Synthesis and anti-Trypanosoma cruzi activity of β-lapachone analogues

European Journal of Medicinal Chemistry

Volumn 46, Issue 7, 2011, Pages 3071-3077

  Ferreira, Sabrina Baptista ^a   Salomão, Kelly ^b   De Carvalho Da Silva, Fernando ^c   Pinto, Antônio Ventura ^a   Kaiser, Carlos Roland ^a   Pinto, Angelo C ^a   Ferreira, Vitor Francisco ^c   De Castro, Solange L ^b  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

Author keywords

Chagas' disease; Chemotherapy; Lapachones; Naphthoquinones; Trypanosoma cruzi

Indexed keywords

10 ETHOXY 7A,8,9,10 TETRAHYDROBENZO[H]PYRANO[2,3-B]CHROMENE 5,6(7H,11AH)DIONE; 10 METHOXY 7A,8,9,10 TETRAHYDROBENZO[H]PYRANO[2,3 B]CHROMENE 5,6(7H,11AH)DIONE; 2 (2,4 DIMETHYLPHENYL) 3,4 DIHYDRO 2H BENZO[H]CHROMENE 5,6 DIONE; 2 (4 CHLOROPHENYL) 3,4 DIHYDRO 2H BENZO[H]CHROMENE 5,6 DIONE; 2 (4 ETHOXYPHENYL) 3,4 DIHYDRO 2H BENZO[H]CHROMENE 5,6 DIONE; 2 (4 FLUOROPHENYL) 3,4 DIHYDRO 2H BENZO[H]CHROMENE 5,6 DIONE; 2 (4 METHOXYPHENYL) 3,4 DIHYDRO 2H BENZO[H]CHROMENE 5,6 DIONE; 2 4 TOLYL 3,4 DIHYDRO 2H BENZO[H]CHROMENE 5,6 DIONE; 2 METHYL 2 PHENYL 3,4 DIHYDRO 2H BENZO[H]CHROMENE 5,6 DIONE; 2 PHENYL 3,4 DIHYDRO 2H BENZO[H]CHROMENE 5,6 DIONE; 4 (4 NITROPHENYL) 2 4 TOLYL 3,4 DIHYDRO 2H BENZO[H]CHROMENE 5,6 DIONE; 4 (THIOPHEN 2 YL) 2 4 TOLYL 3,4 DIHYDRO 2H BENZO[H]CHROMENE 5,6 DIONE; 7,7A,8,9 TETRAHYDRO 5H BENZO[C]XANTHENE 5,6(11AH)DIONE; 7A,8 DIHYDROBENZO[H]CYCLOPENTA[B]CHROMENE 5,6(7H,10AH)DIONE; 7A,8,9,10 TETRAHYDROBENZO[H]PYRANO[2,3 B]CHROMENE 5,6(7H,11AH)DIONE; ANTITRYPANOSOMAL AGENT; BETA LAPACHONE; PHENYL 2 4 TOLYL 3,4 DIHYDRO 2H BENZO[H]CHROMENE 5,6 DIONE; UNCLASSIFIED DRUG; BETA-LAPACHONE; NAPHTHOQUINONE; PYRAN DERIVATIVE;

ANTIMICROBIAL ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; NONHUMAN; TRYPANOSOMA CRUZI; ANIMAL; BLOOD CELL; CHAGAS DISEASE; CHEMISTRY; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; IC50; LIFE CYCLE STAGE; MOUSE; PARASITOLOGY; PHYSIOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; BLOOD CELLS; CHAGAS DISEASE; INHIBITORY CONCENTRATION 50; LIFE CYCLE STAGES; MICE; NAPHTHOQUINONES; PYRANS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 79957466569     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.03.012     Document Type: Article

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