, S.; Ogawa, S.; Conrad, C.; Muramatsu, M.; Shackelford, D.; Maliah, E. Rapid fragmentation of vimentin in human skin fibroblasts exposed to tamoxifen: a possible involvement of caspase-3. Biochem. Biophys. Res. Commun., 1998, 247, 401-406. (Pubitemid 28420837)
200. Belichenko, I.; Morishima, N.; Separovic, D. Caspase-resistant vimentin suppressed apoptosis after photodynamic treatment with a silicon phthalocyanine in Jurkat cells. Arch. Biochem. Biophys., 2001, 390, 57-63. (Pubitemid 32493570)
201. Perry, R.; Matthews, W.; Mitchell, J.; Russo, A.; Evans, S.; Pass, H. Sensitivity of different human lung cancer histologies to Photodynamic Therapy. Cancer Res., 1990, 50, 4272-4276. (Pubitemid 20225663)
202. Dodson, J.W.; Hay, E.D. Secretion of Collagen by Corneal Epithelium. II. Effect of the Underlying Substratum on Secretion and Polymerisational Epithelial Cell Products. J. Exptl. Zool., 1974, 789, 51-72.
203. Gospodarowicz, D.; Greenburg, G.; Birdwell, C.R. Determination of cellular shape by the extracellular matrix and its correlation with the control of cellular growth. Cancer Res., 1978, 38, 4155-4171. (Pubitemid 9060155)
204. Brambilla, E.; Moro, D.; Gazzeri, S.; Brichon, P.; Nagy-Mignotte, H.; Morel, F.; Jacrot, M.; Brambilla, C. Cytotoxic chemotherapy induces cell differentiation in small-cell lung carcinoma. J. Clin. Oncol., 1991, 9, 50-61.
205. Richter, A.; Kelly, B.; Chow, J.; Liu, D.; Towers, G.; Dolphin, D.; Levy, J. Preliminary studies on a more effective phototoxic agent than hematoporphyrin. J. Natl. Cancer Inst., 1987, 79, 1327-1332. (Pubitemid 18036738)
206. Girotti A: Photodynamic lipid peroxidation in biological systems. Photochem. Photobiol., 1990, 51, 497-509.
207. Smith, W.L.; De Witt, D.L.; Garavito, R.M. Cyclooxygenases: structural, cellular, and molecular biology. Annu. Rev. Biochem., 2000, 69, 145-182.
208. Williams, C.S.; Mann, M.; DuBois, R.N. The role of cyclooxygenases in inflammation, cancer, and development. Oncogene, 1999, 18, 7908-7916. (Pubitemid 30066236)
209. Cao, Y.; Prescott, S.M. Many actions of cyclooxygenase-2 in cellular dynamics and in cancer. J. Cell. Physiol., 2002, 190, 279-286. (Pubitemid 34111968)
210. Liao, Z.; Mason, K.A.; Milas, L. Cyclo-oxygenase-2 and its inhibition in cancer: is there a role? Drugs, 2007, 67, 821-845. (Pubitemid 46607385)
211. Ferrario, A.; Von Tiehl, K.; Wong, S.; Luna, M.; Gomer, C.J. Cyclooxygenase-2 inhibitor treatment enhances photodynamic therapymediated tumor response. Cancer Res., 2002, 62, 3956-3961. (Pubitemid 34791059)
212. Hendrickx, N.; Volanti, C.; Moens, U.; Seternes, O.M.; de Witte, P.; Vandenheede, J.R.; Piette, J.; Agostinis, P. Up-regulation of cyclooxygenase- 2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells. J. Biol. Chem., 2003, 278, 52231-52239. (Pubitemid 38035811)
213. Henderson, B.W.; Donovan, J.M. Release of prostaglandin E2 from cells by photodynamic treatment in vitro. Cancer Res., 1989, 49, 6896-6900. (Pubitemid 20016563)
214. Penning, L.C.; Keirse, M.J.; Van Steveninck, J.; Dubbelman, T.M. Ca(2+)- mediated prostaglandin E2 induction reduces haematoporphyrin-derivativeinduced cytotoxicity of T24 human bladder transitional carcinoma cells in vitro. Biochem. J., 1993, 292(Pt 1), 237-240. (Pubitemid 23158987)
