Nuclear factor-κB activation by the photochemotherapeutic agent verteporfin

Blood

Volumn 95, Issue 1, 2000, Pages 256-262

  Granville, D J ^b   Carthy, C M ^b   Jiang, H ^b   Levy, J G ^b   McManus, B M ^b   Matroule, J Y ^b   Piette, J ^b   Hunt, David W C ^a  

^a QLT PhotoTherapeutics Inc   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BENZOPORPHYRIN DERIVATIVE; CASPASE 3; CASPASE 9; CASPASE INHIBITOR; DNA FRAGMENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOTOSENSITIZING AGENT; TUMOR NECROSIS FACTOR ALPHA; BENZYLOXYCARBONYLVALYL ALANYL ASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CASP3 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; CASPASE; CYSTEINE PROTEINASE INHIBITOR; DNA BINDING PROTEIN; I KAPPA B; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; PEPTIDE CHLOROMETHYL KETONE; PORPHYRIN;

APOPTOSIS; ARTICLE; CELL STRAIN HL 60; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENE ACTIVATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATION; OXIDATIVE STRESS; PHOTOCHEMOTHERAPY; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; REPORTER GENE; TRANSACTIVATION; CELL NUCLEUS; CELL SURVIVAL; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; LIGHT; METABOLISM; RADIATION EXPOSURE;

AMINO ACID CHLOROMETHYL KETONES; CASPASE 3; CASPASE 9; CASPASES; CELL NUCLEUS; CELL SURVIVAL; CYSTEINE PROTEINASE INHIBITORS; DNA FRAGMENTATION; DNA-BINDING PROTEINS; GENES, REPORTER; HL-60 CELLS; HUMANS; I-KAPPA B PROTEINS; LIGHT; LUCIFERASES; NF-KAPPA B; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; POLY(ADP-RIBOSE) POLYMERASES; PORPHYRINS; TRANSFECTION;

EID: 0033628631     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.1.256     Document Type: Article

References (67)

