Functional compensation of motor function in pre-symptomatic Huntingtons disease

Brain

Volumn 132, Issue 6, 2009, Pages 1624-1632

  Klppel, Stefan ^a,b,f   Draganski, Bogdan ^b   Siebner, Hartwig R ^c   Tabrizi, Sarah J ^b   Weiller, Cornelius ^a   Frackowiak, Richard S J ^b,d,e  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c HVIDOVRE HOSPITAL   (Denmark)

^d LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^e IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^f Department of Psychiatry und Psychotherapy ^*  (Germany)

Author keywords

FMRI; Motor control; Pre symptomatic Huntingtons disease

Indexed keywords

ADULT; ANALYTICAL ERROR; ARTICLE; BRAIN REGION; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HAND MOVEMENT; HETEROZYGOTE; HUMAN; HUNTINGTON CHOREA; IMAGE ANALYSIS; MALE; MOTOR CONTROL; MOTOR PERFORMANCE; PARIETAL LOBE; PRIORITY JOURNAL; TASK PERFORMANCE; BRAIN MAPPING; COMPUTER ASSISTED DIAGNOSIS; FINGER; METHODOLOGY; MIDDLE AGED; MOTOR CORTEX; NERVE CELL PLASTICITY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; PSYCHOMOTOR PERFORMANCE;

ADULT; BRAIN MAPPING; FEMALE; FINGERS; HETEROZYGOTE; HUMANS; HUNTINGTON DISEASE; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MOTOR CORTEX; NEURONAL PLASTICITY; PARIETAL LOBE; PSYCHOMOTOR PERFORMANCE; YOUNG ADULT;

EID: 67649403555     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awp081     Document Type: Article

References (32)

