From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans

Biochemical Pharmacology

Volumn 82, Issue 1, 2011, Pages 9-16

  Bock, Karl Walter ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Ah receptor; CAR PXR; Crosstalk; Hepatic UGTs; Induction; Ligand activated transcription factors

Indexed keywords

GLUCURONOSYLTRANSFERASE; HYDROCARBON; TRANSCRIPTION FACTOR NRF2;

ARTICLE; DETOXIFICATION; HOMEOSTASIS; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN INTERACTION; XENOBIOTIC METABOLISM;

EID: 79957603666     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.03.011     Document Type: Note

References (98)

1. A.H. Conney, E.C. Miller, and J.A. Miller The metabolism of methylated aminoazo dyes V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene Cancer Res 16 1956 450 459
2. A.H. Conney Pharmacological implications of microsomal enzyme induction Pharmacol Rev 19 1967 317 366
3. Remmer H. Die Beschleunigung des Evipanabbaues unter der Wirkung von Barbituraten. Naturwissenschaften 1958;8:189
4. H. Remmer, and H.J. Merker Drug-induced changes in the liver endoplasmic reticulum: association with drug-metabolizing enzymes Science 142 1963 1657 1658
5. D.W. Nebert, and F. Gonzalez P450 genes: structure, evolution, and regulation Annu Rev Biochem 56 1987 945 993
6. D.R. Nelson, L. Koymans, T. Kamataki, J.J. Stegeman, R. Feyereisen, and D.J. Waxman P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature Pharmacogenet 6 1996 1 42 (Pubitemid 26096749)
7. Y.Z. Gu, J.B. Hogenesch, C.A. Bradfield, and The PAS superfamily: sensors of environmental and developmental signals Annu Rev Pharmacol Toxicol 40 2000 519 561 (Pubitemid 30340692)
8. L.P. Nguyen, and C.A. Bradfield The search for endogenous activators of the aryl hydrocarbon receptor Chem Res Toxicol 21 2008 102 116 (Pubitemid 351219712)
9. T. Sueyoshi, and M. Negishi Phenobarbital response elements of cytochrome P450 genes and nuclear receptors Annu Rev Pharmacol Toxicol 41 2001 123 143 (Pubitemid 32385885)
10. Y.E. Timsit, and M. Negishi CAR and PXR: the xenobiotic sensing receptors Steroids 72 2007 231 246 (Pubitemid 46273513)
11. A. Chawla, J.J. Repa, R.M. Evans, and D.J. Mangelsdorf Nuclear receptors and lipid physiology: opening the X-files Science 294 2001 1866 1870 (Pubitemid 33101573)
12. R. Hess, W. Stäubli, and W. Riess Nature of the hepatomegalic effect produced by ethylchlorophenoxyisobutyrate in the rat Nature 208 1965 856 858
13. I. Issemann, and S. Green Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators Nature 347 1990 645 650
14. P.I. Mackenzie, K.W. Bock, B. Burchell, C. Guillemette, S.I. Ikushiro, and T. Iyanagi Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily Pharmacogenet Genom 15 2005 677 685 (Pubitemid 41345319)
15. K.W. Bock, W. Fröhling, H. Remmer, and B. Rexer Effects of phenobarbital and 3-methylcholanthrene on substrate specificity of rat liver microsomal UDP-glucuronyltransferase Biochim Biophys Acta 327 1973 46 56
16. W. Lilienblum, A.K. Walli, and K.W. Bock Differential induction of rat liver microsomal UDP-glucuronosyltransferase activities by various inducing agents Biochem Pharmacol 31 1982 907 913
17. M.K. Shelby, and Klaassen Induction of rat UDP-glucuronosyltransferases in liver and duodenum by microsomal enzyme inducers that activate various transcriptional pathways Drug Metab Dispos 34 2006 1772 1778 (Pubitemid 44427481)
