메뉴 건너뛰기




Volumn 140, Issue 9, 2010, Pages 1615-1620

The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and women

Author keywords

[No Author keywords available]

Indexed keywords

AURANTIIN; CELLULOSE; CHOLESTEROL; HESPERIDIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; TRIACYLGLYCEROL;

EID: 77956582061     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.110.124735     Document Type: Article
Times cited : (110)

References (42)
  • 1
    • 34247468812 scopus 로고    scopus 로고
    • Citrus flavonoids: Molecular structure, biological activity and nutritional properties: A review
    • Tripoli E, La Guardia M, Giammanco S, Di Majo D, Giammanco M. Citrus flavonoids: molecular structure, biological activity and nutritional properties: a review. Food Chem. 2007;104:466-79.
    • (2007) Food Chem , vol.104 , pp. 466-479
    • Tripoli, E.1    La Guardia, M.2    Giammanco, S.3    Di Majo, D.4    Giammanco, M.5
  • 2
    • 0023548365 scopus 로고
    • Hydrolysis of dietary flavonoid glycosides by strains of intestinal bacteroides from humans
    • Bokkenheuser VD, Shackleton CH, Winter J. Hydrolysis of dietary flavonoid glycosides by strains of intestinal bacteroides from humans. Biochem J. 1987;248:953-6.
    • (1987) Biochem J , vol.248 , pp. 953-956
    • Bokkenheuser, V.D.1    Shackleton, C.H.2    Winter, J.3
  • 3
    • 4544360864 scopus 로고    scopus 로고
    • Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits
    • Jeon SM, Park YB, Choi MS. Antihypercholesterolemic property of naringin alters plasma and tissue lipids, cholesterol-regulating enzymes, fecal sterol and tissue morphology in rabbits. Clin Nutr. 2004;23: 1025-34.
    • (2004) Clin Nutr , vol.23 , pp. 1025-1034
    • Jeon, S.M.1    Park, Y.B.2    Choi, M.S.3
  • 5
    • 33845709998 scopus 로고    scopus 로고
    • Hypocholesterolemic and antioxidative effects of naringenin and its two metabolites in high-cholesterol fed rats
    • Jeon SM, Kim HK, Kim HJ, Do GM, Jeong TS, Park YB, Choi MS. Hypocholesterolemic and antioxidative effects of naringenin and its two metabolites in high-cholesterol fed rats. Transl Res. 2007;149:15-21.
    • (2007) Transl Res , vol.149 , pp. 15-21
    • Jeon, S.M.1    Kim, H.K.2    Kim, H.J.3    Do, G.M.4    Jeong, T.S.5    Park, Y.B.6    Choi, M.S.7
  • 7
    • 23944489850 scopus 로고    scopus 로고
    • Red Star Ruby (Sunrise) and blond qualities of Jaffa grapefruits and their influence on plasma lipid levels and plasma antioxidant activity in rats fed with cholesterol-containing and cholesterol-free diets
    • Gorinstein S, Leontowicz H, Leontowicz M, Drzewiecki J, Jastrzebski Z, Tapia MS, Katrich E, Trakhtenberg S. Red Star Ruby (Sunrise) and blond qualities of Jaffa grapefruits and their influence on plasma lipid levels and plasma antioxidant activity in rats fed with cholesterol-containing and cholesterol-free diets. Life Sci. 2005;77:2384-97.
    • (2005) Life Sci , vol.77 , pp. 2384-2397
    • Gorinstein, S.1    Leontowicz, H.2    Leontowicz, M.3    Drzewiecki, J.4    Jastrzebski, Z.5    Tapia, M.S.6    Katrich, E.7    Trakhtenberg, S.8
  • 9
    • 0033181104 scopus 로고    scopus 로고
    • Hypocholesterolemic effect of hesperetin mediated by inhibition of 3-hydroxy-3-methylgultaryl coenzyme a reductase and acyl coenzyme a: Cholesterol acyltransferase in rats fed high-cholesterol diet
    • Lee SH, Jeong TS, Park YB, Kwon YK, Choi MS, Bok SH. Hypocholesterolemic effect of hesperetin mediated by inhibition of 3-hydroxy-3-methylgultaryl coenzyme a reductase and acyl coenzyme a: cholesterol acyltransferase in rats fed high-cholesterol diet. Nutr Res. 1999;19:1245-58.
    • (1999) Nutr Res , vol.19 , pp. 1245-1258
    • Lee, S.H.1    Jeong, T.S.2    Park, Y.B.3    Kwon, Y.K.4    Choi, M.S.5    Bok, S.H.6
  • 10
    • 0033008969 scopus 로고    scopus 로고
    • Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy- 3-methyl-glutaryl-CoA reductase and acyl CoA: Cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids
    • Bok SH, Lee SH, Park YB, Bae KH, Son KH, Jeong TS, Choi MS. Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy- 3-methyl-glutaryl-CoA reductase and acyl CoA: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids. J Nutr. 1999;129:1182-5.
    • (1999) J Nutr , vol.129 , pp. 1182-1185
    • Bok, S.H.1    Lee, S.H.2    Park, Y.B.3    Bae, K.H.4    Son, K.H.5    Jeong, T.S.6    Choi, M.S.7
  • 11
    • 2442613051 scopus 로고    scopus 로고
    • Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia
    • Kurowska EM, Manthey JA. Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia. J Agric Food Chem. 2004;52:2879-86.
    • (2004) J Agric Food Chem , vol.52 , pp. 2879-2886
    • Kurowska, E.M.1    Manthey, J.A.2
  • 12
    • 33645892889 scopus 로고    scopus 로고
    • Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice
    • Jung UJ, Lee MK, Park YB, Kang MA, Choi MS. Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. Int J Biochem Cell Biol. 2006;38:1134-45.
    • (2006) Int J Biochem Cell Biol , vol.38 , pp. 1134-1145
    • Jung, U.J.1    Lee, M.K.2    Park, Y.B.3    Kang, M.A.4    Choi, M.S.5
  • 13
    • 33645985463 scopus 로고    scopus 로고
    • Activity and mRNA levels of enzymes involved in hepatic fatty acid oxidation in mice fed citrus flavonoids
    • Huong DT, Takahashi Y, Ide T. Activity and mRNA levels of enzymes involved in hepatic fatty acid oxidation in mice fed citrus flavonoids. Nutrition. 2006;22:546-52.
    • (2006) Nutrition , vol.22 , pp. 546-552
    • Huong, D.T.1    Takahashi, Y.2    Ide, T.3
  • 15
    • 0034813893 scopus 로고    scopus 로고
    • Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits
    • Lee CH, Jeong TS, Choi YK, Hyun BH, Oh GT, Kim EH, Kim JR, Han JI, Bok SH. Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits. Biochem Biophys Res Commun. 2001;284:681-8.
    • (2001) Biochem Biophys Res Commun , vol.284 , pp. 681-688
    • Lee, C.H.1    Jeong, T.S.2    Choi, Y.K.3    Hyun, B.H.4    Oh, G.T.5    Kim, E.H.6    Kim, J.R.7    Han, J.I.8    Bok, S.H.9
  • 16
    • 0034989204 scopus 로고    scopus 로고
    • Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP
    • Wilcox LJ, Borradaile NM, de Dreu LE, Huff MW. Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J Lipid Res. 2001;42:725-34.
    • (2001) J Lipid Res , vol.42 , pp. 725-734
    • Wilcox, L.J.1    Borradaile, N.M.2    De Dreu, L.E.3    Huff, M.W.4
  • 17
    • 0033043969 scopus 로고    scopus 로고
    • Regulation of HepG2 cell apolipoprotein B metabolism by the citrus flavanones hesperetin and naringenin
    • Borradaile NM, Carroll KK, Kurowska EM. Regulation of HepG2 cell apolipoprotein B metabolism by the citrus flavanones hesperetin and naringenin. Lipids. 1999;34:591-8.
    • (1999) Lipids , vol.34 , pp. 591-598
    • Borradaile, N.M.1    Carroll, K.K.2    Kurowska, E.M.3
  • 18
    • 46249094192 scopus 로고    scopus 로고
    • The citrus flavonoids hesperetin and nobiletin differentially regulate low density lipoprotein receptor gene transcription in HepG2 liver cells
    • Morin B, Nichols LA, Zalasky KM, Davis JW, Manthey JA, Holland LJ. The citrus flavonoids hesperetin and nobiletin differentially regulate low density lipoprotein receptor gene transcription in HepG2 liver cells. J Nutr. 2008;138:1274-81. (Pubitemid 351930989)
    • (2008) Journal of Nutrition , vol.138 , Issue.7 , pp. 1274-1281
    • Morin, B.1    Nichols, L.A.2    Zalasky, K.M.3    Davis, J.W.4    Manthey, J.A.5    Holland, L.J.6
  • 19
    • 33645453199 scopus 로고    scopus 로고
    • Red grapefruit positively influences serum triglyceride level in patients suffering from coronary atherosclerosis: Studies in vitro and in humans
    • Gorinstein S, Caspi A, Libman I, Lerner HT, Huang D, Leontowicz H, Leontowicz M, Tashma Z, Katrich E, et al. Red grapefruit positively influences serum triglyceride level in patients suffering from coronary atherosclerosis: studies in vitro and in humans. J Agric Food Chem. 2006;54:1887-92.
    • (2006) J Agric Food Chem , vol.54 , pp. 1887-1892
