Abnormal Error-Related Antisaccade Activation in Premanifest and Early Manifest Huntington Disease

Neuropsychology

Volumn 25, Issue 3, 2011, Pages 306-318

  Rupp, Jason ^a   Dzemidzic, Mario ^a,b   Blekher, Tanya ^a   Bragulat, Veronique ^a   West, John ^a,c   Jackson, Jacqueline ^a   Hui, Siu ^d   Wojcieszek, Joanne ^a   Saykin, Andrew J ^a,c   Kareken, David ^a,b   Foroud, Tatiana ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Division of Imaging Sciences ^*  (United Kingdom)

^c Division of Imaging Sciences   (United Kingdom)

^d REGENSTRIEF INSTITUTE   (United States)

Author keywords

Error monitoring; Functional MRI; Huntington's disease; Premanifest; Saccades

Indexed keywords

ADULT; ANTERIOR CINGULATE; ARTICLE; BLOOD OXYGENATION; CAG REPEAT; CLINICAL ARTICLE; CONTROLLED STUDY; EYE MOVEMENT; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HUNTINGTON CHOREA; MALE; NEUROPSYCHOLOGICAL TEST; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; SACCADIC EYE MOVEMENT; TASK PERFORMANCE;

ADOLESCENT; ADULT; AGE FACTORS; AGED; BRAIN; FEMALE; GYRUS CINGULI; HUMANS; HUNTINGTON DISEASE; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MOTOR CORTEX; NEUROPSYCHOLOGICAL TESTS; RISK FACTORS; SACCADES; TRINUCLEOTIDE REPEAT EXPANSION; YOUNG ADULT;

EID: 79955749487     PISSN: 08944105     EISSN: 19311559     Source Type: Journal    
DOI: 10.1037/a0021873     Document Type: Article

References (118)