18. J.V. Goldstone, A. Hamdoun, B.J. Cole, M. Howard-Ashby, D.W. Nebert, and M. Scally The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome Dev Biol 300 2006 366 384 (Pubitemid 44827001)
19. C. Köhle, and K.W. Bock Coordinate regulation of drug-metabolizing enzymes, and conjugate transporters by the Ah receptor, pregnane X receptor and constitutive androstane receptor Biochem Pharmacol 77 2009 689 699
20. D.W. Nebert Proposed role of drug-metabolizing enzymes: regulation of steady state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions Mol Endocrinol 5 1991 1203 1214
21. C. Handschin, and U.A. Meyer Induction of drug metabolism: the role of nuclear receptors Pharmacol Rev 55 2003 649 673 (Pubitemid 37504978)
22. J.M. Pascussi, S. Gerbal-Chaloin, C. Duret, M. Daujat-Chavanieu, M.J. Vilarem, and P. Maurel The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences Ann Rev Pharmacol Toxocol 48 2008 1 32 (Pubitemid 351738147)
23. A.J. Hansen, Y.H. Lee, E. Sterneck, F.J. Gonzalez, and P.I. Mackenzie C/EBPα is a regulator of the UDP glucuronosyltransferase UGT2B1 gene Mol Pharmacol 53 1998 1027 1033 (Pubitemid 28280444)
24. P.I. Mackenzie, D.G. Hu, and D.A. Gardner-Stephen The regulation of UDP-glucuronosyltransferase genes by tissue-specific and ligand-activated transcription factors Drug Metab Rev 42 2010 95 105
25. H. Lu, F.J. Gonzalez, and C. Klaassen Alterations in hepatic mRNA expression of Phase-II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha Toxicol Sci 118 2010 380 390
26. M. Benet, A. Lahoz, C. Guzman, J.V. Castell, and R. Jover CCAAT/enhancer-binding protein α (C/EBPα) and hepatocyte nuclear factor 4α (HNF4α) synergistically cooperate with constitutive androstane receptor to transactivate the human cytochrome P450 2B6 (CYP2B6) gene J Biol Chem 285 2010 28457 28471
27. A. Braeuning, R. Sanna, J. Huelsken, and M. Schwarz Inducibility of drug-metabolizing enzymes by xenobiotics in mice with liver-specific knockout of Ctnnb1 Drug Metab Dispos 37 2009 1138 1145
28. M.S. Denison, J.M. Fisher, and J.P. Whitlock The DNA recognition site for the dioxin-Ah receptor complex J Biol Chem 263 1988 17221 17224
29. Y. Emi, S. Ikushiro, and T. Iyanagi Xenobiotic responsive element-mediated transcriptional activation in the UDP-glucuronosyltransferase family 1 complex J Biol Chem 271 1996 3952 3958 (Pubitemid 26065720)
30. P.A. Münzel, T. Lehmköster, M. Brück, J.K. Ritter, and K.W. Bock Aryl hydrocarbon-inducible or constitutive expression of human UDP glucuronosyltransferase UGT1A6 Arch Biochem Biophys 350 1998 72 78 (Pubitemid 28371170)
31. P.A. Münzel, S. Schmohl, F. Buckler, J. Jaehrling, F.T. Raschko, and C. Köhle Contribution of the Ah receptor to the phenolic antioxidant-mediated expression of human and rat UDP-glucuronosyltransferase UGT1A6 in Caco-2 and rat hepatoma 5L cells Biochem Pharmacol 66 2003 841 847 (Pubitemid 37011423)
32. M.F. Yueh, Y.H. Huang, A. Hiller, S. Chen, N. Nguyen, and R.H. Tukey Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1 J Biol Chem 278 2003 15001 15006 (Pubitemid 36799832)
33. S. Chen, D. Beaton, N. Nguyen, K. Seneko-Effenberger, E. Brace Sinnokrak, and U. Argikar Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus J Biol Chem 280 2005 37547 37557 (Pubitemid 41642363)
34. L.W. Wattenberg Effects of dietary constituents on the metabolism of chemical carcinogens Cancer Res 35 1975 3326 3331
