Oculomotor deficits indicate the progression of Huntington's Disease

Progress in Brain Research

Volumn 171, Issue , 2008, Pages 555-558

  Hicks, Stephen L ^a   P A Robert, Matthieu ^a,b   V P Golding, Charlotte ^a   Tabrizi, Sarah J ^b   Kennard, Christopher ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

Author keywords

biomarker; Huntington's Disease; preclinical; saccades; switch cost

Indexed keywords

CLINICAL ARTICLE; COGNITION; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE COURSE; EYE MOVEMENT DISORDER; HETEROZYGOTE; HUMAN; HUNTINGTON CHOREA; NERVE CELL DEGENERATION; NEUROPATHOLOGY; PRIORITY JOURNAL; REVIEW; SACCADIC EYE MOVEMENT; STIMULUS RESPONSE; STRIATE CORTEX; TASK PERFORMANCE;

EID: 49349101320     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6123(08)00678-X     Document Type: Chapter

References (7)

1. Ali F.R., Michell A.W., Barker R.A., and Carpenter R.H.S. The use of quantitative oculometry in the assessment of Huntington's disease. Exp. Brain Res. 169 2 (2006) 237-245
2. Aron A.R., Watkins L., Sahakian B.J., Monsell S., Barker R.A., and Robbins T.W. Task-set switching deficits in early-stage Huntington's disease: implications for basal ganglia function. J. Cogn. Neurosci. 15 5 (2003) 629-642
3. Blekher T., Johnson S.A., Marshall J., White K., Hui S., Weaver M., Gray J., Yee R., Stout J.C., and Beristain X. Saccades in presymptomatic and early stages of Huntington disease. Neurology 67 3 (2006) 394
4. Carpenter R.H., and Williams M.L. Neural computation of log likelihood in control of saccadic eye movements. Nature 377 6544 (1995) 59-62
5. Golding C.V.P., Danchaivijitr C., Hodgson T.L., Tabrizi S.J., and Kennard C. Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology 67 3 (2006) 485
6. Langbehn D.R., Brinkman R.R., Falush D., Paulsen J.S., and Hayden M.R. A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length. Clin. Genet. 65 4 (2004) 267-277
7. The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72 6 (1993) 971-983