1. Ali F.R., Michell A.W., Barker R.A., Carpenter R.H. The use of quantitative oculometry in the assessment of Huntington's disease. Experimental Brain Research 2006, 169:237-245.
2. Amador N., Schlag-Rey M., Schlag J. Primate antisaccade. II. Supplementary eye field neuronal activity predicts correct performance. Journal of Neurophysiology 2004, 91:1672-1689.
3. Anderson E.J., Husain M., Sumner P. Human intraparietal sulcus (IPS) and competition between exogenous and endogenous saccade plans. Neuroimage 2008, 40:838-851.
4. Antoniades C.A., Altham P.M., Mason S.L., Barker R.A., Carpenter R. Saccadometry: A new tool for evaluating presymptomatic Huntington patients. Neuroreport 2007, 18:1133-1136.
5. Aylward E.H., Brandt J., Codori A.M., Mangus R.S., Barta P.E., Harris G.J. Reduced basal ganglia volume associated with the gene for Huntington's disease in asymptomatic at-risk persons. Neurology 1994, 44:823-828.
6. Aylward E.H., Codori A.M., Barta P.E., Pearlson G.D., Harris G.J., Brandt J. Basal ganglia volume and proximity to onset in presymptomatic Huntington disease. Archives of Neurology 1996, 53:1293-1296.
7. Becker W., Jurgens R., Kassubek J., Ecker D., Kramer B., Landwehrmeyer B. Eye-head coordination in moderately affected Huntington's Disease patients: Do head movements facilitate gaze shifts?. Experimental Brain Research 2009, 192:97-112.
8. Beckmann M., Johansen-Berg H., Rushworth M.F. Connectivity-based parcellation of human cingulate cortex and its relation to functional specialization. The Journal of Neuroscience 2009, 29:1175-1190.
9. Berridge K.C. The debate over dopamine's role in reward: The case for incentive salience. Psychopharmacology 2007, 191:391-431.
10. Beste C., Saft C., Andrich J., Gold R., Falkenstein M. Error processing in Huntington's disease. PLoS One 2006, 1:e86.
11. Blekher T., Johnson S.A., Marshall J., White K., Hui S., Weaver M., Foroud T. Saccades in presymptomatic and early stages of Huntington disease. Neurology 2006, 67:394-399.
12. Blekher T., Weaver M., Rupp J., Nichols W.C., Hui S.L., Gray J., Foroud T. Multiple step pattern as a biomarker in Parkinson disease. Parkinsonism and Related Disorders 2009, 15:506-510.
13. Blekher T.M., Yee R.D., Kirkwood S.C., Hake A.M., Stout J.C., Weaver M.R., Foroud T. Oculomotor control in asymptomatic and recently diagnosed individuals with the genetic marker for Huntington's disease. Vision Research 2004, 44:2729-2736.
14. Bond C.E., Hodes M.E. Direct amplification of the CAG repeat of huntingtin without amplification of CCG. Clinical Chemistry 1996, 42:773-774.
15. Brandt J., Bylsma F.W., Aylward E.H., Rothlind J., Gow C.A. Impaired source memory in Huntington's disease and its relation to basal ganglia atrophy. Journal of Clinical and Experimental Neuropsychology 1995, 17:868-877.
16. Braver T.S., Barch D.M., Gray J.R., Molfese D.L., Snyder A. Anterior cingulate cortex and response conflict: Effects of frequency, inhibition and errors. Cerebral Cortex 2001, 11:825-836.
17. Brown M.R., Goltz H.C., Vilis T., Ford K.A., Everling S. Inhibition and generation of saccades: Rapid event-related fMRI of prosaccades, antisaccades, and nogo trials. Neuroimage 2006, 33:644-659.
18. Brown M.R., Vilis T., Everling S. Frontoparietal activation with preparation for antisaccades. Journal of Neurophysiology 2007, 98:1751-1762.
19. Campodonico J.R., Aylward E., Codori A.M., Young C., Krafft L., Magdalinski M., Brandt J. When does Huntington's disease begin?. Journal of the International Neuropsychological Society 1998, 4:467-473.
20. Carter C.S., Braver T.S., Barch D.M., Botvinick M.M., Noll D., Cohen J.D. Anterior cingulate cortex, error detection, and the online monitoring of performance. Science 1998, 280:747-749.
