A cyano analogue of boswellic acid induces crosstalk between p53/PUMA/Bax and telomerase that stages the human papillomavirus type 18 positive HeLa cells to apoptotic death

European Journal of Pharmacology

Volumn 660, Issue 2-3, 2011, Pages 241-248

  Khan, Sheema ^a   Chib, Renu ^a   Shah, Bhahwal A ^a   Wani, Z A ^a   Dhar, Niha ^a   Mondhe, Dilip M ^a   Lattoo, Surrinder ^a   Jain, S K ^b   Taneja, Subhash C ^a   Singh, Jaswant ^a  

^a CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

^b HAMDARD UNIVERSITY   (India)

Author keywords

Apoptosis; Cytotoxicity; Human papilloma virus; p53; Telomerase

Indexed keywords

BOSWELLIC ACID; BUTYL 2 CYANO 3,11 DIOXOURS 1,12 DIEN 24 OATE; CASPASE 8; FLUOROURACIL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN DRP 1; PROTEIN E6; PROTEIN KINASE B; PROTEIN P21; PROTEIN P53; PUMA PROTEIN; TELOMERASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GRADING; CANCER REGRESSION; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; EHRLICH ASCITES TUMOR; ENZYME ACTIVATION; HELA CELL; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 18; IN VIVO STUDY; MITOCHONDRION; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; UTERINE CERVIX CANCER; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, EHRLICH TUMOR; CASPASES; CELL PROLIFERATION; CELL SURVIVAL; DNA FRAGMENTATION; DNA-BINDING PROTEINS; ENZYME ACTIVATION; G0 PHASE; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMAN PAPILLOMAVIRUS 18; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; NITRILES; ONCOGENE PROTEINS, VIRAL; POLYCYCLIC COMPOUNDS; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TELOMERASE; TRITERPENES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79956132773     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.03.013     Document Type: Article

References (43)

