Alterations in hepatic mRNA expression of phase II enzymes and xenobiotic transporters after targeted disruption of hepatocyte nuclear factor 4 alpha

Toxicological Sciences

Volumn 118, Issue 2, 2010, Pages 380-390

  Lu, Hong ^a   Gonzalez, Frank J ^b   Klaassen, Curtis ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Gst; HNF4a; Knockout; Sult; Transporter; Ugt

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; GLUTATHIONE S TRANSFERASE M4; GLUTATHIONE S TRANSFERASE M6; GLUTATHIONE TRANSFERASE; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; LIVER ENZYME; MEMBRANE PROTEIN; MESSENGER RNA; MULTIDRUG AND TOXIN EXTRUSION 1; MULTIDRUG RESISTANCE PROTEIN 6; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1A1; ORGANIC ANION TRANSPORTING POLYPEPTIDE 2B1; ORGANIC CATION TRANSPORTER 1; SODIUM DEPENDENT VITAMIN C TRANSPORTER 1; SODIUM PHOSPHATE COTRANSPORTER 1; SULFATE ANION TRANSPORTER 1; SULFOTRANSFERASE; SULFOTRANSFERASE 1A1; SULFOTRANSFERASE 1B1; SULFOTRANSFERASE 5A1; UNCLASSIFIED DRUG; UNINDEXED DRUG; URIDINE 5' DIPHOSPHO GLUCURONOSYLTRANSFERASE 1A5; URIDINE 5' DIPHOSPHO GLUCURONOSYLTRANSFERASE 1A9; URIDINE 5' DIPHOSPHO GLUCURONOSYLTRANSFERASE 2A3; URIDINE 5' DIPHOSPHO GLUCURONOSYLTRANSFERASE 2B1; URIDINE 5' DIPHOSPHO GLUCURONOSYLTRANSFERASE 3A1; URIDINE 5' DIPHOSPHO GLUCURONOSYLTRANSFERASE 3A2; URIDINE DIPHOSPHATE GLUCOSE; XENOBIOTIC TRANSPORTER DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; GENE DISRUPTION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SEX DIFFERENCE;

ANIMALS; BIOLOGICAL TRANSPORT; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTE NUCLEAR FACTOR 4; HEPATOCYTES; LIVER; MALE; MEMBRANE TRANSPORT PROTEINS; METABOLIC DETOXICATION, PHASE II; MICE; MICE, KNOCKOUT; RNA, MESSENGER;

MUS;

EID: 78549256786     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq280     Document Type: Article

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