215. Hendrickx, N.; Dewaele, M.; Buytaert, E.; Marsboom, G.; Janssens, S., Van Boven, M.; Vandenheede, J.R., de Witte, P.; Agostinis, P. Targeted inhibition of p38alpha MAPK suppresses tumor-associated endothelial cell migration in response to hypericin-based photodynamic therapy. Biochem. Biophys. Res. Commun., 2005, 337, 928-935. (Pubitemid 41447003)
216. Kleban, J.; Mikes, J.; Szilárdiová, B.; Koval, J.; Sacková, V.; Solár, P.; Horváth, V.; Hofmanová, J.; Kozubík, A.; Fedorocko, P. Modulation of hypericin photodynamic therapy by pretreatment with 12 various inhibitors of arachidonic acid metabolism in colon adenocarcinoma HT-29 cells. Photochem Photobiol., 2007, 83, 1174-1185. (Pubitemid 47438512)
217. Makowski, M.; Grzela, T.; Niderla, J.; śAzarczyk, M.; Mróz, P.; Kopeé, M.; Legat, M.; Strusičska, K.; Koziak, K.; Nowis, D.; Mrówka, P.; Wasik, M.; Jakóbisiak, M.; Gołab, J. Inhibition of cyclooxygenase-2 indirectly potentiates antitumor effects of photodynamic therapy in mice. Clin. Cancer Res., 2003, 9, 5417-5422. (Pubitemid 37413598)
218. Foultier, M.T.; Patrice, T.; Yactayo, S.; Lajat, Y.; Resche, F. Photodynamic treatment of normal endothelial cells or glioma cells in vitro. Surg. Neurol., 1992, 37, 83-88.
219. Esteban, F.J.; Horcajadas, A.; El-Rubaidi, O.; Luque-Barona, R.; Ibáñez, G.; García-Carriazo, A.; Segovia, M.; del Moral-Leal, M.L. Nitric oxide in malignant astrocytes. Rev. Neurol., 2005, 40, 437-440. (Pubitemid 46639023)
220. Porro, A.; Chrochemore, C.; Cambuli, F.; Iraci, N.; Contestabile, A., Perini, G. Nitric oxide control of MYCN expression and multi drug resistance genes in tumours of neural origin. Curr. Pharm. Des., 2010, 16, 431-439.
221. Fetz, V.; Bier, C.; Habtemichael, N.; Schuon, R.; Schweitzer, A.; Kunkel, M.; Engels, K.; Kovács, A.F.; Schneider, S.; Mann, W.; Stauber, RH, Knauer S.K. Inducible NO synthase confers chemoresistance in head and neck cancer by modulating survivin. Int. J. Cancer, 2009, 124, 2033-2041.
222. Leung, E.L.; Fraser, M.; Fiscus, R.R.; Tsang, B.K..Cisplatin alters nitric oxide synthase levels in human ovarian cancer cells: involvement in p53 regulation and cisplatin resistance. Br. J. Cancer, 2008, 98, 1803-1809. (Pubitemid 351748840)
223. Rubbo, H.; Radi, R.; Trujillo, M.; Kalyanaraman, B.; Barnes, S.; Freeman, B.A. Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. J. Biol. Chem., 1994, 269, 26066-26075
224. Niziolek, M.; Korytowski, W.; Girotti, A.W. Chain-breaking antioxidant and cytoprotective action of nitric oxide on photodynamically stressed tumor cells. Photochem. Photobiol., 2003, 78, 262-270.
225. Kim, Y.M.; Bergonia, H.; Lancaster, J. R. Nitric oxide-induced autoprotection of isolated rat hepatocytes. FEBS Lett., 1995, 374, 228-232.
226. Joshi, M.S.; Ponthier, J.L.; Lancaster, J.R. Cellular antioxidant and prooxidant actions of nitric oxide. Free Radic. Biol. Med.,1999, 27,1357-1366. (Pubitemid 30001498)
227. Niziolek-Kierecka, M.; Pilat, A.; Korytowski, W.; Girotti, A.W. Apoptosisaccommodating effect of nitric oxide in photodynamically stressed tumor cells. Photochem. Photobiol., 2010, 86, 681-686.