1. Atadja, P., Wong, H., Garkavtsev, I., Veillette, C., Riabowol, K., 1995. Increased activity of p53 in senescing fibroblasts. Proc. Nat. Acad. Sci. U.S.A. 92, 8348-8352.
2. Baldwin Jr., A.S., 2001. Series introduction: the transcription factor NF-kappaB and human disease. J. Clin. Investig. 107, 3-6.
3. Bodnar, A.G., Ouellette, M., Frolkis, M., Holt, S.E., Chiu, C.P., Morin, G.B., Harley, C.B., Shay, J.W., Lichtsteiner, S., Wright, W.E., 1998. Extension of safe-span by introduction of telomerase into normal human cells. Science 279, 349-352. (Pubitemid 28063364)
4. Bryan, T.M., Englezou, A., Gupta, J., Bacchetti, S., Reddel, R.R., 1995. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 14, 4240-4248.
5. Butz, K., Shahabeddin, L., Geisen, C., Spitkovsky, D., Ullmann, A., Hoppe-Seyler, F., 1995. Functional p53 protein in human papillomavirus-positive cancer cells. Oncogene 10, 927-936.
6. Butz, K., Whitaker, N., Denk, C., Ullmann, A., Geisen, C., Hoppe-Seyler, F., 1999. Induction of the p53-target gene GADD45 in HPV-positive cancer cells. Oncogene 18, 2381-2386. (Pubitemid 29192716)
7. Chipuk, J.E., Kuwana, T., Bouchier-Hayes, L., Droin, N.M., Newmeyer, D.D., Schuler, M., Green, D.R., 2004. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303, 1010-1014. (Pubitemid 38209704)
8. Chipuk, J.E., Bouchier-Hayes, L., Kuwana, T., Newmeyer, D.D., Green, D.R., 2005. PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science 309, 1732-1735. (Pubitemid 41285944)
9. Clarke, A.R., Purdie, C.A., Harrison, D.J., Morris, R.G., Bird, C.C., Hooper, M.L., Wyllie, A.H., 1993. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362, 849-852. (Pubitemid 23132162)
10. Cragg, G.M., Newman, D.J., 2005. Plants as a source of anticancer agents. J. Ethnopharmacol. 100, 72-79.
11. Datta, S.R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., Greenberg, M.E., 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241. (Pubitemid 27456390)
12. Datta, S.R., Brunet, A., Greenberg, M.E., 1999. Cellular survival: a play in three Akts. Genes Dev. 13, 2905-2927.
13. Ding, W.X., Ni, H.M., Chen, X., Yu, J., Zhang, L., Yin, X.M., 2007. A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells. Mol. Cancer Ther. 6, 1062-1069.
14. El-Deiry, W.S., Harper, J.W., O'Connor, P.M., Velculescu, V.E., Canman, C.E., Jackman, J., Pietenpol, J.A., Burrell,M., Hill, D.E., Wang, Y., Wiman, K.G.,Mercer, W.E., Kastan, M.B., Kohn, K.W., Elledge, S.J., Kinzler, K.W., Vogelstein, B., 1994. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 54, 1169-1174. (Pubitemid 24108052)
15. Hanahan, D., Weinberg, R.A., 2000. The hallmarks of cancer. Cell 100, 57-70. (Pubitemid 30046295)
16. Hawley-Nelson, P., Vousden, K.H., Hubbert, N.L., Lowy, D.R., Schiller, J.T., 1989. HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. EMBO J. 8, 3905-3910. (Pubitemid 20016074)
17. Hoernlein, R.F., Orlikowsky, T., Zehrer, C., Niethammer, D., Sailer, E.R., Simmet, T., Dannecker, G.E., Ammon, H.P.T., 1999. Ammon acetyl-11-keto-beta-boswellic acid induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I. J. Pharmacol. Exp. Ther. 288, 613-619.
18. Karin, M., Cao, Y., Greten, F.R., Li, Z.W., 2002. NF-kappaB in cancer: from innocent bystander to major culprit. Nat. Rev. Cancer 2, 301-310.
19. Klingelhutz, A.J., Foster, S.A., McDougall, J.K., 1996. Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature 380, 79-82. (Pubitemid 26076241)
20. Kumar, A., Malik, F., Bhushan, S., Sethi, V.K., Shahi, A.K., kaur, J., Taneja, S.C., Qazi, G.N., Singh, J., 2007. An essential oil and its major constituent isointermedeol induce apoptosis by increased expression of mitochondrial cytochrome c and apical death receptors in human leukaemia HL-60 cells. Chem. Biol. Interact. 171, 332-347.
21. Kuwana, T., Bouchier-Hayes, L., Chipuk, J.E., Bonzon, C., Sullivan, B.A., Green, D.R., Newmeyer, D.D., 2005. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol. Cell 17, 525-535. (Pubitemid 40269117)
22. Li1, H., Ying, C., Berndt, M.C., Funder, J.W., Liu, J.P., 1999. Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro. Oncogene 18, 6785-6794.
23. Malik, F., Kumar, A., Bhushan, S., Khan, S., Bhatia, A., Suri, K.A., Qazi, G.N., Singh, J., 2007. Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic cell death of humanmyeloid leukemia HL-60 cells by a dietary compound with aferin A with concomitant protection by N-acetyl cysteine. Apoptosis 12, 2115-2133. (Pubitemid 47498235)
24. Mans, D.R., Rocha, A.B., Schwartsmann, G., 2005. Plant-based anticancer drug discovery and development. Oncologist 5, 185-198.
25. Marone, M., Mozzetti, S., De Ritis, D., Pierelli1, L., Scambia, G., 2001. Semiquantitative RT-PCR analysis to assess the expression levels of multiple transcripts from the same sample. Biol. Proced. Online 3, 19-25.
26. Mayo, L.D., Donner, D.B., 2001. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc. Natl Acad. Sci. U.S.A. 98, 11598-11603.
27. Ming, L., Wang, P., Bank, A., Yu, J., Zhang, L., 2006. PUMA dissociates Bax and BCL-XL to induce apoptosis in colon cancer cells. J. Biol. Chem. 281, 16034-16042.
28. Mingy, L., Sakaiday, T., Yue, W., Jha, A., Zhang, L., Yu, J., 2008. Sp1 and p73 activate PUMA following serum starvation. Carcinogenesis 29, 1878-1884.
29. Munger, K., Phelps, W.C., Bubb, V., Howley, P.M., Schlegel, R., 1989. The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes. J. Virol. 63, 4417-4421. (Pubitemid 19229441)
30. Niculescu 3rd., A.B., Chen, X., Smeets, M., Hengst, L., Prives, C., Reed, S.I., 1998. Effects of p21 (Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol. Cell. Biol. 18, 629-643.
31. 1 arrest and caspase-dependent apoptosis involving mitochondrial membrane depolarization in MCF-7 and MDA MB-231 human breast cancer cells. Life Sci. 82, 577-590.
32. Ozes, O.N., Mayo, L.D., Gustin, J.A., Pfeffer, S.R., Pfeffer, L.M., Donner, D.B., 1999. NFkappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401, 82-85.
33. Parra, V., Eisner, V., Chiong, M., Criollo, A., Moraga, F., Garcia, A., Härtel, S., Jaimovich, E., Zorzano, A., Hidalgo, C., Lavandero, S., 2008. Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis. Cardiovasc. Res. 77, 387-397.
34. Pim, D., Massimi, P., Banks, L., 1997. Alternatively spliced HPV-18 E6* protein inhibits E6 mediated degradation of p53 and suppresses transformed cell growth. Oncogene 15, 257-264. (Pubitemid 27370872)
35. Sakahira, H., Enari, M., Nagata, S., 1999. Functional differences of two forms of the inhibitor of caspase-activated DNase, ICAD-L, and ICAD-S. J. Biol. Chem. 274, 15740-15744.
36. Scheffner, M., Huibregtse, J.M., Vierstra, R.D., Howley, P.M., 1993. The HPV-16 E6 and E6-AP complex functions as a ubiquitin - protein ligase in the ubiquitination of p53. Cell 75, 495-505. (Pubitemid 23335075)
37. Shah, B.A., Qazi, G.N., Taneja, S.C., 2009. Boswellic acids: a group of medicinally important compounds. Nat. Prod. Rep. 26, 72-89.
38. Vivanco, I., Sawyers, C.L., 2002. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat. Rev. Cancer 2, 489-501.
39. Vogelstein, B., Lane, D., Levine, A.J., 2000. Surfing the p53 network. Nature 408, 307-310.
40. Vousden, K.H., Lu, X., 2002. Live or let die: the cell's response to p53. Nat. Rev. Cancer 2, 594-604.
41. Waldman, T., Lengauer, C., Kinzler, K.W., Vogelstein, B., 1996. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 381, 713-716. (Pubitemid 26196573)
42. Wang, P., Yu, J., Zhang, L., 2007. The nuclear function of p53 is required for PUMA mediated apoptosis induced by DNA damage. Proc. Natl Acad. Sci. U.S.A. 104, 4054-4059.
43. Yu, J., Zhang, L., Hwang, P.M., Kinzler, K.W., Vogelstein, B., 2001. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol. Cell 7, 673-682. (Pubitemid 32706358)