Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism

Journal of Lipid Research

Volumn 49, Issue 11, 2008, Pages 2379-2389

  Fer, Maude ^a   Corcos, Laurent ^a,b   Dréano, Yvonne ^a   Plée Gautier, Emmanuelle ^a   Salaün, Jean Pierre ^a,c   Berthou, François ^a   Amet, Yolande ^a  

^a UNIVERSITÉ DE BRETAGNE OCCIDENTALE   (France)

^b FACULTÉ DE MÉDECINE ET DES SCIENCES DE LA SANTÉ   (France)

^c CNRS   (France)

Author keywords

(v 1) hydroxylation; Inhibition; V hydroxylation

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; ALKANE 1 MONOOXYGENASE; ARACHIDONIC ACID; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C18; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 2J2; CYTOCHROME P450 3A4; CYTOCHROME P450 4F2; CYTOCHROME P450 4F3A; CYTOCHROME P450 4F3B; CYTOCHROME P450 4FA11; CYTOCHROME P450 4FA12; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; ICOSATRIENOIC ACID; OMEGA 3 FATTY ACID; POLYUNSATURATED FATTY ACID; UNCLASSIFIED DRUG; CYP4F3 PROTEIN, HUMAN; UNSATURATED FATTY ACID;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SUBSTRATE; FATTY ACID METABOLISM; HUMAN; HYDROXYLATION; LIVER MICROSOME; METABOLIC INHIBITION; METABOLIC RATE; METABOLIC REGULATION; METABOLITE; PRIORITY JOURNAL; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; ENZYMOLOGY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY;

CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; FATTY ACIDS, UNSATURATED; HUMANS; HYDROXYLATION; MASS SPECTROMETRY; MICROSOMES, LIVER;

EID: 54349093845     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M800199-JLR200     Document Type: Article

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