228. Zareba, M.; Niziolek, M.; Korytowski, W.; Girotti, A.W. Merocyanine 540- sensitized photokilling of leukemia cells: role of post-irradiation chain peroxidation of plasma membrane lipids as revealed by nitric oxide protection. Biochim. Biophys. Acta, 2005, 1722, 51-59. (Pubitemid 40222405)
229. Di Venosa, G.; Casas, A.; Fukuda, H.; Perotti, C.; Batlle, A. No crossresistance between ALA-mediated photodynamic therapy and nitric oxide. Nitric Oxide, 2005, 13,155-162. (Pubitemid 41443559)
230. Di Venosa, G.; Perotti, C.; Fukuda, H.; Batlle, A.; Casas, A. Sensitivity to ALA-PDT of cell lines with different nitric oxide production and resistance to NO cytotoxicity. J. Photochem. Photobiol. B, 2005, 80,195-202. (Pubitemid 41150648)
231. Bhowmick, R.; Girotti, A.W. Cytoprotective Induction of Nitric Oxide Synthase in a Cellular Model of 5-Aminolevulinic Acid-Based Photodynamic Therapy. Free Radic. Biol. Med., 2010, 48, 1296-1301
232. Mita, A.C.; Mita, M.M.; Nawrocki, S.T.; Giles, F.J. Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics. Clin. Cancer Res., 2008, 14, 5000-5005.
233. Altieri, D.C. Validating survivin as a cancer therapeutic agent. Nat. Rev. Cancer, 2003, 3, 46-54. (Pubitemid 37328886)
234. Zhen, H.N.; Zhang, X.; Hu, P.Z. Survivin expression and its relation with proliferation, apoptosis, and angiogenesis in brain gliomas. Cancer, 2005, 104, 2775-2783. (Pubitemid 41798288)
235. Fortugno, P.; Beltrami, E.; Plescia, J.; Fontana, J.; Pradhan, D.; Marchisio, P.C.; Sessa, W.C.; Altieri, D.C. Regulation of survivin function by HSP90. Proc. Natl. Acad. Sci. USA, 2003, 100,13791-13796. (Pubitemid 37499145)
236. Ferrario, A.; Rucker, N.; Wong, S.; Luna, M.; Gomer, C.J. Survivin, a member of the inhibitor of apoptosis family, is induced by photodynamic therapy and is a target for improving treatment response. Cancer Res., 2007, 67:4989-4995. (Pubitemid 46910208)
237. He, G.F.; Bian, M.L.; Zhao, Y.W.; Xiang, Q.; Li, H.Y.; Xiao, C. A study on the mechanism of 5-aminolevulinic acid photodynamic therapy in vitro and in vivo in cervical cancer. Oncol. Rep., 2009, 21, 861-868.
238. He, G.F.; Bian, M.L.; Zhao, Y.W.; Xiang, Q.; Li, H.Y.; Xiao, C. Apoptosisinducing effect of 5-aminolevulinic acid-mediated photodynamic therapy (5- ALA-PDT) on cervical cancer cell lines. Ai Zheng, 2008, 27, 897-904.
239. Ferrario, A.; Gomer, C.J. Targeting the 90 kDa heat shock protein improves photodynamic therapy. Cancer Lett., 2010, 289,188-194.
240. Vaupel, P.; Harrison, L. Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response. Oncologist, 2004, 9 Suppl 5, 4-9. (Pubitemid 39658340)
241. Ferrario, A.; von Tiehl, K.F.; Rucker, N.; Schwarz, M.A.; Gill, P.S.; Gomer, C.J. Antiangiogenic treatment enhances photodynamic therapy responsiveness in a mouse mammary carcinoma. Cancer Res., 2000, 60, 4066-4069. (Pubitemid 30636586)
242. Okunaka, T.; Usuda, J.; Ichinose, S.; Hirata, H.; Ohtani, K.; Maehara, S.; Inoue, T.; Imai, K.; Kubota, M.; Tsunoda, Y.; Kuroiwa, Y.; Tsutsui, H.; Furukawa, K.; Nishio, K.; Kato, H. A possible relationship between the anticancer potency of photodynamic therapy using the novel photosensitizer ATX-s10-Na(II) and expression of the vascular endothelial growth factor in vivo. Oncol. Rep., 2007, 18, 679-683.