1. Thompson JE, Phillips RJ, Erdjument-Bromage H, Tempst P, Ghosh S. IκB-β regulates the persistent response in a biphasic activation of NF-κB. Cell. 1995;80:573-582.
2. Muller JM, Ziegler-Heitbrock HML, Baeuerle PA. Nuclear factor kappa B, a mediator of lipopolysaccharide effects. Immunobiology. 1993;187: 233-256.
3. Baeuerle PA, Henkel T. Function and activation of NF-κB in the immune system. Annu Rev Immunol. 1994;12:141-179.
4. May MM, Ghosh S. Signal transduction through NF-κB. Immunol Today. 1998;19:80-88.
5. Schreck R, Albermann K, Baeuerle PA. Nuclear factor κB: an oxidative stress-responsive transcription factor of eukaryotic cells [review]. Free Radic Res Commun. 1992;17:221-237.
6. Tran K, Merika M, Thanos D. Distinct functional properties of IκBα and IκBβ. Mol Cell Biol. 1997; 17:5386-5399.
7. DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M. A cytokine-responsive IκB kinase that activates the transcription factor NFκB. Nature. 1997;388:548-554.
8. Chen Z, Hagler CZ, Palombella VJ, et al. Signal-induced site-specific phosphorylation targets IκBα to the ubiquitin-proteasome pathway. Genes Dev. 1995;9:1586-1597.
9. DiDonato J, Mercurio F, Rosette C, et al. Mapping of the inducible IκB phosphorylation sites that signal its ubiquination and degradation. Mol Cell Biol. 1996;16:1295-1304.
10. Chu ZL, McKinsey TA, Liu L, Gentry JJ, Malim MH, Ballard DW. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control. Proc Natl Acad Sci U S A. 1997;94:10,057-10,062.
11. Wang CY, Mayo MW, Baldwin AS. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science. 1996;274:784-787.
12. Stehlik C, de Martin R, Kumabashiri I, Schmid JA, Binder BR, Lipp J. Nuclear factor (NF)-κB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor α-induced apoptosis. J Exp Med. 1998;188: 211-216.
13. Wu MX, Ao Z, Prasad KV, Wu R, Schlossman SF. IEX-1L, an apoptosis inhibitor involved in NF-κB-mediated cell survival. Science. 1998;281:998-1001.
14. Gomer CJ, Ferrario A, Hayashi N, Rucker N, Szirth B, Murphree A. Molecular, cellular, and tissue responses following photodynamic therapy. Lasers Surg Med. 1988;8:450-463.
15. Henderson BW, Dougherty TJ. How does photodynamic therapy work? Photochem Photobiol. 1992;55:145-157.
16. Dougherty TJ, Gomer CJ, Henderson BW, Jori G, Kessel D, Moan J, Peng Q. Photodynamic therapy. J Natl Cancer Inst. 1998;90:889-905.
17. Agarwal M, Clay ME, Harvey EJ, Evans HH, Antunez AR, Oleinick NL. Photodynamic therapy induces rapid cell death by apoptosis in L5178Y mouse lymphoma cells. Cancer Res. 1991;51: 5993-5996.
18. Luo Y, Chang CK, Kessel D. Rapid initiation of apoptosis by photodynamic therapy. Photochem Photobiol. 1996;63:528-534.
19. Granville DJ, Levy JG, Hunt DW. Photodynamic therapy induces caspase-3 activation in HL-60 cells. Cell Death Differ. 1997;4:623.
20. Gluck S, Chadderton A, Ho A. The selective uptake of benzoporphyrin derivative mono-acid ring A results in differential cell kill of multiple myeloma cells in vitro. Photochem Photobiol. 1996; 63:846-853.
21. Levy JG. Photodynamic therapy. Trends Biotech. 1995;13:14-18.
22. Hunt DWC, Levy JG. Immunomodulatory aspects of photodynamic therapy. Expert Opin Invest Drugs. 1998;7:57-64.
23. Jamieson CH, McDonald WN, Levy JG. Preferential uptake of benzoporphyrin derivative by leukemic versus normal cells. Leuk Res. 1990;14:209-219.
24. Jamieson C, Hornby A, Richter A, Mitchell D, Levy J. Relative sensitivity of leukemic (CML) and normal progenitor cells to treatment with the pnotosensitizer benzoporphyrin derivative and light. J Hematother. 1993;2:383-386.
25. Granville DJ, Levy JG, Hunt DWC. Photodynamic therapy with benzoporphyrin derivative monoacid ring A produces protein tyrosine phosphorylation events and DNA fragmentation in murine P815 cells. Photochem Photobiol. 1998;67:358-362.
26. Tao J, Sanghera JS, Pelech SL, Wong G, Levy JG. Stimulation of stress-activated kinase in murine keratinocytes following photodynamic therapy with benzoporphyrin derivative. J Biol Chem. 1996:271:27,107-27,115.
27. Ryter SW, Gomer CJ. Nuclear factor κB activity in mouse L1210 cells following Photofrin II-mediated photosensitization. Photochem Photobiol. 1993;58:753-756.
28. Kick G, Messer G, Goetz A, Plewig G, Kind P. Photodynamic therapy induces expression of interleukin 6 by activation of AP-1 but not NF-κB DNA binding. Cancer Res. 1995;55:2373-2379.
29. Legrand-Poels S, Bours V, Piret B, et al. Transcription factor NF-κB is activated by photosensitization generating oxidative DNA damages. J Biol Chem. 1995;270:6925-6934.
30. Matroule J-Y, Bonizzi G, Morliere P, et al. Pyropheophorbide - a methyl ester-mediated photosensitization activates transcription factor NF-κB through the interleukin-1 receptor-dependent signaling pathway. J Biol Chem. 1999;274:2899-3000.
31. Legrand-Poels S, Schoonbroodts, Matroule J-Y, Piette J. NF-κB: an important transcription factor in Photobiology. J Photochem Photobiol B. 1998; 45:1-8.
32. Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell. 1997;90: 405-413.
33. Li P, Nijhawan D, Budihardjo J, et al. Cytochrome c and dATP-dependent formation of Apaf-1/ caspase-9 complex initiates an apoptotic protease cascade. Cell. 1997;91:479-489.
34. Fernandes-Alnemri T, Litwack G, Alnemri ES. CPP32, a novel human apoptotic protein with homology to Caenornabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J Biol Chem. 1994;269: 30,761-30,764.