21. Clark V.P., Lai S., Deckel A.W. Altered functional MRI responses in Huntington's disease. Neuroreport 2002, 13:703-706.
22. Cummings J.L. Behavioral and psychiatric symptoms associated with Huntington's disease. Advances in Neurology 1995, 65:179-186.
23. Delis D.C., Kramer J.H., Kaplan E., Ober B.A. The California Verbal Learning Test 1987, The Psychological Corporation, New York, NY.
24. De Marchi N., Mennella R. Huntington's disease and its association with psychopathology. Harvard Review of Psychiatry 2000, 7:278-289.
25. DeSouza J.F., Menon R.S., Everling S. Preparatory set associated with pro-saccades and anti-saccades in humans investigated with event-related FMRI. Journal of Neurophysiology 2003, 89:1016-1023.
26. Diamond R., White R.F., Myers R.H., Mastromauro C., Koroshetz W.J., Butters N., Vasterling J. Evidence of presymptomatic cognitive decline in Huntington's disease. Journal of Clinical and Experimental Neuropsychology 1992, 14:961-975.
27. Dierks T., Linden D.E., Hertel A., Gunther T., Lanfermann H., Niesen A., Maurer K. Multimodal imaging of residual function and compensatory resource allocation in cortical atrophy: A case study of parietal lobe function in a patient with Huntington's disease. Psychiatry Research 1999, 90:67-75.
28. Doricchi F., Perani D., Incoccia C., Grassi F., Cappa S.F., Bettinardi V., Fazio F. Neural control of fast-regular saccades and antisaccades: An investigation using positron emission tomography. Experimental Brain Research 1997, 116:50-62.
29. Duff K., Paulsen J.S., Beglinger L.J., Langbehn D.R., Stout J.C. Psychiatric symptoms in Huntington's disease before diagnosis: The predict-HD study. Biological Psychiatry 2007, 62:1341-1346.
30. Dyckman K.A., Camchong J., Clementz B.A., McDowell J.E. An effect of context on saccade-related behavior and brain activity. Neuroimage 2007, 36:774-784.
31. Ettinger U., Ffytche D.H., Kumari V., Kathmann N., Reuter B., Zelaya F., Williams S.C. Decomposing the neural correlates of antisaccade eye movements using event-related FMRI. Cerebral Cortex 2008, 18:1148-1159.
32. Fiorillo C.D., Tobler P.N., Schultz W. Discrete coding of reward probability and uncertainty by dopamine neurons. Science 2003, 299:1898-1902.
33. Fischl B., Salat D.H., Busa E., Albert M., Dieterich M., Haselgrove C., Dale A.M. Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain. Neuron 2002, 33:341-355.
34. Ford K.A., Goltz H.C., Brown M.R., Everling S. Neural processes associated with antisaccade task performance investigated with event-related FMRI. Journal of Neurophysiology 2005, 94:429-440.
35. Foroud T., Siemers E., Kleindorfer D., Bill D.J., Hodes M.E., Norton J.A., Christian J.C. Cognitive scores in carriers of Huntington's disease gene compared to noncarriers. Annals of Neurology 1995, 37:657-664.
36. Friston K.J., Josephs O., Zarahn E., Holmes A.P., Rouquette S., Poline J. To smooth or not to smooth? Bias and efficiency in fMRI time-series analysis. Neuroimage 2000, 12:196-208.
37. Garavan H., Ross T.J., Murphy K., Roche R.A., Stein E.A. Dissociable executive functions in the dynamic control of behavior: Inhibition, error detection, and correction. Neuroimage 2002, 17:1820-1829.
38. Gaymard B., Ploner C.J., Rivaud S., Vermersch A.I., Pierrot-Deseilligny C. Cortical control of saccades. Experimental Brain Research 1998, 123:159-163.
39. Georgiou-Karistianis N., Sritharan A., Farrow M., Cunnington R., Stout J., Bradshaw J., Egan G. Increased cortical recruitment in Huntington's disease using a Simon task. Neuropsychologia 2007, 45:1791-1800.
40. Golding C.V., Danchaivijitr C., Hodgson T.L., Tabrizi S.J., Kennard C. Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology 2006, 67:485-487.
