Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases

ChemMedChem

Volumn 2, Issue 7, 2007, Pages 1010-1013

  Payne, Richard J ^a   Riboldi Tunnicliffe, Alan ^b   Kerbarh, Olivier ^a   Abell, Andrew D ^c   Lapthorn, Adrian J ^b   Abell, Chris ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF CANTERBURY   (New Zealand)

Author keywords

Antibacterials; Cross coupling; Dehydroquinase; Enzyme inhibition; Molecular modeling

Indexed keywords

3 DEHYDROQUINATE DEHYDRATASE; 3-DEHYDROQUINATE DEHYDRATASE; BICYCLO COMPOUND; ENZYME INHIBITOR; HYDROLYASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; ENZYMOLOGY; HELICOBACTER PYLORI; MYCOBACTERIUM TUBERCULOSIS; STREPTOMYCES COELICOLOR; SYNTHESIS;

BICYCLO COMPOUNDS; BINDING SITES; DRUG DESIGN; ENZYME INHIBITORS; HELICOBACTER PYLORI; HYDRO-LYASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; STREPTOMYCES COELICOLOR;

EID: 49649124433     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200700062     Document Type: Article

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