Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms: Intermediacy of H2O2- and p53-dependent pathways

Journal of Biological Chemistry

Volumn 279, Issue 24, 2004, Pages 25535-25543

  Wang, Suwei ^a   Konorev, Eugene A ^a   Kotamraju, Srigiridhar ^a   Joseph, Joy ^a   Kalivendi, Shasi ^a   Kalyanaraman, B ^a,b  

^a FREE RADICAL RESEARCH CENTER   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CELLS; DNA; DRUG PRODUCTS; TOXIC MATERIALS; TUMORS;

FRAGMENTATION; SPECIES;

PROTEINS;

DNA FRAGMENT; DOXORUBICIN; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; METALLOPORPHYRIN; PIFITHRIN ALPHA; PROTEIN INHIBITOR; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL; CANCER PATIENT; CARDIOMYOPATHY; CARDIOTOXICITY; CELL STRAIN MCF 7; CONTROLLED STUDY; DETOXIFICATION; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVATION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; RAT; TERATOCARCINOMA; TRANSCRIPTION INITIATION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIOXIDANTS; APOPTOSIS; CASPASE 3; CASPASES; CATTLE; CELLS, CULTURED; DOXORUBICIN; ENZYME ACTIVATION; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; MALE; METALLOPORPHYRINS; RATS; RATS, SPRAGUE-DAWLEY; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; BOVINAE; MINK CELL FOCUS-FORMING VIRUS;

EID: 2942616456     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400944200     Document Type: Article

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