41. Hahn-Barma V., Deweer B., Durr A., Dode C., Feingold J., Pillon B., Dubois B. Are cognitive changes the first symptoms of Huntington's disease? A study of gene carriers. Journal of Neurology, Neurosurgery, and Psychiatry 1998, 64:172-177.
42. Harris G.J., Codori A.M., Lewis R.F., Schmidt E., Bedi A., Brandt J. Reduced basal ganglia blood flow and volume in pre-symptomatic, gene-tested persons at-risk for Huntington's disease. Brain 1999, 122:1667-1678.
43. Harris G.J., Pearlson G.D., Peyser C.E., Aylward E.H., Roberts J., Barta P.E., Folstein S.E. Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntington's disease. Annals of. Neurology 1992, 31:69-75.
44. Hennenlotter A., Schroeder U., Erhard P., Haslinger B., Stahl R., Weindl A., Ceballos-Baumann A.O. Neural correlates associated with impaired disgust processing in pre-symptomatic Huntington's disease. Brain 2004, 127:1446-1453.
45. Hester R., Fassbender C., Garavan H. Individual differences in error processing: A review and reanalysis of three event-related fMRI studies using the GO/NOGO task. Cerebral Cortex 2004, 14:986-994.
46. Hicks S.L., Robert M.P., Golding C.V., Tabrizi S.J., Kennard C. Oculomotor deficits indicate the progression of Huntington's disease. Progress in Brain Research 2008, 171:555-558.
47. Hochschild R. The H-scan: An instrument for the automatic measurement of physiological markers of aging. Intervention in the Aging Process, Part A: Quantitation, Epidemiology and Clinical Research 1983, 113-125. Alan R. Liss, New York, NY. W. Regelson, F.M. Sinex (Eds.).
48. Hodgson T., Chamberlain M., Parris B., James M., Gutowski N., Husain M., Kennard C. The role of the ventrolateral frontal cortex in inhibitory oculomotor control. Brain 2007, 130:1525-1537.
49. Hofmann N. Understanding the neuropsychiatric symptoms of Huntington's disease. The Journal of Neuroscience Nursing 1999, 31:309-313.
50. Holroyd C.B., Coles M.G. The neural basis of human error processing: Reinforcement learning, dopamine, and the error-related negativity. Psychological Review 2002, 109:679-709.
51. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993, 72:971-983. Huntington's Disease Collaborative Research Group.
52. Unified Huntington's Disease Rating Scale-99 1999, Huntington Study Group, Huntington Study Group, Rochester, NY.
53. Husain M., Parton A., Hodgson T.L., Mort D., Rees G. Self-control during response conflict by human supplementary eye field. Nature Neuroscience 2003, 6:117-118.
54. Hutton S.B. Cognitive control of saccadic eye movements. Brain and Cognition 2008, 68:327-340.
55. Jack C.R., Bernstein M.A., Fox N.C., Thompson P., Alexander G., Harvey D., Weiner M.W. The Alzheimer's Disease Neuroimaging Initiative (ADNI): MRI methods. Journal of Magnetic Resonance Imaging 2008, 27:685-691.
56. Kiehl K.A., Liddle P.F., Hopfinger J.B. Error processing and the rostral anterior cingulate: An event-related fMRI study. Psychophysiology 2000, 37:216-223.
57. Kim J.S., Reading S.A., Brashers-Krug T., Calhoun V.D., Ross C.A., Pearlson G.D. Functional MRI study of a serial reaction time task in Huntington's disease. Psychiatry Research 2004, 131:23-30.
58. Kirkwood S.C., Siemers E., Bond C., Conneally P.M., Christian J.C., Foroud T. Confirmation of subtle motor changes among presymptomatic carriers of the Huntington disease gene. Archives of Neurology 2000, 57:1040-1044.
59. Kirkwood S.C., Siemers E., Hodes M.E., Conneally P.M., Christian J.C., Foroud T. Subtle changes among presymptomatic carriers of the Huntington's disease gene. Journal of Neurology, Neurosurgery, and Psychiatry 2000, 69:773-779.
60. Kirkwood S.C., Siemers E., Viken R., Hodes M.E., Conneally P.M., Christian J.C., Foroud T. Longitudinal personality changes among presymptomatic Huntington disease gene carriers. Neuropsychiatry, Neuropsychology, and Behavioral Neurology 2002, 15:192-197.
