PPARγ1-induced caveolin-1 enhances cholesterol efflux and attenuates atherosclerosis in apolipoprotein E-deficient mice

Journal of Vascular Research

Volumn 47, Issue 1, 2009, Pages 69-79

  Hu, Qin ^a   Zhang, Xian Jun ^b   Liu, Chun Xi ^a   Wang, Xu Ping ^a   Zhang, Yun ^a,b  

^a Chinese Ministry of Education

^b SHANDONG UNIVERSITY   (China)

Author keywords

Atherosclerosis; Caveolin 1; Macrophages; PPAR

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN E; CAVEOLIN 1; CHOLESTEROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PPAR GAMMA 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CAV1 PROTEIN, MOUSE; LIPOPROTEIN;

AORTA; ARTICLE; ATHEROSCLEROSIS; CELL TYPE; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE THERAPY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; ANIMAL; C57BL MOUSE; CELL LINE; DISEASE MODEL; GENETIC TRANSDUCTION; GENETICS; LIVER; MALE; METABOLISM; MOUSE MUTANT; RNA INTERFERENCE; TRANSPORT AT THE CELLULAR LEVEL; UPREGULATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BIOLOGICAL TRANSPORT; CAVEOLIN 1; CELL LINE; CHOLESTEROL; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; LIPOPROTEINS; LIVER; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PPAR GAMMA; RNA INTERFERENCE; TRANSDUCTION, GENETIC; UP-REGULATION;

EID: 69549129239     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000235927     Document Type: Article

References (30)

1. Frank PG, Woodman SE, Park DS, Lisanti MP: Caveolin, caveolae, and endothelial cell function. Arterioscler Thromb Vasc Biol 2003; 23:1161-1168.
2. Hnasko R, Lisanti MP: The biology of caveo-lae: lessons from caveolin knockout mice and implications for human disease. Mol In-terv 2003; 3:445-464.
3. Smart EJ, De Rose RA, Farber SA: Annexin 2-caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport. Proc Natl Acad Sci USA 2004; 101:3450-3455.
4. Frank PG, Cheung MW, Pavlides S, Llaverias G, Park DS, Lisanti MP: Caveolin-1 and regulation of cellular cholesterol homeostasis. Am J Physiol Heart Circ Physiol 2006; 291: H677-H686.
5. Frank PG, Hassan GS, Rodriguez-Feo JA, Lisanti MP: Caveolae and caveolin-1: novel potential targets for the treatment of cardiovascular disease. Curr Pharm Des 2007;13:1761-1769.
6. Lusis AJ: Atherosclerosis. Nature 2000; 407:233-241.
7. Frank PG, Lisanti MP: Caveolin-1 and cave-olae in atherosclerosis: differential roles in fatty streak formation and neointimal hy-perplasia. Curr Opin Lipidol 2004; 15:523-529.
8. Hassan GS, Jasmin JF, Schubert W, Frank PG, Lisanti MP: Caveolin-1 deficiency stimulates neointima formation during vascular injury. Biochemistry 2004; 43:8312-8321.
9. Burgermeister E, Tencer L, Liscovitch M: Peroxisome proliferator- activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells. Oncogene 2003; 22:3888-3900.
10. Yu S, Matsusue K, Kashireddy P, Cao WQ, Yeldandi V, Yeldandi AV, Rao MS, Gonzalez FJ, Reddy JK: Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression. J Biol Chem 2003; 278:498-505.
11. Staels B: PPARgamma and atherosclerosis. Curr Med Res Opin 2005; 21(suppl 1): S13-S20.
12. Hu Q, Zhang XJ, Zhang C, Zhao YX, He H, Liu CX, Feng JB, Jiang H, Yang FL, Zhang CX, Zhang Y: Peroxisome proliferator-acti-vated receptor-gamma1 gene therapy attenuates atherosclerosis and stabilizes plaques in apolipoprotein E-deficient mice. Hum Gene Ther 2008;19:287-299.
13. He TC, Zhou S, da Costa LT, Yu J, Kinzler KW, Vogelstein B: A simplified system for generating recombinant adenoviruses. Proc Nat l Acad Sci USA 1998; 95:2509-2514.
14. Ghering AB, Davidson WS: Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipopro-tein A-I. J Lipid Res 2006; 47:2781-2788.
15. Majdalawieh A, Zhang L, Fuki IV, Rader DJ, Ro HS: Adipocyte enhancer-binding protein 1 is a potential novel atherogenic factor involved in macrophage cholesterol homeostasis and inflammation. Proc Natl Acad Sci USA 2006; 103:2346-2351.
16. Li AC, Glass CK: PPAR-and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis. J Lipid Res 2004; 45:2161-2173.
17. Le Lay S, Kurzchalia TV: Getting rid of caveolins: phenotypes of caveolin-deficient animals. Biochim Biophys Acta 2005; 1746:322-333.
18. Williams TM, Lisanti MP: The caveolin genes: from cell biology to medicine. Ann Med 2004; 36:84-595.
19. Lin WW, Lin YC, Chang TY, Tsai SH, Ho HC, Chen YT, Yang VC: Caveolin-1 expression is associated with plaque formation in hypercholesterolemic rabbits. J Histochem Cytochem 2006; 54:897-904.
20. Sedding DG, Braun-Dullaeus RC: Caveolin-1: dual role for proliferation of vascular smooth muscle cells. Trends Cardiovasc Med 2006; 16:50-55.
21. Frank PG, Lee H, Park DS, Tandon NN, Scherer PE, Lisanti MP: Genetic ablation of caveolin-1 confers protection against atherosclerosis. Arterioscler Thromb Vasc Biol 2004; 24:98-105.
22. Gargalovic P, Dory L: Caveolins and macro-phage lipid metabolism. J Lipid Res 2003; 44:11-21.
23. Fielding CJ, Fielding PE: Intracellular cholesterol transport. J Lipid Res 1997; 38:1503-1521.
24. Matveev S, van der Westhuyzen DR, Smart EJ: Co-expression of scavenger receptor-BI and caveolin-1 is associated with enhanced selective cholesteryl ester uptake in THP-1 macrophages. J Lipid Res 1999; 40:1647-1654.
25. Lei MG, Morrison DC: Differential expression of caveolin-1 in lipopolysaccharide-activated murine macrophages. Infect Immun 2000; 68:5084-5089.
26. Llaverias G, Vázquez-Carrera M, Sánchez RM, Noé V, Ciudad CJ, Laguna JC, Alegret M: Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-de-pendent mechanism. J Lipid Res 2004; 45:2015-2024.
27. Dhaliwal BS, Steinbrecher UP: Cholesterol delivered to macrophages by oxidized low density lipoprotein is sequestered in lyso-somes and fails to efflux normally. J Lipid Res 2000; 41:1658-1665.
28. van Dam MJ, de Groot E, Clee SM, Hovingh GK, Roelants R, Brooks-Wilson A, Zwinder-man AH, Smit AJ, Smelt AH, Groen AK, Hayden MR, Kastelein JJ: Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study. Lancet 2002; 359:37-42.
29. Lin YC, Ma C, Hsu WC, Lo HF, Yang VC: Molecular interaction between caveolin-1 and ABCA1 on high-density lipoprotein-mediated cholesterol efflux in aortic endothelial cells. Cardiovasc Res 2007; 75:575-583.
30. Sessa WC: Atheroprotection in the absence of 'caves': is it the fat, the vessels, or both? Arterioscler Thromb Vasc Biol 2004; 24:4-6.