β-Cryptoxanthin, a novel natural RAR ligand, induces ATP-binding cassette transporters in macrophages

Biochemical Pharmacology

Volumn 74, Issue 2, 2007, Pages 256-264

  Matsumoto, Akira ^a,b   Mizukami, Hajime ^b   Mizuno, Satoshi ^c   Umegaki, Keizo ^d   Nishikawa, Jun ichi ^e   Shudo, Koichi ^f   Kagechika, Hiroyuki ^g   Inoue, Makoto ^a,b  

^a AICHI GAKUIN UNIVERSITY   (Japan)

^b NAGOYA CITY UNIVERSITY   (Japan)

^c Kemin Industries Inc   (United States)

^d NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

^e OSAKA UNIVERSITY   (Japan)

^f Kawasaki   (Japan)

^g TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Cryptoxanthin; ATP binding cassette transporter; Lutein; Retinoic acid receptor; Retinoid X receptor; Xanthopyll

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER A1; ABC TRANSPORTER G1; ALITRETINOIN; ASTAXANTHIN; BETA CAROTENE; BETA CRYPTOXANTHIN; CHOLESTEROL ESTER; LE 540; LYCOPENE; MESSENGER RNA; RECEPTOR BLOCKING AGENT; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR GAMMA; RETINOID X RECEPTOR; TRANSCRIPTION FACTOR GAL4; UNCLASSIFIED DRUG; XANTHOPHYLL; ZEAXANTHIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; BINDING SITE; C57BL 6 MOUSE; CONTROLLED STUDY; DRUG STRUCTURE; LIGAND BINDING; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; TWO HYBRID SYSTEM; WESTERN BLOTTING;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; DIBENZAZEPINES; GENE EXPRESSION REGULATION; LIPOPROTEINS; LUTEIN; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; RECEPTORS, RETINOIC ACID; RNA, MESSENGER; TWO-HYBRID SYSTEM TECHNIQUES; XANTHOPHYLLS;

EID: 34250188856     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.04.014     Document Type: Article

References (50)