61. Kloppel S., Draganski B., Siebner H.R., Tabrizi S.J., Weiller C., Frackowiak R.S. Functional compensation of motor function in pre-symptomatic Huntington's disease. Brain 2009, 132:1624-1632.
62. Langbehn D.R., Brinkman R.R., Falush D., Paulsen J.S., Hayden M.R. A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length. Clinical Genetics 2004, 65:267-277.
63. Lasker A.G., Zee D.S. Ocular motor abnormalities in Huntington's disease. Vision Research 1997, 37:3639-3645.
64. Lawrence A.D., Hodges J.R., Rosser A.E., Kershaw A., Ffrench-Constant C., Rubinsztein D.C. Evidence for specific cognitive deficits in preclinical Huntington's disease. Brain 1998, 121:1329-1341. Evidence for specific cognitive deficits in preclinical Huntington's disease.
65. Leigh R.J., Newman S.A., Folstein S.E., Lasker A.G., Jensen B.A. Abnormal ocular motor control in Huntington's disease. Neurology 1983, 33:1268-1275.
66. MacDonald A.W., Cohen J.D., Stenger V.A., Carter C.S. Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. Science 2000, 288:1835-1838.
67. Matsuda T., Matsuura M., Ohkubo T., Ohkubo H., Matsushima E., Inoue K., Kojima T. Functional MRI mapping of brain activation during visually guided saccades and antisaccades: Cortical and subcortical networks. Psychiatry Research 2004, 131:147-155.
68. McDowell J.E., Brown G.G., Paulus M., Martinez A., Stewart S.E., Dubowitz D.J., Braff D.L. Neural correlates of refixation saccades and antisaccades in normal and schizophrenia subjects. Biological Psychiatry 2002, 51:216-223.
69. McDowell J.E., Dyckman K.A., Austin B.P., Clementz B.A. Neurophysiology and neuroanatomy of reflexive and volitional saccades: Evidence from studies of humans. Brain and Cognition 2008, 68:255-270.
70. McDowell J.E., Kissler J.M., Berg P., Dyckman K.A., Gao Y., Rockstroh B., Clementz B.A. Electroencephalography/magnetoencephalography study of cortical activities preceding prosaccades and antisaccades. Neuroreport 2005, 16:663-668.
71. Menon V., Adleman N.E., White C.D., Glover G.H., Reiss A.L. Error-related brain activation during a Go/NoGo response inhibition task. Human Brain Mapping 2001, 12:131-143.
72. Milea D., Lobel E., Lehericy S., Pierrot-Deseilligny C., Berthoz A. Cortical mechanisms of saccade generation from execution to decision. Annals of the New York Academy of Sciences 2005, 1039:232-238.
73. Miller E.K., Cohen J.D. An integrative theory of prefrontal cortex function. Annual Review of Neuroscience 2001, 24:167-202.
74. Morris M. Dementia and cognitive changes in Huntington's disease. Advances in Neurology 1995, 65:187-200.
75. Muri R.M., Heid O., Nirkko A.C., Ozdoba C., Felblinger J., Schroth G., Hess C.W. Functional organisation of saccades and antisaccades in the frontal lobe in humans: A study with echo planar functional magnetic resonance imaging. Journal of Neurology, Neurosurgery, and Psychiatry 1998, 65:374-377.
76. Nachev P., Rees G., Parton A., Kennard C., Husain M. Volition and conflict in human medial frontal cortex. Current Biology 2005, 15:122-128.
77. Parton A., Nachev P., Hodgson T.L., Mort D., Thomas D., Ordidge R., Husain M. Role of the human supplementary eye field in the control of saccadic eye movements. Neuropsychologia 2007, 45:997-1008.
78. Paulsen J.S., Hayden M., Stout J.C., Langbehn D.R., Aylward E., Ross C.A. Preparing for preventive clinical trials: The Predict-HD study. Archives of Neurology 2006, 63:883-890. Predict-HD Investigators of the Huntington Study Group.
79. Paulsen J.S., Magnotta V.A., Mikos A.E., Paulson H.L., Penziner E., Andreasen N.C., Nopoulos P.C. Brain structure in preclinical Huntington's disease. Biological Psychiatry 2006, 59:57-63.