35. H.J. Prochaska, and P. Talalay Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver Cancer Res 48 1988 4776 4782
36. T.M. Buetler, E.P. Gallagher, C. Wang, D.L. Stahl, J.D. Hayes, and D.L. Eaton Induction of Phase I and Phase II drug-metabolizing enzyme mRNA, protein, and activity by BHA, ethoxyquin, and oltipraz Toxicol Appl Pharmacol 135 1995 45 57
37. Y. Morel, and R. Barouki Down-regulation of cytochrome P450 1A1 gene promoter by oxidative stress J Biol Chem 273 1998 26969 26976
38. K. Itoh, T. Chiba, S. Takahashi, T. Ishii, K. Igarashi, and Y. Katoh An Nrf2/small Maf heterodimer mediates the induction of Phase II detoxifying enzyme genes through antioxidant response elements Biochem Biophys Res Commun 236 1997 313 322 (Pubitemid 27373291)
39. K. Chan, and Y.W. Kan Nrf2 is essential for protection against acute pulmonary injury in mice Proc Natl Acad Sci USA 96 1999 12731 12736 (Pubitemid 29513571)
40. R.K. Thimmulappa, K.H. Mai, S. Srisuma, T.W. Kensler, M. Yamamoto, and S. Biswal Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarrays Cancer Res 62 2002 5196 5203 (Pubitemid 35033454)
41. T. Nguyen, P.J. Sherratt, and C.B. Pickett Regulatory mechanisms controlling gene expression mediated by the antioxidant response element Annu Rev Pharmacol Toxicol 43 2003 233 260 (Pubitemid 37372641)
42. R.L. Yeager, S.A. Reisman, L.M. Aleksunes, and C.D. Klaassen Introducing the 'TCDD-inducible AhR-Nrf2 gene battery' Toxicol Sci 111 2009 238 246
43. P.A. Münzel, S. Schmohl, H. Heel, K. Kälberer, B.S. Bock-Hennig, and K.W. Bock Induction of human UDP glucuronosyltransferases (UGT1A6 UGT1A9, and UGT2B7) by t-butylhydroquinone and 2,3,7,8- tetrachlorodibenzo-p-dioxin in Caco-2 cells Drug Metab Dispos 27 1999 569 573 (Pubitemid 29214467)
44. S. Mutoh, M. Osabe, K. Inoue, R. Moore, L. Pedersen, and L. Perera Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3) J Biol Chem 284 2009 34785 34792
45. I.M. Arias, L.M. Gartner, M. Cohen, J.B. Ezzer, and A.J. Levi Chronic unconjugated hyperbilirubinemia with glucuronyltransferase deficiency Am J Med 47 1969 395 409
46. J. Sugatani, H. Kojima, A. Ueda, S. Kakizaki, K. Yoshinari, and Q.H. Gong The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR Hepatology 33 2001 1232 1238 (Pubitemid 32378224)
47. J. Sugatani, T. Sueoshi, M. Negishi, and M. Miva Regulation of the human UGT1A1 gene by nuclear receptors constitutive active/androstane receptor, pregnane X receptor and glucocorticoid receptor Methods Enzymol 400 2005 92 104 (Pubitemid 43052417)
48. B.M. Forman, J. Chen, and R.M. Evans Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ Proc Natl Acad Sci USA 94 1997 4312 4317 (Pubitemid 27194238)
49. S.A. Kliewer, S.S. Sundseth, S.A. Jones, P.J. Brown, G.B. Wisely, and C.S. Koble Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ Proc Natl Acad Sci USA 94 1997 4318 4323 (Pubitemid 27194239)
50. S.S.T. Lee, T. Pineau, J. Drago, E.J. Lee, J.W. Owens, and D.L. Kroetz Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators Mol Cell Biol 15 1995 3012 3022
51. K. Seneko-Effenberger, S. Chen, E. Brace-Sinnokrak, J.A. Bonzo, M.F. Yueh, and U. Argikar Expression of the human UGT locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor α activation Drug Metab Dispos 35 2007 419 427 (Pubitemid 46333905)