1. Voutilainen S., Nurmi T., Mursu J., and Rissanen T.H. Carotenoids and cardiovascular health. Am J Clin Nutr 83 (2006) 1265-1271
2. Joshipura K.J., Ascherio A., Manson J.E., Stampfer M.J., Rimm E.B., Speizer F.E., et al. Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA 282 (1999) 1233-1239
3. Joshipura K.J., Hu F.B., Manson J.E., Stampfer M.J., Rimm E.B., Speizer F.E., et al. The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med 134 (2001) 1106-1114
4. Bazzano L.A., He J., Ogden L.G., Loria C.M., Vupputuri S., Myers L., et al. Fruit and vegetable intake and risk of cardiovascular disease in US adults: the first national health and nutrition examination survey epidemiologic follow-up study. Am J Clin Nutr 76 (2002) 93-99
5. Hennekens C.H., Buring J.E., Manson J.E., Stampeer M., Rosner B., Cook N.R., et al. Lack of effect of long-term supplementation with beta carotene on the indidence of malignant neoplasms and cardiovascular disease. N Engl J Med 334 (1999) 1145-1149
6. Greenberg E.R., Baron J.A., Karagas M.R., Stukel T.A., Nierenberg D.W., Stevens M.M., et al. Mortality associated with low plasma concentration of beta carotene and the effect of oral supplementation. JAMA 275 (1996) 699-703
7. Hansson G.K. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 352 (2005) 1685-1695
8. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 340 (1999) 115-126
9. Hansson G.K., Libby P., Schönbeck U., and Yan Z.Q. Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ Res 91 (2002) 281-291
10. DeRose JJJr, Madigan J., Umane J.P., Prystowsky J.H., Nowygrod R., Oz M.C., et al. Retinoic acid suppresses intimal hyperplasia and prevents vessel remodeling following arterial injury. Cardiovasc Surg 7 (1999) 633-639
11. Miano J.M., Kelly L.A., Artacho C.A., Nuckolls T.A., Piantedosi R., and Blaner W.S. All-trans-retinoic acid reduces neointimal formation and promotes favorable geometric remodeling of the rat carotid artery balloon withdrawal injury. Circulation 98 (1999) 1219-1227
12. Lee C.W., Park S.J., Park S.W., Kim J.J., Hong M.K., and Song J.K. All-trans-retinoic acid attenuates neointima formation with acceleration of reendothelialization in balloon-injured rat aorta. J Korean Med Sci 15 (2000) 31-36
13. Herdeg C., Oberhoff M., Baumbach A., Schroeder S., Leitritz M., Blattner A., et al. Effects of local all-trans-retinoic acid delivery on experimental atherosclerosis in the rabbit carotid artery. Cardiovasc Res 57 (2003) 544-553
14. Neuville P., Yan Zq, Gidlöf A., Pepper M.S., Hansson G.K., Gabbiani Z.G., et al. Retinoic acid regulates arterial smooth muscle cell proliferation and phenotypic features in vivo and in vitro through an RAR-a-dependent signaling pathway. Arterioscler Throm Vasc Biol 19 (1999) 1430-1436
15. Miano J.M., Topouzis S., Majesky M.J., and Olson E.N. Retinoid receptor expression and all-trans retinoic acid-mediated growth inhibition in vascular smooth muscle cells. Circulation 93 (1996) 1886-1895
16. Kosaka C., Sasaguri T., Komiyama Y., and Takahashi H. All-trans retinoic acid inhibits vascular smooth muscle cell proliferation targeting multiple genes for cyclins and cyclin-dependent kinases. Hypertens Res 24 (2001) 579-588
17. Costet P., Lalanne F., Gerbod-Giannone M.C., Molina J.R., Fu X., Lund E.G., et al. Retinoic acid receptor-mediated induction of ABCA1 in macrophages. Mol Cell Biol 23 (2003) 7756-7766
18. Takeda N., Manabe I., Shindo T., Iwata H., Iimuro S., Kagechika H., et al. Synthetic retinoid Am80 reduces scavenger receptor expression and atherosclerosis in mice by inhibiting IL-6. Arterioscler Thromb Vasc Biol 26 (2006) 1177-1183
19. Langmann T., Liebisch G., Moehle C., Schifferer R., Dayoub R., Heiduczek S., et al. Gene expression profiling identifies retinoids as potent inducers of macrophage lipid efflux. Biochim Biophys Acta 1740 (2005) 155-161
20. h2 development via retinoic acid receptors. Int Immunol 15 (2003) 1017-1025
21. Hoag K.A., Nashold F.E., Goverman J., and Hayes C. Retinoic acid enhances the T helper 2 cell development that is essential for robust antibody responses through its action on antigen-presenting cells. J Nutr 132 (2002) 3736-3739
22. David M., Hodak E., and Lowe N.J. Adverse effects of retinoids. Med Toxicol Adverse Drug Exp 3 (1988) 273-288
23. Frankel S.R., Eardley A., Lauwers G., Weiss M., and Warrell Jr. R.P. The "retinoic acid syndrome" in acute promyelocytic leukemia. Ann Intern Med 117 (1992) 292-296
24. Petkovich M., Brand N.J., Krust A., and Chambon P. A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 330 (1987) 444-450
25. Giguere V., Ong E.S., Segui P., and Evans R.M. Identification of a receptor for the morphogen retinoic acid. Nature 330 (1987) 624-629
26. Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J 10 (1996) 940-954