80. Paulsen J.S., Ready R.E., Hamilton J.M., Mega M.S., Cummings J.L. Neuropsychiatric aspects of Huntington's disease. Journal of Neurology, Neurosurgery, and Psychiatry 2001, 71:310-314.
81. Paulsen J.S., Zimbelman J.L., Hinton S.C., Langbehn D.R., Leveroni C.L., Benjamin M.L., Rao S.M. fMRI biomarker of early neuronal dysfunction in presymptomatic Huntington's Disease. American Journal of Neuroradiology 2004, 25:1715-1721.
82. Peltsch A., Hoffman A., Armstrong I., Pari G., Munoz D.P. Saccadic impairments in Huntington's disease. Experimental Brain Research 2008, 186:457-469.
83. Penney J.B., Young A.B., Shoulson I., Starosta-Rubenstein S., Snodgrass S.R., Sanchez-Ramos J., Wexler N.S. Huntington's disease in Venezuela: 7 years of follow-up on symptomatic and asymptomatic individuals. Movement Disorders 1990, 5:93-99.
84. Picard N., Strick P.L. Imaging the premotor areas. Current Opinion in Neurobiology 2001, 11:663-672.
85. Pierrot-Deseilligny C., Muri R.M., Ploner C.J., Gaymard B., Demeret S., Rivaud-Pechoux S. Decisional role of the dorsolateral prefrontal cortex in ocular motor behaviour. Brain 2003, 126:1460-1473.
86. Pierrot-Deseilligny C., Rivaud S., Gaymard B., Agid Y. Cortical control of reflexive visually-guided saccades. Brain 1991, 114:1473-1485.
87. Pierrot-Deseilligny C., Rivaud-Pechoux S. Contribution of oculomotor examination for the etiological diagnosis of parkinsonian syndromes. Revue Neurologique 2003, 159:75-81.
88. Polli F.E., Barton J.J., Cain M.S., Thakkar K.N., Rauch S.L., Manoach D.S. Rostral and dorsal anterior cingulate cortex make dissociable contributions during antisaccade error commission. Proceedings of the National Academy of Sciences USA 2005, 102:15700-15705.
89. Polli F.E., Barton J.J., Thakkar K.N., Greve D.N., Goff D.C., Rauch S.L. Reduced error-related activation in two anterior cingulate circuits is related to impaired performance in schizophrenia. Brain 2008, 131:971-986.
90. Reading S.A., Dziorny A.C., Peroutka L.A., Schreiber M., Gourley L.M., Yallapragada V., Ross C.A. Functional brain changes in presymptomatic Huntington's disease. Annals of Neurology 2004, 55:879-883.
91. Reitan R.M. Validity of the Trail Making Test as an indicator of organic brain damage. Perceptual & Motor Skills 1958, 8:271-276.
92. Rosas H.D., Goodman J., Chen Y.I., Jenkins B.G., Kennedy D.N., Makris N., Koroshetz W.J. Striatal volume loss in HD as measured by MRI and the influence of CAG repeat. Neurology 2001, 57:1025-1028.
93. Rosenberg N.K., Sorensen S.A., Christensen A.L. Neuropsychological characteristics of Huntington's disease carriers: A double blind study. Journal of Medical Genetics 1995, 32:600-604.
94. Rubia K., Smith A.B., Brammer M.J., Taylor E. Right inferior prefrontal cortex mediates response inhibition while mesial prefrontal cortex is responsible for error detection. Neuroimage 2003, 20:351-358.
95. Rupp J., Blekher T.M., Jackson J.G., Beristain X., Marshall J., Hui S.L., Foroud T. Progression in prediagnostic Huntington disease. Journal of Neurology, Neurosurgery & Psychiatry 2010, 81:379-384.
96. Saft C., Schuttke A., Beste C., Andrich J., Heindel W., Pfleiderer B. fMRI reveals altered auditory processing in manifest and premanifest Huntington's disease. Neuropsychologia 2008, 46:1279-1289.
97. Schall J.D., Boucher L. Executive control of gaze by the frontal lobes. Cognitive, Affective, and Behavioral Neuroscience 2007, 7:396-412.
98. Schlag-Rey M., Amador N., Sanchez H., Schlag J. Antisaccade performance predicted by neuronal activity in the supplementary eye field. Nature 1997, 390:398-401.
99. Schultz W. Behavioral theories and the neurophysiology of reward. Annual Review of Psychology 2006, 57:87-115.
100. Schultz W., Dayan P., Montague P.R. A neural substrate of prediction and reward. Science 1997, 275:1593-1599.
