Nanomolar competitive inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor type II dehydroquinase

ChemMedChem

Volumn 2, Issue 2, 2007, Pages 194-207

  Prazeres, Verónica F V ^a   Sánchez Sixto, Cristina ^a   Castedo, Luis ^a   Lamb, Heather ^b   Hawkins, Alastair R ^b   Riboldi Tunnicliffe, Alan ^c   Coggins, John R ^c   Lapthorn, Adrian J ^c   González Bello, Concepción ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Antibiotics; Competitive inhibitors; Dehydroquinase; Enzymes; Tuberculosis

Indexed keywords

1,3,4 TRIHYDROXY 5 CYCLOHEXENE 1 CARBOXYLIC ACID; 1,3,4-TRIHYDROXY-5-CYCLOHEXENE-1-CARBOXYLIC ACID; 3 DEHYDROQUINATE DEHYDRATASE; 3-DEHYDROQUINATE DEHYDRATASE; CYCLOHEXANOL DERIVATIVE; DRUG DERIVATIVE; ENZYME INHIBITOR; HYDROLYASE; SHIKIMIC ACID; TUBERCULOSTATIC AGENT; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; CATALYSIS; CHEMICAL MODEL; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; ENZYMOLOGY; METABOLISM; MYCOBACTERIUM TUBERCULOSIS; STREPTOMYCES COELICOLOR; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANTITUBERCULAR AGENTS; BINDING, COMPETITIVE; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXANOLS; DRUG DESIGN; ENZYME INHIBITORS; HYDRO-LYASES; MODELS, CHEMICAL; MYCOBACTERIUM TUBERCULOSIS; SHIKIMIC ACID; STREPTOMYCES COELICOLOR; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

EID: 37349108231     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200600208     Document Type: Article

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