243. Reyal, J. Arterial flow focalization could increase tissue oxygen partial pressure, or trigger endothelial shear stress - A new concept to overcome cancer hypoxia-induced radiotherapy resistance, or stimulate liver regeneration during fulminant hepatitis. Med. Hypotheses, 2009, 74, 301-308.
244. Boyer, M. Bioreductive agents: a clinical update. Oncol. Res., 1997, 9, 391-395. (Pubitemid 127825993)
245. Patterson, A.; Williams, K.; Cowen, R.; Jaffar, M.; Telfer, B.; Saunders, M.; Airley, R.; Honess, D.; van der Kogel, A.; Wolf, C.; Stratford, U. Oxygensensitive enzyme-prodrug gene therapy for the eradication of radiationresistant solid tumours. Gene Ther., 2002, 9, 946-954. (Pubitemid 34812285)
246. Datta, S.; Allman, R.; Loh, C.; Mason, M.; Matthews, P. Effect of photodynamic therapy in combination with mitomycin C n a mitomycinresistant bladder cancer cell line. Br. J. Cancer, 1997, 76, 312-317. (Pubitemid 27308080)
247. Miyagi, K.; Sampson, R.W.; Sieber-Blum, M.; Sieber, F. Crystal violet combined with Merocyanine 540 for the ex vivo purging of hematopoietic stem cell grafts. J. Photochem. Photobiol. B, 2003, 70, 133-144. (Pubitemid 37121770)
248. Nishii, Y.; Morishima, M.; Kakehi, Y., Umehara, K.; Kioka, N.; Terano, Y.; Amachi, T.; Ueda, K. CROP/Luc7A, a novel serine/ arginine-rich nuclear protein, isolated from cisplatin-resistant cell line. FEBS Lett., 2000, 465, 153-156. (Pubitemid 30021464)
249. Lottner, C.; Knuechel, R.; Bernhardt, G.; Brunner, H. Combined chemotherapeutic and photodynamic treatment on human bladder cells by hematoporphyrin-platinum(II) conjugates. Cancer Lett., 2004, 203, 171-180. (Pubitemid 38058685)
250. Fisher, A.; Ferrario, A.; Gomer, C. Adriamycin resistance in chinese hamster fibroblasts following oxidative stress induced by photodynamic therapy. Photochem. Photobiol., 1993, 58, 581-588. (Pubitemid 2001684)
251. Guo, B.; Hembruff, S.L.; Villeneuve, D.J.; Kirwan, A.F.; Parissenti, A.M. Potent killing of paclitaxel- and doxorubicin-resistant breast cancer cells by calphostin C accompanied by cytoplasmic vacuolization. Breast Cancer Res. Treat., 2003, 82, 125-141. (Pubitemid 37476012)
252. Kobayashi, E.; Ando, K.; Nakano, H.; Iida, T.; Ohno, H.; Morimoto, M.; Tamaoki, T. Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities. J. Antibiot. (Tokyo), 1989, 42, 1470-1474. (Pubitemid 19263971)
253. Zacal, N.; Rainbow, A.J. Photodynamic therapy resistant human colon carcinoma HT29 cells show cross-resistance to UVA but not UVC light. Photochem. Photobiol., 2007, 83, 730-737. (Pubitemid 46854939)
254. Rodriguez, L.; Batlle, A.; Di Venosa, G.; Battah, S.; Dobbin, P.; Macrobert, A.J.; Casas, A. Mechanisms of 5-aminolevulinic acid ester uptake in mammalian cells. Br. J. Pharmacol., 2006, 147, 825-833
255. Correa García, S.; Casas, A.; Perotti, C.; Batlle, A.; Bermúdez Moretti, M. Mechanistic studies on delta-aminolevulinic acid uptake and efflux in a mammary adenocarcinoma cell line. Br. J. Cancer, 2003, 89, 173-177. (Pubitemid 36897954)
256. Gomer, C.; Rucker, N.; Ferrario, A.; Murphree, A. Expression of potentially lethal damage in Chinese hamster cells exposed to hematoporphyrin derivative photodynamic therapy. Cancer Res., 1986, 46, 3348-3352. (Pubitemid 16096869)
257. Gerlinger, M.; Swanton, C. How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine. Br. J. Cancer, 2010, 103,1139-1143.
258. Fodale, V.; Pierobon, M.; Liotta, L.; Petricoin, E. Mechanism of cell adaptation: when and how do cancer cells develop chemoresistance? Cancer J., 2011, 17, 89-95.