35. Nicholson WD, Ali A, Thornberry NA, et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature. 1995;376:37-43.
36. Tewari M, Quan LT, O'Rourke K, et al. Yama/ CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell. 1995;81:801-809.
37. Salvesen GS, Dixit VM. Caspases: intracellular signaling by proteolysis. Cell. 1997;91:443-446.
38. Atkinson EA, Barry M, Darmon AJ, et al. Cytotoxic T lymphocyte-assisted suicide: caspase 3 activation is primarily the result of direct activation of granzyme B. J Biol Chem. 1998;273:21,261-21,266.
39. Nicholson DW, Thornberry NA. Caspases: killer proteases. Trends Biochem Sci. 1997;22:299-306.
40. Wang X, Zelenski NG, Yang J, Sakai J, Brown MS, Goldstein JL, Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. EMBO J. 1996;15:1012-1020.
41. Casciola-Rosen L, Nicholson DW, Chong T, et al. Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death. J Exp Med. 1996;183:1957-1964.
42. Liu X, Zou H, Slaughter C, Wong X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell. 1997;89:175-184.
43. White DW, Roy A, Gilmore TD. The v-Rel oncoprotein blocks apoptosis and proteolysis of IκBα in transformed chicken spleen cells. Oncogene. 1995;10:857-868.
44. White DW, Gilmore TD. Bcl-2 and CrmA have different effects on transformation, apoptosis and the stability of IκBα in chicken spleen cells transformed by temperature-sensitive v-Rel oncoproteins. Oncogene. 1996;13:891-899.
45. Barkett M, Xue D, Horvitz HR, Gilmore TD. Phosphorylation of IκB-α inhibits its cleavage by caspase CPP32 in vitro. J Biol Chem. 1997;272: 29,419-29,422.
46. Jung M, Zhang Y, Dimtchev A, Dritschilo A. Impaired regulation of nuclear factor-κB results in apoptosis induced by gamma radiation. Radiat Res. 1998;149:596-601.
47. Granville DJ, Jiang H, An MT, Levy JG, McManus BM, Hunt DWC. Overexpression of Bcl-XL prevents caspase-3-mediated activation of DNA fragmentation factor (DFF) produced by treatment with the photochemotherapeutic agent BPD-MA. FEBS Lett. 1998;422:151-154.
48. Carthy CM, Granville DJ, Watson KA, et al. Caspase activation and specific cleavage of substrates after coxsackie B3-induced cytopathic effect in HeLa cells. J Virol. 1998;72:7669-7675.
49. Granville DJ, Carthy CM, Jiang H, Shore GC, McManus, Hunt DWC. Rapid cytochrome c release, activation of caspases 3, 6, 7 and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy. FEBS Lett. 1998;437:5-10.
50. Carthy CM, Granville DJ, Jiang H, et al. Early release of mitochondrial cytochrome c and expression of mitochondrial epitope 7A6 with a porphyrin-derived photosensitizer: Bcl-2 and Bcl-XL overexpression do not prevent early mitochodrial events but still depress caspase activity. Lab Invest. 1999;79:953-965.
51. Granville DJ, Carthy C, Hunt DW, McManus BM. Apoptosis: molecular aspects of cell death and disease. Lab Invest. 1998;78:893-913.
52. Liu X, Kim CN, Yang J, Jemmerson R, Wang X. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell. 1996;86:147-157.
53. Telford WG, King LE, Fraker PJ. Rapid quantitation of apoptosis in pure and heterogenous cell populations using flow cytometry. J Immunol Methods. 1994;172:1-16.
54. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65:55-63.
55. Dignam JD, Lebowitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucl Acids Res. 1983;11:1475-1489.
56. Andrews NC, Faller DV. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucl Acids Res. 1991;19:2499.
57. Melkonyan H, Sorg C, Klempt M. Electroporation efficiency in mammalian cells is increased by dimethyl sulfoxide (DMSO). Nucl Acids Res. 1996; 24:4356-4357.
58. Boland MP, O'Neill LA. Ceramide activates NF-κB by inducing the processing of p105. J Biol Chem. 1998:272:15,494-15,500.
59. Jaffray E, Wood KM, Hay RT. Domain organization of IκBα and sites of interaction with NF-κB p65. Mol Cell Biol. 1995;15:2166-2172.
60. Frankenberger M, Pforte A, Stemsdorf T, et al. Constitutive nuclear NF-κB in cells of the monocyte lineage. Biochem J. 1994;304:87-94.
61. Henkel T, Machleidt T, Alkalay I, Kronke M, Ben-Neriah Y, Baeuerle PA. Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB. Nature. 1993;365:182-185.
62. Sun S-C, Ganchi PA, Ballard DW, Greene WC. NF-κB controls expression of IκBα: evidence for an inducible autoregulatory pathway. Nature. 1993;259:1912-1915.
63. Imbert V, Rupee RA, Livolsi A, et al. Tyrosine phosphorylation of IκB-α activates NF-κB without proteolytic degradation of IκB-α. Cell. 1996;86: 787-798.
64. Nasuhara Y, Adcock IM, Catley M, Barnes PJ, Newton R. Differential IκB kinase and IκBα degradation by interleukin-1β and tumor necrosis factor-α in human U937 monocytic cells: evidence for additional regulatory steps in κB-dependent transcription. J Biol Chem. 1999;274:19,965-19,972.
65. Song Q, Wei T, Lees-Miller S, Alnemri E, Watters D, Lavin MF. Resistance of actin to cleavage during apoptosis. Proc Natl Acad Sci U S A. 1997;84: 157-162.
66. Tang D, Gururajan R, Kidd VJ. Phosphorylation of PITSLRE p110 isoforms accompanies their processing by caspases during Fas-mediated cell death. J Biol Chem. 1998;273:16,601-16,607.
67. Gollnick SO, Liu X, Owczarczak B, Musser DA, Henderson BW. Altered expression of interleukin 6 and interteukin 10 as result of photodynamic therapy in vivo. Cancer Res. 1997;57:3904-3909.