Leptin in immuno-rheumatological diseases

Cellular and Molecular Immunology

Volumn 8, Issue 3, 2011, Pages 203-212

  Vadacca, Marta ^a   Margiotta, Domenico P E ^a   Navarini, Luca ^a   Afeltra, Antonella ^a  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

Author keywords

adipokines; autoimmune diseases; leptin; rheumatic diseases

Indexed keywords

LEPTIN; LEPTIN RECEPTOR;

ADAPTIVE IMMUNITY; HUMAN; IMMUNOLOGICAL TOLERANCE; INNATE IMMUNITY; MULTIPLE SCLEROSIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; RHEUMATIC DISEASE; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS;

CYTOKINES; HUMANS; IMMUNE SYSTEM DISEASES; IMMUNOMODULATION; INFLAMMATION MEDIATORS; LEPTIN; RHEUMATOLOGY; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 79955643523     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2010.75     Document Type: Review

References (93)

1. Kennedy GC. Theroleof depotfat inthehypothalamiccontrol offood intake intherat. Proc R Soc Lond B Biol Sci 1953; 140: 578-596.
2. Ingalls AM, Dickie MM, Snell GD. Obese, a newmutation inthehousemouse. JHered 1950; 41: 317-318.
3. Coleman DL. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 1973; 9: 294-298.
4. Ahima RS, Qi Y, Singhal NS, Jackson MB, Scherer PE. Brainadipocytokineactionand metabolic regulation. Diabetes 2006; 55: 145-154.
5. Lago F, Dieguez C, Gomez-Reino J, Gualillo O. The emerging role of adipokines as mediatorsof inflammation and immuneresponse. Cytokine Growth Factor Rev 2007; 18: 313-325. (Pubitemid 46891288)
6. Fantuzzi G. Adiposetissue, adipokines, and inflammation. J Allergy Clin Immunol 2005; 115: 911-919.
7. Rosen BS, Cook KS, Yaglom J, Groves DL, Volanakis JE, Damm D et al. Adipsin and complement factor D activity: an immune-related defect in obesity. Science 1989; 244: 1483.
8. Hotamisligil GS, Shargill NS, Spiegelman BM. Adiposeexpression oftumor necrosis factor-alpha: direct role inobesity-linked insulin resistance. Science 1993; 259: 87.
9. Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H et al. Recentadvances in the relationship between obesity, inflammation and insulin resistance. Eur Cytokine Netw 2006; 17: 4-12.
10. Fantuzzi G, Sennello JA, Batra A, Fedke I, Lehr AH, Zeitz M et al. Definingtheroleof T cellderived leptin inthemodulationof hepaticor intestinal inflammation inmice. Clin Exp Immunol 2005; 142: 31-38.
11. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM et al. Positional cloningof themouseobesegeneand its human homologue. Nature 1994; 372: 425-432. (Pubitemid 24365442)
12. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouseOB protein: evidenceforaperipheralsignal linkingadiposityandcentral neural networks. Science 1995; 269: 546-549.
13. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269:543-546.
14. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T et al. Effectsof theobesegeneproduct on body weight regulation inob/ob mice. Science 1995; 269: 540-543.
15. Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Cheetham CH et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 2002; 110: 1093-1103. (Pubitemid 35215890)
16. Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T cell immune response and reverses starvation-induced immunosuppression. Nature 1998; 394: 897-901. (Pubitemid 28410912)
17. Baumann H, Morella KK, White DW, Dembski M, Bailon PS, Kim H et al. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 1996; 93: 8374-8378. (Pubitemid 26269565)