259. Mathews, L.A.; Cabarcas, S.M.; Farrar, W.L. DNA repair: the culprit for tumor-initiating cell survival? Cancer Metastasis Rev., 2011 (in press)
260. Nahabedian, M.; Cohen, R.; Contino, M.; Terem, T.; Wright, W.; Berns, M.; Wile, A. Combination cytotoxic chemotherapy with cisplatin or doxorubicin and photodynamic therapy in murine tumors. J. Natl. Cancer Inst., 1988, 80, 739-743.
261. Creekmore, S.; Zaharko, D. Modification of chemotherapeutic effects on L1210 cells using hematoporphyrin and light. Cancer Res., 1983, 43, 5252-5257. (Pubitemid 14230135)
262. Casas, A.; Fukuda, H.; Riley, P.; Batlle, A. Enhancement of aminolevulinic acid based photodynamic therapy by adriamycin. Cancer Lett., 1997, 121, 105-113. (Pubitemid 27504321)
263. Casas, A.; Fukuda, H.; Batlle, A. Potentiation of the 5-aminolevuliniv acidbased photodynamic therapy with cyclophosphamide. Cancer Biochem. Biophys., 1998, 16, 183-196. (Pubitemid 128701530)
264. Sato, Y.; Yamazaki, T.; Yasukawa, K.; Kaneita, Y.; Mochimaru, J.; Hanai, M.; Irie, T.; Kura, Y.; Sawada, U.; Horie, T. Merocyanine 540-mediated photodynamic therapy inhibits P-glycoprotein (P-gp) activity in adriamycinresistant K562 cells. Gan To Kagaku Ryoho, 1999, 26, 2195-2200.
265. Sinha, A.K; Anand, S.; Ortel, B.J.; Chang, Y.; Mai, Z.; Hasan, T.; Maytin, E.V. Methotrexate used in combination with aminolaevulinic acid for photodynamic killing of prostate cancer cells. Br. J. Cancer, 2006, 95, 485-495. (Pubitemid 44232558)
266. Anand, S.; Honari, G.; Hasan, T.; Elson, P.; Maytin, E.V. Low-dose methotrexate enhances aminolevulinate-based photodynamic therapy in skin carcinoma cells in vitro and in vivo. Clin. Cancer Res., 2009, 15, 3333-3343.
267. Kessel, D. Prohing modes of multi-drug resistance via photodynamic effects of anthrapyrazoles. Anticancer Drugs, 1989, 191, 223-232.
268. Edwards, B.; Horn, L.; Twomey, P. Buthionine sulfoxirnine potentiates in vitro phototoxicity in rhodamine-sensitive but not in resistant melanoma cells (Abstract). 31. Proc. Am. Assoc. Cancer Res. Annu. Meet, 1990, 31, A2317.
269. Mitchell, J.B.; Glatstein, E.; Cowan, K.H.; Russo, A. Photodynamic therapy of 33. multi-drug resistant cell lines . Proc. Am. Assoc. Cancer Res. Annu. Meet., 1988, 29, A1254.
270. Lemoli, R.; Igarashi, T.; Knizewski, M.; Acaba, L.; Richter, A.; Jain, A.; Mitchell, D.; Levy, J.; Gulati, S. Dye-mediated photolysis is capable of eliminating drug-resistant (MDR+) tumor cells. Blood, 1993, 81, 793-800. (Pubitemid 23040873)
271. Canti, G.; Lattuada, D.; Morelli, S.; Nicolin, A.; Cubeddu, R.; Taroni, P.; Valentini, G. Efficacy of photodynamic therapy against doxorubicin-resistant murine tumors. Cancer Lett., 1995, 93, 255-259.
272. Kusuzaki, K.; Minami, G.; Takeshita, H.; Murata, H.; Hashiguchi, S.; Nozaki, T.; Ashihara, T.; Hirasawa, Y. Photodynamic inactivation with acridine orange on a multidrug-resistant mouse osteosarcoma cell line. Jpn. J. Cancer Res., 2000, 91, 439-445. (Pubitemid 30312697)
273. Trindade, G.; Farias, S.; Rumjanek, V.; Capella, M. Methylene blue reverts multidrug resistance: sensitivity of multidrug resistant cells to this dye and its photodynamic action. Cancer Lett., 2000, 151, 161-167. (Pubitemid 30156790)
274. Gianotti, C.; Andriamanpandry, A.; Werner, G.H. Studies on resistance of human cancer cells to photosensitizing phthalocyanines (Abstract). Presented at the 3rd Biennial Meeting of the International Photodynamic Association. Buffalo. NY, July, 1990.
