Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: New directions for inhibitor design

Journal of Medicinal Chemistry

Volumn 49, Issue 4, 2006, Pages 1282-1290

  Robinson, David A ^a   Stewart, Kirsty A ^b   Price, Nicholas C ^a   Chalk, Peter A ^c   Coggins, John R ^a   Lapthorn, Adrian J ^b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 ANHYDROQUINIC ACID; 3 DEHYDROQUINATE DEHYDRATASE; AH 9095; CITRIC ACID; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; HELICOBACTER PYLORI; LIGAND BINDING; NONHUMAN; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BINDING SITES; CITRIC ACID; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ESCHERICHIA COLI; HELICOBACTER PYLORI; HYDRO-LYASES; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; QUINIC ACID; SEQUENCE ALIGNMENT; STREPTOMYCES COELICOLOR; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES; XANTHONES;

EID: 33144478623     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0505361     Document Type: Article

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