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ChemMedChem

Volumn 2, Issue 1, 2007, Pages 101-112

Nanomolar inhibition of type II dehydroquinase based on the enolate reaction mechanism

(5) Toscano, Miguel D a Payne, Richard J a Chiba, Akira a Kerbarh, Olivier a Abell, Chris a

a UNIVERSITY OF CAMBRIDGE (United Kingdom)

Author keywords

Antibiotics; Dehydroquinase; Drug design; Inhibitors

Indexed keywords

3 DEHYDROQUINATE DEHYDRATASE; 3-DEHYDROQUINATE DEHYDRATASE; ALCOHOL DERIVATIVE; ANTIINFECTIVE AGENT; CARBOXYLIC ACID; ENZYME INHIBITOR; HYDROLYASE; KETONE; LIGAND; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; ENZYMOLOGY; KINETICS; MYCOBACTERIUM TUBERCULOSIS; STREPTOMYCES COELICOLOR; STRUCTURE ACTIVITY RELATION; SYNTHESIS; THERMODYNAMICS;

ALCOHOLS; ANTI-BACTERIAL AGENTS; BINDING SITES; CARBOXYLIC ACIDS; DRUG DESIGN; ENZYME INHIBITORS; HYDRO-LYASES; KETONES; KINETICS; LIGANDS; MYCOBACTERIUM TUBERCULOSIS; STREPTOMYCES COELICOLOR; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 47049104883 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.200600194 Document Type: Article

Times cited : (25)

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