1. Bartenstein P, Weindl A, Spiegel S, Boecker H, Wenzel R, Ceballos-Baumann AO, et al. Central motor processing in Huntington's disease. A PET study. Brain 1997; 120 (Pt 9): 1553-67.
2. Boecker H, Ceballos-Baumann A, Bartenstein P, Weindl A, Siebner HR, Fassbender T, et al. Sensory processing in Parkinson's and Huntington's disease: investigations with 3D H(2)(15)O-PET. Brain 1999; 122 (Pt 9): 1651-65.
3. Buhmann C, Binkofski F, Klein C, Buchel C, van Eimeren T, Erdmann C, et al. Motor reorganization in asymptomatic carriers of a single mutant Parkin allele: a human model for presymptomatic parkinsonism. Brain 2005; 128: 2281-90.
4. Campodonico JR, Codori AM, Brandt J. Neuropsychological stability over two years in asymptomatic carriers of the Huntington's disease mutation. J Neurol Neurosurg Psychiatry 1996; 61: 621-4.
5. Carbon M, Ghilardi MF, Argyelan M, Dhawan V, Bressman SB, Eidelberg D. Increased cerebellar activation during sequence learning in DYT1 carriers: an equiperformance study. Brain 2008; 131: 146-54.
6. Ciarmiello A, Cannella M, Lastoria S, Simonelli M, Frati L, Rubinsztein DC, et al. Brain white-matter volume loss and glucose hypometabolism precede the clinical symptoms of Huntington's disease. J Nucl Med 2006; 47: 215-22.
7. Deichmann R, Schwarzbauer C, Turner R. Optimisation of the 3D MDEFT sequence for anatomical brain imaging: technical implications at 1.5 and 3 T. Neuroimage 2004; 21: 757-67.
8. Eickhoff SB, Stephan KE, Mohlberg H, Grefkes C, Fink GR, Amunts K, et al. A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data. Neuroimage 2005; 25: 1325-35.
9. Farrow M, Chua P, Churchyard A, Bradshaw JL, Chiu E, Georgiou-Karistianis N. Proximity to clinical onset influences motor and cognitive performance in presymptomatic Huntington disease gene carriers. Cogn Behav Neurol 2006; 19: 208-16.
10. Feigin A, Ghilardi MF, Huang C, Ma Y, Carbon M, Guttman M, et al. Preclinical Huntington's disease: compensatory brain responses during learning. Ann Neurol 2006; 59: 53-9.
11. Feigin A, Tang C, Ma Y, Mattis P, Zgaljardic D, Guttman M, et al. Thalamic metabolism and symptom onset in preclinical Huntington's disease. Brain 2007; 130: 2858-67.
12. Friston KJ, Frith CD, Turner R, Frackowiak RS. Characterizing evoked hemodynamics with fMRI. Neuroimage 1995; 2: 157-65.
13. Gavazzi C, Nave RD, Petralli R, Rocca MA, Guerrini L, Tessa C, et al. Combining functional and structural brain magnetic resonance imaging in Huntington disease. J Comput Assist Tomogr 2007; 31: 574-80.
14. Ghilardi MF, Carbon M, Silvestri G, Dhawan V, Tagliati M, Bressman S, et al. Impaired sequence learning in carriers of the DYT1 dystonia mutation. Ann Neurol 2003; 54: 102-9.
15. Giordani B, Berent S, Boivin MJ, Penney JB, Lehtinen S, Markel DS, et al. Longitudinal neuropsychological and genetic linkage analysis of persons at risk for Huntington's disease. Arch Neurol 1995; 52: 59-64.
16. HD Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group. Cell 1993; 72: 971-83.
17. Hinton SC, Paulsen JS, Hoffmann RG, Reynolds NC, Zimbelman JL, Rao SM. Motor timing variability increases in preclinical Huntington's disease patients as estimated onset of motor symptoms approaches. J Int Neuropsychol Soc 2007; 13: 539-43.
18. Johansen-Berg H, Behrens TE, Robson MD, Drobnjak I, Rushworth MF, Brady JM, et al. Changes in connectivity profiles define functionally distinct regions in human medial frontal cortex. Proc Natl Acad Sci USA 2004; 101: 13335-40.
19. Klöppel S, Draganski B, Golding CV, Chu C, Nagy Z, Cook PA, et al. White matter connections reflect changes in voluntary-guided saccades in pre-symptomatic Huntington's disease. Brain 2008; 131: 196-204.
20. Langbehn DR, Brinkman RR, Falush D, Paulsen JS, Hayden MR. A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length. Clin Genet 2004; 65: 267-77.
21. Lee L, Siebner HR, Rowe JB, Rizzo V, Rothwell JC, Frackowiak RS, et al. Acute remapping within the motor system induced by low-frequency repetitive transcranial magnetic stimulation. J Neurosci 2003; 23: 5308-18.
22. Lehericy S, Bardinet E, Tremblay L, Van de Moortele PF, Pochon JB, Dormont D, et al. Motor control in basal ganglia circuits using fMRI and brain atlas approaches. Cereb Cortex 2006; 16: 149-61.
23. Muhlau M, Gaser C, Wohlschlager AM, Weindl A, Stadtler M, Valet M, et al. Striatal gray matter loss in Huntington's disease is leftward biased. Mov Disord 2007; 22: 1169-73.
24. Picard N, Strick PL. Imaging the premotor areas. Curr Opin Neurobiol 2001; 11: 663-72.
25. Rosas HD, Hevelone ND, Zaleta AK, Greve DN, Salat DH, Fischl B. Regional cortical thinning in preclinical Huntington disease and its relationship to cognition. Neurology 2005; 65: 745-7.
26. Rosas HD, Tuch DS, Hevelone ND, Zaleta AK, Vangel M, Hersch SM, et al. Diffusion tensor imaging in presymptomatic and early Huntington's disease: selective white matter pathology and its relationship to clinical measures. Mov Disord 2006; 21: 1317-25.
27. Rushworth MF, Ellison A, Walsh V. Complementary localization and lateralization of orienting and motor attention. Nat Neurosci 2001; 4: 656-61.
28. Thieben MJ, Duggins AJ, Good CD, Gomes L, Mahant N, Richards F, et al. The distribution of structural neuropathology in pre-clinical Huntington's disease. Brain 2002; 125: 1815-28.
29. van Nuenen BFL, Weiss MM, Bloem BR, Reetz K, van Eimeren T, Lohmann K, et al. Heterozygous carriers of a Parkin or PINK1 mutation share a common functional endophenotype. Neurology 2009; 72: 1041-47.
30. Walker FO. Huntington's disease. Lancet 2007; 369: 218-28.
31. Weeks RA, Ceballos-Baumann A, Piccini P, Boecker H, Harding AE, Brooks DJ. Cortical control of movement in Huntington's disease. A PET activation study. Brain 1997; 120 (Pt 9): 1569-78.
32. Wolf RC, Vasic N, Schonfeldt-Lecuona C, Landwehrmeyer GB, Ecker D. Dorsolateral prefrontal cortex dysfunction in presymptomatic Huntington's disease: evidence from event-related fMRI. Brain 2007; 130: 2845-57.