52. O. Barbier, L. Villeneuve, V. Bocher, C. Fontaine, I. Pineda Torra, and C. Duhem The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor α and γ target gene J Biol Chem 278 2003 13975 13983 (Pubitemid 36799940)
53. O. Barbier, D. Duran-Sandoval, I. Pineda-Torra, V. Kosykh, J.C. Fruchart, and B. Staels Peroxisome proliferator-activated receptor α induces hepatic expression of the human bile acid glucuronidating UDP- glucuronosyltransferase 2B4 enzyme J Biol Chem 278 2003 32852 32860 (Pubitemid 37055727)
54. P. Fernandez-Salguero, T. Pineau, D.M. Hilbert, T. McPhail, S.S.T. Lee, and S. Kimura Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor Science 268 1995 722 726
55. M.G. Soars, D.M. Petullo, J.A. Eckstein, S.C. Kasper, and S.A. Wrighton An assessment of UDP-glucuronosyltransferase induction using primary human hepatocytes Drug Metab Dispos 32 2004 140 148 (Pubitemid 38112546)
56. M.H. Court Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system Drug Metab Rev 42 2010 202 217
57. T. Izukawa, M. Nakajima, R. Fujiwara, H. Yamanaka, T. Fukami, and M. Takamiya Quantitative analysis of UDP-glucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers Drug Metab Dispos 37 2009 1759 1768
58. S. Chouinard, M.F. Yueh, R.H. Tukey, F. Giton, J. Fiet, and G. Pelletier Inactivation by UDP-glucuronosyltransferase enzymes: the end of androgen signaling J Steroid Biochem Mol Biol 109 2008 247 253
59. C. Köhle, and K.W. Bock Activation of coupled Ah receptor and Nrf2 gene batteries by dietary phytochemicals in relation to chemoprevention Biochem Pharmacol 72 2006 795 805 (Pubitemid 44301047)
60. S. Kalthoff, U. Ehmer, N. Freiberg, M.P. Manns, and C.P. Strassburg Coffee induces expression of glucuronosyltransferases via the aryl hydrocarbon receptor and Nrf2 in liver and stomach Gastroenterology 139 2010 1699 1710
61. A. Nakamura, M. Nakajima, E. Higashi, H. Yamanaka, and T. Yokoi Genetic polymorphisms in the 5'-flanking region of human UDP-glucuronosyltransferase 2B7 affect the Nrf2-dependent transcriptional regulation Pharmacogenet Genom 18 2008 709 720
62. D. Sacerdoti, M. Balazy, P. Angeli, A. Gatta, and J.C. McGiff Eicosanoid excretion in hepatic cirrhosis. Predominance of 20-HETE J Clin Invest 100 1997 1264 1270 (Pubitemid 27386313)
63. P. Puri, M.M. Wiest, O. Cheung, F. Mirshahi, C. Sargeant, and H.K. Min The plasma lipidomic signature of nonalcoholic steatohepatitis Hepatology 50 2009 1827 1838
64. C. Guillemette, E. Levesque, M. Harvey, J. Bellemare, and V. Menard UGT genomic diversity: beyond gene duplication Drug Metab Rev 42 2010 22 42
65. M. Finel, and M. Kurkela The UDP-glucuronosyltransferases as oligomeric enzymes Curr Drug Metab 9 2008 70 76 (Pubitemid 351201672)
66. P.S. Mitra, N.K. Basu, M. Basu, S. Chakraborty, T. Saha, and I.S. Owens Regulated phosphorylation of a major UDP-glucuronosyltransferase isoenzyme by tyrosine kinases dictates endogenous substrate selection for detoxification J Biol Chem 286 2011 1639 1648
67. D.W. Nebert, T.P. Dalton, A.B. Okey, and F.J. Gonzalez Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer J Biol Chem 279 2004 23847 23850 (Pubitemid 38725238)
68. C. Köhle, and K.W. Bock Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2 Biochem Pharmacol 73 2007 1853 1862 (Pubitemid 46677898)
69. S.W. Burchiel, T.A. Thompson, F.T. Lauer, and T.I. Oprea Activation of dioxin response element (DRE)-associated genes by benzo(a)pyrene 3,6-quinone and benzo(a)pyrene 1,6-quinone in MCF-10A human mammary epithelial cells Toxicol Appl Pharmacol 221 2007 203 214 (Pubitemid 46764801)
