Induction of apoptosis by a novel indirubin-5-nitro-3′-monoxime, a CDK inhibitor, in human lung cancer cells

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 17, 2005, Pages 3948-3952

  Lee, Jong Won ^a   Moon, Myoung Ju ^b   Min, Hye Young ^a   Chung, Hwa Jin ^a   Park, Eun Jung ^a   Park, Hyen Joo ^a   Hong, Ji Young ^a   Kim, Yong Chul ^b   Lee, Sang Kook ^a  

^a Ewha Womans University   (South Korea)

^b Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

A549 human lung cancer cells; Apoptosis; Indirubin 5 nitro 3 monoxime; p21; p53

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; INDIRUBIN; INDIRUBIN 3' MONOXIME; INDIRUBIN 5 NITRO 3' MONOXIME; INDIRUBIN 5 SULFONATE; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; LUNG CANCER; MITOCHONDRION;

ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASES; HUMANS; INDOLES; INTERPHASE; LUNG NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 23244449448     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.05.105     Document Type: Article

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