Structural instability and Cu-dependent pro-oxidant activity acquired by the apo form of mutant SOD1 associated with amyotrophic lateral sclerosis

Biochemistry

Volumn 50, Issue 20, 2011, Pages 4242-4250

  Kitamura, Furi ^a   Fujimaki, Nobuhiro ^a   Okita, Wakana ^a   Hiramatsu, Hirotsugu ^a   Takeuchi, Hideo ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION BAND; AMYOTROPHIC LATERAL SCLEROSIS; ANTIOXIDANT ENZYME; BINDING MODES; CATALYTIC PROPERTIES; CONFORMATIONAL CHANGE; CU ,ZN SUPEROXIDE DISMUTASE; CYTOSOLIC; DISEASE PROGRESSION; FLUOROGENIC PROBES; IRREGULAR STRUCTURES; MOTOR NEURONS; NON-NATIVE; OXIDATION REACTIONS; PATHOGENIC MECHANISMS; PHYSIOLOGICAL TEMPERATURE; PROOXIDANT; STRUCTURAL INSTABILITY; TOXIC PROPERTIES; TWO-STATE TRANSITIONS;

BINDING ENERGY; BINDING SITES; CIRCULAR DICHROISM SPECTROSCOPY; DENATURATION; DICHROISM; NEURODEGENERATIVE DISEASES; NEURONS; OXIDANTS; OXYGEN; ZINC;

COPPER;

COPPER ZINC SUPEROXIDE DISMUTASE; HYDROGEN PEROXIDE;

ABSORPTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; BINDING SITE; CATALYST; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISEASE COURSE; HALF LIFE TIME; MUTANT; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE;

AMYOTROPHIC LATERAL SCLEROSIS; APOPROTEINS; CIRCULAR DICHROISM; COPPER; DISEASE PROGRESSION; ENZYME STABILITY; HUMANS; MODELS, MOLECULAR; MUTANT PROTEINS; MUTATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; SUPEROXIDE DISMUTASE;

EID: 79956203702     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200338h     Document Type: Article

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