70. H. Gschaidmeier, A. Seidel, F. Oesch, B. Burchell, and K.W. Bock Formation of mono- and diglucuronides and of other glycosides of benzo(a)pyrene-3,6-quinol by V79 cell-expressed human phenol UDP-glucuronosyltransferases of the UGT1 gene complex Biochem Pharmacol 49 1995 1601 1606
71. C. Köhle, O.A. Badary, K. Nill, B.S. Bock-Hennig, and K.W. Bock Serotonin glucuronidation by Ah receptor- and oxidative stress-inducible human UDP-glucuronosyltransferase (UGT) 1A6 in Caco-2 cells Biochem Pharmacol 69 2005 1397 1402
72. Y. Jin, and T.M. Penning Aldo-keto reductases and bioactivation/ detoxification Ann Rev Pharmacol Toxicol 47 2007 263 292
73. Z. Zheng, J.Y. Park, C. Guillemette, S.P. Schantz, and P. Lazarus Tobacco carcinogen-detoxifying enzyme UGT1A7 and its association with orolarygeal cancer risk J Natl Cancer Inst 93 2001 1411 1418 (Pubitemid 32936819)
74. G.J. Wishart Functional heterogeneity of UDP-glucuronosyltransferase as revealed by its differential development and inducibility by glucocorticoids Biochem J 174 1978 485 489
75. J. Kapitulnik Bilirubin: an endogenous product of heme degradation with both cytotoxic and cytoprotective properties Mol Pharmacol 66 2004 773 779 (Pubitemid 39319447)
76. M.F. Yueh, and R.H. Tukey Nrf2-Keap signaling pathway regulates UGT1A1 expression in vitro and in transgenic UGT1 mice J Biol Chem 282 2007 8749 8758 (Pubitemid 47093470)
77. C.S. Caspersen, B. Reznik, P.L. Weldy, K.M. Abildskov, Stark Ri, and M. Garland Molecular cloning of the baboon UDP-glucuronosyltransferase 1A gene family. Evolution of the primate UGT1 locus and relevance for models of human drug metabolism Pharmacogenet Genom 17 2007 11 24 (Pubitemid 46195059)
78. W. Huang, J. Zhang, S.S. Chua, M. Qatanani, Y. Han, and R. Granata Induction of bilirubin clearance by the constitutive androstane receptor (CAR) Proc Natl Acad Sci USA 100 2003 4156 4161 (Pubitemid 36418173)
79. J.K. Ritter, F.K. Kessler, M.T. Thompson, A.D. Grove, D.J. Auyeung, and R.A. Fisher Expression and inducibility of the human bilirubin UDP-glucuronosyltransferase UGT1A1 in liver and cultured primary hepatocytes: evidence for both genetic and environmental influences Hepatology 30 1999 476 484 (Pubitemid 29357514)
80. W. Xie, M.F. Yueh, A. Radominska-Pandya, S.P.S. Saini, Y. Negishi, and B.S. Bottroff Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor Proc Natl Acad Sci USA 100 2003 4150 4155 (Pubitemid 36418172)
81. R. Stocker, Y. Yamamoto, A.F. McDonagh, A.N. Glazer, and B.N. Ames Bilirubin is an antioxidant of possible physiological importance Science 235 1987 1043 1046 (Pubitemid 17049750)
82. T.W. Sedlak, M. Saleh, D.S. Higginson, B.D. Paul, K.R. Juluri, and S.H. Snyder Bilirubin and glutathione have complementary antioxidant and cytoprotective roles Proc Natl Acad Sci USA 106 2009 5171 5176
83. J.P. Lin, C.J. O'Donnell, J.P. Schwaiger, L.A. Cupples, A. Lingenhel, and S.C. Hunt Association between the UGT1A1*28 allele, bilirubin levels, and coronary heart disease in the Framingham Heart Study Circulation 114 2006 1476 1481 (Pubitemid 44527002)
84. J. Sugatani, S. Nishitani, K. Yamakawa, K. Yoshinari, T. Sueoshi, and M. Negishi Transcriptional regulation of human UGT1A1 gene expression through distal and proximal promoter motifs: implication of defects in the UGT1A1 gene promoter Naunyn-Schmiedeberg's Arch Pharmacol 377 2008 597 605
