A trypanocidal phenazine derived from β-lapachone

Journal of Medicinal Chemistry

Volumn 45, Issue 10, 2002, Pages 2112-2115

  Neves Pinto, Cleverson ^a   Malta, Valéria R S ^b   Pinto, Maria do Carmo F R ^a   Santos, Regina H A ^b   De Castro, Solange L ^c   Pinto, António Ventura ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANILINE DERIVATIVE; ANTITRYPANOSOMAL AGENT; BETA LAPACHONE; CRYSTAL VIOLET; NAPHTHOQUINONE; PHENAZINE DERIVATIVE;

ARTICLE; CHAGAS DISEASE; DERIVATIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENDEMIC DISEASE; PROPHYLAXIS; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE; X RAY ANALYSIS;

ANILINE COMPOUNDS; ANIMALS; CRYSTALLOGRAPHY, X-RAY; PHENAZINES; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 0037046522     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010377v     Document Type: Article

References (41)

1. Chagas disease
2. Etiological treatment for infection by Trypanosoma cruzi
3. The southern cone initiative against Chagas disease
4. Acute Chagas disease: Plasma levels of α-2-macroglobulin and C-reactive protein in children under 13 years in a high endemic area of Bolivia
5. The challenge of Chagas' disease chemotherapy: An update of drugs assayed against Trypanosoma cruzi
6. Chemotherapy of Chagas' disease: The how and the why
7. Quimioterapia de la enfermedad de Chagas
8. Medicine and magic among the Maka Indians of the Paraguayan Chaco
9. Autooxidation of naphthoquinones: Effects of metals, chelating agents, and superoxide dismutase
10. Synthesis and trypanocidal activity of naphthoquinones isolated from Tabebuia and heterocyclic derivatives: A review from an interdisciplinary study
11. Potent inhibition of tumor survival in vivo by β-lapachone plus taxol: Combining drugs imposes different artificial checkpoints
12. Schistosoma mansoni: Blockage of cercarial skin penetration by chemical agents. I. Naphthoquinones and derivatives
13. Síntese de naftoquinonas naturais a partir do lapachol
14. Transformações do lapachol em nafto-[1,2-b]-furanaquinonas naturais
15. Reaction of 2-amino-1,4-naphthoquinone derivatives with dimethyl acetylenedicarboxylate
16. Activity of some naphthoquinones on bloodstream forms of Trypanosoma cruzi
17. Antiviral activity of naphthoquinones. I. Lapachol derivatives against enteroviruses
18. Fluorescent symmetric phenazines from naphthoquinones
19. Efficient synthesis of cytotoxic quinones: 2-Acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione
20. Heterocyclics from quinones. I - Reaction of lapachol with primary alkylamines
21. Screening of natural and synthetic drugs against Trypanosoma cruzi. 1 - Establishing a structure/activity relationship
22. Molluscicidal activity of 2-hydroyx-3-alkyl-1,4-naphthoquinones and derivatives
23. Trypanocidal activity of synthetic heterocyclic derivatives from active quinones from Tabebuia sp.
24. Chemical reactivity studies with naphthoquinones from Tabebuia with anti-trypanosomal efficacy
25. Antimycobacterial activities of riminophenazines
26. In vitro investigation of the antimicrobial activities of novel tetramethylpiperidine-substituted phenazines against Mycobacterium tuberculosis
27. Bis(phenazine-1-carboxamides): Structure-activity relationships for a new class of dual topoisomerase I/II-directed anticancer drugs
28. Nontuberculous mycobacteriosis; the present status and in the future. The view of development of new drugs against nontuberculous mycobacterial infections
29. Generation of free radicals from phenazine methosulfate in Trypanosoma cruzi epimastigotes
30. Destruction of intracellular Trypanosoma cruzi after treatment of infected macrophages with cationic electron carriers
31. Destruction of Leishmania mexicana amazonensis amastigotes within macrophages in culture by phenazine methosulfate and other electron carriers
32. Reconstitution of respiratory chain enzymes systems. IX. Use of artificial electron acceptors in the assay of succinate dehydrogenating enzymes
33. Generation of free radicals from phenazine methosulfate, streptonigrin and rubiflavin in bacterial suspensions
34. In vitro and in vivo evaluation of the toxicity of 1,4-naphthoquinone and 1,2-naphthoquinone derivatives against Trypanosoma cruzi
35. Sensitivity of parasites to free radical damage by antiparasitic drugs
36. The biochemistry of the mode of action of drugs and the detoxication mechanisms in Trypanosoma cruzi
37. WinGX suite for small-molecule single-crystal crystallography
38. Sobre uma cepa de Trypanosoma cruzi virulenta para o camundongo branco