Malignant mesothelioma cells are rapidly sensitized to TRAIL-induced apoptosis by low-dose anisomycin via Bim

Molecular Cancer Therapeutics

Volumn 6, Issue 10, 2007, Pages 2766-2776

  Abayasiriwardana, Keith S ^a   Barbone, Dario ^a   Kim, Ki Up ^a   Vivo, Claire ^a   Lee, Kevin K ^a   Dansen, Tobias B ^b   Hunt, Abigail E ^b   Evan, Gerard I ^b   Broaddus, V Courtney ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANISOMYCIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BH3 PROTEIN; BIM PROTEIN; ETOPOSIDE; PROTEIN BID; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; CANCER CELL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG MECHANISM; DRUG SENSITIZATION; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MALIGNANT MESOTHELIOMA; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RNA TRANSLATION; SENSITIZATION; SIGNAL TRANSDUCTION;

ANISOMYCIN; ANNEXIN A5; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; COMBINED MODALITY THERAPY; CYCLOHEXIMIDE; DRUG SYNERGISM; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ETOPOSIDE; HUMANS; IMMUNOBLOTTING; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIGANDS; MEMBRANE PROTEINS; MESOTHELIOMA; PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITORS; PROTO-ONCOGENE PROTEINS; RNA, SMALL INTERFERING; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR CELLS, CULTURED;

EID: 35848937160     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-07-0278     Document Type: Article

References (45)

