Facile synthesis, vasorelaxant properties and molecular modeling studies of 2-amino-8a-methoxy-4H-pyrano[3,2-c]pyridine-3-carbonitriles

European Journal of Medicinal Chemistry

Volumn 46, Issue 6, 2011, Pages 2397-2407

  Girgis, Adel S ^a   Ismail, Nasser S M ^b   Farag, Hanaa ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b Ain Shams University   (Egypt)

Author keywords

4 Piperidones; 4H Pyrano 3,2 c pyridine 3 carbonitriles; Molecular modeling; Vasodilation; Ylidenemalononitriles

Indexed keywords

2 AMINO 4 (4 CHLOROPHENYL) 4A,5,6,7,8,8A HEXAHYDRO 8A METHOXY 6 METHYL 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 4 (4 CHLOROPHENYL) 6 ETHYL 4A,5,6,7,8,8A HEXAHYDRO 8A METHOXY 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 4 (4 FLUOROPHENYL) 4A,5,6,7,8,8A HEXAHYDRO 8A METHOXY 6 METHYL 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 4A,5,6,7,8,8A HEXAHYDRO 8A METHOXY 4 (4 METHOXYPHENYL) 6 METHYL 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 4A,5,6,7,8,8A HEXAHYDRO 8A METHOXY 6 METHYL 4 (2 THIENYL) 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 4A,5,6,7,8,8A HEXAHYDRO 8A METHOXY 6 METHYL 4 (4 METHYLPHENYL) 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 4A,5,6,7,8,8A HEXAHYDRO 8A METHOXY 6 METHYL 4 [4 (1 PIPERIDINYL)PHENYL] 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 4A,5,6,7,8,8A HEXAHYDRO 8A METHOXY 6 METHYL 4 [4 (4 MORPHOLINYL)PHENYL] 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 4A,5,6,7,8,8A HEXAHYDRO 8A METHOXY 6 METHYL 4 PHENYL 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 6 ETHYL 4A,5,6,7,8,8A HEXAHYDRO 8A METHOXY 4 (2 THIENYL) 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 6 ETHYL 4A,5,6,7,8,8A HEXAHYDRO 8A METHOXY 4 (4 METHOXYPHENYL) 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 6 ETHYL 4A,5,6,7,8,8A HEXAHYDRO 8A METHOXY 4 [4 (1 PIPERIDINYL)PHENYL] 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 6 ETHYL 4A,5,6,7,8,8A HEXAHYDRO 8A METHOXY 4 [4 (4 MORPHOLINYL)PHENYL] 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 6 ETHYL 4A,5,6,7,8,8A HEXAHYDRO 8A METHOXY 4 PHENYL 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; 2 AMINO 8A METHOXY 4H PYRANO[3,2 C]PYRIDINE 3 CARBONITRILE; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; NORADRENALIN; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG FORMULATION; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; MALE; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; RAT; THORACIC AORTA; VASODILATATION;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRANS; PYRIDINES; RATS; RATS, WISTAR; STEREOISOMERISM; VASODILATION; VASODILATOR AGENTS;

EID: 79955577689     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.03.023     Document Type: Article

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