18. Lam QLK, Lu L. Roleof Leptin in Immunity. Cell Mol Immunol 2007; 4: 2-13.
19. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR et al. Serum immune-reactine leptin concentrations in normal weight and obese humans. N Engl J Med 1996; 334: 292.
20. Flier JS. Obesity wars: molecular progress confronts an expanding epidemic. Cell 2004; 116: 337-350. (Pubitemid 38167322)
21. Chan JL, Matarese G, Shetty GK, Raciti P, Kelesidis I, Aufiero D et al. Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans. Proc Natl Acad Sci USA 2006; 103: 8481-8486. (Pubitemid 43838481)
22. Bluher S, Mantsoros CS. Leptin in humans: lessonsfromtranslational research. Am J Clin Nutr 2009; 89: 991S-997S.
23. Bodosi B, Gardi J, Hajdu I, Szentirmai E, Obal F Jr, Krueger JM. Rhythmsof ghrelin, leptin, and sleep in rats: effects of the normal diurnal cycle, restricted feeding, and sleep deprivation. Am J Physiol Regul Integr Comp Physiol 2004; 287: R1071-R1079. (Pubitemid 39391051)
24. Stofkova A. Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity. Endocrine Regul 2009; 43: 157-168.
25. La Cava A, Matarese G. The weight of leptin in immunity. Nat Rev Immunol 2004; 4: 371-379. (Pubitemid 38649279)
26. Lee KN, Jeong IC, Lee SJ, Oh SH, Cho MY. Regulation of leptin gene expression by insulinandgrowth hormone in mouseadipocytes. Exp Mol Med 2001; 33: 234-239. (Pubitemid 34534282)
27. Blum WF, Englaro P, Hanitsch S, Juul A, Hertel NT, Muller J et al. Plasma leptin levels in healthychildren and adolescents: dependenceon body mass index, body fat mass, gender, pubertal stage, and testosterone. Clin Endocrinol Metab 1997; 82: 2904-2910. (Pubitemid 27385646)
28. Sarraf P, Frederich RC, Turner EM, Ma G, Jaskowiak NT, Rivet DJ 3rd et al. Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatoryanorexia. J Exp Med 1997; 185: 171-175. (Pubitemid 27039451)
29. Yarasheski KE, Zachwieja JJ, Horgan MM, Powderly WG, Santiago JV, Landt M. Serum leptin concentrations in human immunodeficiency virus-infected men with low adiposity. Metabolism 1997; 46: 303-305. (Pubitemid 27106789)
30. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995; 83: 1263-1271. (Pubitemid 26007816)
31. Friedman JM. Obesity: causes and control of excess body fat. Nature 2009; 459: 340-342.
32. Gamba M, Pralong FP. Control of GnRH neuronal activity by metabolic factors: therole of leptin and insulin. Mol Cell Endocrinol 2006; 133: 254-255.
33. Guzik TJ, Mangalat D, Korbut R. Adipocytokines. A novel linkbetween inflammation and vascular function? J Physiol Pharmacology 2006; 57: 505-528 (Pubitemid 46096102)
34. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature 2000; 404: 661-671. (Pubitemid 30205071)
35. Bennett BD, Solar GP, Yuan JQ, Mathias J, Thomas GR, Matthews W. Arolefor leptin and its cognate receptor in hematopoiesis. Curr Biol 1996; 6: 1170-1180. (Pubitemid 26368751)
36. Fernandez-Riejos P, Najib S, Santos-Alvarez J, Martin-Romero C, Perez-Perez A, Gonzalez-Yanes C et al. Role of leptin in the activation of immune cells. Mediators Inflamm 2010; 2010: 568343.
37. Lam QL, Liu S, Cao X, Lu L. Involvement of leptin signaling in the survival and maturation of bone marrow-derived dendritic cells. Eur J Immunol 2006; 36: 3118-3130. (Pubitemid 44932714)
38. Mattioli B, Straface E, Quaranta MG, Giordani L, Viora M. Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming. J Immunol 2005; 174: 6820-6828. (Pubitemid 40705645)