1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
2. Evan GI, Wyllie AH, Gilbert CS, et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell 1992;69:119-28.
3. Schmitt CA, Lowe SW. Apoptosis and chemoresistance in transgenic cancer models. J Mol Med 2002;80:137-46.
4. Igney FH, Krammer PH. Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer 2002;2:277-88.
5. Certo M, Moore VCG, Nishino M, et al. Mitochondria primed by death signals determine cellular addiction to antiapoptotic Bcl-2 family members. Cancer Cell 2006;9:351-65.
6. Ashkenazi A, Pai RC, Fong S, et al. Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest 1999;104:155-62.
7. Liu W, Bodle E, Chen JY, et al. Tumor necrosis factor-related apoptosis-inducing ligand and chemotherapy cooperate to induce apoptosis in mesothelioma cell lines. Am J Respir Cell Mol Biol 2001;25:111-8.
8. Vivo C, Liu W, Broaddus VC. c-Jun N-terminal kinase contributes to apoptotic synergy induced by tumor necrosis factor-related apoptosis-inducing ligand plus DNA damage in chemoresistant, p53 inactive mesothelioma cells. J Biol Chem 2003;278:25461-7.
9. Broaddus VC, Dansen TB, Abayasiriwardana KS, et al. Bid mediates apoptotic synergy between TNF-related apoptosis-inducing ligand (TRAIL) and DNA damage. J Biol Chem 2005;280:12486-93.
10. Iordanov MS, Pribnow D, Magun JL, et al. Ribotoxic stress response: activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the α-sarcin/ricin loop in the 28S rRNA. Mol Cell Biol 1997;17:3373-81.
11. Torocsik B, Szeberenyi J. Anisomycin affects both pro- and antiapoptotic mechanisms in PC12 cells. Biochem Biophys Res Commun 2000;278:550-6.
12. Santibanez JF, Hurtado C. Ha-Ras sensitizes transformed mouse skin cells to anisomycin-induced apoptosis. FEBS Lett 2005;579:6459-64.
13. Hoppe J, Kilic M, Hoppe V, Sachinidis A, Kagerhuber U. Formation of caspase-3 complexes and fragmentation of caspase-12 during anisomycin-induced apoptosis in AKR-2B cells without aggregation of Apaf-1. Eur J Cell Biol 2002;81:567-76.
14. Sah NK, Munshi A, Kurland JF, et al. Translation inhibitors sensitize prostate cancer cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by activating c-Jun N-terminal kinase. J Biol Chem 2003;278:20593-602.
15. Curtin JF, Cotter TG. Anisomycin activates JNK and sensitises DU 145 prostate carcinoma cells to Fas mediated apoptosis. Br J Cancer 2002;87:1188-94.
16. Harasawa R, Mizusawa H, Nozawa K, et al. Detection and tentative identification of dominant Mycoplasma species in cell cultures by restriction analysis of the 16-23S rRNA intergenic spacer regions. Res Microbiol 1993;144:489-93.
17. Broaddus VC, Yang L, Scavo LM, Ernst JD, Boylan AM. Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species. J Clin Invest 1996;98:2050-9.
18. Marani M, Hancock D, Lopes R, et al. Role of Bim in the survival pathway induced by Raf in epithelial cells. Oncogene 2004;23:2431-41.
19. Roux J, Kawakatsu H, Gartland B, et al. Interleukin-1β decreases expression of the epithelial sodium channel α-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. J Biol Chem 2005;280:18579-89.
20. Liu JW, Chandra D, Rudd MD, et al. Induction of prosurvival molecules by apoptotic stimuli: involvement of FOXO3a and ROS. Oncogene 2005;24:2020-31.
21. Ley R, Balmanno K, Hadfield K, Weston C, Cook SJ. Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. J Biol Chem 2003;278:18811-6.
22. Ley R, Ewings KE, Hadfield K, et al. Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover. J Biol Chem 2004;279:8837-47.
23. Lei K, Davis RJ. JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci U S A 2003;100:2432-7.
24. Shi J, Zheng D, Man K, Fan ST, Xu R. TRAIL: a potential agent for cancer therapy. Curr Mol Med 2003;3:727-36.
25. Ruller S, Stahl C, Kohler G, et al. Sensitization of tumor cells to ribotoxic stress-induced apoptotic cell death: a new therapeutic strategy. Clin Cancer Res 1999;5:2714-25.
26. Kim H, Rafiuddin-Shah M, Tu H-C, et al. Hierarchical regulation of mitochondrion-dependent apoptosis by Bcl-2 subfamilies. Nat Cell Biol 2006;8:1348-58.
27. Adachi M, Zhao X, Imai K. Nomenclature of dynein light chain-linked BH3-only protein Bim isoforms. Cell Death Differ 2005;12:192-3.
28. Puthalakath H, Huang DC, O'Reilly LA, King SM, Strasser A. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol Cell 1999;3:287-96.
29. Reginato MJ, Mills KR, Paulus JK, et al. Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol 2003;5:733-40.
30. Putcha GV, Le S, Frank S, et al. JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron 2003;38:899-914.
31. Tan T-T, Degenhardt K, Nelson DA, et al. Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy. Cancer Cell 2005;7:227-38.
32. Stadheim TA, Kucera GL. c-Jun N-terminal kinase/stress-activated protein kinase is required for mitoxantrone- and anisomycin-induced apoptosis in HL-60 cells. Leuk Res 2002;26:55-65.
33. Harris CA, Johnson EM, Jr. BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons. J Biol Chem 2001;276:37754-60.
34. Ley R, Ewings KE, Hadfield K, Cook SJ. Regulatory phosphorylation of Bim: sorting out the ERK from the JNK. Cell Death Differ 2005;12:1008-14.
35. Luciano F, Jacquel A, Colosetti P, et al. Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. Oncogene 2003;22:6785-93.
36. Sharma SV, Gajowniczek P, Way IP, et al. A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes. Cancer Cell 2006;10:425-35.
37. Robinson BW, Lake RA. Advances in malignant mesothelioma. N Engl J Med 2005;353:1591-603.
38. Ong ST, Vogelzang NJ. Chemotherapy in malignant pleural mesothelioma. A review. J Clin Oncol 1996;14:1007-17.
39. Fennell DA, Rudd RM. Defective core-apoptosis signalling in diffuse malignant pleural mesothelioma: opportunities for effective drug development. Lancet Oncol 2004;5:354-62.
40. Yang CT, You L, Yeh CC, et al. Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells. J Natl Cancer Inst 2000;92:636-41.
41. Ozvaran MK, Cao XX, Miller SD, et al. Antisense oligonucleotides directed at the bcl-xl gene product augment chemotherapy response in mesothelioma. Mol Cancer Ther 2004;3:545-50.
42. Narasimhan SR, Yang L, Gerwin BI, Broaddus VC. Resistance of pleural mesothelioma cell lines to apoptosis: relation to expression of Bcl-2 and Bax. Am J Physiol 1998;275:L165-71.
43. Soini Y, Kinnula V, Kaarteenaho-Wiik R, et al. Apoptosis and expression of apoptosis regulating proteins bcl-2, mcl-1, bcl-X, and bax in malignant mesothelioma. Clin Cancer Res 1999;5:3508-15.
44. Villunger A, Michalak EM, Coultas L, et al. p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 2003;302:1036-8.
45. Wyttenbach A, Tolkovsky AM. The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons. J Neurochem 2006;96:1213-26.