Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis

Biochemical Journal

Volumn 436, Issue 3, 2011, Pages 729-739

  Dias, Marcio V B ^a   Snee, William C ^b   Bromfield, Karen M ^a   Payne, Richard J ^a,c   Palaninathan, Satheesh K ^b   Ciulli, Alessio ^a   Howard, Nigel I ^a   Abell, Chris ^a   Sacchettini, James C ^b   Blundell, Tom L ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b TEXAS A AND M UNIVERSITY   (United States)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

3 dehydroquinate dehydratase (dehydroquinase); Drug discovery; Inhibitor design; Mycobacterium tuberculosis; Shikimate pathway; Transition state analogue

Indexed keywords

2,3 ANHYDROQUINATE; 3 DEHYDROQUINATE DEHYDRATASE; LIGAND; LYASE INHIBITOR; SHIKIMIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CRYSTALLIZATION; DRUG DESIGN; DRUG TARGETING; ENZYME ASSAY; GENE OVEREXPRESSION; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; MOLECULAR CLONING; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PURIFICATION; PROTEIN STRUCTURE; PROTEIN TARGETING; SHIKIMATE PATHWAY;

BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HYDRO-LYASES; ISONICOTINIC ACIDS; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; QUINIC ACID;

MYCOBACTERIUM TUBERCULOSIS;

EID: 79957723201     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20110002     Document Type: Article

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