Chemical reactivity studies with naphthoquinones from Tabebuia with anti-trypanosomal efficacy

Arzneimittel-Forschung/Drug Research

Volumn 50, Issue 12, 2000, Pages 1120-1128

  Pinto, C N ^a   Dantas, A P ^a   De Moura, K C G ^a   Emery, F S ^a   Polequevitch, P F ^a   Pinto, M C F R ^a   De Castro, S L ^a   Pinto, A V ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Chagas' disease; Naphthoquinones, chemical reactivity studies; Tabebuia quinones; Trypanosoma cruzi; Lapachone

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; ANTITRYPANOSOMAL AGENT; BETA LAPACHONE; CYCLOPENTENE DERIVATIVE; HETEROCYCLIC COMPOUND; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; LAPACHOL; OIL; OXAZOLE DERIVATIVE; PHENOXAZINE DERIVATIVE; PLANT EXTRACT; PYRAN DERIVATIVE;

ANTIMICROBIAL ACTIVITY; ARTICLE; CHAGAS DISEASE; CHEMICAL REACTION; CYCLIZATION; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

TABEBUIA;

EID: 0034537187     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300337     Document Type: Article

References (50)

1. Antiviral activity of naphthoquinones. I - Lapachol derivatives against enteroviruses
2. In vitro activity of natural and synthetic naphthoquinones against erythrocytic stages of Plasmodium falciparum
3. Comparison of antibacterial and antifungal activities of lapachol and β-lapachone
4. Antifungal and antibacterial naphthoquinones from Newbouldia laevis roots
5. Three inhibitors of type 1 human immunodeficiency virus long terminal repeat -directed gene expression and virus replication
6. Schistosoma mansoni: Blockage of cercarial skin penetration by chemical agents. I - Naphthoquinones and derivatives
7. Substancias antimicrobianas de plantas superiores
8. Antitumor-promoting naphthoquinones from Catalpa ovata
9. Inhibition of radiation-induced neoplastic transformation by β-lapachone
10. Effects of 1,2-naphthoquinones on human tumor cell growth and lack of cross-resistance with other anticancer agents
11. β-Lapachone, an inhibitor of oncornavirus reverse transcriptase and eukaryotic DNA polymerase-α. Inhibitory effect, thiol dependence and specificity
12. Potentiation of halogenated pyrimidine radiosensitizers in human carcinoma cells by beta-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b] pyran-5,6-dione), a novel DNA repair inhibitor
13. Induction of apoptosis by β-lapachone in human prostate cancer cells
14. Bcl-2 protects against β-lapachone-mediated caspase 3 activation and apoptosis in human myeloid leukemia (HL-60) cells
15. Suppression of tumor necrosis factor -activated nuclear transcription factor-kappaB, activator protein -1,c-Jun N-terminal kinase, and apoptosis by β-lapachone
16. Involvement of hydrogen peroxide in topoisomerase inhibitor β-lapachone-induced apoptosis and differentiation in human leukemia cells
17. β-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin
18. Topoisomerase-I inhibitors for human malignant glioma: Differential modulation of p53, p21, bax and bcl-2 expression and of CD95-mediated apoptosis by camptothecin and β-lapachone
19. Trypanosoma cruzi: Ultrastructural and metabolic alterations of epimastigotes by β-lapachone
20. In vitro and in vivo evaluation of the toxicity of 1,4-naphtoquinone and 1,2-naphthoquinone derivatives against Trypanosoma cruzi
21. Activity of some naphtoquinones on bloodstream forms of Trypanosoma cruzi
22. Trypanocidal activity of synthetic heterocyclic derivatives from active quinones from Tabebuia sp.
23. The challenge of Chagas' disease chemotherapy: An update of drugs assayed against Trypanosoma cruzi
24. Chemotherapy of Chagas' disease: The how and the why
25. Epidemiology of Chagas disease
26. Superoxide anion production and trypanocidal action of naphthoquinones on Trypanosoma cruzi
27. Effect of β-lapachone, a peroxide -generating quinone, on macromolecule synthesis and degradation in Trypanosoma cruzi
28. Redox cycling of o-naphthoquinones in trypanosomatids. Superoxide and hydrogen peroxide production
29. Sintese de naftoquinones naturais a partir do lapachol
30. Sintese das α- e β-nor-lapachonas, propriedades em meio acido e reacoes com N-bromosuccinimida
31. Reaction of 2 -amino -1,4 -naphthoquinone derivatives with dimethyl acetylenedicarboxylate
32. Heterocyclics from quinones. I-Reaction of lapachol with primary alkyl amines
33. Synthesis of some naturally occurring naphthoquinones from Paratecoma and Tabebuia sp
34. Screening of natural and synthetic drugs against Trypanosoma cruzi. 1 - Establishing a structure/activity relationship
35. Fluorescent symmetric phenazines from naphthoquinones
36. Six-membered rings with more than one oxygen or sulfur atom
37. Evaluation of the toxicity of 3-allyl-β-lapachone against Trypanosoma cruzi bloodstream forms
38. Effect of gossypol on trypomastigotes and amastigotes of Trypanosoma cruzi
39. Effect of alkyl-lysophospholipids on the proliferation and differentiation of Trypanosoma cruzi
40. Plant metabolites active against Trypanosoma cruzi
41. Chemotherapeutically active nitro compounds. 4.5-Nitroimidazoles (Part II)
42. Ketoconazole protects against infection with Trypanosoma cruzi in a murine model
43. Alteration of lipid order profile and permeability of plasma membranes from Trypanosoma cruzi epimastigotes grown in the presence of ketoconazole
44. 1-(substituted)benzyl-5-aminiimidazole-4-carboxamides are potent orally active inhibitors of Trypanosoma cruzi in mice
45. Adducts of nitroimidazole derivatives with Rhodium(II) carboxylates: Synthesis, characterization and evaluation of antichagasic activities
46. The clinical experience in Panama with metronidazole in treating Chagas' disease in the acute and chronic phases