39. Zhao Y, Sun R, You L, Gao C, Tian Z. Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines. Biochem Biophys Res Commun 2003;300: 247-252. (Pubitemid 38375801)
40. Papathanassoglou E, El-Haschimi K, Li XC, Matarese G, Strom T, Mantzoros C. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J Immunol 2006; 176: 7745-7752. (Pubitemid 43849075)
41. Sanchez-Margalet V, Martin-Romero C, Gonzalez-Yanes C, Goberna R, Rodriguez-Bano J, Muniain MA. Leptin receptor (Ob-R) expression is induced in peripheral blood mononuclear cells by in vitro activation and in vivo in HIV-infected patients. Clin Exp Immunol 2002; 129: 119-124.
42. Madej T, Boguski MS, Bryant SH. Threading analysis suggests that the obese gene product may bea helical cytokine. FEBS Letters 1995; 373: 13-18.
43. Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T cell immune response and reverses starvation-induced immunosuppression. Nature 1998; 394: 897-901. (Pubitemid 28410912)
44. Matarese G, Moschos S, Mantzoros CS. Leptin in immunology. J Immunol 2005; 173: 3137-3142. (Pubitemid 40354011)
45. Sanchez-Margalet V, Martin-Romero C. Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway. Cell Immunol 2001; 211: 30-36. (Pubitemid 32917755)
46. Belouzard S, Rouille Y. Ubiquitylation of leptin receptorOB-Ra regulates its clathrin-mediated endocytosis. EMBO J2006; 25: 932-942. (Pubitemid 43372108)
47. Murakami T, Yamashita T, Iida M, Kuwajima M, Shima K. A short form of leptin receptor performs signal transduction. Biochem Biophys Res Commun 1997; 231: 26-29. (Pubitemid 27212103)
48. Hekerman P, Zeidler J, Bamberg-Lemper S, Knobelspies H, Lavens D, Tavernier J et al. Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellulartyrosines. FEBSJ2005; 272: 109-119. (Pubitemid 40083071)
49. Papathanassoglou E, El-Haschimi K, Li XC, Matarese G, Strom T, Mantzoros C. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J Immunol 2006; 176: 7745-7752. (Pubitemid 43849075)
50. Mansour E, Pereira FG, Araujo EP, Amaral ME, Morari J, Ferraroni NR et al. Leptin inhibits apoptosis in thymus through a janus kinase-2-independent, insulin receptor substrate-1/phosphatidylinositol-3 kinase-dependent pathway. Endocrinology 2006; 147: 5470-5479. (Pubitemid 44790601)
51. Tian Z, Sun R, Wei H, Gao B. Impairednatural killer (NK)cellactivityin leptinreceptor deficient mice: leptin as a critical regulator in NK cell development and activation. Biochem Biophys Res Commun 2002; 298: 297.
52. Montecucco F, Bianchi G, Gnerre P, Bertolotto M, Dallegri F, Ottonello L. Induction of neutrophilchemotaxisby leptin: crucial roleforp38andSrckinases. Ann NY Acad Sci 2006; 1069: 463-471. (Pubitemid 43989890)
53. Matarese G, Carrieri PB, LaCava A, Perna F, Sanna V, de Rosa V et al. Leptin increase in multiplesclerosis associateswith reducednumber of CD4()CD25regulatoryTcells. Proc Natl Acad Sci USA2005; 102: 5150-5155.
54. Sanchez-Margalet V, Martin-Romero C, Santos-Alvarez C, Goberna R, Najib S, Gonzalez-Yanes C. Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action. Clin Exp Immun 2003; 133: 11-19. (Pubitemid 36791936)
55. Matarese G, Leiter EH, La Cava A. Leptin in autoimmunity: many questions, some answers. Tissue Antigens 2007; 70: 87-95 (Pubitemid 47024837)
56. Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation and hematopoiesis. J Leukoc Biol 2000; 68: 437-446.
57. Palmer G, Gabay C. Arolefor leptin in rheumaticdiseases? Ann Rheum Dis 2003; 62: 913-915.
