Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-xL

Journal of Cellular and Molecular Medicine

Volumn 11, Issue 3, 2007, Pages 509-520

  Reeve, Janice L V ^a   Szegezdi, Eva ^a   Logue, Susan E ^a   Chonghaile, Tríona Ní ^a   O'Brien, Timothy ^a   Ritter, Thomas ^a   Samali, Afshin ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Apoptosis; Gene transfer; Hypoxia anoxia; Mitochondria; SR (function)

Indexed keywords

CASPASE 9; CYTOCHROME C; DEXAMETHASONE; DOXORUBICIN; FAS ANTIGEN; FAS LIGAND; MESSENGER RNA; PROTEIN BCL X;

ADENOVIRUS; ANIMAL; APOPTOSIS; ARTICLE; CELL HYPOXIA; CELL LINE; CYTOLOGY; DRUG EFFECT; ENDOPLASMIC RETICULUM; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HEART MUSCLE CELL; HUMAN; METABOLISM; MITOCHONDRION; PATHOLOGY; RAT;

ADENOVIRIDAE; ANIMALS; ANTIGENS, CD95; APOPTOSIS; BCL-X PROTEIN; CASPASE 9; CELL HYPOXIA; CELL LINE; CYTOCHROMES C; DEXAMETHASONE; DOXORUBICIN; ENDOPLASMIC RETICULUM; FAS LIGAND PROTEIN; GENE EXPRESSION REGULATION; HUMANS; MITOCHONDRIA; MYOCYTES, CARDIAC; RATS; RNA, MESSENGER;

ADENOVIRIDAE;

EID: 34547310495     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2007.00042.x     Document Type: Article

References (31)