27. Uppenberg J., Svensson C., Jaki M., Bertilsson G., Jendeberg L., and Berkenstam A. Crystal structure of the ligand binding domain of the human nuclear receptor PPARγ. J Biol Chem 273 (1998) 31108-31112
28. Kim K.R., Lee J.H., Kim S.J., Rhee S.D., Jung W.H., Yang S.D., et al. KR-62980: a novel peroxisome proliferator-activated receptor γ agonist with weak adipogenic effects. Biochem Pharmacol 72 (2006) 446-454
29. Allen T., Zhang F., Moodie S.A., Clemens L.E., Smith A., Gregoire F., et al. Halofenate is a selective peroxisome proliferators-activated receptor γ modulator with antidiabetic activity. Diabetes 55 (2006) 2523-2533
30. Napoli J.L. Biosynthesis and metabolism of retinoid acid: roles of CRBP and CRABP in retinoic acid homeostasis. J Nutr 123 (1993) 362-366
31. Heyman R.A., Mangelsdorf D.J., Dyck J.A., Stein R.B., Eichele G., Evans R.M., et al. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 68 (1992) 397-406
32. Nishikawa J., Saito K., Goto J., Dakeyama F., Matsuo M., and Nishihara T. New screening methods for chemicals with hormonal activities using interaction of nuclear hormone receptor with coactivator. Toxicol Appl Pharmacol 154 (1999) 76-83
33. Kanayama T., Mamiya S., Nishihara T., and Nishikawa J. Basis of a high-throughput method for nuclear receptor agonists. J Biochem 133 (2003) 791-797
34. Ono Y., Inoue M., Mizukami H., and Ogihara Y. Suppressive effect of Kanzo-bushi-to, a Kampo medicine, on collagen-induced arthritis. Biol Pharm Bull 27 (2004) 1406-1413
35. Umemiya H., Fukasawa H., Ebisawa M., Eyrolles L., Kawachi E., Eisenmann G., et al. Regulation of retinoidal actions byu doazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterdimers. J Med Chem 40 (1997) 4222-4234
36. Redmond T.M., Gentleman S., Duncan T., Yu S., Wiggert B., Gantt E., et al. Identification, expression, and substrate specificity of a mammalian β-carotene 15, 15′-dioxygenase. J Biol Chem 276 (2001) 6560-6565
37. De Leenheer A.P., Lambert W.E., and Claeys I. All-trans-retinoic acid: measurement of reference values in human serum by high performance liquid chromatography. J Lipid Res 23 (1982) 1362-1367
38. Urbach J., and Rando R.R. Isomerization of all-trans retinoic acid to 9-cis-retinoic acid. Biochem J 299 (1994) 459-465
39. El-Sohemy A., Baylin A., Kabagambe E., Ascherio A., Spiegelman D., and Campos H. Individual carotenoid concentrations in adipose tissue and plasma as biomarkers of dietary intake. Am J Clin Nutr 76 (2002) 172-179
40. Wingerath T., Stahl W., and Sies H. β-Cryptoxanthin selectively increases in human chylomicrons upon ingestion of tangerine concentrate rich in β-cryptoxanthin esters. Arch Biochem Biophys 324 (1995) 385-390
41. Riso P., Visioli F., Gardana C., Grande S., Brusamolino A., Galvano F., et al. Effects of blood orange juice intake on antioxidant bioavailability and on different markers related to oxidative stress. J Agric Food Chem 53 (2005) 941-947
42. Gruszecki W.I., and Strzalka K. Carotenoids as modulators of lipid membrane physical properties. Biochim Biophys Acta 1740 (2005) 108-115
43. Wisniewska A., Widomska J., and Subczynski W.K. Carotenoid-membrane interactions in liposomes: effect of dipolar, monopolar, and nonpolar carotenoids. Acta Biochim Pol 53 (2006) 475-484
44. Bhosale P., Larson A.J., Frederick J.M., Southwick K., Thulin C.D., and Bernstein P.S. Identification and characterization of a Pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein in the macula of the human eye. J Biol Chem 279 (2004) 49447-49454
45. Kagechika H., and Shudo K. Synthetic retinoids: recent developments concerning structure and clinical utility. J Med Chem 48 (2005) 5875-5883
46. Yamaguchi M., and Uchiyama S. Effect of carotenoid on calcium content and alkaline phosphatase activity in rat femoral tissues in vitro: the unique anabolic effect of β-cryptoxanthin. Biol Pharm Bull 26 (2003) 1188-1191
47. Uchiyama S., and Yamaguchi M. Inhibitory effect of β-cryptoxanthin on osteoclast-like cell formation in mouse marrow cultures. Biochem Pharmacol 67 (2004) 1297-1305
48. Lian F., Hu K.Q., Russell R.M., and Wang X.D. β-Cryptoxanthin suppresses the growth of immortalized human bronchial epithelial cells and non-small-cell lung cancer cells and up-regulates retinoic acid receptor β expression. Int J Cancer 119 (2006) 2084-2089
49. Yuan J.M., Stram D.O., Arakawa K., Lee H.P., and Yu M.C. Dietary cryptoxanthin and reduced risk of lung cancer: the siggapore Chinese health study. Cancer Epidemiol Biomark Prev 12 (2003) 890-898
50. Pattison D.J., Symmons D.P.M., Welch M.L.A., Bingham S.A., Day N.E., Silman A.J., et al. β-cryptoxanthin and inflammatory polyarthritis: results from a population-based prospective study. Am J Clin Nutr 82 (2005) 451-455