58. de Rosa V, Procaccini C, CalìG, Pirozzi G, Fontana S, Zappacosta S et al. Akeyroleof leptin inthecontrol of regulatoryTcell proliferation. Immunity 2007; 26: 241-255. (Pubitemid 46329441)
59. Taleb S, Herbin O, Ait-Oufella H, Verreth W, Gourdy P, Barateau V et al. Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosis. Arterioscler Thromb Vasc Biol 2007; 27: 2691-2698. (Pubitemid 350158924)
60. Gualillo O, Eiras S, Lago F, Dieguez C, Casanueva FF. Elevated serum leptin concentrations induced by experimental acute inflammation. Life Sci 2000; 67: 2433-2441
61. Sato T, Laviano A, Meguid MM, Chen C, Rossi-Fanelli F, Hatakeyama K. Involvement of plasma leptin, insulin and freetryptophan in cytokine-induced anorexia. Clin Nutr 2003; 22: 139-146. (Pubitemid 36372457)
62. Firestein GS, Budd RC, Harris ED, McInnes IB, Ruddy S, Sergent JS. Kelley'stextbook of rheumatology. 8th edn. Philadelphia, PA: Saunders, 2009.
63. Harle P, Pangratz G, Weidler C, Büttner R, Schölmerich J, Straub RH. Possible roleof leptin in hypoandrogenicity in patients with SLE and RA. Ann Rheum Dis 2004; 63: 809-816.
64. Vadacca M, Margiotta D, Rigon A, Cacciapaglia F, Coppolino G, Amoroso A et al. Adipokines and systemic lupus erythematosus: relationship with metabolic syndrome and cardiovascular disease riskfactors. J Rheumatol 2009; 36: 295-297
65. Chung CP. Adipocytokines in SLE: relationship to inflammation, insulin resistance andcoronaryatherosclerosis. Lupus 2009; 18: 799-806.
66. Garcia-Gonzalez A, Gonzalez-Lopez L, Valera-Gonzalez IC, Cardona-Muñoz EG, Salazar-Paramo M, González-Ortiz M et al. Serum leptin levels in women with systemic lupuserythematosus. Rheumatol Int 2002; 22: 138-141. (Pubitemid 35002203)
67. Wislowska M, Rok M, Stepien K. Serum leptin inSLE. Rheumatol Int 2008; 28: 467-473.
68. De Sanctis JB, Zabaleta M, Bianco NE, Garmendia J. Serum adipokine levels in patientswith SLE. Autoimmunity 2009: 42: 272-274.
69. Busso N, So A, Chobaz V, Morad C, Martinez-Soria E, Talabot D et al. Leptinsygnaling deficiency impairs humoral and cellular responses and attenuates experimental arthritis. JImmunol 2002; 168: 875-882. (Pubitemid 34049591)
70. Otero M, Lago R, Gomez R, Lago F, Dieguez C, Gomez Rejino JJ et al. Changes in fat derives hormones plasma concentrations: adiponectin, leptin, resistin and visfatinin rheumatoid arthritis subjects. Ann Rheum Dis 2006; 65: 1198-1201. (Pubitemid 44277396)
71. Bokarewa M, Bokarew D, Hultgren O, Tarkowski A. leptinconsumption inthe inflamed joints of patients with RA. Ann Rheum Dis 2003; 62: 952-956. (Pubitemid 37159493)
72. Fraser DA, Thoen J, Reseland JE, Forre O. Decreased CD4 lymphocyteactivation and increased Il-4production inperipheral bloodof RApatientsafteracutestarvation. Clin Rheumatol 1999; 18: 394-401.
73. Young HR, Solus J, Sokka T, Oeser A, Chung CP, Gebretsadik A et al. Adipocytokines areassociatedwithradiographicjointdamagein rheumatoidarthritis. Arthritis Rheum 2009; 60: 1906-1914.
74. Anders HJ, Rihl M, Heufelder A, Loch O, Schattenkirchner M. Leptin serum levelsare not correlated with disease activity in patients with rheumatoid arthritis. Metabolism 1999;48:745-748. (Pubitemid 29277646)
75. Targonska-Stepniak B, Majdan M, Dryglewska M. Leptin serum levels in rheumatoid arthritis patients: relationtodiseasedurationandactivity. Rheumatol Int 2008; 28: 585-591. (Pubitemid 351422621)
76. Gomez R, Lago F, Gomez-Reino D, Dieguez C, Gualillo O. Adipokines intheskeleton: influence on cartilage function and joint degenerative diseases. J Mol Endocrinology 2009; 43: 11-18.