    • Gorinstein, S.1    Caspi, A.2    Libman, I.3    Lerner, H.T.4    Huang, D.5    Leontowicz, H.6    Leontowicz, M.7    Tashma, Z.8    Katrich, E.9
  • 20
    • 2942604944 scopus 로고    scopus 로고
    • Preventive effects of diets supplemented with sweetie fruits in hypercholesterolemic patients suffering from coronary artery disease
    • DOI 10.1016/j.ypmed.2003.12.021, PII S0091743504000106
    • Gorinstein S, Caspi A, Libman I, Katrich E, Lerner HT, Trakhtenberg S. Preventive effects of diets supplemented with Sweetie fruits in hypercholesterolemic patients suffering from coronary artery disease. Prev Med. 2004;38:841-7. (Pubitemid 38757536)
    • (2004) Preventive Medicine , vol.38 , Issue.6 , pp. 841-847
    • Gorinstein, S.1    Caspi, A.2    Libman, I.3    Katrich, E.4    Lerner, H.T.5    Trakhtenberg, S.6
  • 21
    • 3843080892 scopus 로고    scopus 로고
    • Fresh Israeli Jaffa Sweetie juice consumption improves lipid metabolism and increases antioxidant capacity in hypercholesterolemic patients suffering from coronary artery disease: Studies in vitro and in humans and positive changes in albumin and fibrinogen fractions
    • Gorinstein S, Caspi A, Libman I, Katrich E, Lerner HT, Trakhtenberg S. Fresh Israeli Jaffa Sweetie juice consumption improves lipid metabolism and increases antioxidant capacity in hypercholesterolemic patients suffering from coronary artery disease: studies in vitro and in humans and positive changes in albumin and fibrinogen fractions. J Agric Food Chem. 2004;52:5215-22.
    • (2004) J Agric Food Chem , vol.52 , pp. 5215-5222
    • Gorinstein, S.1    Caspi, A.2    Libman, I.3    Katrich, E.4    Lerner, H.T.5    Trakhtenberg, S.6
  • 23
    • 0029044344 scopus 로고
    • Dietary supplementation with orange and carrot juice in cigarette smokers lowers oxidation products in copper-oxidized low density lipoproteins
    • Abbey M, Noakes M, Nestel PJ. Dietary supplementation with orange and carrot juice in cigarette smokers lowers oxidation products in copper-oxidized low density lipoproteins. J Am Diet Assoc. 1995;95:671-5.
    • (1995) J Am Diet Assoc , vol.95 , pp. 671-675
    • Abbey, M.1    Noakes, M.2    Nestel, P.J.3
  • 24
    • 22244485668 scopus 로고    scopus 로고
    • Bioavailability and antioxidant effects of orange juice components in humans
    • Franke AA, Cooney RV, Henning SM, Custer LJ. Bioavailability and antioxidant effects of orange juice components in humans. J Agric Food Chem. 2005;53:5170-8.
    • (2005) J Agric Food Chem , vol.53 , pp. 5170-5178
    • Franke, A.A.1    Cooney, R.V.2    Henning, S.M.3    Custer, L.J.4
  • 25
    • 0345256647 scopus 로고    scopus 로고
    • Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects
    • Jung UJ, Kim HJ, Lee JS, Lee MK, Kim HO, Park EJ, Kim HK, Jeong TS, Choi MS. Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects. Clin Nutr. 2003;22:561-8.
    • (2003) Clin Nutr , vol.22 , pp. 561-568
    • Jung, U.J.1    Kim, H.J.2    Lee, J.S.3    Lee, M.K.4    Kim, H.O.5    Park, E.J.6    Kim, H.K.7    Jeong, T.S.8    Choi, M.S.9
  • 28
    • 34247184192 scopus 로고    scopus 로고
    • Grapefruit juice, a glass full of drug interactions?
    • Kirby BJ, Unadkat JD. Grapefruit juice, a glass full of drug interactions? Clin Pharmacol Ther. 2007;81:631-3.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 631-633
    • Kirby, B.J.1    Unadkat, J.D.2
  • 30
    • 0033839411 scopus 로고    scopus 로고
    • Effect of grapefruit juice dose on grapefruit juice-triazolam interaction: Repeated consumption prolongs triazolam halflife
    • Lilja JJ, Kivisto KT, Backman JT, Neuvonen PJ. Effect of grapefruit juice dose on grapefruit juice-triazolam interaction: repeated consumption prolongs triazolam halflife. Eur J Clin Pharmacol. 2000;56:411-5.
    • (2000) Eur J Clin Pharmacol , vol.56 , pp. 411-415
    • Lilja, J.J.1    Kivisto, K.T.2    Backman, J.T.3    Neuvonen, P.J.4
  • 32
    • 0003447646 scopus 로고    scopus 로고
    • National Center for Health Statistics [Internet] [Cited 2007 June 2]. Available from
