Selective inhibition of type II dehydroquinases

Journal of Organic Chemistry

Volumn 64, Issue 8, 1999, Pages 2612-2613

  Frederickson, Martyn ^a   Parker, Emily J ^a,d   Hawkins, Alastair R ^b   Coggins, John R ^c   Abell, Chris ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d MASSEY UNIVERSITY   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

3 DEHYDROQUINATE DEHYDRATASE; ALLYL ALCOHOL; BENZALDEHYDE; BENZOIC ACID DERIVATIVE; ESTER DERIVATIVE; HYDROLYASE INHIBITOR; QUINIC ACID; SHIKIMIC ACID; TOLUENE;

ARTICLE; ASPERGILLUS NIDULANS; CHEMICAL REACTION; DRUG DESIGN; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME MECHANISM; INHIBITION KINETICS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; SALMONELLA TYPHIMURIUM; STREPTOMYCES COELICOLOR;

EID: 0033574513     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo990004q     Document Type: Article

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17. All assays were performed at 25 °C in quartz cuvettes (total reaction volume 1 mL) buffered at pH 7.0 (type I, 50 mM phosphate; type II, 50 mM Tris-HCl) and were monitored spectrophotometrically at 234 nm for the appearance of dehydroshikimate.
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