Acetyl-11-keto-β-boswellic acid induces apoptosis in HL-60 and CCRF- CEM cells and inhibits topoisomerase I

Journal of Pharmacology and Experimental Therapeutics

Volumn 288, Issue 2, 1999, Pages 613-619

  Hoernlein, R F ^a   Orlikowsky, Th ^b   Zehrer, C ^b   Niethammer, D ^b   Sailer, E R ^a   Simmet, Th ^c   Dannecker, G E ^b   Ammon, H P T ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL 11 OXO BETA BOSWELLIC ACID; ALPHA AMYRIN; BOSWELLIC ACID; CAMPTOTHECIN; DNA TOPOISOMERASE INHIBITOR; TRITERPENE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CELL STRAIN HL 60; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; APOPTOSIS; ARACHIDONATE 5-LIPOXYGENASE; CELL DIVISION; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA, NEOPLASM; DNA-BINDING PROTEINS; HL-60 CELLS; HUMANS; ISOENZYMES; LEUKEMIA, T-CELL; LIPOXYGENASE INHIBITORS; OLEANOLIC ACID; RATS; RNA, MESSENGER; TRITERPENES; TUMOR CELLS, CULTURED;

EID: 0032989028     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Ammon HP, Mack T, Singh GB and Safayhi H (1991) Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum resin exudate of Boswellia serrata. Planta Med 57:203-207.
2. Anderson KM, Seed T, Plate JM, Jajeh A, Meng J and Harris JE (1995) Selective inhibitors of 5-lipoxygenase reduce CML blast cell proliferation and induce limited differentiation and apoptosis. Leukotr Res 19:789-801.
3. Beck J, Handgretinger R, Dopfer R, Klingebiel T, Niethammer D and Gekeler V (1995) Expression of mdr1 mrp topoisomerase II alpha/beta and cyclin A in primary or relapsed states of acute lymphoblastic leukaemias. Br J Haematol 89:356-363.
4. Boege F, Straub T, Kehr A, Boesenberg C, Christiansen K, Andersen A, Jakob F and Kohrle J (1996) Selected novel flavones inhibit the DNA binding or the DNA religation step of eukaryotic topoisomerase I. J Biol Chem 271:2262-2270.
5. Brungs M, Radmark O, Samuelsson B and Steinhilber D (1994) On the induction of 5-lipoxygenase expression and activity in HL-60 cells: Effects of vitamin D3 retinoic acid and TGF beta. Biochem Biophys Res Commun 205:1572-1580.
6. Cohen JJ, Duke RC, Fadok VA and Sellins KS (1992) Apoptosis and programmed cell death in immunity. Annu Rev Immunol 10:267-293.
7. Ellis RE, Yuan JY and Horvitz HR (1991) Mechanisms and functions of cell death. Annu Rev Cell Biol 7:663-698.
8. Gupta I, Parihar A, Malhotra P, Singh GB, Luettke R, Safayhi H and Ammon HP (1997) Effect of Boswellia serrata gum resin in patients with ulcerative colitis. Eur J Med Res 2:1-7.
9. Jakobsson PJ, Steinhilber D, Odlander B, Radmark O, Claesson HE and Samuelsson B (1992) On the expression and regulation of 5-lipoxygenase in human lymphocytes. Proc Natl Acad Sci USA 89:3521-3525.
10. Kargman S and Rouzer CA (1989) Studies on the regulation biosynthesis and activation of 5-lipoxygenase in differentiated HL-60 cells. J Biol Chem 264:13313-13320.
11. Korsmeyer SJ (1992) Bcl-2 initiates a new category of oncogenes: Regulators of cell death. Blood 80:879-886.
12. Mack TH (1990) Hemmung der Biosynthese der 5-Lipoxygenaseprodukte stimulierter neutrophiler Granulozyten der Ratte durch Extrakte aus dem Harz von Boswellia serrata Roxbund durch Boswelliasäuren. Doctoral thesis, University of Tuebingen.
13. Mahato SB, Nandy AK and Roy G (1992) Triterpenoids. Phytochemistry 31:2199-2149.
14. Martinez D, Lohs K and Janzen J (1989) Weihrauch als Arzneimittel, in Weihrauch und Myrrhe (Martinez D ed), pp 125-140, Wissenschaftliche Verlagsgesellschaft, Stuttgart.
15. Pisha E, Chai H, Lee IS, Chagwedera TE, Farnsworth NR, Cordell GA, Beecher CW, Fong HH, Kinghorn AD and Brown DM (1995) Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nat Med 1:1046-1051.
16. Podack ER and Kupfer A (1991) T-cell effector functions: Mechanisms for delivery of cytotoxicity and help. Annu Rev Cell Biol 7:479-504.
17. Raff MC, Barres BA, Burne JF, Coles HS, Ishizaki Y and Jacobson MD (1993) Programmed cell death and the control of cell survival: Lessons from the nervous system. Science (Wash DC) 262:695-700.
18. Rougier P and Bugat R (1996) CPT-11 in the treatment of colorectal cancer: Clinical efficacy and safety profile. Semin Oncol 23:34-41.
19. Safayhi H, Mack T, Sabieraj J, Anazodo MI, Subramanian LR and Ammon HP (1992) Boswellic acids: Novel specific nonredox inhibitors of 5-lipoxygenase. J Pharmacol Exp Ther 261:1143-1146.
20. Safayhi H, Rall B, Sailer ER and Ammon HP (1997) Inhibition by boswellic acids of human leukocyte elastase. J Pharmacol Exp Ther 281:460-463
21. Sailer ER, Subramanian LR, Rall B, Hoernlein RF, Ammon HP and Safayhi H (1996) Acetyl-11-keto-beta-boswellic acid (AKBA): Structure requirements for binding and 5-lipoxygenase inhibitory activity. Br J Pharmacol 117:615-618.
22. Solary E, Bertrand R and Pommier Y (1994) Apoptosis induced by DNA topoisomerase I and II inhibitors in human leukemic HL-60 cells. Leukemia Lymphoma 15:21-32.
23. Walker NI, Harmon BV, Gobe GC and Kerr JF (1988) Patterns of cell death. Methods Achiev Exp Pathol 13:18-54.
24. Wang LG, Liu XM and Ji XJ (1991) Determination of DNA topoisomerase II activity from L1210 cells: A target for screening antitumor agents. Chung Kuo Yao Li Hsueh Pao 12:108-114.
25. Winterstein A and Stein G (1932) Untersuchungen in der Saponinreihe Zur Kenntnis der Mono-oxy-triterpensäuren. Hoppe-Seyler's Z Physiol Chem 208:9-25.
26. Wyllie AH, Morris RG, Smith AL and Dunlop D (1984) Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis. J Pathol 142:67-77.