101. Siemers E., Foroud T., Bill D.J., Sorbel J., Norton J.A., Hodes M.E., Christian J.C. Motor changes in presymptomatic Huntington disease gene carriers. Archives of Neurology 1996, 53:487-492.
102. Smith A. Symbol-Digit Modalities Test (SDMT) manual 1982, Western Psychological Services, Los Angeles, CA.
103. Stout J.C., Weaver M., Solomon A.C., Queller S., Hui S., Johnson S.A., Foroud T. Are cognitive changes progressive in prediagnostic HD?. Cognitive & Behavioral Neurology 2007, 20:212-218.
104. Stroop J.R. Studies of interference in serial verbal reactions. Journal of Experimental Psychology 1935, 18:643-662.
105. Sweeney J.A., Mintun M.A., Kwee S., Wiseman M.B., Brown D.L., Rosenberg D.R., Carl J.R. Positron emission tomography study of voluntary saccadic eye movements and spatial working memory. Journal of Neurophysiology 1996, 75:454-468.
106. Thakkar K.N., Polli F.E., Joseph R.M., Tuch D.S., Hadjikhani N., Barton J.J., Manoach D.S. Response monitoring, repetitive behaviour and anterior cingulate abnormalities in autism spectrum disorders (ASD). Brain 2008, 131:2464-2478.
107. Thiruvady D.R., Georgiou-Karistianis N., Egan G.F., Ray S., Sritharan A., Farrow M., Cunnington R. Functional connectivity of the prefrontal cortex in Huntington's disease. Journal of Neurology, Neurosurgery, and Psychiatry 2007, 78:127-133.
108. Ullsperger M., von Cramon D.Y. Subprocesses of performance monitoring: A dissociation of error processing and response competition revealed by event-related fMRI and ERPs. Neuroimage 2001, 14:1387-1401.
109. Ullsperger M., von Cramon D.Y. Error monitoring using external feedback: Specific roles of the habenular complex, the reward system, and the cingulate motor area revealed by functional magnetic resonance imaging. The Journal of Neuroscience 2003, 23:4308-4314.
110. Vecsei L., Beal M.F. Huntington's disease, behavioral disturbances, and kynurenines: Preclinical findings and therapeutic perspectives. Biological Psychiatry 1996, 39:1061-1063.
111. Wechsler D. Wechsler Adult Intelligence Scale-Revised 1981, The Psychological Corporation, New York, NY.
112. Wechsler D. Wechsler Adult Intelligence Scale-Third Edition 1997, The Psychological Corporation, San Antonio TX.
113. Witjes-Ane M.N., Mertens B., van Vugt J.P., Bachoud-Levi A.C., van Ommen G.J., Roos R.A. Longitudinal evaluation of "presymptomatic" carriers of Huntington's disease. The Journal of Neuropsychiatry and Clinical Neurosciences 2007, 19:310-317.
114. Wolf R.C., Sambataro F., Vasic N., Schonfeldt-Lecuona C., Ecker D., Landwehrmeyer B. Altered frontostriatal coupling in pre-manifest Huntington's disease: Effects of increasing cognitive load. European Journal of Neurology 2008, 15:1180-1190.
115. Wolf R.C., Sambataro F., Vasic N., Schonfeldt-Lecuona C., Ecker D., Landwehrmeyer B. Aberrant connectivity of lateral prefrontal networks in presymptomatic Huntington's disease. Experimental Neurology 2008, 213:137-144.
116. Wolf R.C., Vasic N., Schonfeldt-Lecuona C., Landwehrmeyer G.B., Ecker D. Dorsolateral prefrontal cortex dysfunction in presymptomatic Huntington's disease: Evidence from event-related fMRI. Brain 2007, 130:2845-2857.
117. Yohrling G.J., Jiang G.C., DeJohn M.M., Miller D.W., Young A.B., Vrana K.E., Cha J.H. Analysis of cellular, transgenic and human models of Huntington's disease reveals tyrosine hydroxylase alterations and substantia nigra neuropathology. Brain Research. Molecular Brain Research 2003, 119:28-36.
118. Zimbelman J.L., Paulsen J.S., Mikos A., Reynolds N.C., Hoffmann R.G., Rao S.M. fMRI detection of early neural dysfunction in preclinical Huntington's disease. Journal of the International Neuropsychological Society 2007, 13:758-769.