275. Novichenko, N.L.; Mamchur, A.A.; Lisniak, I.O.; Gamaliya, M.F. Study of photodynamic efficiency of the hematoporphyrin conjugated with antibody to VEGF in mouse Lewis carcinoma. Exp. Oncol., 2008, 30, 315-318.
276. Khdair, A.; Handa, H.; Mao, G.; Panyam, J. Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance in vitro. Eur. J. Pharm. Biopharm., 2009, 71, 214-222.
277. Khdair, A.; Di Chen; Patil, Y.; Ma, L.; Dou, Q.P.; Shekhar, M.P.; Panyam, J. Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance. J. Control Release., 2010, 141:137-144.
278. Hornung, R.; Walt, H.; Crompton, N.; Keefe, K.; Jentsch, B.; Perewusnyk, G.; Haller, U.; Kochli, O. m-THPC-mediated photodynamic therapy (PDT) does not induce resistance to chemotherapy, radiotherapy or PDT on human breast cancer cells in vitro. Photochem. Photobiol., 1998, 68, 569-574. (Pubitemid 128471994)
279. Baroja, A.; de la Hoz, C.; Alvarez, A.; Vielba, R.; Sarrat, R.; Arechaga, J.; Gandarias, J. Polyploidization and exit from cell cycle as mechanisms of cultured melanoma cell resistance to methotrexate. Life Sci., 1998, 62, 2275-2282. (Pubitemid 28273156)
280. Brodsky, V.; Uryvaeva, I. In: Genome multiplication in growth and development, Cambridge University Press, Cambridge, UK, 1985; pp. 205-210.
281. Tew K. Glutathione-associated enzymes in anticancer drug resistance. Cancer Res., 1994, 54, 4313-4320. (Pubitemid 24273141)
282. Goodwin, A.; Mesiter, A.; O'Dwyer, P.; Huang, C.; Hamilton, T.; Anderson M. High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis. Proc. Natl. Acad. Sci. USA, 1992, 89, 3070-3074.
283. Yeung, B.H.; Wong, K.Y.; Lin, M.C.; Wong, C.K.; Mashima, T.; Tsuruo, T.; Wong, A.S. Chemosensitisation by manganese superoxide dismutase inhibition is caspase-9 dependent and involves extracellular signal-regulated kinase 1/2. Br. J. Cancer., 2008, 99, 283-293.
284. Sarkaria, J.N.; Kitange, G.J.; James, C.D.; Plummer, R.; Calvert, H.; Weller, M.; Wick, W. Mechanisms of chemoresistance to alkylating agents in malignant glioma. Clin. Cancer Res., 2008, 14, 2900-2908.
285. Rosell, R.; Cecere, F.; Santarpia, M.; Reguart, N.; Taron, M. Predicting the outcome of chemotherapy for lung cancer. Curr. Opin. Pharmacol., 2006, 6, 323-331.
286. Jorgensen, T.J. Enhancing radiosensitivity: targeting the DNA repair pathways. Cancer Biol. Ther., 2009, 8, 665-670.
287. Tetu, B.; Lacasse, B.; Bouchard, H.L.; Lagace, R.; Huot, J.; Landry, J. Prognostic influence of HSP-27 expression in malignant fibrous histiocytoma: a clinicopathological and immunohistochemical study. Cancer Res., 1992, 52, 2325-2328.
288. Huot, J.; Roy, G.; Lambert, H.; Chretien, P.; Landry, J. Increased survival after treatments with anticancer agents of Chinese hamster cells expressing the human Mr 27,000 heat shock protein. Cancer Res., 1991, 51, 5245-5252.
