Design and evaluation of 3-aminopyrazolopyridinone kinase inhibitors inspired by the natural product indirubin

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 11, 2011, Pages 3569-3578

  Smyth, Lynette A ^a   Matthews, Thomas P ^a   Collins, Ian ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Indirubin; Kinase inhibitor; Pyrazolopyridinone; Screening library

Indexed keywords

3 AMINOPYRAZOLOPYRIDONE KINASE INHIBITOR; INDIRUBIN; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHILICITY; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; LIPOPHILICITY; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; POLYMERIZATION; PROTEIN MOTIF;

BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; HUMANS; INDOLES; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PYRIDONES;

EID: 79957470685     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.03.069     Document Type: Article

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