77. Vadacca M, Arcarese L, Taccone A, Rigon A, Buzzulini F, Fiori E et al. Circulating leptin, bone metabolism and inflammation in rheumatic diseases. Ann Rheum Dis 2010; 69(Suppl3): 521.
78. Saeki H, Shibata S, Tada Y, Karakawa M, Minatani Y, Tamaki K. Psoriasis arthropathica associated with severe obesity showing high serum leptin level. J Dermatol 2009; 36: 364-366.
79. Park MC, Chung SJ, Park YB, Lee SK. Pro-inflammatoryeffectof leptinon peripheral blood mononuclear cells of patients with ankylosing spondylitis. Joint Bone Spine 2009; 76: 170-175.
80. Toussirot E, Streit G, Nguyen NU, Dumoulin G, Le Huédé G, Saas P et al. Adipose tissue, serum adipokines, and ghrelin in patients with ankylosing spondylitis. Metabolism 2007; 56:1383-1389. (Pubitemid 47404601)
81. Matarese G, Di Giacomo A, Sanna V, Lord GM, Koward JK, Di Tuoro A et al. Requirement for leptin in the induction and progression of acute encephalomyelitis. J Immunol 2001; 166: 5909-5916. (Pubitemid 32440714)
82. Sanna V, Di Giacomo A, La Cava A, Lechler RI, Fontana S, Zappacosta S et al. Leptin surge precede onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell response. J Clin Invest 2003; 111: 241-250. (Pubitemid 36105923)
83. Matarese G, Procaccini C, de Rosa V. The intricate interface between immune and metabolicregulation: a rolefor leptin inthepathogenesisof multiplesclerosis? JLeuk Biol 2008; 84: 893-899.
84. Batocchi AP, Rotondi M, Caggiula M, Frisullo G, Odoardi F, Nociti V et al. Leptin asa marker of multiple sclerosis activity in patients treated with interferon. J. Neuroimmunol 2003; 139: 150-154. (Pubitemid 36700419)
85. Vadacca M, Margiotta D, Buzzulini F, Sambataro G, Vernuccio A, Afeltra A. Leptin levels in patients with Sjogren's syndrome and systemic lupus erythematosus: relationship with metabolic syndrome and cardiovascular disease risk factors. Proceedings ofthe 7th International Congress on Autoimmunity; 2010 May 5-9; Lubijana, Slovenia.
86. Kotulska A, Kucharz EJ, Brzezińska-Wciso L, Wadas U. A decreased serum leptin level in patientswith systemic sclerosis. Clin Rheumatol 2001; 20: 300-302. (Pubitemid 32776482)
87. Kreiner F, Galbo H. Insulin sensitivity and related cytokines, chemokines, and adipokines in polymyalgia rheumatica. Scand J Rheumatol 2010; 39: 402-408.
88. Siegmund B, Lear-Kaul KC, Faggioni R, Fantuzzi G. Leptin deficiency, not obesity, protects mice from Con A-induced hepatitis. Eur J Immunol 2002: 32: 552-560. (Pubitemid 34173346)
89. Siegmund B, Sennello J, Jones-Carson J, Gamboni-Robertson F, Lehr HA, Batra A et al. Leptin receptor expression on T lymphocytes modulates chronic intestinal inflammation in mice. Gut 2004; 53: 965.
90. Matarese G, Sanna V, Lecher RI, Sarvetinik N, Fontana S, Zappacosta S et al. Leptin accelerates autoimmune diabetes in female NOD mice. Diabetes 2002; 51: 1356-1361. (Pubitemid 34826599)
91. Lee CH, Chen YG, Chen J, Reifsnyder PC, Serreze DV, Clare-Sakzker M et al. Novel leptin receptormutation in NOD/LtJ micesuppressestype 1 diabetes progression: II. Immunologic analysis. Diabetes 2006; 55: 171-178. (Pubitemid 43343312)
92. Tarzi RM, Cook HT, Jackson I, Pusey CD, Lord GM. Leptin- deficientmiceareprotected from accelerated nephrotoxic nephritis. Am J Pathol 2004: 164: 385-390.
93. Kim HA, Choi GS, Jeon JY, Yoon JM, Sung JM, Suh CH. Leptin and ghrelin in Korean systemic lupus erythematosus. Lupus 2010; 19: 170-174.