289. Lee, A.S. The glucose-regulated proteins: stress induction and clinical applications. Trends Biochem. Sci., 2001, 26, 504-510. (Pubitemid 32735452)
290. Lee, E.; Nichols, P.; Spicer, D.; Groshen, S.; Yu, M.C.; Lee, A.S. GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer. Cancer Res., 2006, 66, 7849-7853. (Pubitemid 44299145)
291. Ling, V.; Thompson, L. Reduced permeability in CHO cells as a mechanism of resistance to colchicine. J. Cell Physiol., 1974, 83, 103-116.
292. Keizer, H.G.; Schuurhuis, G.J.; Broxterman, H.J.; Lankelma, J.; Schoonen, W.G.; van Rijn, J.; Pinedo, H.M.; Joenje, H. Correlation of multidrug resistance with decreased drug accumulation, altered subcellular drug distribution, and increased P-glycoprotein expression in cultured SW-1573 human lung tumor cells. Cancer Res., 1989, 49, 2988-2993. (Pubitemid 19148637)
293. Luna, M.C.; Wong, S.; Gomer, C.J. Photodynamic therapy mediated induction of early response genes. Cancer Res., 1994, 54,1374-1380. (Pubitemid 24108084)
294. Øyan, A.M.; Anensen, N.; Bø, T.H.; Stordrange, L.;
295. Jones, H.A.; Hahn, S.M.; Bernhard, E.; McKenna, W.G. Ras inhibitors and radiation therapy. Semin. Radiat. Oncol., 2001, 11, 328-337. (Pubitemid 32959667)
296. Andrews, P.; Albright, K. Mitochondrial defects in cis- diamminedichloroplatinum( II)-resistant human ovarian carcinoma cell lines. Cancer Res., 1992, 52, 1895-1901.
297. Hazlehurst, L.; Damiano, J.; Buyuksal, I.; Pledger, W.; Dalton, W. Adhesion to fibronectin via α1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR). Oncogene, 2000, 19, 4319-4327.
298. Puchner, M.; Giese, A. Tamoxifen-resistant glioma-cell sub-populations are characterized by increased migration and proliferation. Int. J. Cancer, 2000, 86, 468-473. (Pubitemid 30249724)
299. Liang, Y.; Meleady P., Cleary, I..; McDonnell, S.; Connolly, L.; Clynes, M. Selection with melphalan or paclitaxel (Taxol) yields variants with different patterns of multidrug resistance, integrin expression and in vitro invasiveness. Eur. J. Cancer, 2001, 37, 1041-1052. (Pubitemid 32397691)
300. Tsujimoto Y. Stress-resistance conferred by high level of bcl-2 alpha protein in human B lymphoblastoid cell. Oncogene, 1989, 4, 1331-1336. (Pubitemid 19273387)
301. Jansen, B.; Schlagbauer-Wadl, H.; Brown, B.; Bryan, R.; van Elsas, A.; Muller, M.; Wolff, K.; Eichler, H.; Pehamberger, H. Bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice. Nat. Med., 1998, 4, 232-234. (Pubitemid 28137379)
302. Strano, S.; Dell'Orso, S.; Di Agostino, S.; Fontemaggi, G.; Sacchi, A.; Blandino, G. Mutant p53: an oncogenic transcription factor. Oncogene, 2007, 26, 2212-2219. (Pubitemid 46536646)
303. Bichat, F.; Mouawad, R.; Solis-Recendez, G.; Khayat, D.; Bastian, G. Cytoskeleton alteration in MCF7R cells, a multidrug resistant human breast cancer cell line. Anticancer Res., 1997, 17, 3393-3401. (Pubitemid 27522300)
304. Gilchrist, A.; Meuser, R.; Turchinsky, J.; Shaw, A.; Pasdar, M.; Dixon, W. Cell adhesion-mediated transformation of a human SCLC cell line is associated with the development of a normal phenotype. Exp. Cell Res., 2002, 276, 63-78. (Pubitemid 34948352)
305. Conforti, G.; Codegoni, A.; Scanziani, E.; Dolfini, E.; Dasdia, T.; Calza, M.; Caniatti, M.; Broggini, M. Different vimentin expression in two clones derived from a human colocarcinoma cell line (LoVo) showing different sensitivity to doxorubicin. Br. J. Cancer, 1995, 71, 505-11.
306. Byun, Y.; Chen, F.; Chang, R.; Trivedi, M.; Green, K.; Cryns, V. Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis. Cell Death Differ., 2001, 8, 443-450. (Pubitemid 32492764)