1. Reeve JL, Duffy AM, O'Brien T, Samali A. Don't lose heart-therapeutic value of apoptosis prevention in the treatment of cardiovascular disease. J Cell Mol Med. 2005 9 : 609 22.
2. Gill C, Mestril R, Samali A. Losing heart: the role of apoptosis in heart disease-a novel therapeutic target? FASEB J. 2002 16 : 135 46.
3. Logue SE, Gustafsson AB, Samali A, Gottlieb RA. Ischaemia/reperfusion injury at the intersection with cell death. J Mol Cell Cardiol. 2005 38 : 21 33.
4. Fischer U, Janicke RU, Schulze-Osthoff K. Many cuts to ruin: a comprehensive update of caspase substrates. Cell Death Differ. 2003 10 : 76 100.
5. Samali A, Zhivotovsky B, Jones D, Nagata S, Orrenius S. Apoptosis: cell death defined by caspase activation. Cell Death Differ. 1999 6 : 495 6.
6. Muzio M, Stockwell BR, Stennicke HR, Salvesen GS, Dixit VM. An induced proximity model for caspase- 8 activation. J Biol Chem. 1998 273 : 2926 30.
7. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 1997 91 : 479 89.
8. Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell. 1997 90 : 405 13.
9. Kaufman RJ. Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev. 1999 13 : 1211 33.
10. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature. 2000 403 : 98 103.
11. Sugioka R, Shimizu S, Funatsu T, Tamagawa H, Sawa Y, Kawakami T, Tsujimoto Y. BH4-domain peptide from Bcl-xL exerts anti-apoptotic activity in vivo. Oncogene. 2003 22 : 8432 40.
12. Kunisada K, Tone E, Negoro S, Nakaoka Y, Oshima Y, Osugi T, Funamoto M, Izumi M, Fujio Y, Hirota H, Yamauchi-Takihara K. Bcl-xl reduces doxorubicininduced myocardial damage but fails to control cardiac gene downregulation. Cardiovasc Res. 2002 53 : 936 43.
13. Chen Z, Chua CC, Ho YS, Hamdy RC, Chua BH. Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice. Am J Physiol Heart Circ Physiol. 2001 280 : H2313 20.
14. Gewirtz DA. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem Pharmacol. 1999 57 : 727 41.
15. Concannon CG, FitzGerald U, Holmberg CI, Szegezdi E, Sistonen L, Samali A. CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization. Cell Stress Chaperones. 2005 10 : 59 65.
16. Ritter T, Vogt K, Rieck P, Schilling-Schon A, Kolls J, Hartmann C, Volk HD, Pleyer U. Adenovirus-mediated gene transfer of interleukin-4 to corneal endothelial cells and organ cultured corneas leads to high IL-4 expression. Exp Eye Res. 1999 69 : 563 8.
17. Fallaux FJ, Kranenburg O, Cramer SJ, Houweling A, Van Ormondt H, Hoeben RC, Van Der Eb AJ. Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors. Hum Gene Ther. 1996 7 : 215 22.
18. Graham FL, Prevec L. Manipulation of adenovirus vectors. In : Murray EJ, Walker JM, editors. Methods in molecular biology. Gene transfer and expression protocols. Clifton, NJ : Humana Press 1991. 109 27.
19. Szegezdi E, Logue SE, Gorman AM, Samali A. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep. 2006 7 : 880 5.
20. Chen QM, Alexander D, Sun H, Xie L, Lin Y, Terrand J, Morrissy S, Purdom S. Corticosteroids inhibit cell death induced by doxorubicin in cardiomyocytes: induction of antiapoptosis, antioxidant, and detoxification genes. Mol Pharmacol. 2005 67 : 1861 73.
21. Ni Chonghaile T, Concannon CG, Szegezdi E, Gorman AM, Samali A. Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-X(L). Apoptosis. 2006 11 : 1247 55.
22. Arola OJ, Saraste A, Pulkki K, Kallajoki M, Parvinen M, Voipio-Pulkki LM. Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosis. Cancer Res. 2000 60 : 1789 92.
23. O'Mahoney ME, Logue S, Szegezdi E, Stenson-Cox C, Fitzgerald U, Samali A. Hypoxia and ischaemia induce nuclear condensation and caspase activation in cardiomyocytes. Ann N Y Acad Sci. 2003 1010 : 728 32.
24. Szegezdi E, Duffy A, O'Mahoney ME, Logue SE, Mylotte LA, O'Brien T, Samali A. ER stress contributes to ischaemia-induced cardiomyocyte apoptosis. Biochem Biophys Res Commun. 2006 349 : 1406 11.
25. Wu S, Ko YS, Teng MS, Ko YL, Hsu LA, Hsueh C, Chou YY, Liew CC, Lee YS. Adriamycin-induced cardiomyocyte and endothelial cell apoptosis: in vitro and in vivo studies. J Mol Cell Cardiol. 2002 34 : 1595 607.
26. Tanaka M, Ito H, Adachi S, Akimoto H, Nishikawa T, Kasajima T, Marumo F, Hiroe M. Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes. Circ Res. 1994 75 : 426 33.
27. Yaniv G, Shilkrut M, Lotan R, Berke G, Larisch S, Binah O. Hypoxia predisposes neonatal rat ventricular myocytes to apoptosis induced by activation of the Fas (CD95/Apo-1) receptor: Fas activation and apoptosis in hypoxic myocytes. Cardiovasc Res. 2002 54 : 611 23.
28. Nitobe J, Yamaguchi S, Okuyama M, Nozaki N, Sata M, Miyamoto T, Takeishi Y, Kubota I, Tomoike H. Reactive oxygen species regulate FLICE inhibitory protein (FLIP) and susceptibility to Fas-mediated apoptosis in cardiac myocytes. Cardiovasc Res. 2003 57 : 119 28.
29. Yamaoka M, Yamaguchi S, Suzuki T, Okuyama M, Nitobe J, Nakamura N, Mitsui Y, Tomoike H. Apoptosis in rat cardiac myocytes induced by Fas ligand: priming for Fas-mediated apoptosis with doxorubicin. J Mol Cell Cardiol. 2000 32 : 881 9.
30. Di Sano F, Ferraro E, Tufi R, Achsel T, Piacentini M, Cecconi F. Endoplasmic reticulum stress induces apoptosis by an apoptosome-dependent but caspase 12-independent mechanism. J Biol Chem. 2006 281 : 2693 700.
31. Spallarossa P, Garibaldi S, Altieri P, Fabbi P, Manca V, Nasti S, Rossettin P, Ghigliotti G, Ballestrero A, Patrone F, Barsotti A, Brunelli C. Carvedilol prevents doxorubicin-induced free radical release and apoptosis in cardiomyocytes in vitro. J Mol Cell Cardiol. 2004 37 : 837 46.