    • National Center for Health Statistics. National Health and Nutrition Examination Survey: 2001-2002 [Internet] [Cited 2007 June 2]. Available from: http://www.cdc.gov/nchs/nhanes/nhanes01-02.htm.
    • National Health and Nutrition Examination Survey: 2001-2002
  • 33
    • 0037126526 scopus 로고    scopus 로고
    • Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report
    • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002;106:3143-421.
    • (2002) Circulation , vol.106 , pp. 3143-3421
  • 34
    • 0030898403 scopus 로고    scopus 로고
    • Design criteria for studies examining individual fatty acid effects on cardiovascular disease risk factors: Human and animal studies
    • Kris-Etherton PM, Dietschy J. Design criteria for studies examining individual fatty acid effects on cardiovascular disease risk factors: human and animal studies. Am J Clin Nutr. 1997;65 Suppl:S1590-6.
    • (1997) Am J Clin Nutr , vol.65 , Issue.SUPPL.
    • Kris-Etherton, P.M.1    Dietschy, J.2
  • 35
    • 0031745196 scopus 로고    scopus 로고
    • Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects
    • Weststrate JA, Meijer GW. Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr. 1998;52:334-43.
    • (1998) Eur J Clin Nutr , vol.52 , pp. 334-343
    • Weststrate, J.A.1    Meijer, G.W.2
  • 36
    • 51749101039 scopus 로고    scopus 로고
    • Lipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (SINETROL) in human body fat adipocytes. Mechanism of action by inhibition of cAMP-phosphodiesterase (PDE)
    • Dallas C, Gerbi A, Tenca G, Juchaux F, Bernard FX. Lipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (SINETROL) in human body fat adipocytes. Mechanism of action by inhibition of cAMP-phosphodiesterase (PDE). Phytomedicine. 2008; 15:783-92.
    • (2008) Phytomedicine , vol.15 , pp. 783-792
    • Dallas, C.1    Gerbi, A.2    Tenca, G.3    Juchaux, F.4    Bernard, F.X.5
  • 37
    • 0037327340 scopus 로고    scopus 로고
    • Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice
    • Manach C, Morand C, Gil-Izquierdo A, Bouteloup-Demange C, Rémésy C. Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice. Eur J Clin Nutr. 2003;57:235-42.
    • (2003) Eur J Clin Nutr , vol.57 , pp. 235-242
    • Manach, C.1    Morand, C.2    Gil-Izquierdo, A.3    Bouteloup-Demange, C.4    Rémésy, C.5
  • 38
    • 0028973416 scopus 로고
    • The fate of naringin in humans: A key to grapefruit juice-drug interactions?
    • Fuhr U, Kummert AL. The fate of naringin in humans: a key to grapefruit juice-drug interactions? Clin Pharmacol Ther. 1995;58:365-73.
    • (1995) Clin Pharmacol Ther , vol.58 , pp. 365-373
    • Fuhr, U.1    Kummert, A.L.2
  • 39
    • 58949100907 scopus 로고    scopus 로고
    • Bioavailability and metabolism of orange juice flavanones in humans: Impact of a full-fat yogurt
    • Mullen W, Archeveque MA, Edwards CA, Matsumoto H, Crozier A. Bioavailability and metabolism of orange juice flavanones in humans: impact of a full-fat yogurt. J Agric Food Chem. 2008;56:11157-64.
    • (2008) J Agric Food Chem , vol.56 , pp. 11157-11164
    • Mullen, W.1    Archeveque, M.A.2    Edwards, C.A.3    Matsumoto, H.4    Crozier, A.5
  • 40
    • 0035150315 scopus 로고    scopus 로고
    • Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice
    • Erlund I, Meririnne E, Alfthan G, Aro A. Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice. J Nutr. 2001;131:235-41.
    • (2001) J Nutr , vol.131 , pp. 235-241
    • Erlund, I.1    Meririnne, E.2    Alfthan, G.3    Aro, A.4
  • 41
    • 34247212317 scopus 로고    scopus 로고
    • Pharmacokinetics of the citrus flavanone aglucones hesperetin and naringenin after single oral administration in human subjects
    • Kanaze FI, Bounartzi MI, Georgarakis M, Niopas I. Pharmacokinetics of the citrus flavanone aglucones hesperetin and naringenin after single oral administration in human subjects. Eur J Clin Nutr. 2007;61:472-7.
    • (2007) Eur J Clin Nutr , vol.61 , pp. 472-477
    • Kanaze, F.I.1    Bounartzi, M.I.2    Georgarakis, M.3    Niopas, I.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.