Rational design of new bifunctional inhibitors of type II dehydroquinase

Organic and Biomolecular Chemistry

Volumn 3, Issue 17, 2005, Pages 3102-3104

  Toscano, Miguel D ^a   Stewart, Kirsty A ^b   Coggins, John R ^c   Lapthorn, Adrian J ^b   Abell, Chris ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL STRUCTURE; MATHEMATICAL MODELS; MOLECULAR DYNAMICS; SYNTHESIS (CHEMICAL);

BIFUNCTIONAL INHIBITORS; MOLECULAR MODELLING; TYPE II DEHYDROQUINASE;

ENZYMES;

3 DEHYDROQUINATE DEHYDRATASE; 3-DEHYDROQUINATE DEHYDRATASE; ENZYME INHIBITOR; HYDROLYASE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; DRUG DESIGN; ENZYMOLOGY; PROTEIN CONFORMATION; STEREOISOMERISM; STREPTOMYCES COELICOLOR; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HYDRO-LYASES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN CONFORMATION; STEREOISOMERISM; STREPTOMYCES COELICOLOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 25444487754     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b507156a     Document Type: Article

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