85. Y. Li, D. Buckley, S. Wang, C.D. Klaassen, and X.B. Zhong Genetic polymorphisms in the TATA box and upstream phenobarbital-responsive enhancer module of the UGT1A1 promoter have combined effects on UDP- glucuronosyltransferase 1A1 transcription mediated by constitutive androstane receptor, pregnane X receptor, or glucocorticoid receptor in human liver Drug Metab Dispos 37 2009 1978 1986
86. M. Fer, L. Corcos, Y. Dreano, E. Plee-Gautier, J.P. Salaün, and F. Berthou Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metaboliosm J Lipid Res 49 2008 2379 2389
87. D. Turgeon, S. Chouinard, P. Belanger, S. Picard, J.F. Labbe, and P. Borgeat Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases J Lipid Res 44 2003 1182 1191 (Pubitemid 37279636)
88. J.M. Little, M. Kurkela, J. Sonka, S. Jäntti, R. Ketola, and S. Bratton Glucuronidation of oxidized fatty acids and prostaglandin B1 and E2 by human hepatic and recombinant UDP-glucuronosyltransferases J Lipid Res 45 2004 1694 1703 (Pubitemid 39296209)
89. S. Kalthoff, U. Ehmer, N. Freiberg, M.P. Manns, and C.P. Strassburg Interaction between oxidative stress sensor Nrf2 and xenobiotic-activated aryl hydrocarbon receptor in the regulation of the human phase II detoxifying UDP-glucuronosyltransferase 1A10 J Biol Chem 285 2010 5993 6002
90. W. Miao, L. Hu, J. Scrivens, and G. Batist Transcriptional regulation of NF-E2 p45-related factor (Nrf2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway J Biol Chem 280 2005 20340 20348 (Pubitemid 40776732)
91. S. Shin, N. Wakabayashi, V. Misra, S. Biswal, G.H. Lee, and E.S. Agoston Nrf2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis Mol Cell Biol 27 2007 7188 7197 (Pubitemid 47549754)
92. Q. Ma, K. Kinneer, Y. Bi, J.Y. Chan, and Y.W. Kan Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachloro-p-dioxin requires the CNC (cap'n'collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2): cross-interaction between AhR (aryl hydrocarbon receptor) and Nrf2 signal transduction Biochem J 377 2004 205 213 (Pubitemid 38114447)
93. R.D. Patel, B.D. Hollingshead, C.J. Omiecinski, and G.H. Perdew Aryl-hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver Hepatology 46 2007 209 218 (Pubitemid 47171938)
94. J.M. Maglich, C.M. Stoltz, B. Goodwin, D. Hawkins-Brown, J.T. Moore, and S.A. Kliewer Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification Mol Pharmacol 62 2002 638 646 (Pubitemid 36329382)
95. S. Aouabdi, G. Gibson, and N. Plant Transcriptional regulation of the PXR gene: Identification and characterization of a functional peroxisome proliferator-activated receptor α binding site within the proximal promoter of PXR Drug Metab Disp 34 2006 138 144 (Pubitemid 43042655)
96. J. Sugatani, S. Nishitani, K. Yamakawa, K. Yoshinari, T. Sueoshi, and M. Negishi Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1 Mol Pharmacol 67 2004 845 855 (Pubitemid 40365332)
97. Y. Jia, G.L. Guo, S. Surapureddi, J. Sarkar, C. Qi, and D. Guo Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity Proc Natl Acad Sci USA 102 2005 12531 12536 (Pubitemid 41266393)
98. H. Masuyama, H. Nakatsukasa, and Y. Hiramatsu Effect of oncostatin M on uridine diphosphate-5′-glucuronosyltransferase 1A1 through cross talk with constitutive androstane receptor Mol Endocrinol 24 2010 745 753